209
Views
1
CrossRef citations to date
0
Altmetric
Special Report

FG-4497: a new target for acute respiratory distress syndrome?

, &

References

  • Shaver CM, Bastarache JA. Clinical and biological heterogeneity in acute respiratory distress syndrome: direct versus indirect lung injury. Clin Chest Med 2014;35(4):639-53
  • Riva DR, Oliveira MB, Rzezinski AF, et al. Recruitment maneuver in pulmonary and extrapulmonary experimental acute lung injury. Crit Care Med 2008;36(6):1900-8
  • Chao MC, Garcia CS, de Oliveira MB, et al. Degree of endothelium injury promotes fibroelastogenesis in experimental acute lung injury. Respir Physiol Neurobiol 2012;173(2):179-88
  • Mehta D, Ravindran K, Kuebler WM. Novel regulators of endothelial barrier function. Am J Physiol Lung Cell Mol Physiol 2014;307(12):L924-35
  • Amato MB, Meade MO, Slutsky AS, et al. Driving pressure and survival in the acute respiratory distress syndrome. N Engl J Med 2015;372(8):747-55
  • Silva PL, Cruz FF, Fujisaki LC, et al. Hypervolemia induces and potentiates lung damage after recruitment maneuver in a model of sepsis-induced acute lung injury. Crit Care 2010;14(3):R114
  • Silva PL, Moraes L, Santos RS, et al. Recruitment maneuvers modulate epithelial and endothelial cell response according to acute lung injury etiology. Crit Care Med 2013;41(10):e256-65
  • Saddy F, Moraes L, Santos CL, et al. Biphasic positive airway pressure minimizes biological impact on lung tissue in mild acute lung injury independent of etiology. Crit Care 2013;17(5):R228
  • Santos CL, Moraes L, Santos RS, et al. The biological effects of higher and lower positive end-expiratory pressure in pulmonary and extrapulmonary acute lung injury with intra-abdominal hypertension. Crit Care 2014;18(3):R121
  • Spieth PM, Silva PL, Garcia CS, et al. Modulation of stress versus time product during mechanical ventilation influences inflammation as well as alveolar epithelial and endothelial response in rats. Anesthesiology 2015;122(1):106-16
  • Matthay MA, Zimmerman GA. Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management. Am J Respir Cell Mol Biol 2005;33(4):319-27
  • Rubenfeld GD. Confronting the frustrations of negative clinical trials in acute respiratory distress syndrome. Ann Am Thorac Soc 2015;12(Suppl 1):S58-63
  • Gong H, Rehman J, Tang H, et al. HIF2alpha signaling inhibits adherens junctional disruption in acute lung injury. J Clin Invest 2015;125(2):652-64
  • Ivan M, Kondo K, Yang H, et al. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 2001;292(5516):464-8
  • Wenger RH. Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression. Faseb J 2002;16(10):1151-62
  • Hirsila M, Koivunen P, Gunzler V, et al. Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. J Biol Chem 2003;278(33):30772-80
  • Laitala A, Aro E, Walkinshaw G, et al. Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis. Blood 2012;120(16):3336-44
  • Robinson A, Keely S, Karhausen J, et al. Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition. Gastroenterology 2008;134(1):145-55
  • Herwig MC, Tsokos M, Hermanns MI, et al. Vascular endothelial cadherin expression in lung specimens of patients with sepsis-induced acute respiratory distress syndrome and endothelial cell cultures. Pathobiology 2013;80(5):245-51
  • Bernhardt WM, Gottmann U, Doyon F, et al. Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model. Proc Natl Acad Sci U S A 2009;106(50):21276-81
  • Rosenberger C, Pratschke J, Rudolph B, et al. Immunohistochemical detection of hypoxia-inducible factor-1alpha in human renal allograft biopsies. J Am Soc Nephrol 2007;18(1):343-51
  • Trollmann R, Richter M, Jung S, et al. Pharmacologic stabilization of hypoxia-inducible transcription factors protects developing mouse brain from hypoxia-induced apoptotic cell death. Neuroscience 2014;278:327-42
  • Brackmann FA, Link AS, Jung S, et al. Activin A regulation under global hypoxia in developing mouse brain. Brain Res 2013;1531:65-74
  • Keranen MA, Tuuminen R, Syrjala S, et al. Differential effects of pharmacological HIF preconditioning of donors versus recipients in rat cardiac allografts. Am J Transplant 2013;13(3):600-10
  • Eliasson P, Rehn M, Hammar P, et al. Hypoxia mediates low cell-cycle activity and increases the proportion of long-term-reconstituting hematopoietic stem cells during in vitro culture. Exp Hematol 2010;38(4):301-10 e302
  • Santos FB, Nagato LK, Boechem NM, et al. Time course of lung parenchyma remodeling in pulmonary and extrapulmonary acute lung injury. J Appl Physiol 1985 2006;100(1):98-106
  • Menezes SL, Bozza PT, Neto HC, et al. Pulmonary and extrapulmonary acute lung injury: inflammatory and ultrastructural analyses. J Appl Physiol (1985) 2005;98(5):1777-83
  • Uhlig C, Silva PL, Ornellas D, et al. The effects of salbutamol on epithelial ion channels depend on the etiology of acute respiratory distress syndrome but not the route of administration. Respir Res 2014;15:56
  • Nagai J, Yamamoto A, Katagiri Y, et al. Fatty acid-bearing albumin but not fatty acid-depleted albumin induces HIF-1 activation in human renal proximal tubular epithelial cell line HK-2. Biochem Biophys Res Commun 2014;450(1):476-81

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.