Host homeostatic responses to alcohol-induced cellular stress in animal models of alcoholic liver disease

References

• O’Shea RS, Dasarathy S, McCullough AJ. Alcoholic liver disease. Hepatology 2010;51(1):307-28
   PubMed Web of Science ®Google Scholar
• Edmondson HA, Peters RL, Frankel HH, et al. The early stage of liver injury in the alcoholic. Medicine (Baltimore) 1967;46(2):119-29
   PubMed Web of Science ®Google Scholar
• Mathurin P, Beuzin F, Louvet A, et al. Fibrosis progression occurs in a subgroup of heavy drinkers with typical histological features. Aliment Pharmacol Ther 2007;25(9):1047-54
   PubMed Web of Science ®Google Scholar
• Lieber CS, Jones DP, Decarli LM. Effects of prolonged ethanol intake: production of fatty liver despite adequate diets. J Clin Invest 1965;44:1009-21
   PubMed Web of Science ®Google Scholar
• Yoon YH, Chen CM, Yi HY. Liver cirrhosis mortality in the United States: National, State, and Regional Trends, 2000-2011. Surveillance Report 2014;2014:100
   Google Scholar
• Lucey MR, Mathurin P, Morgan TR. Alcoholic hepatitis. N Engl J Med 2009;360(26):2758-69
   PubMed Web of Science ®Google Scholar
• Lieber CS, DeCarli L, Rubin E. Sequential production of fatty liver, hepatitis, and cirrhosis in sub-human primates fed ethanol with adequate diets. Proc Natl Acad Sci USA 1975;72(2):437-41
   PubMed Web of Science ®Google Scholar
• Brandon-Warner E, Schrum LW, Schmidt CM, et al. Rodent models of alcoholic liver disease: of mice and men. Alcohol 2012;46(8):715-25
   PubMed Web of Science ®Google Scholar
• Mathews S, Xu M, Wang H, et al. Animals models of gastrointestinal and liver diseases. Animal models of alcohol-induced liver disease: pathophysiology, translational relevance, and challenges. Am J Physiol Gastrointest Liver Physiol 2014;306(10):G819-23
   PubMed Web of Science ®Google Scholar
• Tsukamoto H, Machida K, Dynnyk A, et al. “Second hit” models of alcoholic liver disease. Semin Liver Dis 2009;29(2):178-87
   PubMed Web of Science ®Google Scholar
• Lieber CS. Metabolism of alcohol. Clin Liver Dis 2005;9(1):1-35
   PubMedGoogle Scholar
• Zhong Z, Ramshesh VK, Rehman H, et al. Acute ethanol causes hepatic mitochondrial depolarization in mice: role of ethanol metabolism. PLoS ONE 2014;9(3):e91308
   PubMedGoogle Scholar
• Lane BP, Lieber CS. Ultrastructural alterations in human hepatocytes following ingestion of ethanol with adequate diets. Am J Pathol 1966;49(4):593-603
   PubMed Web of Science ®Google Scholar
• Bertola A, Park O, Gao B. Chronic plus binge ethanol feeding synergistically induces neutrophil infiltration and liver injury in mice: a critical role for E-selectin. Hepatology 2013;58(5):1814-23
   PubMed Web of Science ®Google Scholar
• Tikhanovich I, Cox J, Weinman SA. Forkhead box class O transcription factors in liver function and disease. J Gastroenterol Hepatol 2013;28(Suppl 1):125-31
   Google Scholar
• McClain CJ, Barve SS, Barve A, et al. Alcoholic liver disease and malnutrition. Alcohol Clin Exp Res 2011;35(5):815-20
   PubMed Web of Science ®Google Scholar
• Gao B, Bataller R. Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology 2011;141(5):1572-85
   PubMed Web of Science ®Google Scholar
• Louvet A, Mathurin P. Alcoholic liver disease: mechanisms of injury and targeted treatment. Nat Rev Gastroenterol Hepatol 2015;12(4):231-42
   PubMed Web of Science ®Google Scholar
• Bailey SM, Cunningham CC. Contribution of mitochondria to oxidative stress associated with alcoholic liver disease. Free Radic Biol Med 2002;32(1):11-16
   PubMed Web of Science ®Google Scholar
• Galligan JJ, Smathers RL, Shearn CT, et al. Oxidative stress and the ER stress response in a murine model for early-stage alcoholic liver disease. J Toxicol 2012;2012:207594
   PubMedGoogle Scholar
• Kono H, Rusyn I, Yin M, et al. NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease. J Clin Invest 2000;106(7):867-72
   PubMed Web of Science ®Google Scholar
• Pastorino JG, Hoek JB. Ethanol potentiates tumor necrosis factor-alpha cytotoxicity in hepatoma cells and primary rat hepatocytes by promoting induction of the mitochondrial permeability transition. Hepatology 2000;31(5):1141-52
   PubMed Web of Science ®Google Scholar
• Roca FJ, Ramakrishnan L. TNF dually mediates resistance and susceptibility to mycobacteria via mitochondrial reactive oxygen species. Cell 2013;153(3):521-34
   PubMed Web of Science ®Google Scholar
• Malhotra JD, Kaufman RJ. Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? Antioxid Redox Signal 2007;9(12):2277-93
   PubMed Web of Science ®Google Scholar
• Schieber M, Chandel NS. ROS function in redox signaling and oxidative stress. Curr Biol 2014;24(10):R453-62
   PubMed Web of Science ®Google Scholar
• Moon KH, Hood BL, Kim BJ, et al. Inactivation of oxidized and S-nitrosylated mitochondrial proteins in alcoholic fatty liver of rats. Hepatology 2006;44(5):1218-30
   PubMed Web of Science ®Google Scholar
• Hoek JB, Cahill A, Pastorino JG. Alcohol and mitochondria: a dysfunctional relationship. Gastroenterology 2002;122(7):2049-63
   PubMed Web of Science ®Google Scholar
• French SW. Effect of acute and chronic ethanol ingestion on rat liver ATP. Proc Soc Exp Biol Med 1966;121(3):681-5
   PubMed Web of Science ®Google Scholar
• Gordon ER. ATP metabolism in an ethanol induced fatty liver. Biochem Pharmacol 1977;26(13):1229-34
   PubMed Web of Science ®Google Scholar
• Young TA, Bailey SM, Van Horn CG, Cunningham CC. Chronic ethanol consumption decreases mitochondrial and glycolytic production of ATP in liver. Alcohol Alcohol 2006;41(3):254-60
   PubMed Web of Science ®Google Scholar
• Yang L, Rozenfeld R, Wu D, et al. Cannabidiol protects liver from binge alcohol-induced steatosis by mechanisms including inhibition of oxidative stress and increase in autophagy. Free Radic. Biol Med 2014;68:260-7
   Google Scholar
• Guo R, Xu X, Babcock SA, et al. Aldehyde dedydrogenase-2 plays a beneficial role in ameliorating chronic alcohol-induced hepatic steatosis and inflammation through regulation of autophagy. J Hepatol 2015;62(3):647-56
   PubMed Web of Science ®Google Scholar
• Beckett AG, Livingstone AV, Hill KR. Acute alcoholic hepatitis. Br Med J 1961;2(5260):1113-19
   PubMedGoogle Scholar
• Luedde T, Kaplowitz N, Schwabe RF. Cell death and cell death responses in liver disease: mechanisms and clinical relevance. Gastroenterology 2014;147(4):765-83e4
   PubMed Web of Science ®Google Scholar
• Huebener P, Pradere JP, Hernandez C, et al. The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis. J Clin Invest 2015;125(2):539-50
   PubMed Web of Science ®Google Scholar
• Petrasek J, Iracheta-Vellve A, Saha B, et al. Metabolic danger signals, uric acid and ATP, mediate inflammatory cross-talk between hepatocytes and immune cells in alcoholic liver disease. J Leukoc Biol 2015. [Epub ahead of print]
   PubMed Web of Science ®Google Scholar
• Zhao M, Laissue JA, Zimmermann A. TUNEL-positive hepatocytes in alcoholic liver disease. A retrospective biopsy study using DNA nick end-labelling. Virchows Arch 1977;431(5):337-44
   Google Scholar
• Higuchi H, Adachi M, Miura S, et al. The mitochondrial permeability transition contributes to acute ethanol-induced apoptosis in rat hepatocytes. Hepatology 2001;34(2):320-8
   PubMed Web of Science ®Google Scholar
• Zhou Z, Wang L, Song Z, et al. A critical involvement of oxidative stress in acute alcohol-induced hepatic TNF-alpha production. Am J Pathol 2003;163(3):1137-46
   PubMed Web of Science ®Google Scholar
• Bala S, Marcos M, Gattu A, et al. Acute binge drinking increases serum endotoxin and bacterial DNA levels in healthy individuals. PLoS One 2014;9(5):e96864
   PubMed Web of Science ®Google Scholar
• Cook RT, Schlueter AJ, Coleman RA, et al. Thymocytes, pre-B cells, and organ changes in a mouse model of chronic ethanol ingestion–absence of subset-specific glucocorticoid-induced immune cell loss. Alcohol Clin Exp Res 2007;31(10):1746-58
   PubMed Web of Science ®Google Scholar
• Hiratani K, Haruta T, Tani A, et al. Roles of mTOR and JNK in serine phosphorylation, translocation, and degradation of IRS-1. Biochem Biophys Res Commun 2005;335(3):836-42
   PubMed Web of Science ®Google Scholar
• Vari R, D’Archivio M, Filesi C, et al. Protocatechuic acid induces antioxidant/detoxifying enzyme expression through JNK-mediated Nrf2 activation in murine macrophages. J Nutr Biochem 2011;22(5):409-17
   PubMed Web of Science ®Google Scholar
• Czaja MJ. JNK regulation of hepatic manifestations of the metabolic syndrome. Trends Endocrinol Metab 2010;21(12):707-13
   PubMed Web of Science ®Google Scholar
• Donovan N, Becker EB, Konishi Y, et al. JNK phosphorylation and activation of BAD couples the stress-activated signaling pathway to the cell death machinery. J Biol Chem 2002;277(43):40944-9
   PubMed Web of Science ®Google Scholar
• Chen J, Ishac EJ, Dent P, et al. Effects of ethanol on mitogen-activated protein kinase and stress-activated protein kinase cascades in normal and regenerating liver. Biochem J 1998;334(Pt 3):669-76
   PubMedGoogle Scholar
• Lee YJ, Shukla SD. Pro- and anti-apoptotic roles of c-Jun N-terminal kinase (JNK) in ethanol and acetaldehyde exposed rat hepatocytes. Eur J Pharmacol 2005;508(1-3):31-45
   PubMed Web of Science ®Google Scholar
• Chung J, Chavez PR, Russell RM, et al. Retinoic acid inhibits hepatic Jun N-terminal kinase-dependent signaling pathway in ethanol-fed rats. Oncogene 2002;21(10):1539-47
   PubMed Web of Science ®Google Scholar
• Aroor AR, Jackson DE, Shukla SD. Elevated activation of ERK1 and ERK2 accompany enhanced liver injury following alcohol binge in chronically ethanol-fed rats. Alcohol Clin Exp Res 2011;35(12):2128-38
   PubMed Web of Science ®Google Scholar
• Liangpunsakul S, Rahmini Y, Ross RA, et al. Imipramine blocks ethanol-induced ASMase activation, ceramide generation, and PP2A activation, and ameliorates hepatic steatosis in ethanol-fed mice. Am J Physiol Gastrointest Liver Physiol 2012;302(5):G515-23
   PubMed Web of Science ®Google Scholar
• Xiao J, Wang J, Xing F, et al. Zeaxanthin dipalmitate therapeutically improves hepatic functions in an alcoholic fatty liver disease model through modulating MAPK pathway. PLoS ONE 2014;9(4):e95214
   PubMedGoogle Scholar
• Lee YJ, Aroor AR, Shukla SD. Temporal activation of p42/44 mitogen-activated protein kinase and c-Jun N-terminal kinase by acetaldehyde in rat hepatocytes and its loss after chronic ethanol exposure. J Pharmacol Exp Ther 2002;301(3):908-14
   PubMed Web of Science ®Google Scholar
• Nishitani Y, Matsumoto H. Ethanol rapidly causes activation of JNK associated with ER stress under inhibition of ADH. FEBS Lett 2006;580(1):9-14
   PubMed Web of Science ®Google Scholar
• Yang L, Wu D, Wang X, et al. Cytochrome P4502E1, oxidative stress, JNK, and autophagy in acute alcohol-induced fatty liver. Free Radic Biol Med 2012;53(5):1170-80
   PubMed Web of Science ®Google Scholar
• Roychowdhury S, McMullen MR, Pisano SG, et al. Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury. Hepatology 2013;57(5):1773-83
   PubMed Web of Science ®Google Scholar
• Gautheron J, Vucur M, Reisinger F, et al. A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis. EMBO Mol Med 2014;6(8):1062-74
   PubMed Web of Science ®Google Scholar
• Mihaylova MM, Shaw RJ. The AMPK signaling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol 2011;13(9):1016-23
   PubMed Web of Science ®Google Scholar
• Ji C, Kaplowitz N. Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology 2003;124(5):1488-99
   PubMed Web of Science ®Google Scholar
• Longato L, Ripp K, Setshedi M, et al. Insulin resistance, ceramide accumulation, and endoplasmic reticulum stress in human chronic alcohol-related liver disease. Oxid Med Cell Longev 2012;2012:479348
   PubMed Web of Science ®Google Scholar
• You M, Matsumoto M, Pacold CM, et al. The role of AMP-activated protein kinase in the action of ethanol in the liver. Gastroenterology 2004;127(6):1798-808
   PubMed Web of Science ®Google Scholar
• Shen Z, Liang X, Rogers CQ, et al. Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice. Am J Physiol Gastrointest Liver Physiol 2010;298(3):G364-74
   PubMed Web of Science ®Google Scholar
• You M, Considine RV, Leone TC, et al. Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice. Hepatology 2005;42(3):568-77
   PubMed Web of Science ®Google Scholar
• Everitt H, Hu M, Ajmo JM, et al. Ethanol administration exacerbates the abnormalities in hepatic lipid oxidation in genetically obese mice. Am J Physiol Gastrointest Liver Physiol 2013;304(1):G38-47
   PubMed Web of Science ®Google Scholar
• Jiang Z, Zhou J, Zhou D, et al. The adiponectin-SIRT1-AMPK pathway in alcoholic fatty liver disease in the rat. Alcohol Clin Exp Res 2015;39(3):424-33
   PubMed Web of Science ®Google Scholar
• Shearn CT, Backos DS, Orlicky DJ, et al. Identification of 5’ AMP-activated kinase as a target of reactive aldehydes during chronic ingestion of high concentrations of ethanol. J Biol Chem 2014;289(22):15449-62
   PubMed Web of Science ®Google Scholar
• Liangpunsakul S, Wou SE, Zeng Y, et al. Effect of ethanol on hydrogen peroxide-induced AMPK phosphorylation. Am J Physiol Gastrointest Liver Physiol 2008;295(6):G1173-81
   PubMed Web of Science ®Google Scholar
• Liangpunsakul S, Sozio MS, Shin E, et al. Inhibitory effect of ethanol on AMPK phosphorylation is mediated in part through elevated ceramide levels. Am J Physiol Gastrointest Liver Physiol 2010;298(6):G1004-12
   PubMed Web of Science ®Google Scholar
• Shearn CT, Smathers RL, Jiang H, et al. Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis. J Nutr Biochem 2013;24(8):1436-45
   PubMed Web of Science ®Google Scholar
• Xu J, Lai KK, Verlinsky A, et al. Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK. J Hepatol 2011;55(3):673-82
   PubMed Web of Science ®Google Scholar
• Zhang M, Dong Y, Xu J, et al. Thromboxane receptor activates the AMP-activated protein kinase in vascular smooth muscle cells via hydrogen peroxide. Circ Res 2008;102(3):328-37
   PubMed Web of Science ®Google Scholar
• Tomita K, Tamiya G, Ando S, et al. AICAR, an AMPK activator, has protective effects on alcohol-induced fatty liver in rats. Alcohol Clin Exp Res 2005;29(12 Suppl):240S-5S
   PubMed Web of Science ®Google Scholar
• Zhang M, Wang C, Zhao H, et al. Enhanced AMPK phosphorylation contributes to the beneficial effects of Lactobacillus rhamnosus GG supernatant on chronic-alcohol-induced fatty liver disease. J Nutr Biochem 2015;26(4):337-44
   PubMed Web of Science ®Google Scholar
• Zhu S, Ma L, Wu Y, et al. FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathway. Acta Biochim Biophys Sin (Shanghai) 2014;46(12):1041-8
   PubMed Web of Science ®Google Scholar
• Zhang P, Qiang X, Zhang M, et al. Demethyleneberberine, a natural mitochondria-targeted antioxidant, inhibits mitochondrial dysfunction, oxidative stress, and steatosis in alcoholic liver disease mouse model. J Pharmacol Exp Ther 2015;352(1):139-47
   PubMed Web of Science ®Google Scholar
• Li Y, Wang S, Ni HM, et al. Autophagy in alcohol-induced multiorgan injury: mechanisms and potential therapeutic targets. Biomed Res Int 2014;2014:498491
   PubMed Web of Science ®Google Scholar
• Ding WX, Li M, Chen X, et al. Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice. Gastroenterology 2010;139(5):1740-52
   PubMed Web of Science ®Google Scholar
• Rubin E, Lieber CS. Early fine structural changes in the human liver induced by alcohol. Gastroenterology 1967;52(1):1-13
   PubMed Web of Science ®Google Scholar
• Donohue TMJr Thomes PG. Ethanol-induced oxidant stress modulates hepatic autophagy and proteasome activity. Redox Biol 2014;3:29-39
   PubMed Web of Science ®Google Scholar
• Ni HM, Du K, You M, et al. Critical role of FoxO3a in alcohol-induced autophagy and hepatotoxicity. Am J Pathol 2013;183(6):1815-25
   Google Scholar
• Klionsky DJ, Abdalla FC, Abeliovich H, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012;8(4):445-544
   PubMed Web of Science ®Google Scholar
• Lin CW, Zhang H, Li M, et al. Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice. J Hepatol 2013;58(5):993-9
   PubMed Web of Science ®Google Scholar
• Karna P, Zughaier S, Pannu V, et al. Induction of reactive oxygen species-mediated autophagy by a novel microtubule-modulating agent. J Biol Chem 2010;285(24):18737-48
   PubMed Web of Science ®Google Scholar
• Alers S, Loffler AS, Wesselborg S, et al. Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks. Mol Cell Biol 2012;32(1):2-11
   PubMed Web of Science ®Google Scholar
• Adachi Y, Bradford BU, Gao W, et al. Inactivation of Kupffer cells prevents early alcohol-induced liver injury. Hepatology 1994;20(2):453-60
   PubMed Web of Science ®Google Scholar
• Wang M, You Q, Lor K, et al. Chronic alcohol ingestion modulates hepatic macrophage populations and functions in mice. J Leukoc Biol 2014;96(4):657-65
   PubMed Web of Science ®Google Scholar
• Lee J, French B, Morgan T, et al. The liver is populated by a broad spectrum of markers for macrophages. In alcoholic hepatitis the macrophages are M1 and M2. Exp Mol Pathol 2014;96(1):118-25
   PubMed Web of Science ®Google Scholar
• Wan J, Benkdane M, Teixeira-Clerc F, et al. M2 Kupffer cells promote M1 Kupffer cell apoptosis: a protective mechanism against alcoholic and nonalcoholic fatty liver disease. Hepatology 2014;59(1):130-42
   PubMed Web of Science ®Google Scholar
• Paidassi H, Tacnet-Delorme P, Garlatti V, et al. C1q binds phosphatidylserine and likely acts as a multiligand-bridging molecule in apoptotic cell recognition. J Immunol 2008;180(4):2329-38
   PubMed Web of Science ®Google Scholar
• Cohen JI, Roychowdhury S, McMullen MR, et al. Complement and alcoholic liver disease: role of C1q in the pathogenesis of ethanol-induced liver injury in mice. Gastroenterology 2010;139(2):664-74
   PubMed Web of Science ®Google Scholar
• Anstee QM, Daly AK, Day CP. Genetics of alcoholic and nonalcoholic fatty liver disease. Semin Liver Dis 2011;31(2):128-46
   PubMed Web of Science ®Google Scholar
• Tsuchiya M, Ji C, Kosyk O, et al. Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice. Hepatology 2012;56(1):130-9
   PubMed Web of Science ®Google Scholar
• Denucci SM, Tong M, Longato L, et al. Rat strain differences in susceptibility to alcohol-induced chronic liver injury and hepatic insulin resistance. Gastroenterol Res Pract 2010;2010:312790
   PubMedGoogle Scholar
• Ki SH, Park O, Zheng M, et al. Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: role of signal transducer and activator of transcription 3. Hepatology 2010;52(4):1291-300
   PubMed Web of Science ®Google Scholar
• Petrasek J, Bala S, Csak T, et al. IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice. J Clin Invest 2012;122(10):3476-89
   PubMed Web of Science ®Google Scholar
• Shukla SD, Pruett SB, Szabo G, et al. Binge ethanol and liver: new molecular developments. Alcohol Clin Exp Res 2013;37(4):550-7
   PubMed Web of Science ®Google Scholar
• Maricic I, Sheng H, Marrero I, et al. Inhibition of type I natural killer T cells by retinoids or following sulfatide-mediated activation of type II natural killer T cells attenuates alcoholic liver disease in mice. Hepatology 2015;61(4):1357-69
   PubMed Web of Science ®Google Scholar
• Lazaro R, Wu R, Lee S, et al. Osteopontin deficiency does not prevent but promotes alcoholic neutrophilic hepatitis in mice. Hepatology 2015;61(1):129-40
   PubMed Web of Science ®Google Scholar