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Expert Review of Hematology Volume 9, 2016 - Issue 2
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Review

Modulation of hepcidin to treat iron deregulation: potential clinical applications

Nicole L. BlanchetteDepartment of Molecular Biology and Biophysics, University of Connecticut Health, Farmington, CT, USA
,
David H. ManzDepartment of Molecular Biology and Biophysics, University of Connecticut Health, Farmington, CT, USA;School of Dental Medicine, University of Connecticut Health, Farmington, CT, USA
,
Frank M. TortiDepartment of Medicine, University of Connecticut Health, Farmington, CT, USA
&
Suzy V. TortiDepartment of Molecular Biology and Biophysics, University of Connecticut Health, Farmington, CT, USACorrespondence[email protected]
Pages 169-186 | Received 01 Oct 2015, Accepted 23 Nov 2015, Published online: 15 Dec 2015

References

  • Papers of special note have been highlighted as:
  • • of interest
  • •• of considerable interest
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• This study serendipitously identified hepcidin as a critical regulator of iron homeostasis.

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•• This study identified ferroportin as the target of hepcidin.

• This article highlights the sites of ferroportin expression and its role in maintaining iron homeostasis in vivo.

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•• This article identified erythroferrone as a key erythroid factor that controls iron homeostasis by suppressing hepcidin during stress erythropoiesis.

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• This study demonstrated that IL-6 is responsible for induction of hepcidin by inflammation.

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•• This study highlights a key role for BMP6 in regulation of hepcidin and iron metabolism in vivo.

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•• This study demonstrated that hemojuvelin, a gene mutated in juvenile hemochromatosis, encodes a BMP coreceptor and is involved in hepcidin regulation.

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