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Review

Hematological manifestations and complications of Gaucher disease

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References

  • Papers of special note have been highlighted as:
  • • of interest
  • •• of considerable interest
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•Emphasizes the importance of early diagnosis in type 1 Gaucher disease, to prevent the onset of irreversible complications

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•• Represents an international consensus on recommendations for diagnosis and treatment of hematological complications in Gaucher disease

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• Points out the different hemostatic mechanisms involved in bleeding diathesis in Gaucher disease

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•• Based on data from 2742 patients enrolled in the Gaucher Registry, suggests that, in general, patients are not at highly increased risk of cancer, other than multiple myeloma

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•• Highlights the association between Gaucher disease and malignancies, in particular monoclonal gammopathy

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•• Analyzes the possible pathogenetic mechanisms of oncogenesis due to the accumulation of sphingolipids

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