Advanced search
Publication Cover
Expert Review of Gastroenterology & Hepatology Volume 7, 2013 - Issue sup1
Submit an article Journal homepage
244
Views
16
CrossRef citations to date
0
Altmetric
Symposium Paper

Emerging receptor target in the pharmacotherapy of irritable bowel syndrome with constipation

L Ashley Blackshaw Nerve–Gut Research Laboratory, Discipline of Medicine, Faculty of Health Sciences, University of Adelaide, Adelaide, Australia. [email protected]; Department of Gastroenterology and Hepatology, Hanson Institute, Royal Adelaide Hospital, Adelaide, Australia; Neurogastroenterology Group, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark St, London, E1 2AT, UK
&
Stuart M Brierley Nerve–Gut Research Laboratory, Discipline of Medicine, Faculty of Health Sciences, University of Adelaide, Adelaide, Australia; Department of Gastroenterology and Hepatology, Hanson Institute, Royal Adelaide Hospital, Adelaide, Australia; Discipline of Physiology, Faculty of Health Sciences, University of Adelaide, Adelaide, Australia; Nerve–Gut Research Laboratory, Discipline of Medicine, Faculty of Health Sciences, University of Adelaide, Adelaide, Australia; Department of Gastroenterology and Hepatology, Hanson Institute, Royal Adelaide Hospital, Adelaide, Australia; Discipline of Physiology, Faculty of Health Sciences, University of Adelaide, Adelaide, Australia
Pages 15-19 | Published online: 10 Jan 2014

References

  • Brierley SM, Hughes PA, Harrington AM, Blackshaw E. Innervation of the gastrointestinal tract by vagal and spinal afferent nerves. In: Physiology of the Gastrointestinal Tract (5th Edition). Johnson LR, Ghishan FK, Kaunitz JD, Merchant JL (Eds). Academic Press, London, UK, 703–731 (2012).
  • Blackshaw LA. Functional targets for pharmacotherapy – an overview. In: Pathophysiology of the Enteric Nervous System: a Basis for Understanding Functional Diseases. Spiller R, Grundy D (Eds). Wiley-Blackwell, NJ, USA (2004).
  • Brierley SM, Carter R, Jones W, Gebhart GF, Blackshaw LA. Splanchnic and pelvic mechanosensory afferents signal different qualities of colonic stimuli in mice. Gastroenterology 127, 166–178 (2004).
  • Brierley SM, Page AJ, Hughes PA et al. Selective role for TRPV4 ion channels in visceral sensory pathways. Gastroenterology 134(7), 2059–2069 (2008).
  • Hughes PA, Brierley SM, Martin CM, Brookes SJ, Linden DR, Blackshaw LA. Post-inflammatory colonic afferent sensitisation: different subtypes, different pathways and different time courses. Gut 58(10), 1333–1341 (2009).
  • Posserud I, Ersryd A, Simrén M. Functional findings in irritable bowel syndrome. World J. Gastroenterol. 12(18), 2830–2838 (2006).
  • Sinhamahapatra P, Saha SP, Chowdhury A, Chakrabarti SK, Ghosh A, Maiti B. Visceral afferent hypersensitivity in irritable bowel syndrome – evaluation by cerebral evoked potential after rectal stimulation. Am. J. Gastroenterol. 96(7), 2150–2157 (2001).
  • Booth CE, Kirkup AJ, Hicks GA, Humphrey PP, Grundy D. Somatostatin sst(2) receptor-mediated inhibition of mesenteric afferent nerves of the jejunum in the anesthetized rat. Gastroenterology 121(2), 358–369 (2001).
  • Sengupta JN, Su X, Gebhart GF. Kappa, but not mu or delta, opioids attenuate responses to distention of afferent fibers innervating the rat colon. Gastroenterology 111(4), 968–980 (1996).
  • Sengupta JN, Medda BK, Shaker R. Effect of GABA(B) receptor agonist on distension-sensitive pelvic nerve afferent fibers innervating rat colon. Am. J. Physiol. Gastrointest. Liver Physiol. 283(6), G1343–G1351 (2002).
  • Camilleri M. Review article: new receptor targets for medical therapy in irritable bowel syndrome. Aliment. Pharmacol. Ther. 31(1), 35–46 (2010).
  • Eutamene H, Bradesi S, Larauche M et al. Guanylate cyclase C-mediated antinociceptive effects of linaclotide in rodent models of visceral pain. Neurogastroenterol. Motil. 22(3), 312–e84 (2010).
  • Johnston JM, Kurtz CB, Macdougall JE et al. Linaclotide improves abdominal pain and bowel habits in a Phase IIb study of patients with irritable bowel syndrome with constipation. Gastroenterology 139(6), 1877–1886 (2010).
  • Chey WD, Lembo AJ, Lavins BJ et al. Linaclotide for irritable bowel syndrome with constipation: a 26-week, randomized, double-blind, placebo-controlled trial to evaluate efficacy and safety. Am. J. Gastroenterol. 107, 1702–1712 (2012).
  • Rao S, Lembo AJ, Shiff SJ et al. A 12-week, randomized, controlled trial with a 4-week randomized withdrawal period to evaluate the efficacy and safety of linaclotide in irritable bowel syndrome with constipation. Am. J. Gastroenterol. 107, 1714–1724 (2012).
  • Quigley EMM, Tack J, Choi HS et al. Randomised clinical trials: linaclotide Phase studies in IBS-C – a prespecified further analysis based on European Medicines Agency-specified endpoints. Aliment. Pharmacol. Ther. 37(1), 49–61 (2013).
  • Brierley SM. Guanylate cyclase-C receptor activation: unexpected biology. Curr. Opin. Pharmacol. 12(6), 632–640 (2012).
  • Bryant AP, Busby RW, Bartolini WP et al. Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract. Life Sci. 86(19–20), 760–765 (2010).
  • Busby RW, Bryant AP, Bartolini WP et al. Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit. Eur. J. Pharmacol. 649, 328–335 (2010).
  • Castro J, Harrington AM, Hughes PA et al. Mechanism of action for linaclotide induced abdominal pain relief. Gastroenterology 142(Suppl. 5), S699 (2012).
  • Castro J, Harrington AM, Hughes PA et al. Guanylate cyclase C receptor agonists, linaclotide and uroguanylin, modulate intestinal nociception. Neurogastroenterol. Motil. 24(Suppl. 12), 17 (2012).
  • Castro J, Martin C, Hughes PA et al. A novel role of cyclic GMP in colonic sensory neurotransmission in healthy and TNBS-treated mice. Gastroenterology 140(Suppl. 5), S538 (2011).
  • Bueno L, Eutamene H, Gillet M. Effect of oral cyclic GMP on TNBS-induced colitis and visceral hypersensitivity in rats. Am. J. Gastroenterol. 103(S458), Abstract 1175 (2008).
  • Lucas KA, Pitari GM, Kazerounian S et al. Guanylyl cyclases and signaling by cyclic GMP. Pharmacol. Rev. 52(3), 375–414 (2000).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.