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Expert Review of Gastroenterology & Hepatology Volume 10, 2016 - Issue 1
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Childhood constipation: finally something is moving!

Ilan J.N. KoppenDepartment of Pediatric Gastroenterology and Nutrition, Emma Children’s Hospital/Academic Medical Center, Amsterdam, The Netherlands;Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Nationwide Children’s Hospital, Columbus, OH, USACorrespondence[email protected]
,
Carlo Di LorenzoDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Nationwide Children’s Hospital, Columbus, OH, USA
,
Miguel SapsDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Nationwide Children’s Hospital, Columbus, OH, USA
,
Phil G. DinningDepartments of Gastroenterology & Surgery, Flinders Medical Centre, Flinders University, South Australia, Australia
,
Desale YacobDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Nationwide Children’s Hospital, Columbus, OH, USA
,
Marc A. LevittCenter for Colorectal and Pelvic Reconstruction, Nationwide Children’s Hospital, Department of Surgery, The Ohio State University, Columbus, OH, USA
&
Marc A. BenningaDepartment of Pediatric Gastroenterology and Nutrition, Emma Children’s Hospital/Academic Medical Center, Amsterdam, The Netherlands
 show all
Pages 141-155 | Published online: 14 Oct 2015

References

** Most recent evidence-based ESPGHAN-NASPGHAN recommendations for the evaluation and treatment of functional constipation in infants and children

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** This was the first work to provide a comprehensive description of colonic motor patterns recorded by high-resolution fiber-optic manometry. It demonstrates an abundance of retrograde propagating motor patterns and describes five distinct colonic motor patterns

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** This study utilized high-resolution fiber-optic and demonstrated that patients with slow transit constipation fail to induce a normal meal response, characterized by a postprandial increase in distal colonic cyclic propagating motor patterns

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** Multicenter double-blind randomized controlled trial in children with constipation revealed that prucalopride was not more effective in increasing stool frequency (defined as ≥3 spontaneous bowel movements per week) or decreasing fecal incontinence frequency (≤1 episode per 2 weeks) than placebo

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* Pediatric multicenter open-label pilot study with different dosages of lubiprostone for a duration of 4 weeks showed that lubiprostone significantly increased bowel movement frequency and was well tolerated in children and adolescents with functional constipation

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* This work presents an overview of the results of various pediatric studies on the effect of transcutaneous electrical stimulation on colonic motility and constipation

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  • Clarke MCC, Chase JW, Gibb S, et al. Improvement of quality of life in children with slow transit constipation after treatment with transcutaneous electrical stimulation. J Pediatr Surg. 2009;44(6):1268–72; discussion 1272.
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* This work describes a series of children with bowel and bladder dysfunction treated with sacral nerve stimulation

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