Diagnosis of pediatric obstructive sleep disordered breathing: beyond the gold standard

References

• Hill W. On some causes of backwardness and stupidity in children. Br. Med. J.2, 711–712 (1889).
   Google Scholar
• Osler W. Chronic tonsillitis. In: The Principles and Practice of Medicine. Appleton and Co., NY, USA 335–339 (1892).
   Google Scholar
• Guilleminault C, Winkle R, Korobkin R, Simmons B. Children and nocturnal snoring: evaluation of the effects of sleep related respiratory resistive load and daytime functioning. Eur. J. Pediatr.139(3), 165–171 (1982).
   PubMed Web of Science ®Google Scholar
• Beebe DW, Wells CT, Jeffries J, Chini B, Kalra M, Amin R. Neuropsychological effects of pediatric obstructive sleep apnea. J. Int. Neuropsychol. Soc.10(7), 962–975 (2004).
   PubMed Web of Science ®Google Scholar
• Beebe DW, Gozal D. Obstructive sleep apnea and the prefrontal cortex: towards a comprehensive model linking nocturnal upper airway obstruction to daytime cognitive and behavioral deficits. J. Sleep Res.11(1), 1–16 (2002).
   PubMed Web of Science ®Google Scholar
• O’Brien LM, Mervis CB, Holbrook CR et al. Neurobehavioral implications of habitual snoring in children. Pediatrics114(1), 44–49 (2004).
   PubMed Web of Science ®Google Scholar
• O’Brien LM, Mervis CB, Holbrook CR et al. Neurobehavioral correlates of sleep-disordered breathing in children. J. Sleep Res.13(2), 165–172 (2004).
   PubMed Web of Science ®Google Scholar
• Guilleminault C, Pelayo R. Sleep-disordered breathing in children. Ann. Med.30(4), 350–356 (1998).
   PubMed Web of Science ®Google Scholar
• Marcus CL. Sleep-disordered breathing in children. Curr. Opin. Pediatr.12(3), 208–212 (2000).
   Web of Science ®Google Scholar
• Wiegand L, Zwillich CW, White DP. Collapsibility of the human upper airway during normal sleep. J. Appl. Physiol.66(4), 1800–1808 (1989).
   Google Scholar
• Katz ES, Marcus CL, White DP. Influence of airway pressure on genioglossus activity during sleep in normal children. Am. J. Respir. Crit. Care Med.173(8), 902–909 (2006).
   Google Scholar
• Arens R, Marcus CL. Pathophysiology of upper airway obstruction: a developmental perspective. Sleep27(5), 997–1019 (2004).
   PubMed Web of Science ®Google Scholar
• Katz ES, White DP. Genioglossus activity in children with obstructive sleep apnea during wakefulness and sleep onset. Am. J. Respir. Crit. Care Med.168(6), 664–670 (2003).
   PubMed Web of Science ®Google Scholar
• Goh DY, Galster P, Marcus CL. Sleep architecture and respiratory disturbances in children with obstructive sleep apnea. Am. J. Respir. Crit. Care Med.162(2 Pt 1), 682–686 (2000).
   PubMed Web of Science ®Google Scholar
• Katz ES, White DP. Genioglossus activity during sleep in normal control subjects and children with obstructive sleep apnea. Am. J. Respir. Crit. Care Med.170(5), 553–560 (2004).
   Google Scholar
• Gozal D, Kheirandish-Gozal L. Neurocognitive and behavioral morbidity in children with sleep disorders. Curr. Opin. Pulm. Med.13(6), 505–509 (2007).
   PubMed Web of Science ®Google Scholar
• Halbower AC, Degaonkar M, Barker PB et al. Childhood obstructive sleep apnea associates with neuropsychological deficits and neuronal brain injury. PLoS. Med.3(8), E301 (2006).
   PubMed Web of Science ®Google Scholar
• Amin RS, Carroll JL, Jeffries JL et al. Twenty-four-hour ambulatory blood pressure in children with sleep-disordered breathing. Am. J. Respir. Crit. Care Med.169(8), 950–956 (2004).
   PubMed Web of Science ®Google Scholar
• Zintzaras E, Kaditis AG. Sleep-disordered breathing and blood pressure in children: a meta-analysis. Arch. Pediatr. Adolesc. Med.161(2), 172–178 (2007).
   Google Scholar
• Amin RS, Kimball TR, Bean JA et al. Left ventricular hypertrophy and abnormal ventricular geometry in children and adolescents with obstructive sleep apnea. Am. J. Respir. Crit. Care Med.165(10), 1395–1399 (2002).
   PubMed Web of Science ®Google Scholar
• Gozal D, Kheirandish-Gozal L. Cardiovascular morbidity in obstructive sleep apnea: oxidative stress, inflammation, and much more. Am. J. Respir. Crit. Care Med.177(4), 369–375 (2008).
   PubMed Web of Science ®Google Scholar
• Gozal D, Serpero LD, Sans CO, Kheirandish-Gozal L. Systemic inflammation in non-obese children with obstructive sleep apnea. Sleep Med.9(3), 254–259 (2008).
   PubMed Web of Science ®Google Scholar
• Flint J, Kothare SV, Zihlif M et al. Association between inadequate sleep and insulin resistance in obese children. J. Pediatr.150(4), 364–369 (2007).
   Google Scholar
• Gozal D, Sans CO, Crabtree VM, Serpero LD, Witcher LA, Kheirandish-Gozal L. Plasma IGF-1 levels and cognitive dysfunction in children with obstructive sleep apnea. Sleep Med. DOI: 10.1016/j.sleep.2008.01.001 (2008) (Epub ahead of print).
   Google Scholar
• Li AM, Chan MH, Yin J et al. C-reactive protein in children with obstructive sleep apnea and the effects of treatment. Pediatr. Pulmonol.43(1), 34–40 (2008).
   PubMed Web of Science ®Google Scholar
• Gozal D, Crabtree VM, Sans CO, Witcher LA, Kheirandish-Gozal L. C-reactive protein, obstructive sleep apnea, and cognitive dysfunction in school-aged children. Am. J. Respir. Crit. Care Med.176(2), 188–193 (2007).
   PubMed Web of Science ®Google Scholar
• Chervin RD, Archbold KH. Hyperactivity and polysomnographic findings in children evaluated for sleep-disordered breathing. Sleep24(3), 313–320 (2001).
   PubMed Web of Science ®Google Scholar
• O’Brien LM, Holbrook CR, Mervis CB et al. Sleep and neurobehavioral characteristics of 5- to 7-year-old children with parentally reported symptoms of attention-deficit/hyperactivity disorder. Pediatrics111(3), 554–563 (2003).
   PubMed Web of Science ®Google Scholar
• Beebe DW. Neurobehavioral morbidity associated with disordered breathing during sleep in children: a comprehensive review. Sleep29(9), 1115–1134 (2006).
   PubMed Web of Science ®Google Scholar
• Kheirandish L, Gozal D. Neurocognitive dysfunction in children with sleep disorders. Dev. Sci.9(4), 388–399 (2006).
   PubMed Web of Science ®Google Scholar
• Kheirandish-Gozal L, Miano S, Bruni O et al. Reduced NREM sleep instability in children with sleep disordered breathing. Sleep30(4), 450–457 (2007).
   Google Scholar
• Ondze B, Espa F, Dauvilliers Y, Billiard M, Besset A. Sleep architecture, slow wave activity and sleep spindles in mild sleep disordered breathing. Clin. Neurophysiol.114(5), 867–874 (2003).
   Google Scholar
• Miano S, Donfrancesco R, Bruni O et al. NREM sleep instability is reduced in children with attention-deficit/hyperactivity disorder. Sleep29(6), 797–803 (2006).
   PubMedGoogle Scholar
• Lopes MC, Guilleminault C. Chronic snoring and sleep in children: a demonstration of sleep disruption. Pediatrics118(3), E741–E746 (2006).
   PubMed Web of Science ®Google Scholar
• Carroll JL, McColley SA, Marcus CL, Curtis S, Loughlin GM. Inability of clinical history to distinguish primary snoring from obstructive sleep apnea syndrome in children. Chest108(3), 610–618 (1995).
   PubMed Web of Science ®Google Scholar
• Wang RC, Elkins TP, Keech D, Wauquier A, Hubbard D. Accuracy of clinical evaluation in pediatric obstructive sleep apnea. Otolaryngol. Head Neck Surg.118(1), 69–73 (1998).
   PubMed Web of Science ®Google Scholar
• Goldstein NA, Pugazhendhi V, Rao SM et al. Clinical assessment of pediatric obstructive sleep apnea. Pediatrics114(1), 33–43 (2004).
   PubMed Web of Science ®Google Scholar
• Xu Z, Cheuk DK, Lee SL. Clinical evaluation in predicting childhood obstructive sleep apnea. Chest130(6), 1765–1771 (2006).
   Google Scholar
• Gottlieb DJ, Chase C, Vezina RM et al. Sleep-disordered breathing symptoms are associated with poorer cognitive function in 5-year-old children. J. Pediatr.145(4), 458–464 (2004).
   PubMed Web of Science ®Google Scholar
• Suratt PM, Peruggia M, D’Andrea L et al. Cognitive function and behavior of children with adenotonsillar hypertrophy suspected of having obstructive sleep-disordered breathing. Pediatrics118(3), E771–E781 (2006).
   Web of Science ®Google Scholar
• Suratt PM, Barth JT, Diamond R et al. Reduced time in bed and obstructive sleep-disordered breathing in children are associated with cognitive impairment. Pediatrics119(2), 320–329 (2007).
   PubMed Web of Science ®Google Scholar
• Weatherly RA, Mai EF, Ruzicka DL, Chervin RD. Identification and evaluation of obstructive sleep apnea prior to adenotonsillectomy in children: a survey of practice patterns. Sleep Med.4(4), 297–307 (2003).
   PubMed Web of Science ®Google Scholar
• Beebe DW. Neurobehavioral effects of obstructive sleep apnea: an overview and heuristic model. Curr. Opin. Pulm. Med.11(6), 494–500 (2005).
   Google Scholar
• Beebe DW, Groesz L, Wells C, Nichols A, McGee K. The neuropsychological effects of obstructive sleep apnea: a meta-analysis of norm-referenced and case-controlled data. Sleep26(3), 298–307 (2003).
   PubMed Web of Science ®Google Scholar
• Gozal D, Pope DW Jr. Snoring during early childhood and academic performance at ages thirteen to fourteen years. Pediatrics107(6), 1394–1399 (2001).
   PubMed Web of Science ®Google Scholar
• Amin RS, Kimball TR, Kalra M et al. Left ventricular function in children with sleep-disordered breathing. Am. J. Cardiol.95(6), 801–804 (2005).
   PubMed Web of Science ®Google Scholar
• Verhulst SL, Schrauwen N, Haentjens D et al. Sleep-disordered breathing and the metabolic syndrome in overweight and obese children and adolescents. J. Pediatr.150(6), 608–612 (2007).
   PubMed Web of Science ®Google Scholar
• Verhulst SL, Van HK, Schrauwen N et al. Sleep-disordered breathing and uric acid in overweight and obese children and adolescents. Chest132(1), 76–80 (2007).
   PubMed Web of Science ®Google Scholar
• Waters KA, Sitha S, O’Brien LM et al. Follow-up on metabolic markers in children treated for obstructive sleep apnea. Am. J. Respir. Crit Care Med.174(4), 455–460 (2006).
   PubMed Web of Science ®Google Scholar
• Bonuck K, Parikh S, Bassila M. Growth failure and sleep disordered breathing: a review of the literature. Int. J. Pediatr. Otorhinolaryngol.70(5), 769–778 (2006).
   PubMed Web of Science ®Google Scholar
• Pepperell JC, Davies RJ, Stradling JR. Sleep studies for sleep apnoea. Physiol. Meas.23(2), R39–R74 (2002).
   Google Scholar
• Iber C, Ancoli IS, Chesson AL Jr, Quan SF. The AASM manual for the scoring of sleep and associated events: rules, terminology and technical specifications. In: American Academy of Sleep Medicine. 2007 Amercian Academy of Sleep Medicine, Westchester, IL, USA (2007).
   Google Scholar
• Guilleminault C, Eldridge FL, Simmons FB, Dement WC. Sleep apnea in eight children. Pediatrics58(1), 23–30 (1976).
   PubMed Web of Science ®Google Scholar
• Owens JA, Mindell JA. Pediatric sleep medicine: priorities for research, patient care, policy and education. J. Clin. Sleep Med.2(1), 77–88 (2006).
   PubMed Web of Science ®Google Scholar
• American Thoracic Society. Standards and indications for cardiopulmonary sleep studies in children. Am. J. Respir. Crit. Care Med.153(2), 866–878 (1996).
   PubMed Web of Science ®Google Scholar
• Hosselet JJ, Norman RG, Ayappa I, Rapoport DM. Detection of flow limitation with a nasal cannula/pressure transducer system. Am. J. Respir. Crit. Care Med.157(5 Pt 1), 1461–1467 (1998).
   PubMedGoogle Scholar
• Hernandez L, Ballester E, Farre R et al. Performance of nasal prongs in sleep studies: spectrum of flow-related events. Chest119(2), 442–450 (2001).
   Web of Science ®Google Scholar
• Griffiths A, Maul J, Wilson A, Stick S. Improved detection of obstructive events in childhood sleep apnoea with the use of the nasal cannula and the differentiated sum signal. J. Sleep Res.14(4), 431–436 (2005).
   Google Scholar
• Ballester E, Badia JR, Hernandez L, Farre R, Navajas D, Montserrat JM. Nasal prongs in the detection of sleep-related disordered breathing in the sleep apnoea/hypopnoea syndrome. Eur. Respir. J.11(4), 880–883 (1998).
   PubMedGoogle Scholar
• Norman RG, Ahmed MM, Walsleben JA, Rapoport DM. Detection of respiratory events during NPSG: nasal cannula/pressure sensor versus thermistor. Sleep20(12), 1175–1184 (1997).
   PubMed Web of Science ®Google Scholar
• Berry RB, Koch GL, Trautz S, Wagner MH. Comparison of respiratory event detection by a polyvinylidene fluoride film airflow sensor and a pneumotachograph in sleep apnea patients. Chest128(3), 1331–1338 (2005).
   Google Scholar
• Montserrat JM, Farre R, Ballester E, Felez MA, Pasto M, Navajas D. Evaluation of nasal prongs for estimating nasal flow. Am. J. Respir. Crit. Care Med.155(1), 211–215 (1997).
   PubMed Web of Science ®Google Scholar
• Heitman SJ, Atkar RS, Hajduk EA, Wanner RA, Flemons WW. Validation of nasal pressure for the identification of apneas/hypopneas during sleep. Am. J. Respir. Crit. Care Med.166(3), 386–391 (2002).
   Web of Science ®Google Scholar
• Thurnheer R, Xie X, Bloch KE. Accuracy of nasal cannula pressure recordings for assessment of ventilation during sleep. Am. J. Respir. Crit. Care Med.164(10 Pt 1), 1914–1919 (2001).
   PubMedGoogle Scholar
• Trang H, Leske V, Gaultier C. Use of nasal cannula for detecting sleep apneas and hypopneas in infants and children. Am. J. Respir. Crit Care Med.166(4), 464–468 (2002).
   PubMed Web of Science ®Google Scholar
• Serebrisky D, Cordero R, Mandeli J, Kattan M, Lamm C. Assessment of inspiratory flow limitation in children with sleep-disordered breathing by a nasal cannula pressure transducer system. Pediatr. Pulmonol.33(5), 380–387 (2002).
   PubMed Web of Science ®Google Scholar
• BaHammam A. Comparison of nasal prong pressure and thermistor measurements for detecting respiratory events during sleep. Respiration71(4), 385–390 (2004).
   PubMedGoogle Scholar
• Ayappa I, Norman RG, Suryadevara M, Rapoport DM. Comparison of limited monitoring using a nasal-cannula flow signal to full polysomnography in sleep-disordered breathing. Sleep27(6), 1171–1179 (2004).
   Google Scholar
• Lorino AM, Lorino H, Dahan E et al. Effects of nasal prongs on nasal airflow resistance. Chest118(2), 366–371 (2000).
   Web of Science ®Google Scholar
• Clark SA, Wilson CR, Satoh M, Pegelow D, Dempsey JA. Assessment of inspiratory flow limitation invasively and noninvasively during sleep. Am. J. Respir. Crit. Care Med.158(3), 713–722 (1998).
   Google Scholar
• Carry PY, Baconnier P, Eberhard A, Cotte P, Benchetrit G. Evaluation of respiratory inductive plethysmography: accuracy for analysis of respiratory waveforms. Chest111(4), 910–915 (1997).
   PubMedGoogle Scholar
• Kaplan V, Zhang JN, Russi EW, Bloch KE. Detection of inspiratory flow limitation during sleep by computer assisted respiratory inductive plethysmography. Eur. Respir. J.15(3), 570–578 (2000).
   PubMedGoogle Scholar
• Redline S, Budhiraja R, Kapur V et al. The scoring of respiratory events in sleep: reliability and validity. J. Clin. Sleep Med.3(2), 169–200 (2007).
   Google Scholar
• Gleeson K, Zwillich CW, White DP. The influence of increasing ventilatory effort on arousal from sleep. Am. Rev. Respir. Dis.142(2), 295–300 (1990).
   PubMed Web of Science ®Google Scholar
• Guilleminault C, Pelayo R, Leger D, Clerk A, Bocian RC. Recognition of sleep-disordered breathing in children. Pediatrics98(5), 871–882 (1996).
   PubMed Web of Science ®Google Scholar
• Foo JY. Pulse transit time in paediatric respiratory sleep studies. Med. Eng. Phys.29(1), 17–25 (2007).
   Google Scholar
• Kushida CA, Giacomini A, Lee MK, Guilleminault C, Dement WC. Technical protocol for the use of esophageal manometry in the diagnosis of sleep-related breathing disorders. Sleep Med.3(2), 163–173 (2002).
   Google Scholar
• Guilleminault C, Poyares D, Palombini L, Koester U, Pelin Z, Black J. Variability of respiratory effort in relation to sleep stages in normal controls and upper airway resistance syndrome patients. Sleep Med.2(5), 397–405 (2001).
   Google Scholar
• Guilleminault C, Pelayo R, Leger D, Clerk A, Bocian RC. Recognition of sleep-disordered breathing in children. Pediatrics98(5), 871–882 (1996).
   PubMed Web of Science ®Google Scholar
• Guilleminault C, Khramtsov A. Upper airway resistance syndrome in children: a clinical review. Semin. Pediatr. Neurol.8(4), 207–215 (2001).
   PubMedGoogle Scholar
• Chervin RD, Aldrich MS. Effects of esophageal pressure monitoring on sleep architecture. Am. J. Respir. Crit. Care Med.156(3 Pt 1), 881–885 (1997).
   Google Scholar
• Smith RP, Argod J, Pepin JL, Levy PA. Pulse transit time: an appraisal of potential clinical applications. Thorax54(5), 452–457 (1999).
   PubMed Web of Science ®Google Scholar
• Groswasser J, Scaillon M, Rebuffat E et al. Naso-oesophageal probes decrease the frequency of sleep apnoeas in infants. J. Sleep Res.9(2), 193–196 (2000).
   Google Scholar
• Berry RB, Kouchi KG, Bower JL, Light RW. Effect of upper airway anesthesia on obstructive sleep apnea. Am. J. Respir. Crit.Care Med.151(6), 1857–1861 (1995).
   PubMedGoogle Scholar
• Miyazaki S, Itasaka Y, Yamakawa K, Okawa M, Togawa K. Respiratory disturbance during sleep due to adenoid-tonsillar hypertrophy. Am. J. Otolaryngol.10(2), 143–149 (1989).
   Google Scholar
• Katz ES, Lutz J, Black C, Marcus CL. Pulse transit time as a measure of arousal and respiratory effort in children with sleep-disordered breathing. Pediatr. Res.53(4), 580–588 (2003).
   PubMed Web of Science ®Google Scholar
• Guilleminault C, Pelayo R, Leger D, Clerk A, Bocian RC. Recognition of sleep-disordered breathing in children. Pediatrics98(5), 871–882 (1996).
   PubMed Web of Science ®Google Scholar
• Masa JF, Corral J, Martin MJ et al. Assessment of thoracoabdominal bands to detect respiratory effort-related arousal. Eur. Respir. J.22(4), 661–667 (2003).
   Google Scholar
• Brouillette RT, Lavergne J, Leimanis A, Nixon GM, Ladan S, McGregor CD. Differences in pulse oximetry technology can affect detection of sleep-disorderd breathing in children. Anesth. Analg.94(1 Suppl.), S47–S53 (2002).
   Google Scholar
• Bass JL, Corwin M, Gozal D et al. The effect of chronic or intermittent hypoxia on cognition in childhood: a review of the evidence. Pediatrics114(3), 805–816 (2004).
   PubMed Web of Science ®Google Scholar
• Guilleminault C, Lopes MC, Hagen CC, da Rosa A. The cyclic alternating pattern demonstrates increased sleep instability and correlates with fatigue and sleepiness in adults with upper airway resistance syndrome. Sleep30(5), 641–647 (2007).
   PubMed Web of Science ®Google Scholar
• Grigg-Damberger M, Gozal D, Marcus CL et al. The visual scoring of sleep and arousal in infants and children. J. Clin. Sleep Med.3(2), 201–240 (2007).
   PubMed Web of Science ®Google Scholar
• Bonnet MH, Doghramji K, Roehrs T et al. The scoring of arousal in sleep: reliability, validity, and alternatives. J. Clin. Sleep Med.3(2), 133–145 (2007).
   PubMedGoogle Scholar
• Traeger N, Schultz B, Pollock AN, Mason T, Marcus CL, Arens R. Polysomnographic values in children 2–9 years old: additional data and review of the literature. Pediatr. Pulmonol.40(1), 22–30 (2005).
   PubMed Web of Science ®Google Scholar
• Bruni O, Ferri R, Miano S et al. Sleep cyclic alternating pattern in normal school-age children. Clin. Neurophysiol.113(11), 1806–1814 (2002).
   PubMedGoogle Scholar
• Montgomery-Downs HE, O’Brien LM, Gulliver TE, Gozal D. Polysomnographic characteristics in normal preschool and early school-aged children. Pediatrics117(3), 741–753 (2006).
   PubMed Web of Science ®Google Scholar
• Stores G, Crawford C. Arousal norms for children age 5–16 years based on home polysomnography. Technol. Health Care8(5), 285–290 (2000).
   PubMedGoogle Scholar
• McNamara F, Issa FG, Sullivan CE. Arousal pattern following central and obstructive breathing abnormalities in infants and children. J. Appl. Physiol.81(6), 2651–2657 (1996).
   Google Scholar
• Chervin RD, Weatherly RA, Ruzicka DL et al. Subjective sleepiness and polysomnographic correlates in children scheduled for adenotonsillectomy vs other surgical care. Sleep29(4), 495–503 (2006).
   PubMed Web of Science ®Google Scholar
• Fuentes-Pradera MA, Botebol G, Sanchez-Armengol A et al. Effect of snoring and obstructive respiratory events on sleep architecture in adolescents. Arch. Pediatr. Adolesc. Med.157(7), 649–654 (2003).
   Google Scholar
• Frank Y, Kravath RE, Pollak CP, Weitzman ED. Obstructive sleep apnea and its therapy: clinical and polysomnographic manifestations. Pediatrics71(5), 737–742 (1983).
   Google Scholar
• Marcus CL, Carroll JL, Koerner CB, Hamer A, Lutz J, Loughlin GM. Determinants of growth in children with the obstructive sleep apnea syndrome. J. Pediatr.125(4), 556–562 (1994).
   PubMed Web of Science ®Google Scholar
• Tal A, Bar A, Leiberman A, Tarasiuk A. Sleep characteristics following adenotonsillectomy in children with obstructive sleep apnea syndrome. Chest124(3), 948–953 (2003).
   PubMed Web of Science ®Google Scholar
• Mitchell RB. Adenotonsillectomy for obstructive sleep apnea in children: outcome evaluated by pre- and postoperative polysomnography. Laryngoscope117(10), 1844–1854 (2007).
   PubMed Web of Science ®Google Scholar
• Coble PA, Kupfer DJ, Taska LS, Kane J. EEG sleep of normal healthy children. Part I: findings using standard measurement methods. Sleep7(4), 289–303 (1984).
   PubMed Web of Science ®Google Scholar
• Scholle S, Scholle HC, Kemper A et al. First night effect in children and adolescents undergoing polysomnography for sleep-disordered breathing. Clin. Neurophysiol.114(11), 2138–2145 (2003).
   PubMed Web of Science ®Google Scholar
• Verhulst SL, Schrauwen N, De Backer WA, Desager KN. First night effect for polysomnographic data in children and adolescents with suspected sleep disordered breathing. Arch. Dis. Child.91(3), 233–237 (2006).
   Google Scholar
• Li AM, Wing YK, Cheung A et al. Is a 2-night polysomnographic study necessary in childhood sleep-related disordered breathing? Chest126(5), 1467–1472 (2004).
   PubMedGoogle Scholar
• Morielli A, Ladan S, Ducharme FM, Brouillette RT. Can sleep and wakefulness be distinguished in children by cardiorespiratory and videotape recordings? Chest109(3), 680–687 (1996).
   PubMed Web of Science ®Google Scholar
• Rebuffat E, Groswasser J, Kelmanson I, Sottiaux M, Kahn A. Polygraphic evaluation of night-to-night variability in sleep characteristics and apneas in infants. Sleep17(4), 329–332 (1994).
   Google Scholar
• Katz ES, Greene MG, Carson KA et al. Night-to-night variability of polysomnography in children with suspected obstructive sleep apnea. J. Pediatr.140(5), 589–594 (2002).
   Google Scholar
• Marcus CL, Hamer A, Loughlin GM. Natural history of primary snoring in children. Pediatr. Pulmonol.26(1), 6–11 (1998).
   PubMedGoogle Scholar
• Tang JP, Rosen CL, Larkin EK et al. Identification of sleep-disordered breathing in children: variation with event definition. Sleep25(1), 72–79 (2002).
   Google Scholar
• O’Brien LM, Gozal D. Potential usefulness of noninvasive autonomic monitoring in recognition of arousals in normal healthy children. J. Clin. Sleep Med.3(1), 41–47 (2007).
   Google Scholar
• Friedman NR. Polysomnography should not be required both before and after adenotonsillectomy for childhood sleep disordered breathing. J. Clin. Sleep Med.3(7), 678–680 (2007).
   PubMed Web of Science ®Google Scholar
• Kushida CA, Littner MR, Morgenthaler T et al. Practice parameters for the indications for polysomnography and related procedures: an update for 2005. Sleep28(4), 499–521 (2005).
   PubMed Web of Science ®Google Scholar
• Wagner MH, Torrez DM. Interpretation of the polysomnogram in children. Otolaryngol. Clin. North Am.40(4), 745–759 (2007).
   Google Scholar
• Sargi Z, Younis RT. Pediatric obstructive sleep apnea: current management. ORL J. Otorhinolaryngol. Relat. Spec.69(6), 340–344 (2007).
   PubMedGoogle Scholar
• Mitchell RB, Pereira KD, Friedman NR. Sleep-disordered breathing in children: survey of current practice. Laryngoscope116(6), 956–958 (2006).
   PubMed Web of Science ®Google Scholar
• Hoban TF. Polysomnography should be required both before and after adenotonsillectomy for childhood sleep disordered breathing. J. Clin. Sleep Med.3(7), 675–677 (2007).
   Google Scholar
• Lewin DS, Rosen RC, England SJ, Dahl RE. Preliminary evidence of behavioral and cognitive sequelae of obstructive sleep apnea in children. Sleep Med.3(1), 5–13 (2002).
   PubMed Web of Science ®Google Scholar
• Blunden S, Lushington K, Lorenzen B, Martin J, Kennedy D. Neuropsychological and psychosocial function in children with a history of snoring or behavioral sleep problems. J. Pediatr.146(6), 780–786 (2005).
   PubMed Web of Science ®Google Scholar
• Kennedy JD, Blunden S, Hirte C et al. Reduced neurocognition in children who snore. Pediatr. Pulmonol.37(4), 330–337 (2004).
   PubMed Web of Science ®Google Scholar
• Blunden S, Lushington K, Kennedy D, Martin J, Dawson D. Behavior and neurocognitive performance in children aged 5–10 years who snore compared with controls. J. Clin. Exp. Neuropsychol.22(5), 554–568 (2000).
   PubMed Web of Science ®Google Scholar
• Chervin RD, Weatherly RA, Garetz SL et al. Pediatric sleep questionnaire: prediction of sleep apnea and outcomes. Arch. Otolaryngol. Head Neck Surg.133(3), 216–222 (2007).
   PubMedGoogle Scholar
• Terzano MG, Mancia D, Salati MR, Costani G, Decembrino A, Parrino L. The cyclic alternating pattern as a physiologic component of normal NREM sleep. Sleep8(2), 137–145 (1985).
   PubMed Web of Science ®Google Scholar
• Terzano MG, Parrino L. Origin and significance of the cyclic alternating pattern (CAP). Sleep Med. Rev.4(1), 101–123 (2000).
   Google Scholar
• Monahan KJ, Larkin EK, Rosen CL, Graham G, Redline S. Utility of noninvasive pharyngometry in epidemiologic studies of childhood sleep-disordered breathing. Am. J. Respir. Crit. Care Med.165(11), 1499–1503 (2002).
   Google Scholar
• Marcus CL, McColley SA, Carroll JL, Loughlin GM, Smith PL, Schwartz AR. Upper airway collapsibility in children with obstructive sleep apnea syndrome. J. Appl. Physiol.77(2), 918–924 (1994).
   Web of Science ®Google Scholar
• Marcus CL. Evaluating the upper airway during wakefulness: what can it tell us about sleep? Am. J. Respir. Crit. Care Med.169(2), 140–141 (2004).
   Google Scholar
• Gozal D, Burnside MM. Increased upper airway collapsibility in children with obstructive sleep apnea during wakefulness. Am. J. Respir. Crit. Care Med.169(2), 163–167 (2004).
   PubMed Web of Science ®Google Scholar
• Krishna J, Shah ZA, Merchant M, Klein JB, Gozal D. Urinary protein expression patterns in children with sleep-disordered breathing: preliminary findings. Sleep Med.7(3), 221–227 (2006).
   PubMed Web of Science ®Google Scholar
• Shah ZA, Jortani SA, Tauman R, Valdes R Jr, Gozal D. Serum proteomic patterns associated with sleep-disordered breathing in children. Pediatr. Res.59(3), 466–470 (2006).
   Google Scholar
• Kheirandish-Gozal L, Capdevila OS, Tauman R, Gozal D. Plasma C-reactive protein in nonobese children with obstructive sleep apnea before and after adenotonsillectomy. J. Clin. Sleep Med.2(3), 301–304 (2006).
   PubMed Web of Science ®Google Scholar
• Tauman R, Ivanenko A, O’Brien LM, Gozal D. Plasma C-reactive protein levels among children with sleep-disordered breathing. Pediatrics113(6), E564–E569 (2004).
   PubMed Web of Science ®Google Scholar
• Goldbart AD, Krishna J, Li RC, Serpero LD, Gozal D. Inflammatory mediators in exhaled breath condensate of children with obstructive sleep apnea syndrome. Chest130(1), 143–148 (2006).
   PubMed Web of Science ®Google Scholar
• Tam CS, Wong M, McBain R, Bailey S, Waters KA. Inflammatory measures in children with obstructive sleep apnoea. J. Paediatr. Child Health42(5), 277–282 (2006).
   PubMed Web of Science ®Google Scholar
• O’Brien LM, Serpero LD, Tauman R, Gozal D. Plasma adhesion molecules in children with sleep-disordered breathing. Chest129(4), 947–953 (2006).
   PubMed Web of Science ®Google Scholar
• Li AM, Hung E, Tsang T et al. Induced sputum inflammatory measures correlate with disease severity in children with obstructive sleep apnoea. Thorax62(1), 75–79 (2007).
   PubMed Web of Science ®Google Scholar
• Kaditis AG, Alexopoulos EI, Hatzi F et al. Overnight change in brain natriuretic peptide levels in children with sleep-disordered breathing. Chest130(5), 1377–1384 (2006).
   Web of Science ®Google Scholar
• El-Sheikh M, Buckhalt JA, Granger DA, Erath SA, Acebo C. The association between children’s sleep disruption and salivary interleukin-6. J. Sleep Res.16(2), 188–197 (2007).
   Google Scholar
• Kaditis AG, Alexopoulos EI, Kalampouka E et al. Morning levels of C-reactive protein in children with obstructive sleep-disordered breathing. Am. J. Respir. Crit Care Med.171(3), 282–286 (2005).
   PubMed Web of Science ®Google Scholar
• Kalra M, Chakraborty R. Genetic susceptibility to obstructive sleep apnea in the obese child. Sleep Med.8(2), 169–175 (2007).
   Google Scholar
• Kalra M, Pal P, Kaushal R et al. Association of ApoE genetic variants with obstructive sleep apnea in children. Sleep Med.9(3), 260–265 (2007).
   Google Scholar
• Gottlieb DJ, DeStefano AL, Foley DJ et al. APOE ε4 is associated with obstructive sleep apnea/hypopnea: the Sleep Heart Health Study. Neurology63(4), 664–668 (2004).
   PubMed Web of Science ®Google Scholar
• Gozal D, Capdevila OS, Kheirandish-Gozal L, Crabtree VM. APOE ε4 allele, cognitive dysfunction, and obstructive sleep apnea in children. Neurology69(3), 243–249 (2007).
   PubMed Web of Science ®Google Scholar
• de Almeida FR, Ayas NT, Otsuka R et al. Nasal pressure recordings to detect obstructive sleep apnea. Sleep Breath.10(2), 62–69 (2006).
   Google Scholar
• Budhiraja R, Goodwin JL, Parthasarathy S, Quan SF. Comparison of nasal pressure transducer and thermistor for detection of respiratory events during polysomnography in children. Sleep28(9), 1117–1121 (2005).
   PubMedGoogle Scholar
• Epstein MD, Chicoine SA, Hanumara RC. Detection of upper airway resistance syndrome using a nasal cannula/pressure transducer. Chest117(4), 1073–1077 (2000).
   Google Scholar
• Ayappa I, Norman RG, Krieger AC, Rosen A, O’malley RL, Rapoport DM. Non-Invasive detection of respiratory effort-related arousals (REras) by a nasal cannula/pressure transducer system. Sleep23(6), 763–771 (2000).
   PubMed Web of Science ®Google Scholar
• Loube DI, Andrada T, Howard RS. Accuracy of respiratory inductive plethysmography for the diagnosis of upper airway resistance syndrome. Chest115(5), 1333–1337 (1999).
   PubMedGoogle Scholar
• Kohyama J, Sakuma H, Shiiki T, Shimohira M, Hasegawa T. Quantitative analysis of paradoxical inward rib cage movement during sleep in children. Psychiatry Clin. Neurosci.54(3), 328–329 (2000).
   Google Scholar
• Gaultier C, Praud JP, Canet E, Delaperche MF, d’Allest AM. Paradoxical inward rib cage motion during rapid eye movement sleep in infants and young children. J. Dev. Physiol.9(5), 391–397 (1987).
   Google Scholar
• Pitson DJ, Sandell A, van den HR, Stradling JR. Use of pulse transit time as a measure of inspiratory effort in patients with obstructive sleep apnoea. Eur. Respir. J.8(10), 1669–1674 (1995).
   PubMedGoogle Scholar
• Argod J, Pepin JL, Smith RP, Levy P. Comparison of esophageal pressure with pulse transit time as a measure of respiratory effort for scoring obstructive nonapneic respiratory events. Am. J. Respir. Crit. Care Med.162(1), 87–93 (2000).
   PubMedGoogle Scholar
• Foo JY, Wilson SJ, Williams G, Harris MA, Cooper D. Age-related factors that confound peripheral pulse timing characteristics in Caucasian children. J. Hum. Hypertens.19(6), 463–466 (2005).
   PubMed Web of Science ®Google Scholar
• Allen J, Murray A. Age-related changes in peripheral pulse timing characteristics at the ears, fingers and toes. J. Hum. Hypertens.16(10), 711–717 (2002).
   PubMed Web of Science ®Google Scholar
• Pepin JL, Bettega G, Orliaguet O, Raphael B, Levy P. Tools available for the diagnosis of obstructive sleep apnea syndrome. Measurements for the evaluation of therapeutic efficacy. Rev. Stomatol. Chir. Maxillofac.103(3), 151–157 (2002).
   Google Scholar
• Stoohs RA, Blum HC, Knaack L, Butsch-von-der-Heydt B, Guilleminault C. Comparison of pleural pressure and transcutaneous diaphragmatic electromyogram in obstructive sleep apnea syndrome. Sleep28(3), 321–329 (2005).
   PubMed Web of Science ®Google Scholar
• Loube DI, Andrada TF. Comparison of respiratory polysomnographic parameters in matched cohorts of upper airway resistance and obstructive sleep apnea syndrome patients. Chest115(6), 1519–1524 (1999).
   Google Scholar
• Black JE, Guilleminault C, Colrain IM, Carrillo O. Upper airway resistance syndrome. Central electroencephalographic power and changes in breathing effort. Am. J. Respir. Crit. Care Med.162(2 Pt 1), 406–411 (2000).
   PubMed Web of Science ®Google Scholar
• Chervin RD, Burns JW, Subotic NS, Roussi C, Thelen B, Ruzicka DL. Correlates of respiratory cycle-related EEG changes in children with sleep-disordered breathing. Sleep27(1), 116–121 (2004).
   Google Scholar
• Ferri R, Parrino L, Smerieri A et al. Cyclic alternating pattern and spectral analysis of heart rate variability during normal sleep. J. Sleep Res.9(1), 13–18 (2000).
   PubMed Web of Science ®Google Scholar
• Thomas RJ, Terzano MG, Parrino L, Weiss JW. Obstructive sleep-disordered breathing with a dominant cyclic alternating pattern – a recognizable polysomnographic variant with practical clinical implications. Sleep27(2), 229–234 (2004).
   Google Scholar
• Terzano MG, Parrino L, Anelli S, Boselli M, Clemens B. Effects of generalized interictal EEG discharges on sleep stability: assessment by means of cyclic alternating pattern. Epilepsia33(2), 317–326 (1992).
   Google Scholar
• Catcheside PG, Chiong SC, Mercer J, Saunders NA, McEvoy RD. Noninvasive cardiovascular markers of acoustically induced arousal from non-rapid-eye-movement sleep. Sleep25(7), 797–804 (2002).
   Google Scholar
• Pitson D, Chhina N, Knijn S, van HM, Stradling J. Changes in pulse transit time and pulse rate as markers of arousal from sleep in normal subjects. Clin. Sci. (Lond.)87(2), 269–273 (1994).
   Web of Science ®Google Scholar
• Foo JY, Wilson SJ, Bradley AP, Williams GR, Harris MA, Cooper DM. Use of pulse transit time to distinguish respiratory events from tidal breathing in sleeping children. Chest128(4), 3013–3019 (2005).
   PubMedGoogle Scholar
• Pitson DJ, Stradling JR. Autonomic markers of arousal during sleep in patients undergoing investigation for obstructive sleep apnoea, their relationship to EEG arousals, respiratory events and subjective sleepiness. J. Sleep Res.7(1), 53–59 (1998).
   Google Scholar
• Bennett LS, Barbour C, Langford B, Stradling JR, Davies RJ. Health status in obstructive sleep apnea: relationship with sleep fragmentation and daytine sleepiness, and effects of continuous positive airway pressure treatment. Am. J. Respir. Crit. Care Med.159(6), 1884–1890 (1999).
   Google Scholar
• Poyares D, Guilleminault C, Rosa A, Ohayon M, Koester U. Arousal, EEG spectral power and pulse transit time in UARS and mild OSAS subjects. Clin. Neurophysiol.113(10), 1598–1606 (2002).
   PubMed Web of Science ®Google Scholar
• Brietzke SE, Katz ES, Roberson DW. Pulse transit time as a screening test for pediatric sleep-related breathing disorders. Arch. Otolaryngol. Head Neck Surg.133(10), 980–984 (2007).
   PubMedGoogle Scholar
• Foo JY, Bradley AP, Wilson SJ, Williams GR, Dakin C, Cooper DM. Screening of obstructive and central apnoea/hypopnoea in children using variability: a preliminary study. Acta. Paediatr.95(5), 561–564 (2006).
   PubMed Web of Science ®Google Scholar
• Foo JY, Wilson SJ, Williams GR, Harris MA, Cooper DM. Pulse transit time changes observed with different limb positions. Physiol. Meas.26(6), 1093–1102 (2005).
   Google Scholar
• Foo JY, Wilson SJ, Williams GR, Coates A, Harris MA, Cooper DM. Predictive regression equations and clinical uses of peripheral pulse timing characteristics in children. Physiol. Meas.26(3), 317–328 (2005).
   PubMedGoogle Scholar
• Tauman R, O’Brien LM, Mast BT, Holbrook CR, Gozal D. Peripheral arterial tonometry events and electroencephalographic arousals in children. Sleep27(3), 502–506 (2004).
   PubMed Web of Science ®Google Scholar