Perinatal factors in neonatal and pediatric lung diseases

References

• Asher MI, Montefort S, Bjorksten B et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet 368(9537), 733–743 (2006).
   PubMed Web of Science ®Google Scholar
• Wenzel SE. Asthma phenotypes: the evolution from clinical to molecular approaches. Nat. Med. 18(5), 716–725 (2012).
   PubMed Web of Science ®Google Scholar
• Bush A, Menzies-Gow A. Phenotypic differences between pediatric and adult asthma. Proc. Am. Thorac. Soc. 6(8), 712–719 (2009).
   PubMedGoogle Scholar
• Holgate ST. Innate and adaptive immune responses in asthma. Nat. Med. 18(5), 673–683 (2012).
   PubMed Web of Science ®Google Scholar
• Reich ES. Pre-term births on the rise. Nature 485(7396), 20 (2012).
   PubMedGoogle Scholar
• Petrou S, Khan K. Economic costs associated with moderate and late preterm birth: primary and secondary evidence. Semin. Fetal. Neonatal. Med. 17(3), 170–178 (2012).
   PubMed Web of Science ®Google Scholar
• Jaakkola JJ, Ahmed P, Ieromnimon A et al. Preterm delivery and asthma: a systematic review and meta-analysis. J. Allergy Clin. Immunol. 118(4), 823–830 (2006).
   PubMedGoogle Scholar
• Kumar R, Yu Y, Story RE et al. Prematurity, chorioamnionitis, and the development of recurrent wheezing: a prospective birth cohort study. J. Allergy Clin. Immunol. 121(4), 878–884 e876 (2008).
   PubMed Web of Science ®Google Scholar
• Duijts L. Fetal and infant origins of asthma. Eur. J. Epidemiol. 27(1), 5–14 (2012).
   PubMed Web of Science ®Google Scholar
• Jobe AH. The new bronchopulmonary dysplasia. Curr. Opin. Pediatr. 23(2), 167–172 (2011).
   PubMed Web of Science ®Google Scholar
• Henschen M, Stocks J, Brookes I, Frey U. New aspects of airway mechanics in pre-term infants. Eur. Respir. J. 27(5), 913–920 (2006).
   PubMedGoogle Scholar
• Martin RJ, Prakash YS, Hibbs AM. Why do former preterm infants wheeze? J. Pediatr. 162(3), 443–444 (2013).
   PubMed Web of Science ®Google Scholar
• McEvoy C, Venigalla S, Schilling D, Clay N, Spitale P, Nguyen T. Respiratory function in healthy late preterm infants delivered at 33-36 weeks of gestation. J. Pediatr. 162(3), 464–469 (2013).
   PubMed Web of Science ®Google Scholar
• Warner JO. The early life origins of asthma and related allergic disorders. Arch. Dis. Child. 89(2), 97–102 (2004).
   PubMedGoogle Scholar
• Turner S. Perinatal programming of childhood asthma: early fetal size, growth trajectory during infancy, and childhood asthma outcomes. Clin. Dev. Immunol. 2012, 962923 (2012).
   PubMedGoogle Scholar
• Fahey JO. Clinical management of intra-amniotic infection and chorioamnionitis: a review of the literature. J. Midwifery Womens Health 53(3), 227–235 (2008).
   PubMed Web of Science ®Google Scholar
• Rusconi F, Galassi C, Forastiere F et al. Maternal complications and procedures in pregnancy and at birth and wheezing phenotypes in children. Am. J. Respir. Crit. Care Med. 175(1), 16–21 (2007).
   PubMed Web of Science ®Google Scholar
• Getahun D, Strickland D, Zeiger RS et al. Effect of chorioamnionitis on early childhood asthma. Arch. Pediatr. Adolesc. Med. 164(2), 187–192 (2010).
   PubMedGoogle Scholar
• Velten M, Heyob KM, Rogers LK, Welty SE. Deficits in lung alveolarization and function after systemic maternal inflammation and neonatal hyperoxia exposure. J. Appl. Physiol. 108(5), 1347–1356 (2010).
   PubMedGoogle Scholar
• Muratore CS, Luks FI, Zhou Y, Harty M, Reichner J, Tracy TF. Endotoxin alters early fetal lung morphogenesis. J. Surg. Res. 155(2), 225–230 (2009).
   PubMedGoogle Scholar
• Weinstein M, Xu X, Ohyama K, Deng CX. FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung. Development 125(18), 3615–3623 (1998).
   PubMed Web of Science ®Google Scholar
• Benjamin JT, Carver BJ, Plosa EJ et al. NF-kappaB activation limits airway branching through inhibition of Sp1-mediated fibroblast growth factor-10 expression. J. Immunol. 185(8), 4896–4903 (2010).
   PubMed Web of Science ®Google Scholar
• Miller JD, Benjamin JT, Kelly DR, Frank DB, Prince LS. Chorioamnionitis stimulates angiogenesis in saccular stage fetal lungs via CC chemokines. Am. J. Physiol. Lung Cell. Mol. Physiol. 298(5), L637–L645 (2010).
   Google Scholar
• Jobe AH, Newnham JP, Willet KE et al. Endotoxin-induced lung maturation in preterm lambs is not mediated by cortisol. Am. J. Respir. Crit. Care Med. 162(5), 1656–1661 (2000).
   PubMedGoogle Scholar
• Watterberg KL, Demers LM, Scott SM, Murphy S. Chorioamnionitis and early lung inflammation in infants in whom bronchopulmonary dysplasia develops. Pediatrics 97(2), 210–215 (1996).
   PubMed Web of Science ®Google Scholar
• Moss TJ, Newnham JP, Willett KE, Kramer BW, Jobe AH, Ikegami M. Early gestational intra-amniotic endotoxin: lung function, surfactant, and morphometry. Am. J. Respir. Crit. Care Med. 165(6), 805–811 (2002).
   PubMedGoogle Scholar
• Prince LS, Okoh VO, Moninger TO, Matalon S. Lipopolysaccharide increases alveolar type II cell number in fetal mouse lungs through Toll-like receptor 4 and NF-kappaB. Am. J. Physiol. Lung Cell. Mol. Physiol. 287(5), L999–L1006 (2004).
   PubMed Web of Science ®Google Scholar
• Westover AJ, Hooper SB, Wallace MJ, Moss TJ. Prostaglandins mediate the fetal pulmonary response to intrauterine inflammation. Am. J. Physiol. Lung Cell. Mol. Physiol. 302(7), L664–L678 (2012).
   Google Scholar
• Morsy MA, Isohama Y, Miyata T. Prostaglandin E(2) increases surfactant secretion via the EP(1) receptor in rat alveolar type II cells. Eur. J. Pharmacol. 426(1–2), 21–24 (2001).
   PubMedGoogle Scholar
• May M, Marx A, Seidenspinner S, Speer CP. Apoptosis and proliferation in lungs of human fetuses exposed to chorioamnionitis. Histopathology 45(3), 283–290 (2004).
   PubMedGoogle Scholar
• Collins JJ, Kunzmann S, Kuypers E et al. Antenatal glucocorticoids counteract LPS changes in TGF-beta pathway and caveolin-1 in ovine fetal lung. Am. J. Physiol. Lung. Cell Mol. Physiol. 304(6), L438–L444 (2013).
   Google Scholar
• Hartman WR, Smelter DF, Sathish V et al. Oxygen dose responsiveness of human fetal airway smooth muscle cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 303(8), L711–L719 (2012).
   PubMed Web of Science ®Google Scholar
• Sweet DG, Curley AE, Chesshyre E et al. The role of matrix metalloproteinases -9 and -2 in development of neonatal chronic lung disease. Acta. Paediatr. 93(6), 791–796 (2004).
   PubMedGoogle Scholar
• Kuypers E, Collins JJ, Kramer BW et al. Intra-amniotic LPS and antenatal betamethasone: inflammation and maturation in preterm lamb lungs. Am. J. Physiol. Lung Cell. Mol. Physiol. 302(4), L380–L389 (2012).
   PubMed Web of Science ®Google Scholar
• Tang JR, Seedorf GJ, Muehlethaler V et al. Moderate postnatal hyperoxia accelerates lung growth and attenuates pulmonary hypertension in infant rats after exposure to intra-amniotic endotoxin. Am. J. Physiol. Lung Cell. Mol. Physiol. 299(6), L735–L748 (2010).
   Google Scholar
• Tamashiro KL, Moran TH. Perinatal environment and its influences on metabolic programming of offspring. Physiol. Behav. 100(5), 560–566 (2010).
   PubMedGoogle Scholar
• Pike KC, Crozier SR, Lucas JS et al. Patterns of fetal and infant growth are related to atopy and wheezing disorders at age 3 years. Thorax 65(12), 1099–1106 (2010).
   PubMedGoogle Scholar
• Sharma P, McKay K, Rosenkrantz TS, Hussain N. Comparisons of mortality and pre-discharge respiratory outcomes in small-for-gestational-age and appropriate-for-gestational-age premature infants. BMC Pediatr. 4, 9 (2004).
   PubMedGoogle Scholar
• Gortner L, Hilgendorff A, Bahner T, Ebsen M, Reiss I, Rudloff S. Hypoxia-induced intrauterine growth retardation: effects on pulmonary development and surfactant protein transcription. Biol. Neonate 88(2), 129–135 (2005).
   PubMedGoogle Scholar
• Rozance PJ, Seedorf GJ, Brown A et al. Intrauterine growth restriction decreases pulmonary alveolar and vessel growth and causes pulmonary artery endothelial cell dysfunction in vitro in fetal sheep. Am. J. Physiol. Lung Cell. Mol. Physiol. 301(6), L860–L871 (2011).
   PubMed Web of Science ®Google Scholar
• Maritz GS, Cock ML, Louey S, Joyce BJ, Albuquerque CA, Harding R. Effects of fetal growth restriction on lung development before and after birth: a morphometric analysis. Pediatr. Pulmonol. 32(3), 201–210 (2001).
   PubMed Web of Science ®Google Scholar
• Joyce BJ, Louey S, Davey MG, Cock ML, Hooper SB, Harding R. Compromised respiratory function in postnatal lambs after placental insufficiency and intrauterine growth restriction. Pediatr. Res. 50(5), 641–649 (2001).
   PubMedGoogle Scholar
• Calvani M, Alessandri C, Sopo SM et al. Infectious and uterus related complications during pregnancy and development of atopic and nonatopic asthma in children. Allergy 59(1), 99–106 (2004).
   PubMedGoogle Scholar
• Collier CH, Risnes K, Norwitz ER, Bracken MB, Illuzzi JL. Maternal Infection in Pregnancy and Risk of Asthma in Offspring. Matern. Child Health J. doi:10.1007/s10995-013-1220-2 (2013) (Epub ahead of print).
   PubMedGoogle Scholar
• Ege MJ, Mayer M, Normand AC et al. Exposure to environmental microorganisms and childhood asthma. N. Engl J. Med. 364(8), 701–709 (2011).
   PubMed Web of Science ®Google Scholar
• Klebanoff M, Searle K. The role of inflammation in preterm birth-focus on periodontitis. BJOG 113(Suppl. 3), 43–45 (2006).
   PubMedGoogle Scholar
• Hasegawa K, Furuichi Y, Shimotsu A et al. Associations between systemic status, periodontal status, serum cytokine levels, and delivery outcomes in pregnant women with a diagnosis of threatened premature labor. J. Periodontol 74(12), 1764–1770 (2003).
   PubMedGoogle Scholar
• Tong VT, Jones JR, Dietz PM, D’Angelo D, Bombard JM. Trends in smoking before, during, and after pregnancy - Pregnancy Risk Assessment Monitoring System (PRAMS), United States, 31 sites, 2000–2005. MMWR Surveill. Summ. 58(4), 1–29 (2009).
   Google Scholar
• Burke H, Leonardi-Bee J, Hashim A et al. Prenatal and passive smoke exposure and incidence of asthma and wheeze: systematic review and meta-analysis. Pediatrics 129(4), 735–744 (2012).
   PubMed Web of Science ®Google Scholar
• Li YF, Langholz B, Salam MT, Gilliland FD. Maternal and grandmaternal smoking patterns are associated with early childhood asthma. Chest 127(4), 1232–1241 (2005).
   PubMed Web of Science ®Google Scholar
• Herrmann M, King K, Weitzman M. Prenatal tobacco smoke and postnatal secondhand smoke exposure and child neurodevelopment. Curr. Opin. Pediatr. 20(2), 184–190 (2008).
   PubMed Web of Science ®Google Scholar
• Rehan VK, Wang Y, Sugano S et al. In utero nicotine exposure alters fetal rat lung alveolar type II cell proliferation, differentiation, and metabolism. Am. J. Physiol. Lung. Cell. Mol. Physiol. 292(1), L323–L333 (2007).
   Google Scholar
• Landau LI. Tobacco smoke exposure and tracking of lung function into adult life. Paediatr. Respir. Rev. 9(1), 39–43; quiz 43–34 (2008).
   PubMed Web of Science ®Google Scholar
• Blacquiere MJ, Timens W, Melgert BN, Geerlings M, Postma DS, Hylkema MN. Maternal smoking during pregnancy induces airway remodelling in mice offspring. Eur. Respir. J. 33(5), 1133–1140 (2009).
   PubMedGoogle Scholar
• Blacquiere MJ, Timens W, van den Berg A, Geerlings M, Postma DS, Hylkema MN. Maternal smoking during pregnancy decreases Wnt signalling in neonatal mice. Thorax 65(6), 553–554 (2010).
   PubMedGoogle Scholar
• Collins MH, Moessinger AC, Kleinerman J et al. Fetal lung hypoplasia associated with maternal smoking: a morphometric analysis. Pediatr. Res. 19(4), 408–412 (1985).
   PubMed Web of Science ®Google Scholar
• Wongtrakool C, Grooms K, Ping XD et al. In utero nicotine exposure promotes M2 activation in neonatal mouse alveolar macrophages. Pediatr. Res. 72(2), 147–153 (2012).
   PubMed Web of Science ®Google Scholar
• Wongtrakool C, Wang N, Hyde DM, Roman J, Spindel ER. Prenatal nicotine exposure alters lung function and airway geometry through alpha7 nicotinic receptors. Am. J. Respir. Cell. Mol. Biol. 46(5), 695–702 (2012).
   PubMed Web of Science ®Google Scholar
• Sekhon HS, Keller JA, Proskocil BJ, Martin EL, Spindel ER. Maternal nicotine exposure upregulates collagen gene expression in fetal monkey lung. Association with alpha7 nicotinic acetylcholine receptors. Am. J. Respir. Cell. Mol. Biol. 26(1), 31–41 (2002).
   PubMed Web of Science ®Google Scholar
• Elliot JG, Carroll NG, James AL, Robinson PJ. Airway alveolar attachment points and exposure to cigarette smoke in utero. Am. J. Respir. Crit. Care Med. 167(1), 45–49 (2003).
   PubMed Web of Science ®Google Scholar
• Dietert RR. Maternal and childhood asthma: risk factors, interactions, and ramifications. Reprod. Toxicol. 32(2), 198–204 (2011).
   PubMedGoogle Scholar
• Paul G, Brehm JM, Alcorn JF, Holguin F, Aujla SJ, Celedon JC. Vitamin D and asthma. Am. J. Respir. Crit. Care Med. 185(2), 124–132 (2012).
   PubMed Web of Science ®Google Scholar
• Ross AC, Manson JE, Abrams SA et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J. Clin. Endocrinol. Metab. 96(1), 53–58 (2011).
   PubMed Web of Science ®Google Scholar
• Devereux G, Litonjua AA, Turner SW et al. Maternal vitamin D intake during pregnancy and early childhood wheezing. Am. J. Clin. Nutr. 85(3), 853–859 (2007).
   PubMed Web of Science ®Google Scholar
• Camargo CA Jr, Rifas-Shiman SL, Litonjua AA et al. Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age. Am. J. Clin. Nutr. 85(3), 788–795 (2007).
   PubMed Web of Science ®Google Scholar
• Pike KC, Inskip HM, Robinson S et al. Maternal late-pregnancy serum 25-hydroxyvitamin D in relation to childhood wheeze and atopic outcomes. Thorax 67(11), 950–956 (2012).
   PubMed Web of Science ®Google Scholar
• Hypponen E, Sovio U, Wjst M et al. Infant vitamin d supplementation and allergic conditions in adulthood: northern Finland birth cohort 1966. Ann. NY Acad. Sci. 1037. 84–95 (2004).
   PubMed Web of Science ®Google Scholar
• Agrawal T, Gupta GK, Agrawal DK. Vitamin D deficiency decreases the expression of VDR and prohibitin in the lungs of mice with allergic airway inflammation. Exp. Mol. Pathol. 93(1), 74–81 (2012).
   PubMedGoogle Scholar
• Banerjee A, Damera G, Bhandare R et al. Vitamin D and glucocorticoids differentially modulate chemokine expression in human airway smooth muscle cells. Br. J. Pharmacol. 155(1), 84–92 (2008).
   PubMed Web of Science ®Google Scholar
• Damera G, Fogle HW, Lim P et al. Vitamin D inhibits growth of human airway smooth muscle cells through growth factor-induced phosphorylation of retinoblastoma protein and checkpoint kinase 1. Br. J. Pharmacol. 158(6), 1429–1441 (2009).
   PubMed Web of Science ®Google Scholar
• Prescott SL, Calder PC. N-3 polyunsaturated fatty acids and allergic disease. Curr. Opin. Clin. Nutr. Metab. Care 7(2), 123–129 (2004).
   PubMedGoogle Scholar
• Maslova E, Strom M, Oken E et al. Fish intake during pregnancy and the risk of child asthma and allergic rhinitis - longitudinal evidence from the Danish National Birth Cohort. Br. J. Nutr. 1–13 (2013).
   Google Scholar
• Romieu I, Torrent M, Garcia-Esteban R et al. Maternal fish intake during pregnancy and atopy and asthma in infancy. Clin. Exp. Allergy 37(4), 518–525 (2007).
   PubMedGoogle Scholar
• Bilal S, Haworth O, Wu L, Weylandt KH, Levy BD, Kang JX. Fat-1 transgenic mice with elevated omega-3 fatty acids are protected from allergic airway responses. Biochim. Biophys. Acta. 1812(9), 1164–1169 (2011).
   PubMed Web of Science ®Google Scholar
• Rogers LK, Valentine CJ, Pennell M et al. Maternal docosahexaenoic acid supplementation decreases lung inflammation in hyperoxia-exposed newborn mice. J. Nutr. 141(2), 214–222 (2011).
   PubMedGoogle Scholar
• Yogev Y, Visser GH. Obesity, gestational diabetes and pregnancy outcome. Semin. Fetal. Neonatal. Med. 14(2), 77–84 (2009).
   PubMed Web of Science ®Google Scholar
• Cnattingius S, Villamor E, Johansson S et al. Maternal obesity and risk of preterm delivery. JAMA 309(22), 2362–2370 (2013).
   PubMed Web of Science ®Google Scholar
• Challier JC, Basu S, Bintein T et al. Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta. Placenta 29(3), 274–281 (2008).
   PubMed Web of Science ®Google Scholar
• Basu S, Haghiac M, Surace P et al. Pregravid obesity associates with increased maternal endotoxemia and metabolic inflammation. Obesity (Silver Spring) 19(3), 476–482 (2011).
   PubMed Web of Science ®Google Scholar
• Haberg SE, Stigum H, London SJ, Nystad W, Nafstad P. Maternal obesity in pregnancy and respiratory health in early childhood. Paediatr. Perinat. Epidemiol. 23(4), 352–362 (2009).
   PubMedGoogle Scholar
• Azad MB, Becker AB, Kozyrskyj AL. Association of maternal diabetes and child asthma. Pediatr Pulmonol, (2012).
   PubMedGoogle Scholar
• Adamo KB, Ferraro ZM, Goldfield G et al. The Maternal Obesity Management (MOM) Trial Protocol: A lifestyle intervention during pregnancy to minimize downstream obesity. Contemp Clin Trials, 35(1), 87–96 (2013).
   PubMed Web of Science ®Google Scholar
• Kumar R, Story RE, Pongracic JA et al. Maternal pre-pregnancy obesity and recurrent wheezing in early childhood. Pediatr. Allergy Immunol. Pulmonol. 23(3), 183–190 (2010).
   PubMedGoogle Scholar
• Reichman NE, Nepomnyaschy L. Maternal pre-pregnancy obesity and diagnosis of asthma in offspring at age 3 years. Matern. Child Health J. 12(6), 725–733 (2008).
   PubMedGoogle Scholar
• Harpsoe MC, Basit S, Bager P et al. Maternal obesity, gestational weight gain, and risk of asthma and atopic disease in offspring: a study within the Danish National Birth Cohort. J. Allergy Clin. Immunol. 131(4), 1033–1040 (2013).
   PubMed Web of Science ®Google Scholar
• Ornoy A, Rand SB, Bischitz N. Hyperglycemia and hypoxia are interrelated in their teratogenic mechanism: studies on cultured rat embryos. Birth Defects Res. B Dev. Reprod. Toxicol. 89(2), 106–115 (2010).
   PubMedGoogle Scholar
• Koskinen A, Lukkarinen H, Moritz N, Aho H, Kaapa P, Soukka H. Fetal hyperglycemia alters lung structural development in neonatal rat. Pediatr. Pulmonol. 47(3), 275–282 (2012).
   PubMedGoogle Scholar
• Bourbon JR, Farrell PM. Fetal lung development in the diabetic pregnancy. Pediatr. Res. 19(3), 253–267 (1985).
   PubMedGoogle Scholar
• Koskinen A, Laiho A, Lukkarinen H, Kaapa P, Soukka H. Maternal hyperglycemia modifies extracellular matrix signaling pathways in neonatal rat lung. Neonatology 98(4), 387–396 (2010).
   PubMedGoogle Scholar
• Dye JA, Madden MC, Richards JH, Lehmann JR, Devlin RB, Costa DL. Ozone effects on airway responsiveness, lung injury, and inflammation. Comparative rat strain and in vivo/in vitro investigations. Inhal. Toxicol. 11(11), 1015–1040 (1999).
   PubMedGoogle Scholar
• Auten RL, Gilmour MI, Krantz QT, Potts EN, Mason SN, Foster WM. Maternal diesel inhalation increases airway hyperreactivity in ozone-exposed offspring. Am. J. Respir. Cell. Mol. Biol. 46(4), 454–460 (2012).
   PubMed Web of Science ®Google Scholar
• Fedulov AV, Leme A, Yang Z et al. Pulmonary exposure to particles during pregnancy causes increased neonatal asthma susceptibility. Am. J. Respir. Cell. Mol. Biol. 38(1), 57–67 (2008).
   PubMed Web of Science ®Google Scholar
• Auten RL, Potts EN, Mason SN, Fischer B, Huang Y, Foster WM. Maternal exposure to particulate matter increases postnatal ozone-induced airway hyperreactivity in juvenile mice. Am. J. Respir. Crit. Care Med. 180(12), 1218–1226 (2009).
   PubMedGoogle Scholar
• Lim RH, Kobzik L. Maternal transmission of asthma risk. Am. J. Reprod. Immunol. 61(1), 1–10 (2009).
   PubMedGoogle Scholar
• Hillman NH, Polglase GR, Pillow JJ, Saito M, Kallapur SG, Jobe AH. Inflammation and lung maturation from stretch injury in preterm fetal sheep. Am. J. Physiol. Lung Cell. Mol. Physiol. 300(2), L232–L241 (2011).
   Google Scholar
• Velten M, Britt RD Jr, Heyob KM et al. Prenatal inflammation exacerbates hyperoxia-induced functional and structural changes in adult mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 303(3), R279–R290 (2012).
   Google Scholar
• Fakhoury KF, Sellers C, Smith EO, Rama JA, Fan LL. Serial measurements of lung function in a cohort of young children with bronchopulmonary dysplasia. Pediatrics 125(6), e1441–e1447 (2010).
   Google Scholar
• Halvorsen T, Skadberg BT, Eide GE, Roksund O, Aksnes L, Oymar K. Characteristics of asthma and airway hyper-responsiveness after premature birth. Pediatr. Allergy Immunol. 16(6), 487–494 (2005).
   PubMed Web of Science ®Google Scholar
• Goyal NK, Fiks AG, Lorch SA. Association of late-preterm birth with asthma in young children: practice-based study. Pediatrics 128(4), e830–e838 (2011).
   PubMed Web of Science ®Google Scholar
• Hershenson MB, Aghili S, Punjabi N et al. Hyperoxia-induced airway hyperresponsiveness and remodeling in immature rats. Am. J. Physiol. 262(3 Pt 1), L263–L269 (1992).
   Google Scholar
• Iben SC, Haxhiu MA, Farver CF, Miller MJ, Martin RJ. Short-term mechanical ventilation increases airway reactivity in rat pups. Pediatr. Res. 60(2), 136–140 (2006).
   PubMedGoogle Scholar
• Alejandre-Alcazar MA, Kwapiszewska G, Reiss I et al. Hyperoxia modulates TGF-beta/BMP signaling in a mouse model of bronchopulmonary dysplasia. Am. J. Physiol. Lung Cell. Mol. Physiol. 292(2), L537–L549 (2007).
   Google Scholar
• Alejandre-Alcazar MA, Michiels-Corsten M, Vicencio AG et al. TGF-beta signaling is dynamically regulated during the alveolarization of rodent and human lungs. Dev. Dyn. 237(1), 259–269 (2008).
   PubMed Web of Science ®Google Scholar
• Warburton D, Shi W, Xu B. TGF-beta-Smad3 signaling in emphysema and pulmonary fibrosis: an epigenetic aberration of normal development? Am. J. Physiol. Lung Cell. Mol. Physiol. 304(2), L83–L85 (2013).
   PubMed Web of Science ®Google Scholar
• Been JV, Debeer A, van Iwaarden JF et al. Early alterations of growth factor patterns in bronchoalveolar lavage fluid from preterm infants developing bronchopulmonary dysplasia. Pediatr. Res. 67(1), 83–89 (2010).
   PubMed Web of Science ®Google Scholar
• Kaarteenaho-Wiik R, Paakko P, Herva R, Risteli J, Soini Y. Type I and III collagen protein precursors and mRNA in the developing human lung. J. Pathol. 203(1), 567–574 (2004).
   PubMedGoogle Scholar
• Cederqvist K, Sorsa T, Tervahartiala T et al. Matrix metalloproteinases-2, -8, and -9 and TIMP-2 in tracheal aspirates from preterm infants with respiratory distress. Pediatrics 108(3), 686–692 (2001).
   PubMedGoogle Scholar
• Sweet DG, McMahon KJ, Curley AE, O’Connor CM, Halliday HL. Type I collagenases in bronchoalveolar lavage fluid from preterm babies at risk of developing chronic lung disease. Arch. Dis. Child Fetal. Neonatal. Ed. 84(3), F168–F171 (2001).
   Google Scholar
• Bozyk PD, Bentley JK, Popova AP et al. Neonatal periostin knockout mice are protected from hyperoxia-induced alveolar simplication. PLoS ONE 7(2), e31336 (2012).
   Google Scholar
• Mhanna MJ, Haxhiu MA, Jaber MA et al. Hyperoxia impairs airway relaxation in immature rats via a cAMP-mediated mechanism. J. Appl. Physiol. 96(5), 1854–1860 (2004).
   PubMedGoogle Scholar
• Agani FH, Kuo NT, Chang CH et al. Effect of hyperoxia on substance P expression and airway reactivity in the developing lung. Am. J. Physiol. 273(1 Pt 1), L40–L45 (1997).
   Google Scholar
• Belik J, Jankov RP, Pan J, Yi M, Chaudhry I, Tanswell AK. Chronic O2 exposure in the newborn rat results in decreased pulmonary arterial nitric oxide release and altered smooth muscle response to isoprostane. J. Appl. Physiol. 96(2), 725–730 (2004).
   PubMedGoogle Scholar
• Yao Q, Haxhiu MA, Zaidi SI, Liu S, Jafri A, Martin RJ. Hyperoxia enhances brain-derived neurotrophic factor and tyrosine kinase B receptor expression in peribronchial smooth muscle of neonatal rats. Am. J. Physiol. Lung Cell Mol. Physiol. 289(2), L307–L314 (2005).
   Google Scholar
• Abcejo AJ, Sathish V, Smelter DF et al. Brain-derived neurotrophic factor enhances calcium regulatory mechanisms in human airway smooth muscle. PLoS ONE 7(8), e44343 (2012).
   Google Scholar
• Aravamudan B, Thompson M, Pabelick C, Prakash YS. Brain-derived neurotrophic factor induces proliferation of human airway smooth muscle cells. J. Cell. Mol. Med. 16(4), 812–823 (2012).
   PubMed Web of Science ®Google Scholar
• O’Reilly M, Hooper SB, Allison BJ et al. Persistent bronchiolar remodeling following brief ventilation of the very immature ovine lung. Am. J. Physiol. Lung Cell. Mol. Physiol. 297(5), L992–L1001 (2009).
   Google Scholar
• Fukunaga T, Davies P, Zhang L, Hashida Y, Motoyama EK. Prolonged high intermittent positive-pressure ventilation induces airway remodeling and reactivity in young rats. Am. J. Physiol. 275(3 Pt 1), L567–L573 (1998).
   Google Scholar
• Pandya HC, Snetkov VA, Twort CH, Ward JP, Hirst SJ. Oxygen regulates mitogen-stimulated proliferation of fetal human airway smooth muscle cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 283(6), L1220–L1230 (2002).
   Google Scholar
• Ambalavanan N, Carlo WA, D’Angio CT et al. Cytokines associated with bronchopulmonary dysplasia or death in extremely low birth weight infants. Pediatrics 123(4), 1132–1141 (2009).
   PubMed Web of Science ®Google Scholar
• Brostrom EB, Katz-Salamon M, Lundahl J, Hallden G, Winbladh B. Eosinophil activation in preterm infants with lung disease. Acta. Paediatr. 96(1), 23–28 (2007).
   PubMed Web of Science ®Google Scholar
• Bhattacharya S, Go D, Krenitsky DL et al. Genome-wide transcriptional profiling reveals connective tissue mast cell accumulation in bronchopulmonary dysplasia. Am. J. Respir. Crit. Care Med. 186(4), 349–358 (2012).
   PubMedGoogle Scholar
• Brock TG, Di Giulio C. Prolonged exposure to hyperoxia increases perivascular mast cells in rat lungs. J. Histochem. Cytochem. 54(11), 1239–1246 (2006).
   PubMedGoogle Scholar
• Schultz ED, Potts EN, Mason SN, Foster WM, Auten RL. Mast cells mediate hyperoxia-induced airway hyper-reactivity in newborn rats. Pediatr. Res. 68(1), 70–74 (2010).
   PubMedGoogle Scholar
• Kim do K, Choi SH, Yu J, Yoo Y, Kim B, Koh YY. Bronchial responsiveness to methacholine and adenosine 5'-monophosphate in preschool children with bronchopulmonary dysplasia. Pediatr. Pulmonol. 41(6), 538–543 (2006).
   PubMedGoogle Scholar
• Fitzpatrick AM, Teague WG, Holguin F, Yeh M, Brown LA. Airway glutathione homeostasis is altered in children with severe asthma: evidence for oxidant stress. J. Allergy Clin. Immunol. 123(1), 146–152 e148 (2009).
   PubMed Web of Science ®Google Scholar
• Chawes BL, Buchvald F, Bischoff AL et al. Elevated exhaled nitric oxide in high-risk neonates precedes transient early but not persistent wheeze. Am. J. Respir. Crit. Care Med. 182(2), 138–142 (2010).
   PubMedGoogle Scholar
• Zacharasiewicz A, Wilson N, Lex C et al. Clinical use of noninvasive measurements of airway inflammation in steroid reduction in children. Am. J. Respir. Crit. Care Med. 171(10), 1077–1082 (2005).
   PubMed Web of Science ®Google Scholar
• Filbrun AG, Popova AP, Linn MJ, McIntosh NA, Hershenson MB. Longitudinal measures of lung function in infants with bronchopulmonary dysplasia. Pediatr. Pulmonol. 46(4), 369–375 (2011).
   PubMedGoogle Scholar
• Kurukulaaratchy RJ, Matthews S, Holgate ST, Arshad SH. Predicting persistent disease among children who wheeze during early life. Eur. Respir. J. 22(5), 767–771 (2003).
   PubMed Web of Science ®Google Scholar
• Morgan WJ, Stern DA, Sherrill DL et al. Outcome of asthma and wheezing in the first 6 years of life: follow-up through adolescence. Am. J. Respir. Crit. Care Med. 172(10), 1253–1258 (2005).
   PubMed Web of Science ®Google Scholar
• Palmer LJ, Rye PJ, Gibson NA, Burton PR, Landau LI, Lesouef PN. Airway responsiveness in early infancy predicts asthma, lung function, and respiratory symptoms by school age. Am. J. Respir. Crit. Care Med. 163(1), 37–42 (2001).
   PubMedGoogle Scholar
• Bisgaard H, Jensen SM, Bonnelykke K. Interaction between asthma and lung function growth in early life. Am. J. Respir. Crit. Care Med. 185(11), 1183–1189 (2012).
   PubMed Web of Science ®Google Scholar
• Hovland V, Riiser A, Mowinckel P, Carlsen KH, Lodrup Carlsen KC. The significance of early recurrent wheeze for asthma outcomes in late childhood. Eur. Respir. J. 41(4), 838–845 (2013).
   PubMedGoogle Scholar
• Saglani S, Payne DN, Zhu J et al. Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezers. Am. J. Respir. Crit. Care Med. 176(9), 858–864 (2007).
   PubMed Web of Science ®Google Scholar
• Turato G, Barbato A, Baraldo S et al. Nonatopic children with multitrigger wheezing have airway pathology comparable to atopic asthma. Am. J. Respir. Crit. Care Med. 178(5), 476–482 (2008).
   PubMed Web of Science ®Google Scholar
• Payne DN, Qiu Y, Zhu J et al. Airway inflammation in children with difficult asthma: relationships with airflow limitation and persistent symptoms. Thorax, 59(10), 862–869 (2004).
   PubMedGoogle Scholar
• Saglani S, Malmstrom K, Pelkonen AS et al. Airway remodeling and inflammation in symptomatic infants with reversible airflow obstruction. Am. J. Respir. Crit. Care Med. 171(7), 722–727 (2005).
   PubMed Web of Science ®Google Scholar
• Kusel MM, de Klerk NH, Kebadze T et al. Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma. J. Allergy Clin. Immunol. 119(5), 1105–1110 (2007).
   PubMed Web of Science ®Google Scholar
• Jackson DJ, Gangnon RE, Evans MD et al. Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am. J. Respir. Crit. Care Med. 178(7), 667–672 (2008).
   PubMed Web of Science ®Google Scholar
• Holt PG, Sly PD. Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment. Nat. Med. 18(5), 726–735 (2012).
   PubMed Web of Science ®Google Scholar
• Mandelcwajg A, Moulin F, Menager C, Rozenberg F, Lebon P, Gendrel D. Underestimation of influenza viral infection in childhood asthma exacerbations. J. Pediatr. 157(3), 505–506 (2010).
   PubMedGoogle Scholar
• Resch B, Pasnocht A, Gusenleitner W, Muller W. Rehospitalisations for respiratory disease and respiratory syncytial virus infection in preterm infants of 29-36 weeks gestational age. J. Infect. 50(5), 397–403 (2005).
   PubMed Web of Science ®Google Scholar
• Blanken MO, Rovers MM, Molenaar JM et al. Respiratory syncytial virus and recurrent wheeze in healthy preterm infants. N. Engl J. Med. 368(19), 1791–1799 (2013).
   PubMed Web of Science ®Google Scholar
• Becnel D, You D, Erskin J, Dimina DM, Cormier SA. A role for airway remodeling during respiratory syncytial virus infection. Respir. Res. 6, 122 (2005).
   PubMedGoogle Scholar
• You D, Becnel D, Wang K, Ripple M, Daly M, Cormier SA. Exposure of neonates to respiratory syncytial virus is critical in determining subsequent airway response in adults. Respir. Res. 7, 107 (2006).
   PubMedGoogle Scholar
• Ripple MJ, You D, Honnegowda S et al. Immunomodulation with IL-4R alpha antisense oligonucleotide prevents respiratory syncytial virus-mediated pulmonary disease. J. Immunol. 185(8), 4804–4811 (2010).
   PubMedGoogle Scholar
• Siegle JS, Hansbro N, Dong C, Angkasekwinai P, Foster PS, Kumar RK. Blocking induction of T helper type 2 responses prevents development of disease in a model of childhood asthma. Clin. Exp. Immunol. 165(1), 19–28 (2011).
   PubMed Web of Science ®Google Scholar
• Al-Garawi A, Fattouh R, Botelho F et al. Influenza A facilitates sensitization to house dust mite in infant mice leading to an asthma phenotype in adulthood. Mucosal. Immunol. 4(6), 682–694 (2011).
   PubMedGoogle Scholar
• Horvat JC, Starkey MR, Kim RY et al. Early-life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology. J. Allergy Clin. Immunol. 125(3), 617–625, 625 e611–625 e616 (2010).
   PubMed Web of Science ®Google Scholar
• Illi S, von Mutius E, Lau S, Niggemann B, Gruber C, Wahn U. Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study. Lancet 368(9537), 763–770 (2006).
   PubMed Web of Science ®Google Scholar
• Salo PM, Arbes SJ Jr, Crockett PW, Thorne PS, Cohn RD, Zeldin DC. Exposure to multiple indoor allergens in US homes and its relationship to asthma. J. Allergy Clin. Immunol. 121(3), 678–684 e672 (2008).
   PubMed Web of Science ®Google Scholar
• Arshad SH, Bateman B, Matthews SM. Primary prevention of asthma and atopy during childhood by allergen avoidance in infancy: a randomised controlled study. Thorax 58(6), 489–493 (2003).
   PubMed Web of Science ®Google Scholar
• Mihrshahi S, Peat JK, Marks GB et al. Eighteen-month outcomes of house dust mite avoidance and dietary fatty acid modification in the Childhood Asthma Prevention Study (CAPS). J. Allergy Clin. Immunol. 111(1), 162–168 (2003).
   PubMed Web of Science ®Google Scholar
• Arshad SH. Does exposure to indoor allergens contribute to the development of asthma and allergy? Curr. Allergy Asthma Rep. 10(1), 49–55 (2010).
   PubMed Web of Science ®Google Scholar
• Holt PG, Upham JW, Sly PD. Contemporaneous maturation of immunologic and respiratory functions during early childhood: implications for development of asthma prevention strategies. J. Allergy Clin. Immunol. 116(1), 16–24; quiz 25 (2005).
   PubMedGoogle Scholar
• Carnieli DS, Yoshioka E, Silva LF et al. Inflammation and remodeling in infantile, juvenile, and adult allergic sensitized mice. Pediatr. Pulmonol. 46(7), 650–665 (2011).
   PubMedGoogle Scholar
• Saglani S, Mathie SA, Gregory LG, Bell MJ, Bush A, Lloyd CM. Pathophysiological features of asthma develop in parallel in house dust mite-exposed neonatal mice. Am. J. Respir. Cell. Mol. Biol. 41(3), 281–289 (2009).
   PubMed Web of Science ®Google Scholar
• Evans MJ, Fanucchi MV, Miller LA, Carlson MA, Nishio SJ, Hyde DM. Reduction of collagen VII anchoring fibrils in the airway basement membrane zone of infant rhesus monkeys exposed to house dust mite. Am. J. Physiol. Lung Cell. Mol. Physiol. 298(4), L543–L547 (2010).
   Google Scholar
• Brunekreef B, Janssen NA, de Hartog J, Harssema H, Knape M, van Vliet P. Air pollution from truck traffic and lung function in children living near motorways. Epidemiology 8(3), 298–303 (1997).
   PubMed Web of Science ®Google Scholar
• Carlsten C, Dybuncio A, Becker A, Chan-Yeung M, Brauer M. Traffic-related air pollution and incident asthma in a high-risk birth cohort. Occup. Environ. Med. 68(4), 291–295 (2011).
   PubMed Web of Science ®Google Scholar
• Clark NA, Demers PA, Karr CJ et al. Effect of early life exposure to air pollution on development of childhood asthma. Environ. Health Perspect. 118(2), 284–290 (2010).
   PubMed Web of Science ®Google Scholar
• Miyabara Y, Ichinose T, Takano H, Lim HB, Sagai M. Effects of diesel exhaust on allergic airway inflammation in mice. J. Allergy Clin. Immunol. 102(5), 805–812 (1998).
   PubMed Web of Science ®Google Scholar
• Thevenot PT, Saravia J, Jin N et al. Radical-containing ultrafine particulate matter initiates epithelial-to-mesenchymal transitions in airway epithelial cells. Am. J. Respir. Cell. Mol. Biol. 48(2), 188–197 (2013).
   PubMed Web of Science ®Google Scholar
• Balakrishna S, Saravia J, Thevenot P et al. Environmentally persistent free radicals induce airway hyperresponsiveness in neonatal rat lungs. Part Fibre Toxicol. 8, 11 (2011).
   PubMedGoogle Scholar
• Finkelstein JN, Johnston CJ. Enhanced sensitivity of the postnatal lung to environmental insults and oxidant stress. Pediatrics 113(4 Suppl.), 1092–1096 (2004).
   PubMedGoogle Scholar
• Chan JK, Kodani SD, Charrier JG et al. Age-specific effects on rat lung glutathione and antioxidant enzymes after inhaling ultrafine soot. Am, J. Respir. Cell. Mol. Biol. 48(1), 114–124 (2013).
   PubMedGoogle Scholar
• Lee D, Wallis C, Wexler AS et al. Small particles disrupt postnatal airway development. J. Appl. Physiol. 109(4), 1115–1124 (2010).
   PubMedGoogle Scholar