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Editorial

The great debate: stopping immunomodulators and biologics in Crohn’s disease patients in remission

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Pages 501-503 | Published online: 10 Jan 2014

References

  • Camus M, Seksik P, Bourrier A et al. Long-term outcome of patients with Crohn’s disease who respond to azathioprine. Clin. Gastroenterol. Hepatol. 11(4), 389–394 (2013).
  • Louis E, Mary JY, Vernier-Massouille G et al.; Groupe D’etudes Thérapeutiques Des Affections Inflammatoires Digestives. Maintenance of remission among patients with Crohn’s disease on antimetabolite therapy after infliximab therapy is stopped. Gastroenterology 142(1), 63–70.e5; quiz e31 (2012).
  • Molnár T, Lakatos PL, Farkas K et al. Predictors of relapse in patients with Crohn’s disease in remission after 1 year of biological therapy. Aliment. Pharmacol. Ther. 37(2), 225–233 (2013).
  • Oussalah A, Chevaux JB, Fay R, Sandborn WJ, Bigard MA, Peyrin-Biroulet L. Predictors of infliximab failure after azathioprine withdrawal in Crohn’s disease treated with combination therapy. Am. J. Gastroenterol. 105(5), 1142–1149 (2010).
  • Van Assche G, Magdelaine-Beuzelin C, D’Haens G et al. Withdrawal of immunosuppression in Crohn’s disease treated with scheduled infliximab maintenance: a randomized trial. Gastroenterology 134(7), 1861–1868 (2008).
  • Waugh AW, Garg S, Matic K et al. Maintenance of clinical benefit in Crohn’s disease patients after discontinuation of infliximab: long-term follow-up of a single centre cohort. Aliment. Pharmacol. Ther. 32(9), 1129–1134 (2010).

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