Management of proton pump inhibitor responsive-esophageal eosinophilia and eosinophilic esophagitis: controversies in treatment approaches

References

• Liacouras CA, Furuta GT, Hirano I, et al. Eosinophilic esophagitis: updated consensus recommendations for children and adults. J Allergy Clin Immunol 2011;128(1):3-20
   PubMed Web of Science ®Google Scholar
• Dellon ES, Gonsalves N, Hirano I, et al. ACG clinical guideline: Evidenced based approach to the diagnosis and management of esophageal eosinophilia and eosinophilic esophagitis (EoE). Am J Gastroenterology 2013;108(5):679-92
   PubMed Web of Science ®Google Scholar
• Rodrigo S, Abboud G, Oh D, et al. High intraepithelial eosinophil counts in esophageal squamous epithelium are not specific for eosinophilic esophagitis in adults. Am J Gastroenterol 2008;103(2):435-42
   PubMed Web of Science ®Google Scholar
• Dellon ES, Jensen ET, Martin CF, et al. Prevalence of eosinophilic esophagitis in the United States. Clin Gastroenterol Hepatol 2014;12(4):589-96
   PubMed Web of Science ®Google Scholar
• Dellon ES. Epidemiology of eosinophilic esophagitis. Gastroenterol Clin North Am 2014;43(2):201-18
   PubMed Web of Science ®Google Scholar
• Jensen ET, Kappelman MD, Martin CF, Dellon ES. Health-care utilization, costs, and the burden of disease related to eosinophilic esophagitis in the United States. Am J Gastroenterol 2015;110(5):626-32
   PubMed Web of Science ®Google Scholar
• Ngo P, Furuta GT, Antonioli DA, Fox VL. Eosinophils in the esophagus–peptic or allergic eosinophilic esophagitis? Case series of three patients with esophageal eosinophilia. Am J Gastroenterol 2006;101(7):1666-70
   PubMed Web of Science ®Google Scholar
• Molina-Infante J, Katzka DA, Dellon ES. Proton pump inhibitor-responsive esophageal eosinophilia: a historical perspective on a novel and evolving entity. Rev Esp Enferm Dig 2015;107(1):29-36
   PubMed Web of Science ®Google Scholar
• Winter HS, Madara JL, Stafford RJ, et al. Intraepithelial eosinophils: a new diagnostic criterion for reflux esophagitis. Gastroenterology 1982;83(4):818-23
   PubMed Web of Science ®Google Scholar
• Furuta GT, Liacouras CA, Collins MH, et al. Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment. Gastroenterol 2007;133(4):1342-63
   PubMed Web of Science ®Google Scholar
• Spechler SJ, Genta RM, Souza RF. Thoughts on the complex relationship between gastroesophageal reflux disease and eosinophilic esophagitis. Am J Gastroenterol 2007;102(6):1301-6
   PubMed Web of Science ®Google Scholar
• Dranove JE, Horn DS, Davis MA, et al. Predictors of response to proton pump inhibitor therapy among children with significant esophageal eosinophilia. J Pediatr 2009;154(1):96-100
   PubMed Web of Science ®Google Scholar
• Sayej WN, Patel R, Baker RD, et al. Treatment with high-dose proton pump inhibitors helps distinguish eosinophilic esophagitis from noneosinophilic esophagitis. J Pediatr Gastroenterol Nutr 2009;49(4):393-9
   PubMed Web of Science ®Google Scholar
• Peterson KA, Thomas KL, Hilden K, et al. Comparison of esomeprazole to aerosolized, swallowed fluticasone for eosinophilic esophagitis. Dig Dis Sci 2010;55(5):1313-19
   PubMed Web of Science ®Google Scholar
• Molina-Infante J, Ferrando-Lamana L, Ripoll C, et al. Esophageal eosinophilic infiltration responds to proton pump inhibition in most adults. Clin Gastroenterol Hepatol 2011;9(2):110-17
   PubMed Web of Science ®Google Scholar
• Francis DL, Foxx-Orenstein A, Arora AS, et al. Results of ambulatory pH monitoring do not reliably predict response to therapy in patients with eosinophilic oesophagitis. Aliment Pharmacol Ther 2012;35(2):300-7
   PubMed Web of Science ®Google Scholar
• Dellon ES, Speck O, Woodward K, et al. Clinical and endoscopic characteristics do not reliably differentiate PPI-responsive esophageal eosinophilia and eosinophilic esophagitis in patients undergoing upper endoscopy: a prospective cohort study. Am J Gastroenterol 2013;108(12):1854-60
   PubMed Web of Science ®Google Scholar
• Schroeder S, Capocelli KE, Masterson JC, et al. Effect of proton pump inhibitor on esophageal eosinophilia. J Pediatr Gastroenterol Nutr 2013;56(2):166-72
   PubMed Web of Science ®Google Scholar
• Vazquez-Elizondo G, Ngamruengphong S, Khrisna M, et al. The outcome of patients with oesophageal eosinophilic infiltration after an eight-week trial of a proton pump inhibitor. Aliment Pharmacol Ther 2013;38(10):1312-19
   PubMed Web of Science ®Google Scholar
• Dellon ES, Speck O, Woodward K, et al. Markers of eosinophilic inflammation for diagnosis of eosinophilic esophagitis and proton pump inhibitor-responsive esophageal eosinophilia: a prospective study. Clin Gastroenterol Hepatol 2014;12(12):2015-22
   PubMed Web of Science ®Google Scholar
• Eluri S, Dellon ES. Proton pump inhibitor-responsive oesophageal eosinophilia and eosinophilic oesophagitis: more similarities than differences. Curr Opin Gastroenterol 2015;31(4):309-15
   PubMedGoogle Scholar
• Molina-Infante J, Rivas MD, Hernandez-Alonso M, et al. Proton pump inhibitor-responsive oesophageal eosinophilia correlates with downregulation of eotaxin-3 and Th2 cytokines overexpression. Aliment Pharmacol Ther 2014;40(8):955-65
   PubMed Web of Science ®Google Scholar
• Moawad FJ, Schoepfer AM, Safroneeva E, et al. Eosinophilic oesophagitis and proton pump inhibitor-responsive oesophageal eosinophilia have similar clinical, endoscopic and histological findings. Aliment Pharmacol Ther 2014;39(6):603-8
   PubMed Web of Science ®Google Scholar
• Wen T, Dellon ES, Moawad FJ, et al. Transcriptome analysis of proton pump inhibitor-responsive esophageal eosinophilia reveals proton pump inhibitor-reversible allergic inflammation. J Allergy Clin Immunol 2015;135(1):187-97
   PubMed Web of Science ®Google Scholar
• Molina-Infante J, Katzka DA. Proton-pump inhibitor-responsive esophageal eosinophilia. Curr Opin Gastroenterol 2014;30(4):428-33
   PubMed Web of Science ®Google Scholar
• Asher Wolf W, Dellon ES. Eosinophilic esophagitis and proton pump inhibitors: controversies and implications for clinical practice. Gastroenterol Hepatol 2014;10(7):427-32
   Google Scholar
• Kedika RR, Souza RF, Spechler SJ. Potential anti-inflammatory effects of proton pump inhibitors: a review and discussion of the clinical implications. Dig Dis Sci 2009;54(11):2312-17
   PubMed Web of Science ®Google Scholar
• Park JY, Zhang X, Nguyen N, et al. Proton pump inhibitors decrease eotaxin-3 expression in the proximal esophagus of children with esophageal eosinophilia. PLoS ONE 2014;9(7): e101391
   Web of Science ®Google Scholar
• Cheng E, Zhang X, Huo X, et al. Omeprazole blocks eotaxin-3 expression by oesophageal squamous cells from patients with eosinophilic oesophagitis and GORD. Gut 2013;62(6):824-32
   PubMed Web of Science ®Google Scholar
• van Rhijn BD, Weijenborg PW, Verheij J, et al. Proton pump inhibitors partially restore mucosal integrity in patients with proton pump inhibitor-responsive esophageal eosinophilia but not eosinophilic esophagitis. Clin Gastroenterol Hepatol 2014;12(11):1815-23
   PubMed Web of Science ®Google Scholar
• Molina-Infante J MJ, Martinez-Alcala C, Krajciova J, et al. Long-term efficacy of PPI therapy in patients with PPI-responsive esophageal eosinophilia: An international multicenter study. Gastroenterology 2014;146(Suppl 1 S-17):Ab 58
   Google Scholar
• Dohil R, Newbury RO, Aceves S. Transient PPI responsive esophageal eosinophilia may be a clinical sub-phenotype of pediatric eosinophilic esophagitis. Dig Dis Sci 2012;57(5):1413-19
   PubMed Web of Science ®Google Scholar
• Spergel JM, Brown-Whitehorn TF, Beausoleil JL, et al. 14 years of eosinophilic esophagitis: clinical features and prognosis. J Pediatr Gastroenterol Nutr 2009;48(1):30-6
   PubMed Web of Science ®Google Scholar
• Dellon ES, Gibbs WB, Fritchie KJ, et al. Clinical, endoscopic, and histologic findings distinguish eosinophilic esophagitis from gastroesophageal reflux disease. Clin Gastroenterol Hepatol 2009;7(12):1305-13
   PubMed Web of Science ®Google Scholar
• Desai TK, Stecevic V, Chang CH, et al. Association of eosinophilic inflammation with esophageal food impaction in adults. Gastrointest Endosc 2005;61(7):795-801
   PubMed Web of Science ®Google Scholar
• Kerlin P, Jones D, Remedios M, Campbell C. Prevalence of eosinophilic esophagitis in adults with food bolus obstruction of the esophagus. J Clin Gastroenterol 2007;41(4):356-61
   PubMed Web of Science ®Google Scholar
• Schoepfer AM, Safroneeva E, Bussmann C, et al. Delay in diagnosis of eosinophilic esophagitis increases risk for stricture formation in a time-dependent manner. Gastroenterology 2013;145(6):1230-6
   PubMed Web of Science ®Google Scholar
• Dellon ES, Kim HP, Sperry SL, et al. A phenotypic analysis shows that eosinophilic esophagitis is a progressive fibrostenotic disease. Gastrointest Endosc 2014;79(4):577-85
   PubMed Web of Science ®Google Scholar
• Lipka S, Kumar A, Richter JE. Impact of diagnostic delay and other risk factors on eosinophilic esophagitis phenotype and esophageal diameter. J Clin Gastroenterol 2015. [Epub ahead of print]
   Google Scholar
• Straumann A, Bussmann C, Zuber M, et al. Eosinophilic esophagitis: analysis of food impaction and perforation in 251 adolescent and adult patients. Clin Gastroenterol Hepatol 2008;6(5):598-600
   PubMed Web of Science ®Google Scholar
• Hirano I. Therapeutic end points in eosinophilic esophagitis: is elimination of esophageal eosinophils enough? Clin Gastroenterol Hepatol 2012;10(7):750-2
   PubMed Web of Science ®Google Scholar
• Dellon ES, Liacouras CA. Advances in clinical management of eosinophilic esophagitis. Gastroenterology 2014;147(6):1238-54
   PubMed Web of Science ®Google Scholar
• Assa’ad AH, Gupta SK, Collins MH, et al. An antibody against IL-5 reduces numbers of esophageal intraepithelial eosinophils in children with eosinophilic esophagitis. Gastroenterology 2011;141(5):1593-604
   PubMed Web of Science ®Google Scholar
• Alexander JA, Jung KW, Arora AS, et al. Swallowed fluticasone improves histologic but not symptomatic response of adults with eosinophilic esophagitis. Clin Gastroenterol Hepatol 2012;10(7):742-9
   PubMed Web of Science ®Google Scholar
• Pentiuk S, Putnam PE, Collins MH, Rothenberg ME. Dissociation between symptoms and histological severity in pediatric eosinophilic esophagitis. J Pediatr Gastroenterol Nutr 2009;48(2):152-60
   PubMed Web of Science ®Google Scholar
• Spergel JM, Rothenberg ME, Collins MH, et al. Reslizumab in children and adolescents with eosinophilic esophagitis: results of a double-blind, randomized, placebo-controlled trial. J Allergy Clin Immunol 2012;129(2):456-63
   PubMed Web of Science ®Google Scholar
• Miehlke S, Hruz P, Vieth M, et al. A randomised, double-blind trial comparing budesonide formulations and dosages for short-term treatment of eosinophilic oesophagitis. Gut 2015. [Epub ahead of print]
   PubMedGoogle Scholar
• Green DJ WW, Hughes JT, Cotton CC, et al. Most patients demonstrate correlation between symptoms, endoscopic findings, and histology in response to topical steroid treatment in eosinophilic esophagitis. Gastroenterology 2014;146(Suppl 1):Ab Mo1840
   Google Scholar
• Wolf WA GD, Hughes JT, Cotton CC, et al. What cut-point should be used to define a histologic response to topical steroid use in eosinophilic esophagitis? A data-driven approach using symptoms and endoscopic findings. Gastroenterology 2014;146(Suppl 1):Mo1832
   Google Scholar
• Schoepfer AM, Straumann A, Panczak R, et al. Development and validation of a symptom-based activity index for adults with eosinophilic esophagitis. Gastroenterology 2014;147(6):1255-66
   PubMed Web of Science ®Google Scholar
• Dellon ES, Irani AM, Hill MR, Hirano I. Development and field testing of a novel patient-reported outcome measure of dysphagia in patients with eosinophilic esophagitis. Aliment Pharmacol Ther 2013;38(6):634-42
   PubMed Web of Science ®Google Scholar
• Hirano I, Moy N, Heckman MG, et al. Endoscopic assessment of the oesophageal features of eosinophilic oesophagitis: validation of a novel classification and grading system. Gut 2013;62(4):489-95
   PubMed Web of Science ®Google Scholar
• Taft TH, Kern E, Kwiatek MA, et al. The adult eosinophilic oesophagitis quality of life questionnaire: a new measure of health-related quality of life. Aliment Pharmacol Ther 2011;34(7):790-8
   PubMed Web of Science ®Google Scholar
• Franciosi JP, Hommel KA, DeBrosse CW, et al. Development of a validated patient-reported symptom metric for pediatric eosinophilic esophagitis: qualitative methods. BMC Gastroenterol 2011;11:126-37
   PubMed Web of Science ®Google Scholar
• Franciosi JP, Hommel KA, Greenberg AB, et al. Development of the Pediatric Quality of Life Inventory Eosinophilic Esophagitis module items: qualitative methods. BMC Gastroenterol 2012;12:135-42
   PubMed Web of Science ®Google Scholar
• Martin LJ, Franciosi JP, Collins MH, et al. Pediatric Eosinophilic Esophagitis Symptom Scores (PEESS v2.0) identify histologic and molecular correlates of the key clinical features of disease. J Allergy Clin Immunol 2015;135(6):1519-28
   PubMed Web of Science ®Google Scholar
• Collins MH. Histopathologic features of eosinophilic esophagitis and eosinophilic gastrointestinal diseases. Gastroenterol Clin North Am 2014;43(2):257-68
   PubMed Web of Science ®Google Scholar
• Kwiatek MA, Hirano I, Kahrilas PJ, et al. Mechanical properties of the esophagus in eosinophilic esophagitis. Gastroenterology 2011;140(1):82-90
   PubMed Web of Science ®Google Scholar
• Chuang MY, Chinnaratha MA, Hancock DG, et al. Topical steroid therapy for the treatment of eosinophilic esophagitis (EoE): A systematic review and meta-analysis. Clin Transl Gastroenterol 2015;6:e82
   PubMed Web of Science ®Google Scholar
• Konikoff MR, Noel RJ, Blanchard C, et al. A randomized, double-blind, placebo-controlled trial of fluticasone propionate for pediatric eosinophilic esophagitis. Gastroenterology 2006;131(5):1381-91
   PubMed Web of Science ®Google Scholar
• Schaefer ET, Fitzgerald JF, Molleston JP, et al. Comparison of oral prednisone and topical fluticasone in the treatment of eosinophilic esophagitis: a randomized trial in children. Clin Gastroenterol Hepatol 2008;6(2):165-73
   PubMed Web of Science ®Google Scholar
• Butz BK, Wen T, Gleich GJ, et al. Efficacy, dose reduction, and resistance to high-dose fluticasone in patients with eosinophilic esophagitis. Gastroenterology 2014;147(2):324-33
   PubMed Web of Science ®Google Scholar
• Straumann A, Conus S, Degen L, et al. Budesonide is effective in adolescent and adult patients with active eosinophilic esophagitis. Gastroenterology 2010;139(5):1526-37
   PubMed Web of Science ®Google Scholar
• Dohil R, Newbury R, Fox L, et al. Oral viscous budesonide is effective in children with eosinophilic esophagitis in a randomized, placebo-controlled trial. Gastroenterology 2010;139(2):418-29
   PubMed Web of Science ®Google Scholar
• Dellon ES, Sheikh A, Speck O, et al. Viscous topical is more effective than nebulized steroid therapy for patients with eosinophilic esophagitis. Gastroenterology 2012;143(2):321-4
   PubMed Web of Science ®Google Scholar
• Rubinstein E, Lee JJ, Fried A, et al. Comparison of 2 delivery vehicles for viscous budesonide to treat eosinophilic esophagitis in children. J Pediatr Gastroenterol Nutr 2014;59(3):317-20
   PubMed Web of Science ®Google Scholar
• Gupta SK, Vitanza JM, Collins MH. Efficacy and safety of oral budesonide suspension in pediatric patients with eosinophilic esophagitis. Clin Gastroenterol Hepatol 2015;13(1):66-76
   PubMed Web of Science ®Google Scholar
• Dellon ESKD, Collins MH, Hirano I. For the MPI-101-06 Investigators. Oral budesonide suspension significantly improves dysphagia and esophageal eosinophilia: Results from a multicenter randomized double-blind placebo-controlled trial in adolescents and adults with eosinophilic esophagitis. Gastroenterology 2015;148(Suppl 1):Ab 813
   Google Scholar
• Wolf WA, Cotton CC, Green DJ, et al. Predictors of response to steroid therapy for eosinophilic esophagitis and treatment of steroid-refractory patients. Clin Gastroenterol Hepatol 2015;13(3):452-8
   PubMed Web of Science ®Google Scholar
• Moawad F AD, Heifert T, Min S, et al. Predictors of non-response to topical steroids treatment in eosinophilic esophagitis. Am J Gastroenterol 2013;108(Suppl 1):S14
   Google Scholar
• Rothenberg ME. Molecular, genetic, and cellular bases for treating eosinophilic esophagitis. Gastroenterology 2015;148(6):1143-57
   PubMed Web of Science ®Google Scholar
• Arias A, Gonzalez-Cervera J, Tenias JM, Lucendo AJ. Efficacy of dietary interventions for inducing histologic remission in patients with eosinophilic esophagitis: a systematic review and meta-analysis. Gastroenterology 2014;146(7):1639-48
   PubMed Web of Science ®Google Scholar
• Markowitz JE, Spergel JM, Ruchelli E, Liacouras CA. Elemental diet is an effective treatment for eosinophilic esophagitis in children and adolescents. Am J Gastroenterol 2003;98(4):777-82
   PubMed Web of Science ®Google Scholar
• Liacouras CA, Spergel JM, Ruchelli E, et al. Eosinophilic esophagitis: a 10-year experience in 381 children. Clin Gastroenterol Hepatol 2005;3(12):1198-206
   PubMed Web of Science ®Google Scholar
• Peterson KA, Byrne KR, Vinson LA, et al. Elemental diet induces histologic response in adult eosinophilic esophagitis. Am J Gastroenterol 2013;108(5):759-66
   PubMed Web of Science ®Google Scholar
• Spergel JM, Andrews T, Brown-Whitehorn TF, et al. Treatment of eosinophilic esophagitis with specific food elimination diet directed by a combination of skin prick and patch tests. Ann Allergy Asthma Immunol 2005;95(4):336-43
   PubMed Web of Science ®Google Scholar
• Syrigou E, Angelakopoulou A, Zande M, et al. Allergy-test-driven elimination diet is useful in children with eosinophilic esophagitis, regardless of the severity of symptoms. Pediatr Allergy Immunol 2015;26(4):323-9
   PubMed Web of Science ®Google Scholar
• Spergel JM, Brown-Whitehorn TF, Cianferoni A, et al. Identification of causative foods in children with eosinophilic esophagitis treated with an elimination diet. J Allergy Clin Immunol 2012;130(2):461-7
   PubMed Web of Science ®Google Scholar
• Henderson CJ, Abonia JP, King EC, et al. Comparative dietary therapy effectiveness in remission of pediatric eosinophilic esophagitis. J Allergy Clin Immunol 2012;129(6):1570-8
   PubMed Web of Science ®Google Scholar
• Kagalwalla AF, Sentongo TA, Ritz S, et al. Effect of six-food elimination diet on clinical and histologic outcomes in eosinophilic esophagitis. Clin Gastroenterol Hepatol 2006;4(9):1097-102
   PubMed Web of Science ®Google Scholar
• Gonsalves N, Yang GY, Doerfler B, et al. Elimination diet effectively treats eosinophilic esophagitis in adults; food reintroduction identifies causative factors. Gastroenterology 2012;142(7):1451-9
   PubMed Web of Science ®Google Scholar
• Lucendo AJ, Arias A, Gonzalez-Cervera J, et al. Empiric 6-food elimination diet induced and maintained prolonged remission in patients with adult eosinophilic esophagitis: a prospective study on the food cause of the disease. J Allergy Clin Immunol 2013;131(3):797-804
   PubMed Web of Science ®Google Scholar
• Wolf WA, Jerath MR, Sperry SL, et al. Dietary elimination therapy is an effective option for adults with eosinophilic esophagitis. Clin Gastroenterol Hepatol 2014;12(8):1272-9
   PubMed Web of Science ®Google Scholar
• Molina-Infante J, Arias A, Barrio J, et al. Four-food group elimination diet for adult eosinophilic esophagitis: A prospective multicenter study. J Allergy Clin Immunol 2014;134(5):1093-9
   PubMed Web of Science ®Google Scholar
• Gonsalves NDB, Schwartz S, Guang-Yu Y, et al. Prospective trial of four food elimination diet demonstrates comparable effectiveness in the treatment of adult and pediatric eosinophilic esophagitis. Gastroenterology 2013;144(Suppl 1):AB 877
   Google Scholar
• Kagalwalla A AK, Makhija M, Wechsler JB, et al. A multicenter study assessing the clinical, endoscopic and histologic response to four food elimination diet for the treatment of eosinophilic esophagitis. Gastroenterology 2015;148(Suppl 4):Ab 114
   Google Scholar
• Kagalwalla AF, Amsden K, Shah A, et al. Cow’s milk elimination: a novel dietary approach to treat eosinophilic esophagitis. J Pediatr Gastroenterol Nutr 2012;55(6):711-16
   PubMed Web of Science ®Google Scholar
• Kruszewski PG, Russo JM, Franciosi JP, et al. Prospective, comparative effectiveness trial of cow’s milk elimination and swallowed fluticasone for pediatric eosinophilic esophagitis. Dis Esophagus 2015; Epub ahead of print
   PubMedGoogle Scholar
• Kagalwalla AF, Shah A, Li BU, et al. Identification of specific foods responsible for inflammation in children with eosinophilic esophagitis successfully treated with empiric elimination diet. J Pediatr Gastroenterol Nutr 2011;53(2):145-9
   PubMed Web of Science ®Google Scholar
• Furuta GT, Kagalwalla AF, Lee JJ, et al. The oesophageal string test: a novel, minimally invasive method measures mucosal inflammation in eosinophilic oesophagitis. Gut 2013;62(10):1395-405
   PubMed Web of Science ®Google Scholar
• Friedlander JA, DeBoer EM, Soden JS, et al. Unsedated transnasal esophagoscopy for monitoring therapy in pediatric eosinophilic esophagitis. Gastrointest Endosc 2015. [Epub ahead of print]
   PubMedGoogle Scholar
• Katzka DA, Geno DM, Ravi A, et al. Accuracy, safety, and tolerability of tissue collection by Cytosponge vs endoscopy for evaluation of eosinophilic esophagitis. Clin Gastroenterol Hepatol 2015;13(1):77-83
   PubMed Web of Science ®Google Scholar
• Straumann A, Spichtin HP, Grize L, et al. Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 years. Gastroenterology 2003;125(6):1660-9
   PubMed Web of Science ®Google Scholar
• Schoepfer AM, Gonsalves N, Bussmann C, et al. Esophageal dilation in eosinophilic esophagitis: effectiveness, safety, and impact on the underlying inflammation. Am J Gastroenterol 2010;105(5):1062-70
   PubMed Web of Science ®Google Scholar
• Schoepfer AM, Gschossmann J, Scheurer U, et al. Esophageal strictures in adult eosinophilic esophagitis: dilation is an effective and safe alternative after failure of topical corticosteroids. Endoscopy 2008;40(2):161-4
   PubMed Web of Science ®Google Scholar
• Bohm M, Richter JE, Kelsen S, Thomas R. Esophageal dilation: simple and effective treatment for adults with eosinophilic esophagitis and esophageal rings and narrowing. Dis Esophagus 2010;23(5):377-85
   PubMed Web of Science ®Google Scholar
• Lipka S, Keshishian J, Boyce HW, et al. The natural history of steroid-naive eosinophilic esophagitis in adults treated with endoscopic dilation and proton pump inhibitor therapy over a mean duration of nearly 14 years. Gastrointest Endosc 2014;80(4):592-8
   PubMed Web of Science ®Google Scholar
• Dellon ES, Gibbs WB, Rubinas TC, et al. Esophageal dilation in eosinophilic esophagitis: safety and predictors of clinical response and complications. Gastrointest Endosc 2010;71(4):706-12
   PubMed Web of Science ®Google Scholar
• Madanick RD, Shaheen NJ, Dellon ES. A novel balloon pull-through technique for esophageal dilation in eosinophilic esophagitis (with video). Gastrointest Endosc 2011;73(1):138-42
   PubMed Web of Science ®Google Scholar
• Jung KW, Gundersen N, Kopacova J, et al. Occurrence of and risk factors for complications after endoscopic dilation in eosinophilic esophagitis. Gastrointest Endosc 2011;73(1):15-21
   PubMed Web of Science ®Google Scholar
• Saligram S, McGrath K. The safety of a strict wire-guided dilation protocol for eosinophilic esophagitis. Eur J Gastroenterol Hepatol 2014;26(7):699-703
   PubMed Web of Science ®Google Scholar
• Jacobs JWJr, Spechler SJ. A systematic review of the risk of perforation during esophageal dilation for patients with eosinophilic esophagitis. Dig Dis Sci 2010;55(6):1512-15
   PubMed Web of Science ®Google Scholar
• Robles-Medranda C, Villard F, le Gall C, et al. Severe dysphagia in children with eosinophilic esophagitis and esophageal stricture: an indication for balloon dilation? J Pediatr Gastroenterol Nutr 2010;50(5):516-20
   PubMed Web of Science ®Google Scholar
• Menard-Katcher C FG, Kramer R. Dilation outcomes in pediatric eosinophilic esophagitis. Gastrointestinal Endoscopy 2015;81(Suppl 1):AB 299
   Google Scholar
• Peterson KA, Boynton KK. Which patients with eosinophilic esophagitis (EoE) should receive elemental diets versus other therapies? Curr Gastroenterol Rep 2014;16(1):364
   PubMedGoogle Scholar
• Cotton CC HS, Green DJ, Wolf WA, et al. Six-food elimination diet or topical steroids for first-line treatment of eosinophilic esophagitis: a cost-utility analysis. Gastroenterology 2015;148(Suppl 1):Ab 4
   Google Scholar
• Kavitt RT, Penson DF, Vaezi MF. Eosinophilic esophagitis: dilate or medicate? A cost analysis model of the choice of initial therapy. Dis Esophagus 2014;27(5):418-23
   PubMed Web of Science ®Google Scholar
• Assa’ad AH, Putnam PE, Collins MH, et al. Pediatric patients with eosinophilic esophagitis: an 8-year follow-up. J Allergy Clin Immunol 2007;119(3):731-8
   PubMed Web of Science ®Google Scholar
• DeBrosse CW, Franciosi JP, King EC, et al. Long-term outcomes in pediatric-onset esophageal eosinophilia. J Allergy Clin Immunol 2011;128(1):132-8
   PubMed Web of Science ®Google Scholar
• Elliott EJ, Thomas D, Markowitz JE. Non-surgical interventions for eosinophilic esophagitis. Cochrane Database Syst Rev 2010(3):CD004065
   Google Scholar
• Remedios M, Campbell C, Jones DM, Kerlin P. Eosinophilic esophagitis in adults: clinical, endoscopic, histologic findings, and response to treatment with fluticasone propionate. Gastrointest Endosc 2006;63(1):3-12
   PubMed Web of Science ®Google Scholar
• Straumann A, Conus S, Degen L, et al. Long-term budesonide maintenance treatment is partially effective for patients with eosinophilic esophagitis. Clin Gastroenterol Hepatol 2011;9(5):400-9
   PubMed Web of Science ®Google Scholar
• Helou EF, Simonson J, Arora AS. 3-yr-follow-up of topical corticosteroid treatment for eosinophilic esophagitis in adults. Am J Gastroenterol 2008;103(9):2194-9
   PubMed Web of Science ®Google Scholar
• Kuchen T, Straumann A, Safroneeva E, et al. Swallowed topical corticosteroids reduce the risk for long-lasting bolus impactions in eosinophilic esophagitis. Allergy 2014;69(9):1248-54
   PubMed Web of Science ®Google Scholar
• Andreae DA HM, Magid M, Bagiella E, et al. Swallowed fluticasone is an effective and safe long-term maintenance therapy in children with eosinophilic esophagitis. Gastroenterology 2015;148(Suppl 1):Ab 116
   Google Scholar
• Harel S, Hursh BE, Chan ES, et al. Adrenal suppression in children treated with oral viscous budesonide for eosinophilic esophagitis: A pilot study. J Pediatr Gastroenterol Nutr 2015. [Epub ahead of print]
   PubMedGoogle Scholar
• Dellon ES, Speck O, Woodward K, et al. Distribution and variability of esophageal eosinophilia in patients undergoing upper endoscopy. Mod Pathol 2015;28(3):383-90
   PubMed Web of Science ®Google Scholar
• Kagalwalla AF, Akhtar N, Woodruff SA, et al. Eosinophilic esophagitis: epithelial mesenchymal transition contributes to esophageal remodeling and reverses with treatment. J Allergy Clin Immunol 2012;129(5):1387-96
   PubMed Web of Science ®Google Scholar
• Chehade M, Sampson HA, Morotti RA, Magid MS. Esophageal subepithelial fibrosis in children with eosinophilic esophagitis. J Pediatr Gastroenterol Nutr 2007;45(3):319-28
   PubMed Web of Science ®Google Scholar
• Aceves SS, Newbury RO, Chen D, et al. Resolution of remodeling in eosinophilic esophagitis correlates with epithelial response to topical corticosteroids. Allergy 2010;65(1):109-16
   PubMed Web of Science ®Google Scholar
• Lucendo AJ, Arias A, De Rezende LC, et al. Subepithelial collagen deposition, profibrogenic cytokine gene expression, and changes after prolonged fluticasone propionate treatment in adult eosinophilic esophagitis: a prospective study. J Allergy Clin Immunol 2011;128(5):1037-46
   PubMed Web of Science ®Google Scholar
• Fox VL, Nurko S, Teitelbaum JE, et al. High-resolution EUS in children with eosinophilic “allergic” esophagitis. Gastrointest Endosc 2003;57(1):30-6
   PubMed Web of Science ®Google Scholar
• Stoeck M, Riedel R, Hochhaus G, et al. In vitro and in vivo anti-inflammatory activity of the new glucocorticoid ciclesonide. J Pharmacol Exp Ther 2004;309(1):249-58
   PubMed Web of Science ®Google Scholar
• Derendorf H. Pharmacokinetic and pharmacodynamic properties of inhaled ciclesonide. J Clin Pharmacol 2007;47(6):782-9
   PubMed Web of Science ®Google Scholar
• Schroeder S, Fleischer DM, Masterson JC, et al. Successful treatment of eosinophilic esophagitis with ciclesonide. J Allergy Clin Immunol 2012;129(5):1419-21
   PubMed Web of Science ®Google Scholar
• Lee JJ, Fried AJ, Hait E, et al. Topical inhaled ciclesonide for treatment of eosinophilic esophagitis. J Allergy Clin Immunol 2012;130(4):1011-12
   PubMed Web of Science ®Google Scholar
• Kern E, Hirano I. Emerging drugs for eosinophilic esophagitis. Expert Opin Emerg Drugs 2013;18(3):353-64
   PubMed Web of Science ®Google Scholar
• Netzer P, Gschossmann JM, Straumann A, et al. Corticosteroid-dependent eosinophilic oesophagitis: azathioprine and 6-mercaptopurine can induce and maintain long-term remission. Eur J Gastroenterol Hepatol 2007;19(10):865-9
   PubMed Web of Science ®Google Scholar
• Straumann A, Conus S, Grzonka P, et al. Anti-interleukin-5 antibody treatment (mepolizumab) in active eosinophilic oesophagitis: a randomised, placebo-controlled, double-blind trial. Gut 2010;59(1):21-30
   PubMed Web of Science ®Google Scholar
• Rothenberg ME, Wen T, Greenberg A, et al. Intravenous anti-IL-13 mAb QAX576 for the treatment of eosinophilic esophagitis. J Allergy Clin Immunol 2015;135(2):500-7
   PubMed Web of Science ®Google Scholar
• Dose ranging study of RPC4046 in eosinophilic esophagitis (Ed. national library of Medicine, Bethesda, MD, 2014). Available from: https://clinicaltrials.gov/ct2/show/NCT02098473 [Last accessed 27 July 2015]
   Google Scholar
• Study of dupilumab in adult patients with active eosinophilic esophagitis (EoE). (Ed. National Library of Medicine, Bethesda, MD, 2015). Available from: https://clinicaltrials.gov/ct2/show/NCT02379052 [Last accessed 27 July 2015]
   Google Scholar
• Attwood SE, Lewis CJ, Bronder CS, et al. Eosinophilic oesophagitis: a novel treatment using Montelukast. Gut 2003;52(2):181-5
   PubMed Web of Science ®Google Scholar
• Stumphy J, Al-Zubeidi D, Guerin L, et al. Observations on use of montelukast in pediatric eosinophilic esophagitis: insights for the future. Dis Esophagus 2011;24(4):229-34
   PubMed Web of Science ®Google Scholar
• Lucendo AJ, De Rezende LC, Jimenez-Contreras S, et al. Montelukast was inefficient in maintaining steroid-induced remission in adult eosinophilic esophagitis. Dig Dis Sci 2011;56(12):3551-8
   PubMed Web of Science ®Google Scholar
• Trial of Montelukast in Eosinophilic Esophagitis. (Ed. National Library of Medicine, Bethesda, MD, 2007). Available from: https://clinicaltrials.gov/ct2/show/NCT00511316 [Last accessed 27 July 2015]
   Google Scholar
• Eosinophilic esophagitis treatment: Montelukast vs Fluticasone. (Ed. National Library of Medicine, Bethesda, MD, 2012). Available from: https://clinicaltrials.gov/ct2/show/NCT01702701 [Last accessed 27 July 2015]
   Google Scholar
• Straumann A, Hoesli S, Bussmann C, et al. Anti-eosinophil activity and clinical efficacy of the CRTH2 antagonist OC000459 in eosinophilic esophagitis. Allergy 2013;68(3):375-85
   PubMed Web of Science ®Google Scholar