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Fluticasone propionate/formoterol fumarate in fixed-dose combination for the treatment of asthma

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References

  • GINA FAQs; 2013. Available from: http://ginasthma.org/FAQs
  • Fanta CH. Asthma. N Engl J Med 2009;360(10):1002-14
  • van der Wiel E, ten Hacken NH, Postma DS, van den Berge M. Small-airways dysfunction associates with respiratory symptoms and clinical features of asthma: a systematic review. J Allergy Clin Immunol 2013;131(3):646-57
  • Reddel HK, Taylor DR, Bateman ED, et al. An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med 2009;180(1):59-99
  • Global Initiative for Asthma (GINA). GINA report, Global Strategy for Asthma Management and Prevention, updated 2013. Available from: www.ginasthma.org
  • Demoly P, Annunziata K, Gubba E, Adamek L. Repeated cross-sectional survey of patient-reported asthma control in Europe in the past 5 years. Eur Respir Rev 2012;21(123):66-74
  • Murphy KR, Meltzer EO, Blaiss MS, et al. Asthma management and control in the United States: results of the 2009 Asthma Insight and Management survey. Allergy Asthma Proc 2012;33(1):54-64
  • Accordini S, Corsico AG, Braggion M, et al. The cost of persistent asthma in Europe: an international population-based study in adults. Int Arch Allergy Immunol 2013;160(1):93-101
  • Meltzer EO, Blaiss MS, Nathan RA, et al. Asthma burden in the United States: results of the 2009 Asthma Insight and Management survey. Allergy Asthma Proc 2012;33(1):36-46
  • British Thoracic Society (BTS), Scottish Intercollegiate Guidelines Network (SIGN), British Guideline on the Management of Asthma. A national clinical guideline. May 2008. Available from: http://www.sign.ac.uk/guidelines/fulltext/101/index.html
  • National Asthma Education and Prevention Program. Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. 2007. Available from: http://www.nhlbi.nih.gov/guidelines/asthma/asthgdln.pdf
  • Expert Panel Report 3 (EPR-3): Guidelines for the Diagnosis and Management of Asthma-Summary Report 2007. J Allergy Clin Immunol 2007;120(5 Suppl):S94-138
  • Tamm M, Richards DH, Beghe B, Fabbri L. Inhaled corticosteroid and long-acting beta2-agonist pharmacological profiles: effective asthma therapy in practice. Respir Med 2012;106(suppl 1):S9-19
  • Kelly HW. Comparison of inhaled corticosteroids: an update. Ann Pharmacother 2009;43(3):519-27
  • Chrystyn H, Price D. Not all asthma inhalers are the same: factors to consider when prescribing an inhaler. Prim Care Respir J 2009;18(4):243-9
  • Haughney J, Price D, Barnes NC, et al. Choosing inhaler devices for people with asthma: current knowledge and outstanding research needs. Respir Med 2010;104(9):1237-45
  • Papi A, Haughney J, Virchow JC, et al. Inhaler devices for asthma: a call for action in a neglected field. Eur Respir J 2011;37(5):982-5
  • Small M, Anderson P, Vickers A, et al. Importance of inhaler-device satisfaction in asthma treatment: real-world observations of physician-observed compliance and clinical/patient-reported outcomes. Adv Ther 2011;28(3):202-12
  • Price D, Chrystyn H, Kaplan A, et al. Effectiveness of same versus mixed asthma inhaler devices: a retrospective observational study in primary care. Allergy Asthma Immunol Res 2012;4(4):184-91
  • Marceau C, Lemiere C, Berbiche D, et al. Persistence, adherence, and effectiveness of combination therapy among adult patients with asthma. J Allergy Clin Immunol 2006;118(3):574-81
  • Stoloff SW, Stempel DA, Meyer J, et al. Improved refill persistence with fluticasone propionate and salmeterol in a single inhaler compared with other controller therapies. J Allergy Clin Immunol 2004;113(2):245-51
  • Murphy KR, Bender BG. Treatment of moderate to severe asthma: patient perspectives on combination inhaler therapy and implications for adherence. J Asthma Allergy 2009;2:63-72
  • US Food and Drug Administration (FDA) Long-Acting Beta Agonist (LABA) Information. Available from: http://www.fda.gov/drugs/DrugSafety/InformationbyDrugClass/ucm199565.htm
  • Chowdhury BA, Seymour SM, Levenson MS. Assessing the safety of adding LABAs to inhaled corticosteroids for treating asthma. N Engl J Med 2011;364(26):2473-5
  • Sears MR. Safety of long-acting beta-agonists: are new data really required? Chest 2009;136(2):604-7
  • Electronic Medicines Compendium (eMC) Flutiform 50 microgram/5 microgram, 125 microgram/5 microgram and 250 microgram/10 microgram per actuation pressurised inhalation, suspension. Available from: http://www.medicines.org.uk/emc/medicine/26954
  • Dissanayake S, Grothe B, Kaiser K. Fluticasone/formoterol: a new single-aerosol combination therapy for patients with asthma. Respir Med 2012;106(Suppl 1):S20-8
  • McKeage K. Fluticasone propionate/formoterol fumarate: a review of its use in persistent asthma. Drugs 2013;73(2):195-206
  • Adams NP, Bestall JC, Jones P, et al. Fluticasone at different doses for chronic asthma in adults and children. Cochrane Database Syst Rev 2008;(4):CD003534
  • Adams NP, Bestall JC, Lasserson TJ, et al. Fluticasone versus placebo for chronic asthma in adults and children. Cochrane Database Syst Rev 2008;(4):CD003135
  • Price D, Bousquet J. Real-world perceptions of inhaled corticosteroid/long-acting beta(2)-agonist combinations in the treatment of asthma. Respir Med 2012;106(Suppl 1):S4-8
  • Politiek MJ, Boorsma M, Aalbers R. Comparison of formoterol, salbutamol and salmeterol in methacholine-induced severe bronchoconstriction. Eur Respir J 1999;13(5):988-92
  • Palmqvist M, Persson G, Lazer L, et al. Inhaled dry-powder formoterol and salmeterol in asthmatic patients: onset of action, duration of effect and potency. Eur Respir J 1997;10(11):2484-9
  • Derendorf H, Nave R, Drollmann A, et al. Relevance of pharmacokinetics and pharmacodynamics of inhaled corticosteroids to asthma. Eur Respir J 2006;28(5):1042-50
  • Barnes NC. The properties of inhaled corticosteroids: similarities and differences. Prim Care Respir J 2007;16(3):149-54
  • Palmqvist M, Ibsen T, Mellen A, Lotvall J. Comparison of the relative efficacy of formoterol and salmeterol in asthmatic patients. Am J Respir Crit Care Med 1999;160(1):244-9
  • Welsh EJ, Cates CJ. Formoterol versus short-acting beta-agonists as relief medication for adults and children with asthma. Cochrane Database Syst Rev 2010;(9):CD008418
  • Aalbers R, Brusselle G, Mciver T, et al. Onset of bronchodilation with fluticasone/formoterol combination versus fluticasone/salmeterol in an open-label, randomized study. Adv Ther 2012;29(11):958-69
  • Kanniess F, Diamant Z, Lomax M, Jain M. Effects of low- and high-dose fluticasone/formoterol combination thereapy on AMP challenge in asthmatic patients [abstract]. Annual Congress of the European Respiratory Society; 7–11 September 2013; Barcelona, Spain
  • Tamm M, Kaiser K, Grothe B, Lomax M. Effects on adrenal function of a new combination of fluticasone propionate/formoterol fumarate administered to asthmatic patients and healthy subjects [abstract no. P4010]. 21st Annual Congress of the European Respiratory Society; 24–28 September 2011; Amsterdam
  • Priestley A, Woodward J, McIver T, Mundin G. Effect of high-dose inhaled fluticasone/formoterol combination therapy compared with its separate components on hypothalamo-pituitary-adrenal (HPA) axis function [abstract no.1553]. Allergy 2011;66(Suppl 94):586
  • Heyder J. Deposition of inhaled particles in the human respiratory tract and consequences for regional targeting in respiratory drug delivery. Proc Am Thorac Soc 2004;1(4):315-20
  • Usmani OS, Biddiscombe MF, Barnes PJ. Regional lung deposition and bronchodilator response as a function of beta2-agonist particle size. Am J Respir Crit Care Med 2005;172(12):1497-504
  • Pritchard JN. The influence of lung deposition on clinical response. J Aerosol Med 2001;14(Suppl 1):S19-26
  • Johal B, Howald M, Fischer M, et al. Fine particle profile of fluticasone propionate/formoterol fumarate versus other combination products: the DIFFUSE study. Comb Prod Ther 2013;3(1-2):39-51
  • De Backer W, Devolder A, Poli G, et al. Lung deposition of BDP/formoterol HFA pMDI in healthy volunteers, asthmatic, and COPD patients. J Aerosol Med Pulm Drug Deliv 2010;23(3):137-48
  • Mollmann H, Wagner M, Meibohm B, et al. Pharmacokinetic and pharmacodynamic evaluation of fluticasone propionate after inhaled administration. Eur J Clin Pharmacol 1998;53(6):459-67
  • Holliday SM, Faulds D, Sorkin EM. Inhaled fluticasone propionate. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in asthma. Drugs 1994;47(2):318-31
  • Bartow RA, Brogden RN. Formoterol. An update of its pharmacological properties and therapeutic efficacy in the management of asthma. Drugs 1998;55(2):303-22
  • Nathan RA, D’Urzo A, Blazhko V, Kaiser K. Safety and efficacy of fluticasone/formoterol combination therapy in adolescent and adult patients with mild-to-moderate asthma: a randomised controlled trial. BMC Pulm Med 2012;12:67
  • Corren J, Mansfield LE, Pertseva T, et al. Efficacy and safety of fluticasone/formoterol combination therapy in patients with moderate-to-severe asthma. Respir Med 2013;107(2):180-95
  • Pearlman DS, Laforce CF, Kaiser K. Fluticasone/Formoterol combination therapy compared with monotherapy in adolescent and adult patients with mild to moderate asthma. Clin Ther 2013;35(7):950-66
  • Pertseva T, Dissanayake S, Kaiser K. Superiority of fluticasone propionate/formoterol fumarate versus fluticasone propionate alone in patients with moderate-to-severe asthma: a randomised controlled trial. Curr Med Res Opin 2013;29(10):1357-69
  • Bodzenta-Lukaszyk A, Pulka G, Dymek A, et al. Efficacy and safety of fluticasone and formoterol in a single pressurized metered dose inhaler. Respir Med 2011;105(5):674-682
  • Bodzenta-Lukaszyk A, Van Noord J, Schroder-Babo W, et al. Efficacy and safety profile of fluticasone/formoterol combination therapy compared to its individual components administered concurrently in asthma: a randomised controlled trial. Curr Med Res Opin 2013;29(5):579-88
  • Bodzenta-Lukaszyk A, Dymek A, Mcaulay K, Mansikka H. Fluticasone/formoterol combination therapy is as effective as fluticasone/salmeterol in the treatment of asthma, but has a more rapid onset of action: an open-label, randomized study. BMC Pulm Med 2011;11:28
  • Bodzenta-Lukaszyk A, Buhl R, Balint B, et al. Fluticasone/formoterol combination therapy versus budesonide/formoterol for the treatment of asthma: a randomized, controlled, non-inferiority trial of efficacy and safety. J Asthma 2012;49(10):1060-70
  • Papi A, Price D, Sastre J, et al. Fluticasone propionate/formoterol fumarate improves asthma control and reduces exacerbations compared with fluticasone. Poster P2816. Annual Congress of the European Respiratory Society (ERS); Barcelona; 2013
  • Mansur AH, Kaiser K. Long-term safety and efficacy of fluticasone/formoterol combination therapy in asthma. J Aerosol Med Pulm Drug Deliv 2013;26(4):190-9
  • Cates CJ, Jaeschke R, Schmidt S, Ferrer M. Regular treatment with formoterol and inhaled steroids for chronic asthma: serious adverse events. Cochrane Database Syst Rev 2013;6:CD006924
  • Nelson H, Bonuccelli C, Radner F, et al. Safety of formoterol in patients with asthma: combined analysis of data from double-blind, randomized controlled trials. J Allergy Clin Immunol 2010;125(2):390-6. e398
  • Cates CJ, Lasserson TJ. Regular treatment with formoterol and an inhaled corticosteroid versus regular treatment with salmeterol and an inhaled corticosteroid for chronic asthma: serious adverse events. Cochrane Database Syst Rev 2010;(1):CD007694
  • Haughney J, Price D, Kaplan A, et al. Achieving asthma control in practice: understanding the reasons for poor control. Respir Med 2008;102(12):1681-93
  • Harding G, Leidy NK, Meddis D, et al. Interpreting clinical trial results of patient-perceived onset of effect in asthma: methods and results of a Delphi panel. Curr Med Res Opin 2009;25(6):1563-71
  • Leidy NK, Gutierrez B, Lampl K, et al. Can patients with asthma feel inhaler therapy working right away? Two clinical trials testing the effect of timing of assessment on patient perception. J Asthma 2009;46(10):1006-12
  • Hauber AB, Mohamed AF, Johnson FR, et al. Quantifying asthma patient preferences for onset of effect of combination inhaled corticosteroids and long-acting beta2-agonist maintenance medications. Allergy Asthma Proc 2009;30(2):139-47
  • Bousquet J, Winchester C, Papi A, et al. Inhaled corticosteroid/long-acting beta(2)-agonist combination therapy for asthma: attitudes of specialists in Europe. Int Arch Allergy Immunol 2012;157(3):303-10
  • Price D, Roche N, Christian Virchow J, et al. Device type and real-world effectiveness of asthma combination therapy: an observational study. Respir Med 2011;105(10):1457-66
  • Leach CL, Davidson PJ, Hasselquist BE, Boudreau RJ. Lung deposition of hydrofluoroalkane-134a beclomethasone is greater than that of chlorofluorocarbon fluticasone and chlorofluorocarbon beclomethasone: a cross-over study in healthy volunteers. Chest 2002;122(2):510-16
  • Leach CL, Kuehl PJ, Chand R, et al. Characterization of respiratory deposition of fluticasone-salmeterol hydrofluoroalkane-134a and hydrofluoroalkane-134a beclomethasone in asthmatic patients. Ann Allergy Asthma Immunol 2012;108(3):195-200
  • Haussermann S, Acerbi D, Brand P, et al. Lung deposition of formoterol HFA (Atimos/Forair) in healthy volunteers, asthmatic and COPD patients. J Aerosol Med 2007;20(3):331-41
  • Vos W, De Backer J, Poli G, et al. Novel functional imaging of changes in small airways of patients treated with extrafine beclomethasone/formoterol. Respiration 2013;86(5):393-401
  • Price D, Martin RJ, Barnes N, et al. Prescribing practices and asthma control with hydrofluoroalkane-beclomethasone and fluticasone: a real-world observational study. J Allergy Clin Immunol 2010;126(3):511-18. e511-510
  • Barnes N, Price D, Colice G, et al. Asthma control with extrafine-particle hydrofluoroalkane-beclometasone vs large-particle chlorofluorocarbon-beclometasone: a real-world observational study. Clin Exp Allergy 2011;41(11):1521-32
  • Rigazio A, Buck P, Burden A, et al. Integration of dose-counters into metered-dose inhalers may reduce incidence of respiratory-related emergency room visits [abstract]. American College of Allergy, Asthma & Immunology (ACAAI) Annual Meeting; Baltimore; 2013
  • Krishnan JA, Schatz M, Apter AJ. A call for action: comparative effectiveness research in asthma. J Allergy Clin Immunol 2011;127(1):123-7
  • Price D, Bjermer L, Haughney J, et al. Real-life asthma strategies: the missing piece in the jigsaw. Treatment Strategies - Respiratory 2012;3(2):37-46
  • Price D, Chisholm A, Van Der Molen T, et al. Reassessing the evidence hierarchy in asthma: evaluating comparative effectiveness. Curr Allergy Asthma Rep 2011;11(6):526-38
  • Lemanske RF Jr, Busse WW. Asthma: clinical expression and molecular mechanisms. J Allergy Clin Immunol 2010;125(2 Suppl 2):S95-102
  • Carolan BJ, Sutherland ER. Clinical phenotypes of chronic obstructive pulmonary disease and asthma: recent advances. J Allergy Clin Immunol 2013;131(3):627-34
  • ClinicalTrials.gov. A service of the U.S. National Institutes of Health. Available from: http://clinicaltrials.gov/
  • Respiratory Effectiveness Group. Available from: http://www.effectivenessevaluation.org/
  • Price D, Bateman ED, Chisholm A, et al. Complementing the randomized controlled trial evidence base: evolution not revolution. Ann Am Thor Soc 2014;11(Suppl 2):s92-8
  • Conway PH, Clancy C. Comparative-effectiveness research--implications of the Federal Coordinating Council’s report. N Engl J Med 2009;361(4):328-30
  • Busse WW, Morgan WJ, Taggart V, Togias A. Asthma outcomes workshop: overview. J Allergy Clin Immunol 2012;129(3 Suppl):S1-8

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