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Review

Update on antivirals and vaccines for seasonal and potential pandemic use

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Pages 391-402 | Published online: 09 Jan 2014

References

  • Moscona A. Neuraminidase inhibitors for influenza. N. Engl. J. Med.353, 1363–1373 (2005).
  • Barroso L, Treanor J, Gubareva L, Hayden FG. Efficacy and tolerability of the oral neuraminidase inhibitor peramivir in experimental human influenza: randomized, controlled trials for prophylaxis and treatment. Antivir. Ther.10(8), 901–910 (2005).
  • Nicholson KG, Aoki FY, Osterhaus ADME et al. Efficacy and safety of oseltamivir in treatment of acute influenza: a randomized controlled trial. Lancet355, 1845–1850 (2000).
  • Kawai N, Ikematsu H, Iwaki N et al. A comparison of the effectiveness of oseltamivir for the treatment of influenza A and influenza B: a Japanese multicenter study of the 2003–2004 and 2004–2005 influenza seasons. Clin. Infect. Dis.43, 439–444 (2006).
  • Kaye D. FDA staff urges psych warning for flu drug labels. Clin. Infect. Dis.46, III–IV (2008).
  • The MIST (Management of Influenza in the Southern Hemisphere Trialists) Study Group. Randomised trial of efficacy and safety of inhaled zanamivir in treatment of influenza A and B virus infections. Lancet352(9144), 1877–1881 (1998).
  • Monto AS, Fleming DM, Henry D et al. Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenza A and B virus infections. J. Infect. Dis.180, 254–261 (1999).
  • Kaiser L, Keene ON, Hammond JM, Elliott M, Hayden FG. Impact of zanamivir on antibiotic use for respiratory events following acute influenza in adolescents and adults. Arch. Intern. Med.160, 3234–3240 (2000).
  • Cooper NJ, Sutton AJ, Abrams KR, Wailoo A, Turner D, Nicholson KG. Effectiveness of neuraminidase inhibitors in treatment and prevention of influenza A and B: systematic review and meta-analyses of randomized controlled trials. BMJ326, 1235 (2003).
  • Bowles SK, Lee W, Simor AE et al. Use of oseltamivir during influenza outbreaks in Ontario nursing homes, 1999–2000. J. Am. Geriatr. Soc.50, 608–616 (2002).
  • Lalezari J, Campion K, Keene O, Silagy C. Zanamivir for the treatment of influenza A and B infection in high-risk patients: a pooled analysis of randomized controlled trials. Arch. Intern. Med.161, 212–217 (2001).
  • de Jong MD, Tran TT, Truong HK et al. Oseltamivir resistance during treatment of influenza A (H5N1) infection. N. Engl. J. Med. Dec 22, 353(25), 2667–2672 (2005).
  • Kiso M, Mitamura K, Sakai-Tagawa Y et al. Resistant influenza A viruses in children treated with oseltamivir: descriptive study. Lancet364(9436), 759–765 (2004).
  • McKimm-Breschkin JL, Selleck PW, Usman TB, Johnson MA. Reduced sensitivity of influenza A (H5N1) to oseltamivir. Emerg. Infect. Dis. Sep.13(9), 1354–1357 (2007).
  • Monto AS, McKimm-Breschkin JL, Macken C et al. Detection of influenza viruses resistant to neuraminidase inhibitors in global surveillance during the first 3 years of their use. Antimicrob. Agents Chemother.50, 2395–2402 (2006).
  • Ciancio B, Fernandez de la Hoz K, Kreidl P et al. Oseltamivir resistance in human seasonal influenza viruses (A/H1N1) in EU and EFTA countries: an update. Eur. Surveill.13(6), (2008).
  • Abdel-Ghafar AN, Chotpitayasunondh T, Gao Z et al.; Writing Committee of the Second World Health Organization Consultation on Clinical Aspects of Human Infection with Avian Influenza A (H5N1) Virus. Update on avian influenza A (H5N1) virus infection in humans. N. Engl. J. Med.358(3), 261–273 (2008).
  • Bright RA, Medina M-J, Xu X et al. Incidence of adamantane resistance among influenza A (H3N2) viruses isolated worldwide from 1994 to 2005: a cause for concern. Lancet366, 1175–1181 (2005).
  • Bright RA, Shay DK, Shu B, Cox NJ, Klimov AI. Adamantane resistance among influenza A viruses isolated early during the 2005–2006 influenza season in the United States. JAMA295, 891–894 (2006).
  • Cheung C-L, Rayner JM, Smith GJD et al. Distribution of amantadine-resistant H5N1 avian influenza variants in Asia. J. Infect. Dis.193, 1626–1629 (2006).
  • Barr IG, Hurt AC, Deeda N, Iannello P, Tomasov C, Komadina N. The emergence of adamantane resistance in influenza A(H1) viruses in Australia and regionally in 2006. Antiviral Res.75, 173–176 (2007).
  • Simonsen L, Viboud C, Grenfell BT et al. The genesis and spread of reassortment human influenza A/H3N2 viruses conferring adamantane resistance. Mol. Biol. Evol.24(8), 1811–1820 (2007).
  • Govorkova EA, Fang H-B, Tan M, Webster RG. Neuraminidase inhibitor–rimantadine combinations exert additive and synergistic anti-influenza virus effects in MDCK cells. Antimicrob. Agents Chemother.48, 4855–4863 (2004).
  • Ilyushina NA, Hoffmann E, Salomon R, Webster RG, Govorkova EA. Amantadine–oseltamivir combination therapy for H5N1 influenza virus infection in mice. Antivir. Ther.12(3), 363–370 (2007).
  • Ison MG, Gnann J, Nagy-Agren S et al. Safety and efficacy of nebulized zanamivir in hospitalized patients with serious influenza. Antivir. Ther.8, 183–190 (2003).
  • Govorkova EA, Ilyushina NA, Boltz DA et al. Efficacy of oseltamivir therapy in ferrets inoculated with different clades of H5N1 influenza virus. Antimicrob. Agents Chemother.51(4), 1414–1424 (2007).
  • Kaiser L, Wat C, Mills T et al. Impact of oseltamivir treatment on influenza-related lower respiratory tract complications and hospitalizations. Arch. Intern. Med.163(14), 1667–1672 (2003).
  • Tablan OC, Anderson LJ, Besser R, Bridges C, Hajjeh R; CDC; Healthcare Infection Control Practices Advisory Committee. Guidelines for preventing health-care-associated pneumonia, 2003: recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee. MMWR Recomm. Rep.53(RR-3), 1–36 (2004).
  • Nichols WG, Guthrie KA, Corey L, Boeckh M. Influenza infections after hematopoietic stem cell transplantation: risk factors, mortality, and the effect of antiviral therapy. Clin. Infect. Dis.39(9), 1300–1306 (2004).
  • Monto AS, Robinson DP, Herlocher ML, Hinson JM Jr, Elliott MJ, Crisp A. Zanamivir in the prevention of influenza among healthy adults: a randomized controlled trial. JAMA282, 31–35 (1999).
  • Hayden FG, Atmar RL, Schilling M et al. Use of the selective oral neuraminidase inhibitor oseltamivir to prevent influenza. N. Engl. J. Med.341, 1336–1343 (1999).
  • Hayden FG, Belshe R, Villanueva C et al. Management of influenza in households: a prospective, randomized comparison of oseltamivir treatment with or without postexposure prophylaxis. J. Infect. Dis.189, 440–449 (2004).
  • Welliver R, Monto AS, Carewicz O et al. Effectiveness of oseltamivir in preventing influenza in household contacts: a randomized controlled trial. JAMA285, 748–754 (2001).
  • Monto AS, Pichichero ME, Blanckenberg SJ et al. Zanamivir prophylaxis: an effective strategy for the prevention of influenza types A and B within households. J. Infect. Dis.186, 1582–1588 (2002).
  • Peters PH Jr, Gravenstein S, Norwood P et al. Long-term use of oseltamivir for the prophylaxis of influenza in a vaccinated frail older population. J. Am. Geriatr. Soc.49, 1025–1031 (2001).
  • Monto AS, Rotthoff J, Teich E et al. Detection and control of influenza outbreaks in well-vaccinated nursing home populations. Clin. Infect. Dis.39, 459–464 (2004).
  • Lowen AC, Palese P. Influenza virus transmission: basic science and implications for the use of antiviral drugs during a pandemic. Infect. Disord. Drug Targets7(4), 318–328 (2007).
  • Subbarao K, Chen H, Swayne D et al. Evaluation of a genetically modified reassortant H5N1 influenza A virus vaccine candidate generated by plasmid-based reverse genetics. Virology305(1), 192–200 (2003).
  • Fiore AE, Shay DK, Haber P et al. Prevention and control of influenza recommendations of the Advisory Committee on Immunization Practices (ACIP), 2007. MMWR Morb. Mortal. Wkly. Rep.56(RR06), 1–54 (2007).
  • Treanor J, Wright PF. Immune correlates of protection against influenza in the human challenge model. Dev. Biol. (Basel)115, 97–104 (2003).
  • Negri E, Colombo C, Giordano L et al. Influenza vaccine in healthy children: a meta-analysis. Vaccine23, 2851–2861 (2005).
  • Jefferson T, Smith S, Demicheli V et al. Assessment of the efficacy and effectiveness of influenza vaccines in healthy children: a systematic review. Lancet365, 773–780 (2005).
  • Neuzil KM, Jackson LA, Nelson J et al. Immunogenicity and reactogenicity of 1 versus 2 doses of trivalent inactivated influenza vaccine in vaccine-naive 5–8-year-old children. J. Infect. Dis.194, 1032–1039 (2006).
  • Groothuis JR, Lehr MV, Levin MJ. Safety and immunogenicity of a purified haemagglutinin antigen in very young high-risk children. Vaccine12, 139–141 (1994).
  • Park CL, Frank AL, Sullivan M, Jindal P, Baxter BD. Influenza vaccination of children during acute asthma exacerbation and concurrent prednisone therapy. Pediatrics98(2 Pt 1), 196–200 (1996).
  • Ritzwoller DP, Bridges CB, Shetterly S et al. Effectiveness of the 2003–2004 influenza vaccine among children 6 months to 8 years of age with 1 vs. 2 doses. Pediatrics116, 153–159 (2005).
  • Allison MA, Daley MF, Crane LA et al. Influenza vaccine effectiveness in healthy 6- to 21-month-old children during the 2003–2004 season. J. Pediatr.149, 755–762 (2006).
  • Wilde JA, McMillan JA, Serwint J et al. Effectiveness of influenza vaccine in health care professionals: a randomized trial. JAMA281, 908–913 (1999).
  • Bridges CB, Thompson WW, Meltzer MI et al. Effectiveness and cost–benefit of influenza vaccination of healthy working adults: a randomized controlled trial. JAMA284, 1655–1663 (2000).
  • Demicheli V, Rivetti D, Deeks JJ, Jefferson TO. Vaccines for preventing influenza in healthy adults. Cochrane Database Syst. Rev.3, CD001269 (2004).
  • Nichol KL, Lind A, Margolis KL et al. The effectiveness of vaccination against influenza in healthy, working adults. N. Engl. J. Med.333, 889–893 (1995).
  • Ohmit SE, Victor JC, Rotthoff JR et al. Prevention of antigenically drifted influenza by inactivated and live attenuated vaccines. N. Engl. J. Med.355, 2513–2522 (2006).
  • Herrera GA, Iwane MK, Cortese M et al. Influenza vaccine effectiveness among 50–64-year-old persons during a season of poor antigenic match between vaccine and circulating influenza virus strains: Colorado, United States, 2003–2004. Vaccine25, 154–160 (2007).
  • Blumberg EA, Albano C, Pruett T et al. The immunogenicity of influenza virus vaccine in solid organ transplant recipients. Clin. Infect. Dis.22, 295–302 (1996).
  • Dorrell L, Hassan I, Marshall S et al. Clinical and serological responses to an inactivated influenza vaccine in adults with HIV infection, diabetes, obstructive airways disease, elderly adults and healthy volunteers. Int. J. STD AIDS8, 776–779 (1997).
  • Cates CJ, Jefferson TO, Bara AI, Rowe BH. Vaccines for preventing influenza in people with asthma. Cochrane Database Syst. Rev.2, CD000364 (2004).
  • Poole PJ, Chacko E, Wood-Baker RWB, Cates CJ. Influenza vaccine for patients with chronic obstructive pulmonary disease [update]. Cochrane Database Syst. Rev.1, CD002733 (2006).
  • Govaert TM, Thijs CT, Masurel N et al. The efficacy of influenza vaccination in elderly individuals. A randomized double-blind placebo-controlled trial. JAMA272, 1661–1665 (1994).
  • Nordin J, Mullooly J, Poblete S et al. Influenza vaccine effectiveness in preventing hospitalizations and deaths in persons 65 years or older in Minnesota, New York, and Oregon: data from 3 health plans. J. Infect. Dis.184, 665–670 (2001).
  • Hak E, Nordin J, Wei F et al. Influence of high-risk medical conditions on the effectiveness of influenza vaccination among elderly members of 3 large managed-care organizations. Clin. Infect. Dis.35, 370–377 (2002).
  • Jefferson T, Rivetti D, Rudin M et al. Efficacy and effectiveness of influenza vaccines in elderly people: a systematic review. Lancet366, 1165–1174 (2005).
  • Hambidge SJ, Glanz JM, France EK. Safety of inactivated influenza vaccine in children 6 to 23 months old. JAMA296, 1990–1997 (2006).
  • Daubeney P, Taylor CJ, McGaw J et al. Immunogenicity and tolerability of a trivalent influenza subunit vaccine (Influvac) in high-risk children aged 6 months to 4 years. Br. J. Clin. Pract.51, 87–90 (1997).
  • American Lung Association Asthma Clinical Research Centers. The safety of inactivated influenza vaccine in adults and children with asthma. N. Engl. J. Med.345, 1529–1536 (2001).
  • Bierman CW, Shapiro GG, Pierson WE et al. Safety of influenza vaccination in allergic children. J. Infect. Dis.136(Suppl.), S652–S655 (1977).
  • Bohlke K, Davis RL, Marcy SM et al. Risk of anaphylaxis after vaccination of children and adolescents. Pediatrics112, 815–820 (2003).
  • Fuller JD, Craven DE, Steger KA et al. Influenza vaccination of human immunodeficiency virus (HIV)-infected adults: impact on plasma levels of HIV type 1 RNA and determinants of antibody response. Clin. Infect. Dis.28, 541–547 (1999).
  • Amendola A, Boschini A, Colzani D et al. Influenza vaccination of HIV-1-positive and HIV-1-negative former intravenous drug users. J. Med. Virol.65, 644–648 (2001).
  • Sullivan PS, Hanson DL, Dworkin MS et al. Effect of influenza vaccination on disease progression among HIV-infected persons. AIDS14, 2781–2785 (2000).
  • Lasky T, Terracciano GJ, Magder L et al. The Guillain–Barre syndrome and the 1992–1993 and 1993–1994 influenza vaccines. N. Engl. J. Med.339, 1797–1802 (1998).
  • Haber P, DeStefano F, Angulo FJ et al. Guillain–Barre syndrome following influenza vaccination. JAMA292, 2478–2481 (2004).
  • Schonberger LB, Bregman DJ, Sullivan-Bolyai JZ et al. Guillain–Barre syndrome following vaccination in the National Influenza Immunization Program, United States, 1976–1977. Am. J. Epidemiol.110, 105–123 (1979).
  • Juurlink DN, Stukel TA, Kwong J. Guillain–Barre syndrome after influenza vaccination in adults: a population-based study. Arch. Intern. Med.166, 2217–2221 (2006).
  • Vesikari T, Fleming DM, Aristequi JF et al. Safety, efficacy, and effectiveness of cold-adapted influenza vaccine-trivalent against community-acquired, culture-confirmed influenza in young children attending day care. Pediatrics118, 2298–2312 (2006).
  • Gaglani MJ, Piedra PA, Herschler GB et al. Direct and total effectiveness of the intranasal, live-attenuated, trivalent cold adapted influenza virus vaccine against the 2000–2001 influenza A(H1N1) and B epidemic in healthy children. Arch. Pediatr. Adolesc. Med.158, 65–73 (2004).
  • Nichol KL, Mendelman PM, Mallon KP et al. Effectiveness of live, attenuated intranasal influenza virus vaccine in healthy, working adults: a randomized controlled trial. JAMA282, 137–144 (1999).
  • Belshe RB, Edwards KM, Vesikari T et al. Live attenuated versus inactivated influenza vaccine in infants and young children. N. Engl. J. Med.356, 685–696 (2007); erratum in: N. Engl. J. Med.356, 1283 (2007).
  • Bergen R, Black S, Shinefield H et al. Safety of cold-adapted live attenuated influenza vaccine in a large cohort of children and adolescents. Pediatr. Infect. Dis. J.23, 138–144 (2004).
  • FluMist [package insert]. Medimmune Vaccines, Inc., Gaithersburg, MD, USA (2007).
  • Belshe RB, Nichol KL, Black SB et al. Safety, efficacy, and effectiveness of live, attenuated, cold-adapted influenza vaccine in an indicated population aged 5–49 years. Clin. Infect. Dis.39, 920–927 (2004).
  • King JC Jr, Treanor J, Fast PE et al. Comparison of the safety, vaccine virus shedding, and immunogenicity of influenza virus vaccine, trivalent, types A and B, live cold-adapted, administered to human immunodeficiency virus (HIV)-infected and non-HIV-infected adults. J. Infect. Dis.181, 725–728 (2000).
  • Jackson LA, Holmes SJ, Mendelman PM et al. Safety of a trivalent live attenuated intranasal influenza vaccine, FluMist, administered in addition to parenteral trivalent inactivated influenza vaccine to seniors with chronic medical conditions. Vaccine17, 1905–1909 (1999).
  • Salgado CD, Gianetta ET, Hayden FG, Farr BM. Preventing nosocomial influenza by improving the vaccine acceptance rate of clinicians. Infect. Control Hosp. Epidemiol.25, 923–928 (2004).
  • Sato M, Saito R, Tanabe N et al. Antibody response to influenza vaccination in nursing home residents and health-care workers during four successive seasons in Niigata, Japan. Infect. Control Hosp. Epidemiol.26, 859–866 (2005).
  • Carman WF, Elder AG, Wallace LA et al. Effects of influenza vaccination of health-care personnel on mortality of elderly people in longterm care: a randomised controlled trial. Lancet355, 93–97 (2000).
  • Hayward AC, Harling R, Wetten S et al. Effectiveness of an influenza vaccine programme for care home staff to prevent death, morbidity, and health service use among residents: cluster randomized controlled trial. BMJ333, 1241 (2006).
  • Thomas RE, Jefferson TO, Demicheli V, Rivetti D. Influenza vaccination for health-care workers who work with elderly people in institutions: a systematic review. Lancet Infect. Dis.6, 273–279 (2006).
  • Veits J, Römer-Oberdörfer A, Helferich D et al. Protective efficacy of several vaccines against highly pathogenic H5N1 avian influenza virus under experimental conditions. Vaccine26(13), 1688–1696 (2008).
  • Leroux-Roels I, Borkowski A, Vanwolleghem T et al. Antigen sparing and cross-reactive immunity with an adjuvanted rH5N1 prototype pandemic influenza vaccine: a randomised controlled trial. Lancet370(9587), 580–589 (2007).
  • Lin J, Zhang J, Dong X et al. Safety and immunogenicity of an inactivated adjuvanted whole-virion influenza A (H5N1) vaccine: a Phase I randomised controlled trial. Lancet368(9540), 991–997 (2006).
  • Bresson JL, Perronne C, Launay O et al. Safety and immunogenicity of an inactivated split-virion influenza A/Vietnam/1194/2004 (H5N1) vaccine: Phase I randomised trial. Lancet367(9523), 1657–1664 (2006).
  • Bernstein DI, Edwards KM, Dekker CL et al. Effects of adjuvants on the safety and immunogenicity of an avian influenza H5N1 vaccine in adults. J. Infect. Dis.197(5), 667–675 (2008).
  • Leroux-Roels I, Bernhard R, Gérard P et al. Broad clade 2 cross-reactive immunity induced by an adjuvanted clade 1 rH5N1 pandemic influenza vaccine. PLoS ONE3(2), e1665 (2008).
  • Meeting of the Immunization Strategic Advisory Group of Experts, November 2007 – conclusions and recommendations. Wkly Epidemiol. Rec.83(1), 1–15 (2008).
  • Hoelscher MA, Garg S, Bangari DS et al. Development of adenoviral-vector-based pandemic influenza vaccine against antigenically distinct human H5N1 strains in mice. Lancet367(9509), 475–481 (2006).
  • Gao W, Soloff AC, Lu X et al. Protection of mice and poultry from lethal H5N1 avian influenza virus through adenovirus-based immunization. J. Virol.80(4), 1959–1964 (2006).
  • Laddy DJ, Yan J, Corbitt N et al. Immunogenicity of novel consensus-based DNA vaccines against avian influenza. Vaccine25(16), 2984–2989 (2007).
  • Stoloff GA, Caparros-Wanderley W. Synthetic multi-epitope peptides identified in silico induce protective immunity against multiple influenza serotypes. Eur. J. Immunol.37(9), 2441–2449 (2007).
  • Itoh Y, Ozaki H, Tsuchiya H et al. A vaccine prepared from a non-pathogenic H5N1 avian influenza virus strain confers protective immunity against highly pathogenic avian influenza virus infection in cynomolgus macaques. Vaccine26(4), 562–572 (2008).
  • Sencer DJ, Millar JD. Reflections on the 1976 swine flu vaccination program. Emerg. Infect. Dis.12, 29–33 (2006).
  • Macroepidemiology of Influenza Vaccination (MIV) Study Group. The macroepidemiology of influenza vaccination in 56 countries, 1997–2003. Vaccine23, 5133–5143 (2005).

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