Is obesity an advantage in patients with colorectal cancer?

References

• Keum N, Greenwood DC, Lee DH, et al. Adult weight gain and adiposity-related cancers: a dose-response meta-analysis of prospective observational studies. J Natl Cancer Inst 2015;107:2
   Web of Science ®Google Scholar
• Larsson SC, Wolk A. Obesity and colon and rectal cancer risk: a meta-analysis of prospective studies. Am J Clin Nutr 2007;86(3):556-65
   PubMed Web of Science ®Google Scholar
• Li H, Yang G, Xiang YB, et al. Body weight, fat distribution and colorectal cancer risk: a report from cohort studies of 134 255 Chinese men and women. Int J Obes 2013;37(6):783-9
   PubMed Web of Science ®Google Scholar
• Thygesen LC, Thygesen LC, Grønbaek M, et al. Prospective weight change and colon cancer risk in male US health professionals. Inter J cancer 2008;123(5):1160-5
   PubMed Web of Science ®Google Scholar
• Rodriguez C, Freedland SJ, Deka A, et al. Body mass index, weight change, and risk of prostate cancer in the Cancer Prevention Study II Nutrition Cohort. Am Soc Preven Oncol 2007;16(1):63-9
   Google Scholar
• Laake I, Thune I, Selmer R, et al. A prospective study of body mass index, weight change, and risk of cancer in the proximal and distal colon. Am Soc Preven Oncol 2010;19(6):1511-22
   Google Scholar
• Dignam JJ, Polite BN, Yothers G, et al. Body mass index and outcomes in patients who receive adjuvant chemotherapy for colon cancer. J Natl Cancer Inst 2006;98(22):1647-54
   PubMed Web of Science ®Google Scholar
• Sinicrope FA, Foster NR, Yothers G, et al. Body mass index at diagnosis and survival among colon cancer patients enrolled in clinical trials of adjuvant chemotherapy. Cancer 2013;119(8):1528-36
   PubMed Web of Science ®Google Scholar
• Pischon T, Boeing H, Hoffmann K, et al. General and abdominal adiposity and risk of death in Europe. N Engl J Med 2008;359(20):2105-20
   PubMed Web of Science ®Google Scholar
• Yehuda-Shnaidman E, Schwartz B. Mechanisms linking obesity, inflammation and altered metabolism to colon carcinogenesis. J Inter Assoc Study Obe 2012;13(12):1083-95
   Web of Science ®Google Scholar
• Fazolini NP, Cruz AL, Werneck MB, et al. Leptin activation of mTOR pathway in intestinal epithelial cell triggers lipid droplet formation, cytokine production and increased cell proliferation. Cell cycle 2015:0
   Google Scholar
• Morikawa T, Kuchiba A, Liao X, et al. Tumor TP53 expression status, body mass index and prognosis in colorectal cancer. Inter J Cancer 2012;131(5):1169-78
   PubMed Web of Science ®Google Scholar
• Simkens LH, Koopman M, Mol L, et al. Influence of body mass index on outcome in advanced colorectal cancer patients receiving chemotherapy with or without targeted therapy. Eur J Cancer 2011;47(17):2560-7
   PubMed Web of Science ®Google Scholar
• Griggs JJ, Mangu PB, Anderson H, et al. Appropriate chemotherapy dosing for obese adult patients with cancer: American Society of Clinical Oncology clinical practice guideline. J Clin Oncol 2012;30(13):1553-61
   PubMed Web of Science ®Google Scholar
• Meyerhardt JA, Catalano PJ, Haller DG, et al. Impact of diabetes mellitus on outcomes in patients with colon cancer. J Clin Oncol 2003;21(3):433-40
   PubMed Web of Science ®Google Scholar
• Stein KB, Snyder CF, Barone BB, et al. Colorectal cancer outcomes, recurrence, and complications in persons with and without diabetes mellitus: a systematic review and meta-analysis. Dig Dis Sci 2010;55(7):1839-51
   PubMed Web of Science ®Google Scholar
• Larsson SC, Orsini N, Wolk A. Diabetes mellitus and risk of colorectal cancer: a meta-analysis. J Natl Cancer Inst 2005;97(22):1679-87
   PubMed Web of Science ®Google Scholar
• Zafar Y, Hubbard J, Van Cutsem E, et al. Survival outcomes according to body mass index (BMI): results from a pooled analysis of 5 observational or phase IV studies of bevacizumab in metastatic colorectal cancer (mCRC). ESMO World Congress on Gastrointestinal Cancer. Barcelona, 2015
   Google Scholar
• Adams KF, Schatzkin A, Harris TB, et al. Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old. New Eng J Med 2006;355(8):763-78
   PubMed Web of Science ®Google Scholar
• Bardou M, Barkun AN, Martel M. Republished: obesity and colorectal cancer. Postgrad Med J 2013;89(1055):519-33
   PubMed Web of Science ®Google Scholar
• Guiu B, Petit JM, Bonnetain F, et al. Visceral fat area is an independent predictive biomarker of outcome after first-line bevacizumab-based treatment in metastatic colorectal cancer. Gut 2010;59(3):341-7
   PubMed Web of Science ®Google Scholar
• Sinicrope FA, Foster NR, Yoon HH, et al. Association of obesity with DNA mismatch repair status and clinical outcome in patients with stage II or III colon carcinoma participating in NCCTG and NSABP adjuvant chemotherapy trials. J Clin Oncol 2012;30(4):406-12
   PubMed Web of Science ®Google Scholar
• Chen J, Huang XF. High fat diet-induced obesity increases the formation of colon polyps induced by azoxymethane in mice. Ann Trans Med 2015;3(6):79
   Google Scholar
• Larsson SC, Rutegård J, Bergkvist L, et al. Physical activity, obesity, and risk of colon and rectal cancer in a cohort of Swedish men. Eur J Cancer 2006;42(15):2590-7
   PubMed Web of Science ®Google Scholar
• Martinez ME, Giovannucci E, Spiegelman D, et al. Leisure-time physical activity, body size, and colon cancer in women. Nurses’ Health Study Research Group. J Natl Cancer Inst 1997;89(13):948-55
   PubMed Web of Science ®Google Scholar
• Moore LL, Chadid S, Singer MR, et al. Metabolic health reduces risk of obesity-related cancer in Framingham study adults. Am Soc Preven Oncol 2014;23(10):2057-65
   Google Scholar
• Kantor ED, Udumyan R, Signorello LB, et al. Adolescent body mass index and erythrocyte sedimentation rate in relation to colorectal cancer risk. Gut 2015
   PubMedGoogle Scholar
• Stevens GA, Singh GM, Lu Y, et al. National, regional, and global trends in adult overweight and obesity prevalences. Popul Health Metr 2012;10(1):22
   PubMed Web of Science ®Google Scholar
• Arnold M, Pandeya N, Byrnes G, et al. Global burden of cancer attributable to high body-mass index in 2012: a population-based study. Lancet Oncol 2015;16(1):36-46
   PubMed Web of Science ®Google Scholar
• Cakir H, Heus C, Verduin WM, et al. Visceral obesity, body mass index and risk of complications after colon cancer resection: A retrospective cohort study. Surgery 2015;157(5):909-15
   PubMed Web of Science ®Google Scholar
• Park SW, Lee HL, Doo EY, et al. Visceral Obesity Predicts Fewer Lymph Node Metastases and Better Overall Survival in Colon Cancer. J Gastroint Sur 2015;19(8):1513-21
   PubMed Web of Science ®Google Scholar
• Yoshizumi T, Nakamura T, Yamane M, et al. Abdominal fat: standardized technique for measurement at CT. Radiology 1999;211(1):283-6
   PubMed Web of Science ®Google Scholar