Thiopurine-induced pancreatitis in inflammatory bowel diseases

References

• Griffiths AM, Hugot J-P. Crohn’s Disease. Chapter 41, In: Walker A, Goulet O, Kleinman RE, et al. editors. Pediatric Gastrointestinal Disease. 4th edition. BC Decker; Hamilton Ontario: 2004
   Google Scholar
• Wilson J, Hair C, Knight R, et al. High incidence of Inflammatory Bowel Disease in Australia: a prospective population-based Australian incidence study. Inflamm Bowel Dis 2010;16:1550-6
   PubMed Web of Science ®Google Scholar
• Benchimol EI, Fortinsky KJ, Gozdyra P, et al. Epidemiology of pediatric inflammatory bowel disease: a systematic review of international trends. Inflamm Bowel Dis 2011;17:423-39
   PubMed Web of Science ®Google Scholar
• Bar F, Sina C, Fellermann K. Thiopurines in inflammatory bowel disease revisited. World J Gastroenterol 2013;19:1699-706
   PubMed Web of Science ®Google Scholar
• Lemberg DA, Day AS. Crohn’s and colitis in children: an update for 2014. J Paediatr Child Health 2014. [Epub ahead of print]
   Web of Science ®Google Scholar
• Sidler MA, Leach ST, Day AS. Fecal S100A12 and fecal calprotectin as noninvasive markers for inflammatory bowel disease in children. Inflamm Bowel Dis 2008;14:359-66
   PubMed Web of Science ®Google Scholar
• Froslie K, Jahnsen J, Moum B, et al. Mucosal Healing in Inflammatory Bowel Disease: results From a Norwegian Population-Based Cohort. Gastroenterology 2007;133(2):412-22
   PubMed Web of Science ®Google Scholar
• Borrelli O, Cordischi L, Cirulli M, et al. Polymeric Diet Alone Versus Corticosteroids in the Treatment of Active Pediatric Crohn’s Disease: a randomised Controlled Open-Label Trial. Clin Gastroenterol Hepatol 2006;4:744-53
   PubMed Web of Science ®Google Scholar
• Colombel JF, Rutgeerts P, Reinisch W, et al. Early mucosal healing with infliximab is associated with improved long-term clinical outcomes in ulcerative colitis. Gastroenterology 2011;141:1194-201
   PubMed Web of Science ®Google Scholar
• Dassopoulos T, Sultan S, Falck-Ytter YT, et al. American Gastroenterological Association Institute technical report on the use of thiopurines, methotrexate, and anti-TNF-a biologic drugs for the induction and maintenance of remission in inflammatory Crohn’s disease. Gastroenterology 2013;145:1464-78
   PubMed Web of Science ®Google Scholar
• Dubinksy MC. Azathioprine, 6-mercaptopurine in inflammatory bowel disease: pharmacology, efficacy and safety. Clin Gastroenterol Hepatol 2004;2:731-43
   PubMed Web of Science ®Google Scholar
• Ooi CY, Bohane TD, Lee D, et al. Thiopurine metabolite levels in pediatric inflammatory bowel disease. Aliment Pharmacol Ther 2007;25:941-7
   PubMed Web of Science ®Google Scholar
• Markowitz J, Grancher K, Kohn N, et al. A multicenter trial of 6-mercaptopurine and prednisone in children with newly diagnosed Crohn’s disease. Gastroenterology 2000;119:895-902
   PubMed Web of Science ®Google Scholar
• Punati J, Markowitz J, Lerer T, et al. Effect of early immunomodulator use in moderate to severe pediatric Crohn disease. Inflamm Bowel Dis 2008;14(7):949-54
   PubMed Web of Science ®Google Scholar
• Kuriyawasam VC, Selinger CP, Katelaris PH, et al. Early use of thiopurines or methotrexate reduces major abdominal and perianal surgery in Crohn’s disease. Inflamma Bowel Dis 2014;20:1382-90
   PubMed Web of Science ®Google Scholar
• Panes J, Lopez-Sanroman A, Bermejo F, et al. Early azathioprine therapy is no more effective than placebo for newly diagnosed Crohn’s disease. Gastroenterology 2013;145:766-74
   PubMed Web of Science ®Google Scholar
• Cosnes J, Bourrier A, Laharie D, et al. Early administration of azathioprine vs conventional management of Crohn’s disease: a randomised controlled trial. Gastroenterology 2013;145:758-65
   PubMed Web of Science ®Google Scholar
• Dubinsky MC, Hassard PV, Seidman EG, et al. An open-label pilot study using thioguanine as a therapeutic alternative in Crohn’s disease patients resistant to 6-mercaptopurine therapy. Inflamm Bowel Dis 2001;7:181-9
   PubMed Web of Science ®Google Scholar
• Pavlidis P, Ansari A, Duley J, et al. Splitting a therapeutic dose of thioguanine may avoid liver toxicity and be an efficacious treatment for severe inflammatory bowel disease: a 2-center observational cohort study. Inflamm Bowel Dis 2014;20(12):2239-46
   PubMed Web of Science ®Google Scholar
• Bermejo F, Lopez-Sanroman A, Taxonera C, et al. Acute pancreatitis in inflammatory bowel disease, with special reference to azathioprine induced pancreatitis. Aliment Pharmacol Ther 2008;28:623-8
   PubMed Web of Science ®Google Scholar
• Parenti DM, Steinberg W, Kang P. Infectious causes of acute pancreatitis. Pancreas 1996;13(4):356-71
   PubMed Web of Science ®Google Scholar
• Sibert JR. Pancreatitis in children. A study in the North of England. Arch Dis Child 1975;50(6):443-8
   PubMed Web of Science ®Google Scholar
• Pitchumoni CS, Rubin A, Das K. Pancreatitis in Inflammatory Bowel Disease. J Clin Gastroenterol 2010;44(4):246-53
   PubMed Web of Science ®Google Scholar
• Foutch PG, Ferguson DR. Duodenal Crohn’s disease complicated by common bile duct obstruction: report of a case and review of the literature. Am J Gastroenterol 1984;79:520-4
   PubMed Web of Science ®Google Scholar
• Ravi K, Chari ST, Vege SS, et al. Inflammatory bowel disease in the setting of autoimmune pancreatitis. Inflamm Bowel Dis 2009;15(9):1326-30
   PubMed Web of Science ®Google Scholar
• Saeki K, Hozawa S, Miyata N, et al. IgG4-negative autoimmune pancreatitis with sclerosing cholangitis and colitis: possible association with primary sclerosing cholangitis? Intern Med 2008;47:943-8
   PubMed Web of Science ®Google Scholar
• Haber CJ, Meltzer SJ, Present DH, Korelitz BI. Nature and course of pancreatitis caused by 6-Mercaptopurine in the treatment of inflammatory bowel disease. Gastroenterol 1986;91:982-6
   PubMed Web of Science ®Google Scholar
• Moolsintong P, Loftus EV, Chari ST, et al. Acute pancreatitis in patients with Crohn’s disease: clinical features and outcomes. Inflamm Bowel Dis 2005;11:1080-4
   PubMed Web of Science ®Google Scholar
• Balani AR, Grendell JH. Drug-induced pancreatitis: incidence, management and prevention. Drug Saf 2008;31(10):823-37
   PubMed Web of Science ®Google Scholar
• Krynetski EY, Tai HL, Yates CR, et al. Genetic polymorphism of thiopurine S methyltransferase: clinical importance and molecular mechanisms. Pharmacogenetics 1996;6:279-90
   PubMedGoogle Scholar
• Marinaki AM, Ansari A, Duley JA, et al. Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase). Pharmacogenetics 2004;14:181-7
   PubMedGoogle Scholar
• Van Dieren JM, Hansen BE, Kuipers EJ, et al. Meta-analysis: inosine triphosphate pyrophosphatase polymorphisms and thiopurine toxicity in the treatment of inflammatory bowel disease. Aliment Pharmacol Ther 2007;26:643-52
   PubMed Web of Science ®Google Scholar
• Gearry RB, Roberts RL, Barclay ML, Kennedy MA. Lack of association between the ITPA 94C>A polymorphism and adverse effects from azathioprine. Pharmacogenetics 2004;14:779-81
   PubMedGoogle Scholar
• Wroblova K, Kolorz M, Batovsky M, et al. Gene polymorphisms involved in manifestation of leucopenia, digestive intolerance and pancreatitis in azathioprine-treated patients. Dig Dis Sci 2012;57(9):2394-401
   PubMed Web of Science ®Google Scholar
• Weersma RK, Peters FT, Oostenbrug LE, et al. Increased incidence of azathioprine-induced pancreatitis in Crohn’s disease compared with other diseases. Aliment Pharmacol Ther 2004;20(8):843-50
   PubMed Web of Science ®Google Scholar
• Heap G, Singh A, Bewshea CM, et al. HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants. Nat Genet 2014;46:1131-4
   PubMed Web of Science ®Google Scholar
• Balani AR, Grendell JH. Drug-induced pancreatitis: incidence, management and prevention. Drug Saf 2008;31(10):823-37
   PubMed Web of Science ®Google Scholar
• Kawanishi H, Rudolph E, Bull FE. Azathioprine-induced acute pancreatitis. letter N Engl J Med 1973;289:357
   PubMed Web of Science ®Google Scholar
• Paloyan D, Levin B, Simonowitz D. Azathioprine associated acute pancreatitis. Dig Dis 1977;22:839-46
   Web of Science ®Google Scholar
• Cappell MS, Das KM. Rapid development of pancreatitis following reuse of 6-mercaptopurine. J Clin Gastroenterol 1989;11:679-81
   PubMed Web of Science ®Google Scholar
• Alexander S, Dowling D. Azathioprine pancreatitis in inflammatory bowel disease and successful subsequent treatment with mercaptopurine. Intern Med J 2005;35(9):570-1
   PubMed Web of Science ®Google Scholar
• Lees CW, Maan AK, Hansoti B, et al. Tolerability and safety of mercaptopurine in azathioprine-intolerant patients with inflammatory bowel disease. Aliment Pharmacol Ther 2008;27(3):220-7
   PubMed Web of Science ®Google Scholar
• Ledder O, Lemberg DA, Ooi CY, Day AS. Are thiopurines always contraindicated after thiopurine-induced pancreatitis in inflammatory bowel disease? J Pediatr Gastroenterol Nutr 2013;57(5):583-6
   PubMed Web of Science ®Google Scholar
• Beswick L, Hair CS, Dowling D. Successful mercaptopurine therapy after azathioprine-related pancreatitis in patients with IBD. Aliment Pharmacol Ther 2013;37:162
   PubMed Web of Science ®Google Scholar
• Kennedy NA, Rhatigan E, Arnott ID, et al. A trial of mercaptopurine is a safe strategy in patients with inflammatory bowel disease intolerant to azathioprine: an observational study, systematic review and meta-analysis. Aliment Pharmacol Ther 2014;38:1255-66
   Web of Science ®Google Scholar