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Review

Sticky platelet syndrome: an important cause of life-threatening thrombotic complications

Peter KubiszNational Center of Hemostasis and Thrombosis, Clinic of Hematology and Transfusiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin University Hospital, Martin, Slovak Republic
,
Lucia StanciakovaNational Center of Hemostasis and Thrombosis, Clinic of Hematology and Transfusiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin University Hospital, Martin, Slovak RepublicCorrespondence[email protected]
,
Jan StaskoNational Center of Hemostasis and Thrombosis, Clinic of Hematology and Transfusiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin University Hospital, Martin, Slovak Republic
,
Miroslava DobrotovaNational Center of Hemostasis and Thrombosis, Clinic of Hematology and Transfusiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin University Hospital, Martin, Slovak Republic
,
Maria SkerenovaDepartment of Clinical Biochemistry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin University Hospital, Martin, Slovak Republic
,
Jela IvankovaNational Center of Hemostasis and Thrombosis, Clinic of Hematology and Transfusiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin University Hospital, Martin, Slovak Republic
&
Pavol HollyNational Center of Hemostasis and Thrombosis, Clinic of Hematology and Transfusiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin University Hospital, Martin, Slovak Republic
 show all
Pages 21-35 | Published online: 09 Dec 2015

References

•• Study of patients with transient ischemic attack or cerebral infarction showing in vitro spontaneous platelet aggregation pointed out to the platelet defect as the possible cause of these thrombotic events. It also proved the efficacy of acetylsalicylic acid alone

  • Al-Mefty O, Marano G, Rajaraman S, et al. Transient ischemic attacks due to increased platelet aggregation and adhesiveness. Ultrastructural and function correlation. J Neurosurg. 1979;50:449–453.

•• Report of 22 cases of transient ischemic attack without any well-known risk factor for this ischemic complication. The only abnormality was the excessive platelet adhesiveness and/or platelet aggregation. The consequence of the discontinuation of the successful antiplatelet treatment led to the repeated occurrence of transient ischemic attack and an increase in platelet aggregability and adhesiveness

  • Holliday PL, Mammen E, Gilroy J. Sticky platelet syndrome and cerebral infarction in young adults. Presented at the Ninth International Joint Conference on Stroke and Cerebral Circulation; 1983; Phoenix, Arizona. [Abstract] Phoenix, Arizona 1983;(suppl).

•• At 9th International Conference of Stroke and Cerebral Circulation in Arizona in 1983, the first use of the “term “sticky platelet syndrome” to entitle the platelet hyperaggregability after the use of low doses of epinephrine and/or adenosine diphosphate

•• The summary of 10 years’experiences with sticky platelet syndrome from its initial key study report of a 24-year-old woman who overcame acute myocardial infarction in the seventh month of pregnancy. Although positive family history and laboratory finding of her increased platelet aggregability in response to adenosine diphosphate and epinephrine were present, she had no prothrombotic risk factors and no organic lesion of coronary arteries

  • Frenkel EP, Mammen EF. Sticky platelet syndrome and thrombocythemia. Hematol Oncol Clin N Am. 2003;17:63–83.
  • Rubenfire M, Blevins RD, Barnhart M, et al. Platelet hyperaggregability in patients with chest pain and angiographically normal coronary arteries. Am J Cardiol. 1986;57(8):657–660.
  • Mammen EF, Barnhart MI, Selik NR, et al. “Sticky platelet syndrome”: a congenital platelet abnormality predisposing to thrombosis? Folia Haematol. 1988;115(3):361–365.
  • O´Brien J. Platelet aggregation: Part II Some results from a new method of study. J Clin Pathol. 1962;15(5):452–455.
  • Bick RL. Sticky platelet syndrome: a common cause of unexplained arterial and venous thrombosis. Clin Appl Thromb/Hemost. 1998;4(2):77–81.

•• Two publications providing clearly defined and internationally accepted clinical and laboratory criteria, as well as the classification of the syndrome into three main types, its epidemiology, clinical manifestation and treatment options

  • Šimonová R, Bartosová L, Chudy P, et al. Nine kindreds of familial sticky platelet syndrome phenotype. Clin Appl Thromb Hemost. 2013;19(4):395–401. DOI:10.4081/hr.2014.5326.
  • Kubisz P, Ruiz-Argüelles GJ, Stasko J, et al. Sticky platelet syndrome: history and future perspectives. Semin Thromb Hemost. 2014;40(5):526–534. DOI:10.1055/s-0034-1381235.

•• Review of the two main investigators and their research teams, who made greater steps in the elucidation of the etiopathogenesis of the syndrome. It represents a summary providing an overview on sticky platelet syndrome from the history of discovery of the syndrome, the current state of knowledge to the unresolved issues and the possible trends of future research

  • Kubisz P, Stasko J, Holly P. Sticky platelet syndrome. Semin Thromb Hemost. 2013;39(6):674–683. DOI:10.1055/s-0033-1353394.
  • Kubisz P, Kotuličová D, Chudý P, et al. Sticky platelet syndrome in a patient with transitory ischemic attack and the family. A case report. Rev Hematol Mex. 2011;12(2):99–104.
  • Bick RL. Hereditary and acquired thrombophilic disorders. Clin Appl Thromb/Hemost. 2006;12(2):125–135.
  • Bick RL, Fareed J. Sticky platelet syndrome: the clinical spectrum of thrombosis. Blood (ASH Annual Meeting Abstracts). 2005;106(11). Abstract 4138.
  • Vasil’ev SA, Vinogradov VL, Gemdzhian ÉG, et al. Experience with outpatient treatment for thromboses and thrombophilias. Ter Arkh. 2013;85(12):47–50.
  • Bick RL, Hoppensteadt D. Recurrent miscarriage syndrome and infertility due to blood coagulation protein/platelet defects: a review and update. Clin Appl Thromb Hemost. 2005;11(1):1–13.
  • Ruiz-Argüelles GJ, López-Martínez B, Cruz-Cruz D, et al. Primary thrombophilia in Mexico III: a prospective study of the sticky platelet syndrome. Clin Appl Thromb Hemost. 2002;8(3):273–277.
  • Ruiz-Argüelles GJ, López-Martínez B, Valdés-Tapia P, et al. Primary thrombophilia in Mexico. V. A comprehensive prospective study indicates that most cases are multifactorial. Am J Hematol. 2005;78(1):21–26.
  • Ruiz-Argüelles GJ, Ruiz-Delgado GJ. Trombofilia. In: Ruiz-Argüelles GJ, Ruiz-Delgado GJ, editors. Fundamentos de Hematología. 5th ed. Ciudad de México: Editorial Médicsa Panamericana; 2014. p. 287–296.
  • Andersen JA. Report: bleeding and thrombosis in women. Biomed Progress. 1999;12:40.
  • Tekgündüz E, Demir M, Akyol Erikçi A, et al. Sticky platelet syndrome in patients with uninduced venous thrombosis. Turk J Haematol. 2013;30(1):48–52. DOI:10.5152/tjh.2011.79.
  • Ruiz-Argüelles GJ, González-Carrillo ML, Estrada-Gómez R, et al. Primary thrombophilia in México. VI: lack of statistical association among the inherited thrombophilic conditions. Gac Med Mex. 2007;143(4):317–322.
  • Chaturvedi S, Dzieczkowski J. Multiple hemostatic abnormalities in young adults with activated protein C resistance and cerebral ischemia. J Neurol Sci. 1998;159(2):209–212.
  • Chaturvedi S, Dzieczkowski JS. Protein S deficiency, activated protein C resistance and sticky platelet syndrome in a young woman with bilateral strokes. Cerebrovasc Dis. 1999;9(2):127–130.
  • Lewerenz V, Burchardt T, Büchau A, et al. Livedoid vasculopathy with heterozygous factor V Leiden mutation and sticky platelet syndrome. Hautarzt. 2004;55(4):379–381.
  • Fodor M, Facskó A, Berényi E, et al. Transient visual loss triggered by scuba diving in a patient with a petrous epidermoid and combined thrombotic risk factors. Pathophysiol Haemost Thromb. 2007;36(6):311–314. DOI:10.1159/000297738.
  • Bojalian MO, Akingba AG, Andersen JC, et al. Sticky platelet syndrome: an unusual presentation of arterial ischemia. Ann Vasc Surg. 2010;24(5):691.e1–6. DOI:10.1016/j.avsg.2009.12.005.
  • Moncada B, Ruiz-Arguelles GJ, Martinez C, et al. Laboratory work in primary thrombophilia should be extensive. J Invest Dermatol. 2015;135:S28–S48. DOI:10.1038/jid.2015.69.
  • Kubisz P, Musial J, Staško J, et al. Sticky platelet syndrome (SPS) and platelet glycoprotein polymorphisms. XXIst congress of the international society on thrombosis and haemostasis, Geneva, 6-12 July 2007. J Thromb Haemost. 2007;5(Suppl 2):15.
  • Tripodi A. Laboratory diagnosis of thrombophilic states: where do we stand? Pathophysiol Haemost Thromb. 2002;32(5–6):245–248.
  • Sinzinger H, Samuelsson B, Sir Vane JR, et al. Recent advances in prostaglandin, thromboxane, and leukotriene research. New York: Springer Science & Business Media; 2013.
  • Michelson AD, editor. Platelets. 3rd ed. London, UK: Elsevier Inc.; 2013.
  • Born GV. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature. 1962;194:927–929.
  • Breddin HK. Can platelet aggregometry be standardized? Platelets. 2005;16(3–4):151–158.
  • Mammen EF. Sticky platelet syndrome. Semin Thromb Hemost. 1999;25(4):361–365.

•• Two publications providing clearly defined and internationally accepted clinical and laboratory criteria, as well as the classification of the syndrome into three main types, its epidemiology, clinical manifestation and treatment options

  • Harrison P, Mackie I, Mumford A, et al. Guidelines for the laboratory investigation of heritable disorders of platelet function. London, UK: British Society for Haematology; 2011. [cited 2015 Aug 31]; Available from: http://www.bcshguidelines.com/documents/platelet_invest_BCSHf_aug2011.pdf.
  • Kaushansky K, Lichtman MA, Beutler E, et al. Williams hematology. New York: The McGraw-Hill Companies, Inc.; 2010.
  • McKenzie ME, Malinin AI, Bell CR, et al. Aspirin inhibits surface glycoprotein IIb/IIIa, P-selectin, CD63, and CD107a receptor expression on human platelets. Blood Coagul Fibrinolysis. 2003;14(3):249–253.
  • Staško J, Bartošová L, Mýtnik M, et al. Are the platelets activated in sticky platelet syndrome? Thromb Res. 2011;128(1):96–97. DOI:10.1016/j.thromres.2011.02.005.
  • Merono A, Lucena C, López A, et al. Immunohistochemical analysis of beta3 integrin (CD61): expression in pig tissues and human tumors. Histol Histopathol. 2002;17(2):347–352.
  • Calvete JJ. Platelet integrin GPIIb/IIIa: structure-function correlations. An update and lessons from other integrins. Proc Soc Exp Biol Med. 1999;222(1):29–38.
  • Fullard JF. The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis. Curr Pharm Des. 2004;10(14):1567–1576.
  • Feng D, Lindpaintner K, Larson MG, et al. Increased platelet aggregability associated with platelet GPIIIa PlA2 polymorphism: the Framingham Offspring Study. Arterioscler Thromb Vasc Biol. 1999;19(4):1142–1147.
  • Michelson AD, Furman MI, Goldschmidt-Clermont P, et al. Platelet GP IIIa Pl(A) polymorphisms display different sensitivities to agonists. Circulation. 2000;101(9):1013–1018.
  • Zotz RB, Winkelmann BR, Műller C. Association of polymorphisms of platelet membrane integrins aIIbb3 (HPA-1b/PlA2) and a2b1 (a2807TT) with premature myocardial infarction. J Thromb Haemost. 2005;3:1522–1529.
  • Undas A, Brummel K, Musial J, et al. Pl(A2) polymorphism of beta(3) integrins is associated with enhanced thrombin generation and impaired antithrombotic action of aspirin at the site of microvascular injury. Circulation. 2001;104(22):2666–2672.
  • Kubisz P, Ivankov J, Holly P, et al. The glycoprotein IIIa PL(A1/A2) polymorphism–a defect responsible for the sticky platelet syndrome? Clin Appl Thromb Hemost. 2006;12(1):117–119.
  • Ruiz-Argüelles GJ, Garcés-Eisele J, Camacho-Alarcón C, et al. Primary thrombophilia in Mexico IX: the glycoprotein IIIa PLA1/A2 polymorphism is not associated with the sticky platelet syndrome phenotype. Clin Appl Thromb Hemost. 2013;19(6):689–692. DOI:10.1177/1076029612448418.
  • Laurance S, Lemarié CA, Blostein MD. Growth arrest-specific gene 6 (gas6) and vascular hemostasis. Adv Nutr. 2012;3(2):196–203. DOI:10.3945/an.111.001826.
  • Angelillo-Scherrer A, de Frutos P, Aparicio C, et al. Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis. Nat Med. 2001;7(2):215–221.
  • Muñoz X, Obach V, Hurtado B, et al. Association of specific haplotypes of GAS6 gene with stroke. Thromb Haemost. 2007;98(2):406–412.
  • Kubisz P, Bartosová L, Ivanková J, et al. Is Gas6 protein associated with sticky platelet syndrome? Clin Appl Thromb Hemost. 2010;16(6):701–704. DOI:10.1177/1076029609345687.
  • Jambou D, Candito M, Staccini P, et al. AA genotype of single-nucleotide polymorphism c.834+7G>A in GAS6 gene (rs8191974) is not protective for acute myocardial infarction. Int J Lab Hematol. 2013;35(5):e17–20. DOI:10.1111/ijlh.12055.
  • Jiang L, Liu CY, Yang QF, et al. Plasma level of growth arrest-specific 6 (GAS6) protein and genetic variations in the GAS6 gene in patients with acute coronary syndrome. Am J Clin Pathol. 2009;131(5):738–743. DOI:10.1309/AJCP3CX3AUVRBHCF.
  • Sokol J, Biringer K, Skerenova M, et al. Different models of inheritance in selected genes in patients with sticky platelet syndrome and fetal loss. Semin Thromb Hemost. 2015;41(3):330–335. DOI:10.1055/s-0034-1395351.
  • Moroi M, Jung SM. Platelet glycoprotein VI: its structure and function. Thromb Res. 2004;114(4):221–233.
  • Bigalke B, Elvers M, Schönberger T, et al. Platelet and soluble glycoprotein VI - novel applications in diagnosis and therapy. Curr Drug Targets. 2011;12(12):1821–1830.
  • Kotuličová D, Chudý P, Škereňová M, et al. Variability of GP6 gene in patients with sticky platelet syndrome and deep venous thrombosis and/or pulmonary embolism. Blood Coagul Fibrinolysis. 2012;23(6):543–547. DOI:10.1097/MBC.0b013e328355a808.
  • Cole VJ, Staton JM, Eikelboom JW, et al. Collagen platelet receptor polymorphisms integrin alpha2beta1 C807T and GPVI Q317L and risk of ischemic stroke. J Thromb Haemost. 2003;1(5):963–970.
  • Ollikainen E, Mikkelsson J, Perola M, et al. Platelet membrane collagen receptor glycoprotein VI polymorphism is associated with coronary thrombosis and fatal myocardial infarction in middle-aged men. Atherosclerosis. 2004;176(1):95–99.
  • Shaffer JR, Kammerer CM, Dorn J, et al. Polymorphisms in the platelet-specific collagen receptor GP6 are associated with risk of nonfatal myocardial infarction in Caucasians. Nutr Metab Cardiovasc Dis. 2011;21(8):546–552. DOI:10.1016/j.numecd.2009.12.002.
  • Johnson AD, Yanek LR, Chen MH, et al. Genome-wide metaanalyses identifies seven loci associated with platelet aggregation in response to agonists. Nat Genet. 2010;42(7):608–613.
  • Austin H, De Staercke C, Lally C, et al. New gene variants associated with venous thrombosis: a replication study in White and Black Americans. J Thromb Haemost. 2011;9(3):489–495. DOI:10.1111/j.1538-7836.2011.04185.x.
  • El-Galaly TC, Severinsen MT, Overvad K, et al. Single nucleotide polymorphisms and the risk of venous thrombosis: results from a Danish case-cohort study. Br J Haematol. 2013;160(6):838–841. DOI:10.1111/bjh.12132.
  • Trégouët DA, Heath S, Saut N, et al. Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach. Blood. 2009;113(21):5298–5303. DOI:10.1182/blood-2008-11-190389.
  • Bezemer ID, Bare LA, Doggen CJ, et al. Gene variants associated with deep vein thrombosis. Jama. 2008;299(11):1306–1314. DOI:10.1001/jama.299.11.1306.
  • Kubisz P, Ivanková J, Škereňová M, et al. The prevalence of the platelet glycoprotein VI polymorphisms in patients with sticky platelet syndrome and ischemic stroke. Hematology. 2012;17(6):355–362. DOI:10.1016/j.numecd.2009.12.002.
  • Sokol J, Biringer K, Skerenova M, et al. Platelet aggregation abnormalities in patients with fetal losses: the GP6 gene polymorphism. Fertil Steril. 2012;98(5):1170–1174. DOI:10.1016/j.fertnstert.2012.07.1108.
  • Kritzik M, Savage B, Nugent DJ, et al. Nucleotide polymorphisms in the alpha2 gene define multiple alleles that are associated with differences in platelet alpha2 beta1 density. Blood. 1998;92(7):2382–2388.
  • Nanda N, Bao M, Lin H, et al. Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation. J Biol Chem. 2005;280(26):24680–24689.
  • Faraday N, Yanek LR, Yang XP, et al. Identification of a specific intronic PEAR1 gene variant associated with greater platelet aggregability and protein expression. Blood. 2011;118(12):3367–3375. DOI:10.1182/blood-2010-11-320788.
  • Ferreiro JL, Gómez-Hospital JA, Angiolillo DJ. Platelet abnormalities in diabetes mellitus. Diab Vasc Dis Res. 2010;7(4):251–259.
  • Yagmur E, Frank RD, Neulen J, et al. Platelet hyperaggregability is highly prevalent in patients with chronic kidney disease: an underestimated risk indicator of thromboembolic events. Clin Appl Thromb Hemost. 2015;21(2):132–138. DOI:10.1177/1076029613490828.
  • Surtees PG, Wainwright NW, Luben RN, et al. Physiological distress, major depressive disorders and risk of stroke. Neurology. 2008;70(10):788–794. DOI:10.1212/01.wnl.0000304109.18563.81.
  • Bick RL, Rice J. Long-term outpatient dalteparin (fragmin) therapy for arterial and venous thrombosis: efficacy and safety–a preliminary report. Clin Appl Thromb Hemost. 1999;5(Suppl 1):S67–71.
  • Berg-Dammer E, Henkes H, Trobisch H, et al. Sticky platelet syndrome: a cause of neurovascular thrombosis and thrombo-embolism. Interv Neuroradiol. 1997;3(2):145–154.
  • Hayes C, Kitahara S, Tcherniantchouk O. Decreased threshold of aggregation to low-dose epinephrine is evidence of platelet hyperaggregability in patients with thrombosis. Hematol Rep. 2014;6(3):5326. DOI:10.4081/hr.2014.5326.
  • Randhawa S, Van Stavern GP. Sticky platelet syndrome and anterior ischaemic optic neuropathy. Clin Experiment Ophthalmol. 2007;35(8):779–781.
  • Mears KA, Van Stavern GP. Bilateral simultaneous anterior ischaemic optic neuropathy associated with sticky platelet syndrome. Br J Ophthalmol. 2009;93(7):885–86, 913. DOI:10.1136/bjo.2008.142919.
  • Alexandra AO, Drenser KA. Hypercoagulable state in a patient with a retinal vein occlusion. Retin Cases Brief Rep. 2011;5(1):76–78. DOI:10.1097/ICB.0b013e3181bcf1cd.
  • Sand M, Mann B, Bechara FG, et al. Sticky platelet syndrome type II presenting with arterial microemboli in the fingers. Thromb Res. 2009;124(2):244. DOI:10.1016/j.thromres.2008.08.025.
  • Loeffelbein DJ, Baumann CM, Mücke T, et al. Sticky platelet syndrome as a possible cause for free flap failure–a case report. Microsurgery. 2010;30(6):466–468. DOI:10.1002/micr.20765.
  • Bick RL. Recurrent miscarriage syndrome due to blood coagulation protein/platelet defects: prevalence, treatment and outcome results. DRW metroplex recurrent miscarriage syndrome cooperative group. Clin Appl Thromb Hemost. 2000;6(3):115–125.
  • Rac MW, Minns Crawford N, Worley KC. Extensive thrombosis and first-trimester pregnancy loss caused by sticky platelet syndrome. Obstet Gynecol. 2011;117(2 Pt 2):501–503. DOI:10.1097/AOG.0b013e318206bde4.
  • Dalkara T, Nozari A, Moskowitz MA. Migraine aura pathophysiology: the role of blood vessels and microembolisation. Lancet Neurol. 2010;9(3):309–317. DOI:10.1016/S1474-4422(09)70358-8.
  • Linder SL. Sticky platelet syndrome in adolescent migraine with aura. Cephalalgia. 2001;21:459.
  • Moncada B, Castillo-Martínez C, Ruiz-Argüelles GJ, et al. Sticky platelets syndrome: a frequent cause of primary thrombophilia. J Invest Dermatol. 2013;133(Suppl 1):S180.
  • Mühlfeld AS, Ketteler M, Schwamborn K, et al. Sticky platelet syndrome: an underrecognized cause of graft dysfunction and thromboembolic complications in renal transplant recipients. Am J Transplant. 2007;7(7):1865–1868.
  • El-Amm JM, Andersen J, Gruber SA. Sticky platelet syndrome: a manageable risk factor for posttransplant thromboembolic events. Am J Transplant. 2008;8(2):465.
  • Patrono C. The multifaceted clinical readouts of platelet inhibition by low-dose aspirin. J Am Coll Cardiol. 2015;66(1):74–85. DOI:10.1016/j.jacc.2015.05.012.
  • Sahay T, Faraz H, Haggood AS, et al. “Sticky platelet syndrome”: in vitro response to small dose aspirin is reflected in clinical benefit. Blood (ASH Annual Meeting Abstracts). 2007;110(11, Part 1):943A. Abstract 3212.
  • Lev EI, Solodky A, Harel N, et al. Treatment of aspirin-resistant patients with omega-3 fatty acids versus aspirin dose escalation. J Am Coll Cardiol. 2010;55(2):114–121. DOI:10.1016/j.jacc.2009.08.039.
  • Chittoor Elsehety AE, Roberts GF, Laughlin WR. Sticky platelet syndrome: a case report and review of the literature. Clin Appl Thromb Hemost. 1998;4:280–284.
  • Alsheekh AA, Puggioni A, Hingorani AP, et al. The sticky platelet syndrome during carotid endarterectomy. Ann Vasc Surg, 2015 May 30; DOI:10.1016/j.avsg.2015.02.022. [Epub ahead of print]
  • Kahles H, Trobisch H, Kehren H. Disseminated coronary occlusions and massive pulmonary embolism in a 40-year-old woman. Dtsch Med Wochenschr. 2006;131(13):672–675.
  • Velázquez-Sánchez-de-Cima S, Zamora-Ortiz G, Hernández-Reyes J, et al. Primary thrombophilia in México X: a prospective study of the treatment of the sticky platelet syndrome. Clin Appl Thromb Hemost. 2015;21(1):91–95. DOI:10.1177/1076029613501543.

•• The first prospective study of the treatment of sticky platelet syndrome providing the most extensive experience with antiplatelet therapy. Aspirin and clopidogrel were proved to be safe and effective therapeutic options

  • Kannan S. Recurrent arterial thrombosis in a young male: sticky platelet syndrome. Internet J Hematol. 2008;4(1):4. DOI:10.5580/d76.
  • Savi P, Herbert JM. Clopidogrel and ticlopidine: P2Y12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis. Semin Thromb Hemost. 2005;31(2):174–183.
  • Gehoff A, Kluge JG, Gehoff P, et al. Recurrent strokes under anticoagulation therapy: sticky platelet syndrome combined with a patent foramen ovale. J Cardiovasc Dis Res. 2011;2(1):68–70. DOI:10.4103/0975-3583.78600.

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