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Drug Profile

Topotecan in the treatment of ovarian cancer

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Pages 149-158 | Published online: 10 Jan 2014

References

  • Holschneider CH, Berek JS. Ovarian cancer: epidemiology, biology, and prognostic factors. Semin. Surg. Oncol.19, 3–10 (2000).
  • Ozols RF, Bundy BN, Greer BE et al. Phase III trial of carboplatin and paclitaxel compared with cisplatin and paclitaxel in patients with optimally resected stage III ovarian cancer: a Gynecologic Oncology Group study. J. Clin. Oncol.21, 3194–3200 (2003).
  • du Bois A, Luck HJ, Meier W et al. A randomized clinical trial of cisplatin/paclitaxel versus carboplatin/paclitaxel as first-line treatment of ovarian cancer. J. Natl Cancer Inst.95, 1320–1329 (2003).
  • McGuire WP, Hoskins WJ, Brady MF et al. Cyclophosphamide and cisplatin compared with paclitaxel and cisplatin in patients with stage III and stage IV ovarian cancer. N. Engl. J. Med.334, 1–6 (1996).
  • Piccart MJ, Bertelsen K, James K et al. Randomized intergroup trial of cisplatin–paclitaxel versus cisplatin–cyclophosphamide in women with advanced epithelial ovarian cancer: three-year results. J. Natl Cancer Inst.92, 699–708 (2000).
  • Armstrong DK, Bundy B, Wenzel L et al. Intraperitoneal cisplatin and paclitaxel in ovarian cancer. N. Engl. J. Med.354, 34–43 (2006).
  • Ozols RF. Update of the NCCN ovarian cancer practice guidelines. Oncology (Williston Park)11, 95–105 (1997).
  • Eisenhauer EA, Vermorken JB, van Glabbeke M. Predictors of response to subsequent chemotherapy in platinum pretreated ovarian cancer: a multivariate analysis of 704 patients. Ann. Oncol.8, 963–968 (1997).
  • Markman M, Webster K, Zanotti K et al. Phase 2 trial of single-agent gemcitabine in platinum-paclitaxel refractory ovarian cancer. Gynecol. Oncol.90, 593–596 (2003).
  • Gordon AN, Granai CO, Rose PG et al. Phase II study of liposomal doxorubicin in platinum- and paclitaxel-refractory epithelial ovarian cancer. J. Clin. Oncol.18, 3093–3100 (2000).
  • Gordon AN, Fleagle JT, Guthrie D et al. Recurrent epithelial ovarian carcinoma: a randomized Phase III study of pegylated liposomal doxorubicin versus topotecan. J. Clin. Oncol.19, 3312–3322 (2001).
  • Rose PG, Blessing JA, Mayer AR, Homesley HD. Prolonged oral etoposide as second-line therapy for platinum-resistant and platinum-sensitive ovarian carcinoma: a Gynecologic Oncology Group study. J. Clin. Oncol.16, 405–410 (1998).
  • Keldsen N, Havsteen H, Vergote I, Bertelsen K, Jakobsen A. Altretamine (hexamethylmelamine) in the treatment of platinum-resistant ovarian cancer: a Phase II study. Gynecol. Oncol.88, 118–122 (2003).
  • Sorensen P, Hoyer M, Jakobsen A et al. Phase II study of vinorelbine in the treatment of platinum-resistant ovarian carcinoma. Gynecol. Oncol.81, 58–62 (2001).
  • Slichenmyer WJ, Rowinsky EK, Donehower RC, Kaufmann SH. The current status of camptothecin analogues as antitumor agents. J. Natl Cancer Inst.85, 271–291 (1993).
  • Pratesi G, Tortoreto M, Corti C, Giardini R, Zunino F. Successful local regional therapy with topotecan of intraperitoneally growing human ovarian carcinoma xenografts. Br. J. Cancer71, 525–528 (1995).
  • Burris HA III, Hanauske AR, Johnson RK et al. Activity of topotecan, a new topoisomerase I inhibitor, against human tumor colony-forming units in vitro. J. Natl Cancer Inst.84, 1816–1820 (1992).
  • Houghton PJ, Cheshire PJ, Myers L et al. Evaluation of 9-dimethylaminomethyl-10-hydroxycamptothecin against xenografts derived from adult and childhood solid tumors. Cancer Chemother. Pharmacol.31, 229–239 (1992).
  • Creemers GJ, Lund B, Verweij J. Topoisomerase I inhibitors: topotecan and irenotecan. Cancer Treat. Rev.20, 73–96 (1994).
  • Rowinsky EK, Grochow LB, Hendricks CB et al. Phase I and pharmacologic study of topotecan: a novel topoisomerase I inhibitor. J. Clin. Oncol.10, 647–656 (1992).
  • Saltz L, Sirott M, Young C et al. Phase I clinical and pharmacology study of topotecan given daily for 5 consecutive days to patients with advanced solid tumors, with attempt at dose intensification using recombinant granulocyte colony-stimulating factor. J. Natl Cancer Inst.85, 1499–1507 (1993).
  • Verweij J, Lund B, Beijnen J et al. Phase I and pharmacokinetics study of topotecan, a new topoisomerase I inhibitor. Ann. Oncol.4, 673–678 (1993).
  • Creemers GJ, Bolis G, Gore M et al. Topotecan, an active drug in the second-line treatment of epithelial ovarian cancer: results of a large European Phase II study. J. Clin. Oncol.14, 3056–3061 (1996).
  • Kudelka AP, Tresukosol D, Edwards CL et al. Phase II study of intravenous topotecan as a 5-day infusion for refractory epithelial ovarian carcinoma. J. Clin. Oncol.14, 1552–1557 (1996).
  • Swisher EM, Mutch DG, Rader JS, Elbendary A, Herzog TJ. Topotecan in platinum- and paclitaxel-resistant ovarian cancer. Gynecol. Oncol.66, 480–486 (1997).
  • Bookman MA, Malmstrom H, Bolis G et al. Topotecan for the treatment of advanced epithelial ovarian cancer: an open-label Phase II study in patients treated after prior chemotherapy that contained cisplatin or carboplatin and paclitaxel. J. Clin. Oncol.16, 3345–3352 (1998).
  • McGuire WP, Blessing JA, Bookman MA, Lentz SS, Dunton CJ. Topotecan has substantial antitumor activity as first-line salvage therapy in platinum-sensitive epithelial ovarian carcinoma: a Gynecologic Oncology Group Study. J. Clin. Oncol.18, 1062–1067 (2000).
  • Armstrong DK. Topotecan dosing guidelines in ovarian cancer: reduction and management of hematologic toxicity. Oncologist9, 33–42 (2004).
  • ten Bokkel Huinink W, Gore M, Carmichael J et al. Topotecan versus paclitaxel for the treatment of recurrent epithelial ovarian cancer. J. Clin. Oncol.15, 2183–2193 (1997).
  • Armstrong D, O’Reilly S. Clinical guidelines for managing topotecan-related hematologic toxicity. Oncologist3, 4–10 (1998).
  • Gore M, ten Bokkel Huinink W, Carmichael J et al. Clinical evidence for topotecan-paclitaxel non-cross-resistance in ovarian cancer. J. Clin. Oncol.19, 1893–1900 (2001).
  • ten Bokkel Huinink W, Lane SR, Ross GA. Long-term survival in a Phase III, randomised study of topotecan versus paclitaxel in advanced epithelial ovarian carcinoma. Ann. Oncol.15, 100–103 (2004).
  • Gordon AN, Tonda M, Sun S, Rackoff W. Long-term survival advantage for women treated with pegylated liposomal doxorubicin compared with topotecan in a Phase 3 randomized study of recurrent and refractory epithelial ovarian cancer. Gynecol. Oncol.95, 1–8 (2004).
  • Meier W, Dubois A, Kuhn, Wet al for the AGO Ovarian Cancer Study Group. Topotecan vs treosulfan in recurrent ovarian cancer (OC) after initial therapy with platinum and paclitaxel. A prospective randomized Phase III study. Proc. Am. Soc. Clin. Oncol.22, 1810 (2003).
  • Hochster H, Wadler S, Runowicz C et al. Activity and pharmacodynamics of 21-day topotecan infusion in patients with ovarian cancer previously treated with platinum-based chemotherapy. New York Gynecologic Oncology Group. J. Clin. Oncol.17, 2553–2561 (1999).
  • Gore M, Rustin G, Schuller J et al. Topotecan given as a 21-day infusion in the treatment of advanced ovarian cancer. Br. J. Cancer84, 1043–1046 (2001).
  • Markman M, Kennedy A, Webster K et al. Phase 2 evaluation of topotecan administered on a 3-day schedule in the treatment of platinum- and paclitaxel-refractory ovarian cancer. Gynecol. Oncol.79, 116–119 (2000).
  • Brown JV III, Peters WA III, Rettenmaier MA et al. Three-consecutive-day topotecan is an active regimen for recurrent epithelial ovarian cancer. Gynecol. Oncol.88, 136–140 (2003).
  • Miller DS, Blessing JA, Lentz SS, McMeekin DS. Phase II evaluation of three-day topotecan in recurrent platinum-sensitive ovarian carcinoma: a gynecologic oncology group study. Cancer98, 1664–1669 (2003).
  • Herzog TJ, Powell MA, Rader JS, Gibb R, Mutch DG. Phase II evaluation of a 3-day infusion of topotecan in patients with recurrent ovarian or primary peritoneal cancer. Gynecol. Oncol.103(2), 637–641 (2006).
  • Rose PG, Gordon NH, Fusco N et al. A Phase II and pharmacokinetic study of weekly 72-h topotecan infusion in patients with platinum-resistant and paclitaxel-resistant ovarian carcinoma. Gynecol. Oncol.78, 228–234 (2000).
  • Hoskins P, Eisenhauer E, Beare S et al. Randomized Phase II study of two schedules of topotecan in previously treated patients with ovarian cancer: a National Cancer Institute of Canada Clinical Trials Group study. J. Clin. Oncol.16, 2233–2237 (1998).
  • Homesley HD, Hall DJ, Martin DA et al. A dose-escalating study of weekly bolus topotecan in previously treated ovarian cancer patients. Gynecol. Oncol.83, 394–399 (2001).
  • Hofstra LS, Bos AM, de Vries EG et al. A Phase I and pharmacokinetic study of intraperitoneal topotecan. Br. J. Cancer85, 1627–1633 (2001).
  • Robertson MD, Malpass TW, McGonigle KD, Weiden PL, Muntz H. Phase II study of intraperitoneal topotecan as consolidative therapy in ovarian cancer. J. Clin. Oncol.22, 5077 (2004).
  • Andreopoulou E, Chen T, Liebes L et al. Phase I/pharmacology study of Intraperitoneal (IP) 3–5 day topotecan alone and with cisplatin on day 1 for consolidation in ovarian cancer. J. Clin. Oncol.23(16S Pt 1), 5045 (2005).
  • Bos AM, De Vos FY, de Vries EG et al. A Phase I study of intraperitoneal topotecan in combination with intravenous carboplatin and paclitaxel in advanced ovarian cancer. Eur. J. Cancer41, 539–548 (2005).
  • Markman M, Webster K, Zanotti K et al. Phase 2 trial of prolonged administration of oral topotecan in platinum/taxane-refractory ovarian, fallopian tube, and primary peritoneal cancers. Gynecol. Oncol.95, 109–113 (2004).
  • Clarke-Pearson DL, Van Le L, Iveson T, Whitney CW et al. Oral topotecan as single-agent second-line chemotherapy in patients with advanced ovarian cancer. J. Clin. Oncol.19, 3967–3975 (2001).
  • Gore M, Oza A, Rustin G et al. A randomised trial of oral versus intravenous topotecan in patients with relapsed epithelial ovarian cancer. Eur. J. Cancer38, 57–63 (2002).
  • Greggi S, Salerno MG, D’Agostino G et al. Topotecan and gemcitabine in platinum/paclitaxel-resistant ovarian cancer. Oncology60, 19–23 (2001).
  • Sehouli J, Stengel D, Oskay G et al. A Phase II study of topotecan plus gemcitabine in the treatment of patients with relapsed ovarian cancer after failure of first-line chemotherapy. Ann. Oncol.13, 1749–1755 (2002).
  • Verhaar-Langereis M, Karakus A, van Eijkeren M, Voest E, Witteveen E. Phase II study of the combination of pegylated liposomal doxorubicin and topotecan in platinum-resistant ovarian cancer. Int. J. Gynecol. Cancer16, 65–70 (2006).
  • Culine S, Mayeur D, Mayer F et al. Topotecan and paclitaxel in second line treatment of advanced ovarian cancer (AOC): a GINECO Phase II Trial. Proc. Am. Soc. Clin. Oncol.20, 858 (2001).
  • Chiara S, Tognoni A, Pastrone I et al. Topotecan and ifosfamide as salvage treatment in advanced ovarian cancer. Gynecol. Oncol.93, 474–478 (2004).
  • Hanjani P, Nolte S, Shahin MS. Phase II evaluation of 3-day topotecan with cyclophosphamide in the treatment of recurrent ovarian cancer. Gynecol. Oncol.85, 278–284 (2002).
  • Sehouli J, Sommer H, Klare P et al. A randomized multicenter Phase III trial of topotecan monotherapy versus topotecan + etoposide versus topotecan + gemcitabine for second-line treatment of recurrent ovarian cancer. J. Clin. Oncol.24, 5030 (2006).
  • Scarfone G, Scambia G, Raspagliesi F et al. A multicenter, randomized, Phase III study comparing paclitaxel/carboplatin (PC) versus topotecan/paclitaxel/carboplatin (TPC) in patients with stage III (residual tumor > 1 cm after primary surgery) and stage IV ovarian cancer (OC). J. Clin. Oncol.24, 5003 (2006).
  • Bookman MA. GOG0182-ICON5: 5-arm Phase III randomized trial of paclitaxel (P) and carboplatin (C) vs combinations with gemcitabine (G), PEG-liposomal doxorubicin (D), or topotecan (T) in patients with advanced stage epithelial ovarian (EOC) or primary peritoneal (PPC) carcinoma. J. Clin. Oncol.24, 5002 (2006).
  • Pfisterer J, Weber B, Reuss A et al. Randomized Phase III trial of topotecan following carboplatin and paclitaxel in first-line treatment of advanced ovarian cancer: a gynecologic cancer intergroup trial of the AGO-OVAR and GINECO. J. Natl Cancer Inst.98, 1036–1045 (2006).
  • de Placido S, Scambia G, Di Vagno G et al. Topotecan compared with no therapy after response to surgery and carboplatin/paclitaxel in patients with ovarian cancer: Multicenter Italian Trials in Ovarian Cancer (MITO-1) randomized study. J. Clin. Oncol.22, 2635–2642 (2004).
  • Markman M, Liu PY, Wilczynski S et al. Phase III randomized trial of 12 versus 3 months of maintenance paclitaxel in patients with advanced ovarian cancer after complete response to platinum and paclitaxel-based chemotherapy: a Southwest Oncology Group and Gynecologic Oncology Group trial. J. Clin. Oncol.21, 2460–2465 (2003).

Website

  • National Cancer Institute www.cancer.gov/newscenter/pressreleases/IPchemotherapyrelease

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