Th-17 cells in the lungs?

References

• Rouvier E, Luciani MF, Mattei MG, Denizof F, Golstein P. CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpes virus saimiri gene. J. Immunol.150, 5445–5456 (1993).
   PubMed Web of Science ®Google Scholar
• Wynn TA. TH-17: a giant step from TH1 and TH2. Nat. Immunol.6(11), 1069–1070 (2005).
   PubMed Web of Science ®Google Scholar
• Lindén A, Laan M, Anderson GP. Neutrophils, interleukin-17A and lung disease. Eur. Res. J.25, 159–172 (2005).
   PubMed Web of Science ®Google Scholar
• Medzhitov R, Preston-Hulbart P, Janeway CA Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature388, 394–397 (1997).
   PubMed Web of Science ®Google Scholar
• Mosmann TR, Coffman RL. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol.7, 145–173 (1989).
   PubMed Web of Science ®Google Scholar
• Murphy KM, Reiner SL. The lineage decisions of helper T cells. Nat. Rev. Immunol.2, 933–944 (2002).
   PubMed Web of Science ®Google Scholar
• Hsieh CS, Macatonia SE, Tripp CS, Wolf SF, O’Garra A, Murphy KM. Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science260, 547–549 (1993).
   PubMed Web of Science ®Google Scholar
• Scharton TM, Scott P. Natural killer cells are a source of interferon γ that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in mice. J. Exp. Med.178, 567–577 (1993).
   PubMed Web of Science ®Google Scholar
• Weaver CT, Harrington LE, Mangan PR, Gavrieli M, Murphy KM. Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity24, 677–688 (2006).
   PubMed Web of Science ®Google Scholar
• Mullen AC, High FA, Hutchins AS et al. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science292, 1907–1910 (2002).
   Google Scholar
• Gubler U, Chua AO, Schoenhaut DS et al. Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. Proc. Natl Acad. Sci. USA88, 4143–4147 (1991).
   PubMed Web of Science ®Google Scholar
• Min B, Prout M, Hu-Li J et al. Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite. J. Exp. Med.200, 507–517 (2004).
   PubMed Web of Science ®Google Scholar
• Shinkai K, Mohrs M, Locksley RM. Helper T cells regulate type-2 innate immunity in vivo. Nature420, 825–829. (2002).
   PubMedGoogle Scholar
• Ouyang W, Ranganath SH, Weindel K et al. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity9, 745–755 (1998).
   PubMed Web of Science ®Google Scholar
• Zheng W, Flavell RA. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell89, 587–596 (1997).
   PubMed Web of Science ®Google Scholar
• McKenzie BS, Kastelein R, Cua DJ. Understanding the IL-23–IL-17 immune pathway. Trends Immunol.27, 17–23 (2006).
   PubMed Web of Science ®Google Scholar
• Hunter CA. New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat. Rev. Immunol.5, 521–531 (2005).
   PubMed Web of Science ®Google Scholar
• Constantinescu CS, Wysocka M, Hilliard B et al. Antibodies against IL-12 prevent superantigen-induced and spontaneous relapses of experimental autoimmune encephalomyelitis. J. Immunol.161, 5097–5104 (1998).
   PubMed Web of Science ®Google Scholar
• Leonard JP, Waldburger KE, Goldman SJ. Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12. J. Exp. Med.181, 381–386 (1995).
   PubMed Web of Science ®Google Scholar
• Cua DJ, Sherlock J, Chen Y et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature421, 744–748 (2003).
   PubMed Web of Science ®Google Scholar
• Murphy CA, Langrish CL, Chen Y et al. Divergent pro- and anti-inflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J. Exp. Med.198(12), 1951–1957 (2003).
   PubMed Web of Science ®Google Scholar
• Langrish CL, Chen Yi, Blumenschein WM et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med.201(2), 233–240 (2005).
   PubMed Web of Science ®Google Scholar
• Harrington LE, Hatton RD, Mangan PR et al. Interleukin-17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol.6(11), 1123–1132 (2005).
   PubMed Web of Science ®Google Scholar
• Park H, Li Z, Yang XO et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol.6(11), 1133–1141 (2005).
   PubMed Web of Science ®Google Scholar
• Hoeve MA, Savage NDL, de Boer T et al. Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T-cells. Eur. J. Immunol.36, 661–670 (2006).
   PubMed Web of Science ®Google Scholar
• Higgins SC, Jarnicki AC, Lavelle EC, Mills KHG. TLR4 mediates vaccine-induced protective cellular immunity to Bordetella pertussis: role of IL-17-producing T cells. J. Immunol.177, 7980–7989 (2006).
   PubMed Web of Science ®Google Scholar
• Re F, Strominger JL. Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells. J. Biol. Chem.276(40), 37692–37699 (2001).
   PubMed Web of Science ®Google Scholar
• Happel KI, Zheng M, Young E et al. Cutting edge: roles of Toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae infection. J. Immunol.170, 4432–4436 (2003).
   PubMed Web of Science ®Google Scholar
• Oppmann B, Lesley R, Blom B et al. Novel p19 protein engages IL-12p40 to form a cytokine IL-23, with biological activities similar as well as distinct from IL-12. Immunity715–725 (2000).
   Google Scholar
• Aggarwal S, Ghiraldi N, Xie M-H, de Sauvage FJ, Gurney AL. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of Interleukin-17. J. Biol. Chem.278(3), 1910–1914 (2003).
   PubMed Web of Science ®Google Scholar
• Ghilardi N, Kljavin N, Chen Qi, Lucas S, Gurney AL, de Sauvage FJ. Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice. J. Immunol.172, 2827–2833 (2004).
   PubMed Web of Science ®Google Scholar
• Yen D, Cheung J, Scheerens H et al. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J. Clin. Invest.116, 1310–1316 (2006).
   PubMed Web of Science ®Google Scholar
• Nakae S, Iwakura Y, Suto H, Galli SJ. Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17. J. Leuk. Biol.81(5), 1258–1268 (2007).
   PubMed Web of Science ®Google Scholar
• Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. TGF-β in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity24, 179–189 (2006).
   PubMed Web of Science ®Google Scholar
• Mangan PR, Harrington LE, O’Quinn DB et al. Transforming growth factor-β induces development of the TH17 lineage. Nature441, 231–234 (2006).
   PubMed Web of Science ®Google Scholar
• Bettelli E, Carrier Y, Gao W et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature441, 235–238 (2006).
   PubMed Web of Science ®Google Scholar
• Li OM, Wan YY, Flavell RA. T cell-produced transforming growth factor-β1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity26, 579–591 (2007).
   PubMed Web of Science ®Google Scholar
• Sutton C, Brereton C, Keogh B, Mills KH, Lavelle EC. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J. Exp. Med.203, 1685–1691 (2006).
   PubMed Web of Science ®Google Scholar
• Zhou L, Ivanov II, Spolski R et al. IL-6 programs T(H)-17 differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat. Immunol.8(9), 967–974 (2007).
   PubMed Web of Science ®Google Scholar
• Nurieva R, Yang XO, Martinez G et al. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature448(7152), 480–483 (2007).
   PubMed Web of Science ®Google Scholar
• Ivanov I, McKenzie BS, Zhou L et al. The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell.126, 1121–1133 (2006).
   PubMed Web of Science ®Google Scholar
• Kastelein RA, Hunter CA, Cua DJ. Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. Ann. Rev. Immunol.25, 221–242 (2007).
   PubMed Web of Science ®Google Scholar
• Chen Z, Laurence A, Kanno Y et al. Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. Proc. Natl Acad. Sci. USA103(21), 8137–8142 (2006).
   PubMed Web of Science ®Google Scholar
• Robinson DS, O’Garra A. Further checkpoints in Th1 development. Immunity16, 755–758 (2002).
   PubMed Web of Science ®Google Scholar
• Batten M, Li J, Yi S et al. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat. Immunol.7, 929–936 (2006).
   PubMed Web of Science ®Google Scholar
• Stumhofer JS, Laurence A, Wilson EH et al. Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat. Immunol.7, 937–945 (2006).
   PubMed Web of Science ®Google Scholar
• Kolls JK, Lindén A. Interleukin-17 family members and inflammation. Immunity21, 467–476 (2004).
   PubMed Web of Science ®Google Scholar
• Yao Z, Painter SL, Fanslow WC et al. Human IL-17: a novel cytokine derived from T cells. J. Immunol.155, 5483–5486 (1995).
   PubMed Web of Science ®Google Scholar
• Li H, Chen J, Huang A et al. Cloning and characerization of IL-17B and IL-17C: two new members of the IL-17 cytokine family. Proc. Natl Acad. Sci. USA97, 773–778 (2000).
   PubMedGoogle Scholar
• Starnes T, Broxmeyer HE, Robertson MJ, Hromas R. Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis. J. Immunol.169, 642–646 (2002).
   PubMed Web of Science ®Google Scholar
• Lee J, Ho W-H, Maruoka M et al. IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1. J. Biol. Chem.169(1), 4430–4435 (2001).
   Google Scholar
• Kim MR, Manoukian R, Yeh R et al. Transgenic overexpression of human IL-17E results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production. Blood100, 2330–2340 (2002).
   PubMed Web of Science ®Google Scholar
• Starnes T, Broxmeyer HE, Robertson MJ, Hromas R. Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production. J. Immunol.167, 4137–4140 (2001).
   PubMed Web of Science ®Google Scholar
• Hymowitz SG, Filvaroff EH, Yin JP et al. IL-17s adopt a cysteine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding. EMBO J.20(19), 5332–5341 (2001).
   PubMed Web of Science ®Google Scholar
• Yao Z, Fanslow FC, Seldin MF et al. Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity3, 811–821 (1995).
   PubMed Web of Science ®Google Scholar
• Fossiez F, Djossou O, Chomarat P et al. T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J. Exp. Med.183, 2593–2603 (1996).
   PubMed Web of Science ®Google Scholar
• Infante-Duarte C, Horton HF, Byrne MC, Kamradt T. Microbial lipopeptides induce the production of IL-17 in Th cells. J. Immunol.165, 6107–6115 (2000).
   PubMed Web of Science ®Google Scholar
• Ferretti S, Bonneau O, Dubois GR, Jones CE, Trifilieff A. IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger. J. Immunol.170, 2106–2112 (2003).
   PubMed Web of Science ®Google Scholar
• Shin N, Benbernou N, Esnault S, Guenounou M. Expression of IL-17 in human memory CD45RO+ T lymphocytes and its regulation by protein kinase A pathway. Cytokine11, 257–266 (1999).
   PubMedGoogle Scholar
• Shibata K, Yamada H, Hara H, Kishihara K, Yoshikai Y. Resident Vδ1+ γδ T cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 production. J. Immunol.178, 4466–4472 (2007).
   PubMed Web of Science ®Google Scholar
• Weaver CT, Hatton RD, Mangan PR, Harrington LE. IL-17 Family cytokines and the expanding diversity of effector T cell lineages. Ann. Rev. Immunol.25, 821–852 (2007).
   PubMed Web of Science ®Google Scholar
• Molet S, Hamid Q, Davoine F et al. IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines. J. Allergy Clin. Immunol.108, 430–438 (2001).
   PubMed Web of Science ®Google Scholar
• Miyamoto M, Prause O, Laan M, Sjöstrand M, Lötvall J, Lindén A. Endogenous IL-17 mediates endotoxin-induced airway neutrophilia in mice in vivo. J. Immunol.170, 4665–4672 (2003).
   PubMed Web of Science ®Google Scholar
• Umemura M, Ayano Yahagi A et al. IL-17-mediated regulation of innate and acquired immune response against pulmonary Mycobacterium bovis bacille Calmette–Guérin infection. J. Immunol.178, 3786–3796 (2007).
   PubMed Web of Science ®Google Scholar
• Michel M-L, Keller AC, Paget C et al. Identification of an IL-17-producing NK1.1neg iNKT cell population involved in airway neutrophilia. J. Exp. Med.204, 995–1001 (2007).
   PubMed Web of Science ®Google Scholar
• Ivanov S, Palmberg L, Venge P, Larsson K, Lindén A. Interleukin-17A mRNA and protein expression within cells from the human bronchoalveolar space after exposure to organic dust. Respir. Res.6, 44 (2005).
   PubMed Web of Science ®Google Scholar
• Laan M, Palmberg L, Larsson K, Lindén A. Free, soluble interleukin-17 protein during severe inflammation in human airways. Eur. Respir. J.19, 534–537 (2002).
   PubMed Web of Science ®Google Scholar
• Happel KI, Dubin PJ, Zheng M et al. Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae.J. Exp. Med.202(6), 761–769 (2005).
   PubMed Web of Science ®Google Scholar
• Dubin PJ, Kolls JK. IL-23 mediates inflammatory responses to mucoid Pseudomonas aeruginosa blung infection in mice. Am. J. Physiol. Lung Cell Mol. Physiol.292(2), L519–L528 (2007).
   PubMed Web of Science ®Google Scholar
• Ivanov S, Bozinovski S, Bossios A et al. Functional relevance of the IL-23–IL-17 axis in lings in vivo. Am. J. Respir. Cell Mol. Biol.36(4), 442–451 (2007).
   PubMedGoogle Scholar
• Yao Z, Spriggs M, Derry J et al. Molecular characterisation of the human interleukin (IL)-17 receptor. Cytokine9, 794–800 (1997).
   PubMed Web of Science ®Google Scholar
• Lee J, Ho WH, Maruoka M et al. IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1. J. Biol. Chem.276, 1660–1664 (2001).
   PubMed Web of Science ®Google Scholar
• Shi Y, Ullrich SJ, Zhang J et al. A novel cytokine-receptor ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity. J. Biol. Chem.275, 19167–19176 (2000).
   PubMed Web of Science ®Google Scholar
• Moseley TA, Haudenschild DR, Rose L, Reddi AH. Interleukin-17 family and IL-17 receptors. Cytokine Growth Factor Rev.14, 155–174 (2003).
   PubMed Web of Science ®Google Scholar
• Toy D, Kugler D, Wolfson M et al. Cutting edge: Interleukin 17 signals through a heteromeric receptor complex. J. Immunol.177, 36–39 (2006).
   PubMed Web of Science ®Google Scholar
• Qian Y, Liu C, Hartupee J et al. The adaptor Act1 is required for interleukin 17-dependent signalling associated with autoimmune and inflammatory disease. Nat. Immunol.8(3), 247–256 (2007).
   PubMed Web of Science ®Google Scholar
• Rong Z, Cheng L, Ren Y et al. Interleukin-17F signalling requires ubiquitination of interleukin-17 receptor via TRAF6. Cell. Signal.19(7), 1514–1520 (2007).
   Google Scholar
• Laan M, Cui ZH, Hoshino H et al. Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. J. Immunol.162, 2347–2352 (1999).
   PubMed Web of Science ®Google Scholar
• Laan M,Prause O, Miyamoto M et al. A role of GM-CSF in the accumulation of neutrophils in the airways caused by IL-17 and TNF-α. Eur. Respir. J.21(3), 1–7 (2003).
   Google Scholar
• Hoshino H, Lötvall J, Skoogh BE, Lindén A. Neutrophil recruitment by IL-17 into rat airways in vivo: role of tachykinins. Am. J. Respir. Crit. Care Med.159, 1423–1428 (1999).
   PubMed Web of Science ®Google Scholar
• Hoshino H, Laan M, Sjöstrand M, Lötvall J, Skoogh BE, Lindén A. Increased elastase and myeloperoxidase activity associated with neutrophil recruitment by IL-17 in airways in vivo. J. Allergy Clin. Immunol.105, 143–149. (2000).
   PubMed Web of Science ®Google Scholar
• Hellings PW, Kasran A, Liu Z et al. Interleukin-17 orchestrates the granulocyte influx into airways after allergen inhalation in a mouse model of allergic asthma. Am. J. Respir. Crit. Care Med.28(1), 42–50 (2003).
   Google Scholar
• Prause O, Bozinovski S, Anderson GP, Lindén A. Increased matrix metalloproteinase-9 concentration and activity after stimulation with interleukin-17 in mouse airways. Thorax59(4), 313–317 (2004).
   PubMed Web of Science ®Google Scholar
• Laan M, Lötvall J, Chung KF, Lindén A. IL-17-induced cytokine release in human bronchial epithelial cells in vitro: role of mitogen-activated protein (MAP) kinases. Br. J. Pharmacol.133, 200–206 (2001).
   PubMed Web of Science ®Google Scholar
• Kawaguchi M, Kokubu F, Kuga H. Modulation of bronchial epithelial cells by IL-17. J. Allergy Clin. Immunol.108, 804–809 (2001).
   PubMed Web of Science ®Google Scholar
• Prause O, Laan M, Lötvall J, Lindén A. Pharmacological modulation of interleukin-17-induced GCP-2, GRO-a and interleukin-8 release in human bronchial epithelial cells. Eur. J. Pharmacol.462, 193–198 (2003).
   PubMed Web of Science ®Google Scholar
• Jones CE, Chan K. Interleukin-17 stimulates the expression of interleukin-8, growth-related oncogene-a, and granulocyte-colony-stimulating factor by human airway epithelial cells. Am. J. Respir. Cell Mol. Biol.26, 748–753 (2002).
   PubMed Web of Science ®Google Scholar
• Numasaki M, Lotze MT, Sasaki H. Interleukin-17 augments tumour necrosis factor-α-induced elaboration of proangiogenic factors from fibroblasts. Immunol. Lett.93, 39–43 (2004).
   PubMed Web of Science ®Google Scholar
• Schwander R, Yamaguchi K, Zhaodan C. Requirement of tumour necrosis factor receptor-associated factor (TRAF)-6 in interleukin-17 signal transduction. J. Exp. Med.191, 1233–1239 (2000).
   Google Scholar
• Vanaudenaerde BM, Wuyts WA, Dupont LJ, Van Raemdonck DE, Demedts MM, Verleden GM. Interleukin-17 stimulates release of interleukin-8 by human airway smooth muscle cells in vitro: a potential role for interleukin-17 and airway smooth muscle cells in bronchiolitis obliterans syndrome. J. Heart Lung Transplant.22, 1280–1283 (2003).
   PubMed Web of Science ®Google Scholar
• Dragon S, Rahman MS, Yang J, Unruh H, Halayko A.J, Soussi-Gounni A. IL-17 enhances IL-1{β} mediated CXCL-8 release from human airway smooth muscle cells. Am. J. Physiol. Lung Cell. Mol. Physiol.292(4), L1023–L1029 (2006).
   Google Scholar
• Henness S, van Thoor E, Ge Q, Armour CL, Hughes JM, Ammit AJ. IL-17A acts via p38 MAPK to increase stability of TNF-α-induced IL-8 mRNA in human ASM. Am. J. Physiol. Lung Cell. Mol. Physiol.290(6), L1283–L1290 (2006).
   PubMed Web of Science ®Google Scholar
• Yamasawa H, Oshikawa K, Ohno S, Sugiyama Y. Macrolides inhibit epithelial cell-mediated neutrophil survival by modulating GM-CSF release. Am. J. Respir. Cell Mol. Biol.30, 569–575 (2004).
   PubMed Web of Science ®Google Scholar
• Ottonello L, Frumento G, Arduino N et al. Differential regulation of spontaneous and immune complex-induced neutrophil apoptosis by proinflammatory cytokines. Role of oxidants, Bax and caspase-3. J. Leukoc. Biol.72, 125–132 (2002).
   Google Scholar
• Saba S, Soong G, Greenberg S, Prince A. Bacterial stimulation of epithelial G-CSF and GM-CSF expression promotes PMN survival in CF airways. Am. J. Respir. Cell Mol. Biol.27, 561–567 (2002).
   Google Scholar
• Sergejeva S, Ivanov S, Lötvall J, Lindén A. IL-17 as a recruitment and survival factor for airway macrophages in allergic airway inflammation. Am. J. Respir. Cell Mol. Biol.33, 248–253 (2005).
   PubMed Web of Science ®Google Scholar
• Kiener PA, Davis PM, Starling GC et al. Differential induction of apoptosis by Fas–Fas ligand interactions in human monocytes and macrophages. J. Exp. Med.185, 1511–1516 (1997).
   PubMed Web of Science ®Google Scholar
• Nagata S, Golstein P. The Fas death factor. Science267, 1449–1456 (1995).
   PubMed Web of Science ®Google Scholar
• Atkinson JJ, Senior RM. Matrix metalloproteinase-9 in lung remodeling Am. J. Respir. Cell Mol. Biol.28, 12–24 (2003).
   PubMed Web of Science ®Google Scholar
• Betsuyaku T, Nishimura M, Takeyabu K et al. Neutrophil granule proteins in bronchoalveolar lavage fluid from subjects with subclinical emphysema. Am. J. Respir. Crit. Care Med.159, 1985–1991 (1999).
   PubMed Web of Science ®Google Scholar
• Cundall M, Sun Y, Miranda C, Trudeau JB, Barnes S, Wenzel SE. Neutrophil-derived matrix metalloproteinase-9 is increased in severe asthma and poorly inhibited by glucocorticoids. J. Allergy Clin. Immunol.112, 1064–1071 (2003).
   PubMed Web of Science ®Google Scholar
• Lemjabbar H, Gosset P, Lechapt-Zalcham E et al. Overexpression of alveolar macrophage gelatinase B (MMP-9) in patients with idiopatic pulmonary fibrosis: effects of steroid and immunosuppressive treatment. Am. J. Respir. Cell Mol. Biol.20(5), 903 (1999).
   PubMed Web of Science ®Google Scholar
• Keatings VM, Barnes PJ. Granulocyte activation markers in induced sputum: comparison between chronic obstructive pulmonary disease, asthma, and normal subjects. Am. J. Respir. Cell Mol. Biol.155(2), 449 (1997).
   Google Scholar
• Cataldo DD, Tournoy KG, Vermaelen K et al. Matrix metalloproteinase-9 deficiency impairs cellular infiltration and bronchial hyperresponsiveness during allergen-induced airway inflammation. Am. J. Pathol.161, 491–498 (2002).
   PubMed Web of Science ®Google Scholar
• Chen Y, Thai P, Zhao YH, Ho YS, DeSouza MM, Wu R. Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop. J. Biol. Chem.278, 17036–17043 (2003).
   PubMed Web of Science ®Google Scholar
• Inoue D, Numasaki M, Watanabe M et al. IL-17A promotes the growth of airway epithelial cells through ERK-dependent signaling pathway. Biochem. Biophys. Res. Commun.347, 852–858 (2006).
   PubMed Web of Science ®Google Scholar
• Hashimoto K, Durbin JE, Zhou W et al. Respiratory syncytial virus infection in the absence of STAT1 results in airway dysfunction, airway mucus, and augmented IL-17 levels. J. Allergy Clin. Immunol.116, 550–557 (2005).
   PubMed Web of Science ®Google Scholar
• Larsson R, Rocksén D, Lillienhook B, Jonsson A, Bucht A. Dose-dependent activation of lymphocytes in endotoxin-induced airway inflammation. Infect. Immun.68(12), 6962–6969 (2000).
   PubMedGoogle Scholar
• Ye P, Garvey PB, Zhang P et al. Interleukin-17 and lung host defense against Klebsiella pneumoniae infection. Am. J. Respir. Cell Mol. Biol.25, 335–340 (2001).
   PubMed Web of Science ®Google Scholar
• Ye P, Rodriguez FH, Kanaly S et al. Requirement of interleukin 17 receptor signalling for lung CXC chemokines and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J. Exp. Med.194, 519–528 (2001).
   PubMed Web of Science ®Google Scholar
• Malley R, Srivastava A, Lipsitch M et al. Antibody-independent, Interleukin-17A-mediated, cross-serotype immunity to Pneumococci in mice immunized intranasally with the cell wall polysaccharide. Infect. Immun.74(4), 2187–2195 (2006).
   Google Scholar
• Martin RJ, Kraft M, Chu HW, Berns EA, Cassell GH. A link between chronic asthma and chronic infection. J. Allergy Clin. Immunol.107(4), 595–601 (2001).
   PubMed Web of Science ®Google Scholar
• Lieberman D, Ben-Yaakov M, Lazarovich Z et al. Infectious etiologies in acute exacerbation of COPD. Diagn. Microbiol. Infect. Dis.40, 95–102 (2001).
   PubMed Web of Science ®Google Scholar
• Kraft M, Cassell GH, Henson JE et al. Detection of Mycoplasma pneumoniaein the airways of adults with chronic asthma. Am. J. Respir. Crit. Care Med.158, 998–1001 (1998).
   PubMed Web of Science ®Google Scholar
• Wu Q, Martin RJ, Rino JG, Breed R, Torres RM, Chu HW. IL-23-dependent IL-17 production is essential in neutrophil recruitment and activity in mouse lung defense against respiratory Mycoplasma pneumoniae infection. Microbes Infect.9(1), 78–86 (2007).
   PubMed Web of Science ®Google Scholar
• Khader S, Bell GK, Pearl JE et al. IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat. Immunol.8(4), 369–377 (2007).
   PubMed Web of Science ®Google Scholar
• Khader S, Pearl JE, Sakamoto K et al. IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific INF-γ responses if IL-12p70 is available. J. Immunol.175, 788–795 (2005).
   PubMed Web of Science ®Google Scholar
• Wozniak TA, Ryan AA, Britton WJ. Interleukin-23 Restores immunity to Mycobacterium tuberculosis infection in IL-12p40-deficient mice and is not required for the development of IL-17-secreting T cell responses. J. Immunol.177, 8684–8692 (2006).
   PubMed Web of Science ®Google Scholar
• Rudner XL, Happel KI, Young EA, Shellito JE. The IL-23/IL-17 cytokine axis in murine Pneumocystis infection. Infect. Immun.75(6), 3055–3061 (2007).
   PubMed Web of Science ®Google Scholar
• Huang W, Na L, Fidel PL, Schwarzenberger P. Requirement of interleukin-17a for systemic anti-Candida albicans host defense in mice. J. Infect. Dis.190, 624–631 (2004).
   PubMed Web of Science ®Google Scholar
• Kelly MN, Kolls JK, Happel K et al. Interleukin-17/Interleukin-17 receptor-mediated signaling is important for generation of an optimal polymorphonuclear response against Toxoplasma gondii infection. Infect. Immun.73(1), 617–621 (2005).
   PubMed Web of Science ®Google Scholar
• Filipe-Santos O, Bustamante J, Chapgier A et al. Inborn errors of IL-12/23- and IFN-γ-mediated immunity: molecular, cellular, and clinical features. Semin. Immunol.18, 347–361 (2006).
   PubMed Web of Science ®Google Scholar
• Chakir J, Shannon J, Molet S et al. Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-β IL-11, IL-17, and type I and type III collagen expression. J. Allergy Clin. Immunol.111, 1293–1298 (2003).
   PubMed Web of Science ®Google Scholar
• Barczyk A, Pierzcha W, Sozanska E. Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine. Respir. Med.97, 726–733 (2003).
   PubMed Web of Science ®Google Scholar
• Bullens MAD, Truyen E, Coteur L et al. IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx? Respir. Res.7, 135 (2006).
   PubMed Web of Science ®Google Scholar
• Schnyder-Candrian S, Togbe D, Couillin I et al. Interleukin-17 is a negative regulator of established allergic asthma. J. Exp. Med.203(12), 2715–2725 (2006).
   PubMed Web of Science ®Google Scholar
• Fujiwara M, Hirose K, Kagami S et al. T-bet inhibits both T(H)2 cell-mediated eosinophil recruitment and T(H)17 cell-mediated neutrophil recruitment into the airways. J. Allergy Clin. Immunol.119(3), 662–670 (2007).
   PubMed Web of Science ®Google Scholar
• Gocke A, Cravens PD, Ben L-H et al. T-bet regulates the fate of Th1 and Th17 lymphocytes in autoimmunity. J. Immunol.178, 1341–1348 (2006).
   Google Scholar
• Nakae S, Komiyama Y, Nambu A et al. Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity17, 375–387 (2002).
   PubMed Web of Science ®Google Scholar
• McAllister F, Henry A, Kreindler JL et al. Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-α, granulocyte colony-stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis. J. Immunol.175, 404–412 (2005).
   PubMed Web of Science ®Google Scholar
• Vanaudenaerde BM, Dupont LJ, Wuyts WA et al. The role of interleukin-17 during acute rejection after lung transplantation. Eur. Respir. J.27, 779–787 (2006).
   PubMed Web of Science ®Google Scholar
• Yoshida S, Haque A, Mizobuchi T et al. Anti-type V collagen lymphocytes that express IL-17 and IL-23 induce rejection pathology in fresh and well-healed lung transplants. Am. J. Transplant.6, 724–735 (2006).
   PubMed Web of Science ®Google Scholar
• Kooten C, Boonstra JG, Paape ME et al. Interleukin-1 7 activates human renal epithelial cells in vitro and is expressed during renal allograft rejection. J. Am. Soc. Nephrol.9, 1526–1534 (1998).
   Google Scholar
• Kaufmann CL, Aria N, Toichi E et al. A Phase I study evaluating the safety, pharmacokinetics, and clinical response of a human IL-12 p40 antibody in subjects with plaque psoriasis. J. Invest. Dermatol.123(6), 1037–1044 (2004).
   Google Scholar
• Fuss IJ, Becker C, Yang Z et al. Both IL-12p70 and IL-23 are synthesized during active Crohn’s disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody Inflamm. Bowel Dis.12(1), 9–15 (2006).
   PubMed Web of Science ®Google Scholar