The need to differentiate between adults and children when treating severe asthma

References

• Chung KF, Wenzel SE, Brozek JL, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J 2014;43(2):343-73
   PubMed Web of Science ®Google Scholar
• Bush A, Saglani S. Management of severe asthma in children. Lancet 2010;376(9743):814-25
   PubMed Web of Science ®Google Scholar
• Bracken M, Fleming L, Hall P, et al. The importance of nurse-led home visits in the assessment of children with problematic asthma. Arch Dis Child 2009;94:780-4
   PubMed Web of Science ®Google Scholar
• Bossley CJ, Fleming L, Gupta A, et al. Pediatric severe asthma is characterized by eosinophilia and remodeling without T(H)2 cytokines. J Allergy Clin Immunol 2012;129(4):974-82
   PubMed Web of Science ®Google Scholar
• Regamey N, Ochs M, Hilliard TN, et al. Increased airway smooth muscle mass in children with asthma, cystic fibrosis, and non-cystic fibrosis bronchiectasis. Am J Respir Crit Care Med 2008;177(8):837-43
   PubMed Web of Science ®Google Scholar
• Fleming L, Tsartsali L, Wilson N, et al. Sputum inflammatory phenotypes are not stable in children with asthma. Thorax 2012;67:675-81
   PubMed Web of Science ®Google Scholar
• Ullmann N, Bossley CJ, Fleming L, et al. Blood eosinophil counts rarely reflect airway eosinophilia in children with severe asthma. Allergy 2013;68(3):402-6
   Google Scholar
• Fleming L, Wilson N, Regamey N, Bush A. Inflammatory phenotype of children with severe asthma. Eur Respir J 2007;30:483S
   Google Scholar
• Thomson CC, Welsh CH, Carno MA, et al. ATS/ERS Task Force on Severe Asthma and the American Thoracic Society Implementation Task Force. Severe asthma. Ann Am Thorac Soc 2014;11(6):996-7
   Google Scholar
• Berair R, Brightling CE. Asthma therapy and its effect on airway remodelling. Drugs 2014;74(12):1345-69
   PubMed Web of Science ®Google Scholar
• Panettieri RAJrKotlikoff MI, Gerthoffer WT, et al. National Heart, Lung, and Blood Institute. Airway smooth muscle in bronchial tone, inflammation, and remodeling: basic knowledge to clinical relevance. Am J Respir Crit Care Med 2008;177(3):248-52
   Google Scholar
• Tillie-Leblond I, de Blic J, Jaubert F, et al. Airway remodeling is correlated with obstruction in children with severe asthma. Allergy 2008;63(5):533-41
   Google Scholar
• Fahy JV. Type 2 inflammation in asthma-present in most, absent in many. Nat Rev Immunol 2015;15(1):57-65
   PubMed Web of Science ®Google Scholar
• Haldar P, Pavord ID, Shaw DE, et al. Cluster analysis and clinical asthma phenotypes. Am J Respir Crit Care Med 2008;178(3):218-24
   PubMed Web of Science ®Google Scholar
• Wu W, Bleecker E, Moore W, et al. Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data. J Allergy Clin Immunol 2014;133(5):1280-8
   PubMed Web of Science ®Google Scholar
• Wenzel SE. Asthma phenotypes: the evolution from clinical to molecular approaches. Nat Med 2012;18(5):716-25
   PubMed Web of Science ®Google Scholar
• Bell MC, Busse WW. Severe asthma: an expanding and mounting clinical challenge. J Allergy Clin Immunol Pract 2013;1(2):110-21
   PubMed Web of Science ®Google Scholar
• Moore WC, Fitzpatrick AM, Li X, et al. Clinical heterogeneity in the severe asthma research program. Ann Am Thorac Soc 2013;10(Suppl):S118-24
   Google Scholar
• Fitzpatrick AM, Higgins M, Holguin F, et al. National Institutes of Health/National Heart, Lung, and Blood Institute’s Severe Asthma Research Program. The molecular phenotype of severe asthma in children. J Allergy Clin Immunol 2010;125(4):851-7
   PubMed Web of Science ®Google Scholar
• Al-Samri MT, Benedetti A, Préfontaine D, et al. Variability of sputum inflammatory cells in asthmatic patients receiving corticosteroid therapy: A prospective study using multiple samples. J Allergy Clin Immunol 2010;125(5):1161-3
   PubMed Web of Science ®Google Scholar
• Bourdin A, Molinari N, Vachier I, et al. Prognostic value of cluster analysis of severe asthma phenotypes. J Allergy Clin Immunol 2014;134(5):1043-50
   Google Scholar
• Tan DJ, Walters EH, Perret JL, et al. Age-of-asthma onset as a determinant of different asthma phenotypes in adults: a systematic review and meta-analysis of the literature. Expert Rev Respir Med 2015;9(1):109-23
   PubMed Web of Science ®Google Scholar
• Amelink M, de Groot JC, de Nijs SB, et al. Severe adult-onset asthma: A distinct phenotype. J Allergy Clin Immunol 2013;132(2):336-41
   PubMed Web of Science ®Google Scholar
• Serrano-Pariente J, Rodrigo G, Fiz JA, et al. High Risk Asthma Research Group. Identification and characterization of near-fatal asthma phenotypes by cluster analysis. Allergy 2015. [Epub ahead of print]
   Google Scholar
• Levy ML. National Review of Asthma Deaths (NRAD). Br J Gen Pract 2014;64(628):564
   PubMed Web of Science ®Google Scholar
• Fitzpatrick AM, Teague WG, Meyers DA, et al. National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program. Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program. J Allergy Clin Immunol 2011;127(2):382-9
   PubMed Web of Science ®Google Scholar
• Yan X, Chu JH, Gomez J, et al. Noninvasive analysis of the sputum transcriptome discriminates clinical phenotypes of asthma. Am J Respir Crit Care Med 2015;191(10):1116-25
   Google Scholar
• Gupta S, Hartley R, Singapuri A, et al. Temporal assessment of airway remodeling in severe asthma using quantitative computed tomography. Am J Respir Crit Care Med 2015;191(1):107-10
   Google Scholar
• Pavord ID, Brightling CE, Woltmann G, Wardlaw AJ. Non-eosinophilic corticosteroid unresponsive asthma. Lancet 1999;353:2213-14
   PubMed Web of Science ®Google Scholar
• European Network for Understanding Mechanisms of Severe Asthma. The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma. Eur Respir J 2003;22:470-7
   PubMed Web of Science ®Google Scholar
• ten Brinke A, Sterk PJ, Masclee AA, et al. Risk factors of frequent exacerbations in difficult-to-treat asthma. Eur Respir J 2005;26:812-18
   PubMed Web of Science ®Google Scholar
• Brüske I, Flexeder C, Heinrich J. Body mass index and the incidence of asthma in children. Curr Opin Allergy Clin Immunol 2014;14(2):155-60
   PubMedGoogle Scholar
• Dixon AE, Pratley RE, Forgione PM, et al. Effects of obesity and bariatric surgery on airway hyperresponsiveness, asthma control, and inflammation. J Allergy Clin Immunol 2011;128:508-15
   PubMed Web of Science ®Google Scholar
• Sutherland ER, Goleva E, Strand M, et al. Body mass and glucocorticoid response in asthma. Am J Respir Crit Care Med 2008;178:682-7
   PubMed Web of Science ®Google Scholar
• Jenkins C, Costello J, Hodge L. Systematic review of prevalence of aspirin induced asthma and its implications for clinical practice. BMJ 2004;328(7437):434
   PubMed Web of Science ®Google Scholar
• Bel EH, Ortega HG, Pavord ID. Glucocorticoids and mepolizumab in eosinophilic asthma. N Engl J Med 2014;371(25):2434
   Google Scholar
• Illi S, von Mutius E, Lau S, et al. Multicentre Allergy Study (MAS) group. Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study. Lancet 2006;368(9537):763-70
   PubMed Web of Science ®Google Scholar
• Sly PD, Boner AL, Björksten B, et al. Early identification of atopy in the prediction of persistent asthma in children. Lancet 2008;372(9643):1100-6
   PubMed Web of Science ®Google Scholar
• Stoltz DJ, Jackson DJ, Evans MD, et al. Specific patterns of allergic sensitization in early childhood and asthma & rhinitis risk. Clin Exp Allergy 2013;43(2):233-41
   PubMed Web of Science ®Google Scholar
• Jackson DJ, Evans MD, Gangnon RE, et al. Evidence for a causal relationship between allergic sensitization and rhinovirus wheezing in early life. Am J Respir Crit Care Med 2012;185(3):281-5
   PubMed Web of Science ®Google Scholar
• Forno E, Lasky-Su J, Himes B, et al. Genome-wide association study of the age of onset of childhood asthma. J Allergy Clin Immunol 2012;130:83-90
   PubMed Web of Science ®Google Scholar
• Saglani S, Lui S, Ullmann N, et al. IL-33 promotes airway remodeling in pediatric patients with severe steroid-resistant asthma. J Allergy Clin Immunol 2013;132(3):676-85
   PubMed Web of Science ®Google Scholar
• Préfontaine D, Lajoie-Kadoch S, Foley S, et al. Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells. J Immunol 2009;183(8):5094-103
   PubMed Web of Science ®Google Scholar
• Bønnelykke K, Sleiman P, Nielsen K, et al. A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations. Nat Genet 2014;46(1):51-5
   PubMed Web of Science ®Google Scholar
• Calogero C, Sly PD. Developmental physiology: lung function during growth and development from birth to old age. Eur Respir Mon 2010;47:1-15
   Google Scholar
• Maritz GS, Cock ML, Louey S, et al. Effects of fetal growth restriction on lung development before and after birth: a morphometric analysis. Pediatr Pulmonol 2001;32(3):201-10
   PubMed Web of Science ®Google Scholar
• Larcombe AN, Foong RE, Berry LJ, et al. In utero cigarette smoke exposure impairs somatic and lung growth in BALB/c mice. Eur Respir J 2011;38(4):932-8
   Google Scholar
• Harding R, Maritz G. Maternal and fetal origins of lung disease in adulthood. Semin Fetal Neonatal Med 2012;17(2):67-72
   PubMed Web of Science ®Google Scholar
• Mauad T, Rivero DH, de Oliveira RC, et al. Chronic exposure to ambient levels of urban particles affects mouse lung development. Am J Respir Crit Care Med 2008;178(7):721-8
   Google Scholar
• Tai A, Tran H, Roberts M, et al. Outcomes of childhood asthma to the age of 50 years. J Allergy Clin Immunol 2014;133(6):1572-8
   PubMed Web of Science ®Google Scholar
• Tai A, Tran H, Roberts M, et al. The association between childhood asthma and adult chronic obstructive pulmonary disease. Thorax 2014;69(9):805-10
   PubMed Web of Science ®Google Scholar
• Openshaw PJ, Yamaguchi Y, Tregoning JS. Childhood infections, the developing immune system, and the origins of asthma. J Allergy Clin Immunol 2004;114:1275-7
   PubMed Web of Science ®Google Scholar
• Culley FJ, Pollott J, Openshaw PJ. Age at first viral infection determines the pattern of T cell-mediated disease during reinfection in adulthood. J Exp Med 2002;196:1381-6
   PubMed Web of Science ®Google Scholar
• Jackson DJ, Gangnon RE, Evans MD, et al. Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am J Respir Crit Care Med 2008;178(7):667-72
   PubMed Web of Science ®Google Scholar
• Feldman AS, He Y, Moore ML, et al. Toward primary prevention of asthma. Reviewing the evidence for early-life respiratory viral infections as modifiable risk factors to prevent childhood asthma. Am J Respir Crit Care Med 2015;191(1):34-44
   PubMed Web of Science ®Google Scholar
• Carroll KN, Wu P, Gebretsadik T, et al. The severity-dependent relationship of infant bronchiolitis on the risk and morbidity of early childhood asthma. J Allergy Clin Immunol 2009;123:1055-61
   PubMed Web of Science ®Google Scholar
• Dakhama A, Park JW, Taube C, et al. The enhancement or prevention of airway hyperresponsiveness during reinfection with respiratory syncytial virus is critically dependent on the age at first infection and IL-13 production. J Immunol 2005;175(3):1876-83
   PubMed Web of Science ®Google Scholar
• You D, Becnel D, Wang K, et al. Exposure of neonates to respiratory syncytial virus is critical in determining subsequent airway response in adults. Respir Res 2006;7:107
   PubMed Web of Science ®Google Scholar
• Schneider D, Hong JY, Popova AP, et al. Neonatal rhinovirus infection induces mucous metaplasia and airways hyperresponsiveness. J Immunol 2012;188:2894-904
   PubMed Web of Science ®Google Scholar
• Hong JY, Bentley JK, Chung Y, et al. Neonatal rhinovirus induces mucous metaplasia and airways hyperresponsiveness through IL-25 and type 2 innate lymphoid cells. J Allergy Clin Immunol 2014;134:429-39
   PubMed Web of Science ®Google Scholar
• Horvat JC, Starkey MR, Kim RY, et al. Early-life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology. J Allergy Clin Immunol 2010;125:617-25
   PubMed Web of Science ®Google Scholar
• Jupelli M, Murthy AK, Chaganty BK, et al. Neonatal Chlamydia pneumonia induces altered respiratory structure and function lasting into adult life. Lab Invest 2011;91:1530-9
   Google Scholar
• Hansbro PM, Starkey MR, Mattes J, Horvat JC. Pulmonary immunity during respiratory infections in early life and the development of severe asthma. Ann Am Thorac Soc 2014;11(Suppl(5):S297-302
   Google Scholar
• Li R, Yang X, Wang L, Liu E. Respiratory syncytial virus infection reversed anti-asthma effect of neonatal bacillus Calmette-Guerin vaccination in BALB/c mice. Pediatr Res 2006;59:210-15
   PubMedGoogle Scholar
• Arnold IC, Dehzad N, Reuter S, et al. Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells. J Clin Invest 2011;121:3088-93
   PubMed Web of Science ®Google Scholar
• Calışkan M, Bochkov YA, Kreiner-Møller E, et al. Rhinovirus wheezing illness and genetic risk of childhood-onset asthma. N Engl J Med 2013;368(15):1398-407
   PubMed Web of Science ®Google Scholar
• Gollwitzer ES, Saglani S, Trompette A, et al. Lung microbiota promotes tolerance to allergens in neonates via PD-L1. Nat Med 2014;20(6):642-7
   PubMed Web of Science ®Google Scholar
• Bisgaard H, Hermansen MN, Buchvald F, et al. Childhood asthma after bacterial colonization of the airway in neonates. N Engl J Med 2007;357:1487-95
   PubMed Web of Science ®Google Scholar
• Kloepfer KM, Lee WM, Pappas TE, et al. Detection of pathogenic bacteria during rhinovirus infection is associated with increased respiratory symptoms and asthma exacerbations. J Allergy Clin Immunol 2014;133:1301-7
   PubMed Web of Science ®Google Scholar
• Teo SM, Mok D, Pham K, et al. The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development. Cell Host Microbe 2015;17(5):704-15
   PubMed Web of Science ®Google Scholar
• Trompette A, Gollwitzer ES, Yadava K, et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med 2014;20(2):159-66
   PubMed Web of Science ®Google Scholar
• Luoto R, Ruuskanen O, Waris M, et al. Prebiotic and probiotic supplementation prevents rhinovirus infections in preterm infants: a randomized, placebo-controlled trial. J Allergy Clin Immunol 2014;133:405-13
   PubMed Web of Science ®Google Scholar
• Suter M, Abramovici A, Aagaard-Tillery K. Genetic and epigenetic influences associated with intrauterine growth restriction due to in utero tobacco exposure. Pediatr Endocrinol Rev 2010;8(2):94-102
   PubMedGoogle Scholar
• Kotecha SJ, Watkins WJ, Heron J, et al. Spirometric lung function in school-age children: effect of intrauterine growth retardation and catch-up growth. Am J Respir Crit Care Med 2010;181(9):969-74
   PubMed Web of Science ®Google Scholar
• Barker DJ, Godfrey KM, Fall C, et al. Relation of birth weight and childhood respiratory infection to adult lung function and death from chronic obstructive airways disease. BMJ 1991;303(6804):671-5
   PubMed Web of Science ®Google Scholar
• Canoy D, Pekkanen J, Elliott P, et al. Early growth and adult respiratory function in men and women followed from the fetal period to adulthood. Thorax 2007;62(5):396-402
   Google Scholar
• Moshammer H, Hoek G, Luttmann-Gibson H, et al. Parental smoking and lung function in children: an international study. Am J Respir Crit Care Med 2006;173(11):1255-63
   PubMed Web of Science ®Google Scholar
• Gilliland FD, Li YF, Peters JM. Effects of maternal smoking during pregnancy and environmental tobacco smoke on asthma and wheezing in children. Am J Respir Crit Care Med 2001;163(2):429-36
   PubMed Web of Science ®Google Scholar
• Gilliland FD, Berhane K, Li YF, et al. Effects of early onset asthma and in utero exposure to maternal smoking on childhood lung function. Am J Respir Crit Care Med 2003;167(6):917-24
   PubMed Web of Science ®Google Scholar
• Cohen RT, Raby BA, Van Steen K, et al. In utero smoke exposure and impaired response to inhaled corticosteroids in children with asthma. J Allergy Clin Immunol 2010;126(3):491-7
   PubMed Web of Science ®Google Scholar
• Sharma S, Chhabra D, Kho AT, et al. The genomic origins of asthma. Thorax 2014;69(5):481-7
   Google Scholar
• Maritz GS. Maternal nicotine exposure during gestation and lactation of rats induce microscopic emphysema in the offspring. Exp Lung Res 2002;28:391e403
   Google Scholar
• Blacquiére MJ, Timens W, Melgert BN, et al. Maternal smoking during pregnancy induces airway remodelling in mice offspring. Eur Respir J 2009;33:1133e40
   Google Scholar
• Matsui EC. Environmental exposures and asthma morbidity in children living in urban neighborhoods. Allergy 2014;69(5):553-8
   PubMed Web of Science ®Google Scholar
• Gauderman WJ, Urman R, Avol E, et al. Association of improved air quality with lung development in children. N Engl J Med 2015;372(10):905-13
   PubMed Web of Science ®Google Scholar
• Woolcock AJ. Steroid resistant asthma: what is the clinical definition? Eur Respir J 1993;6(5):743-7
   Google Scholar
• Bossley CJ, Saglani S, Kavanagh C, et al. Corticosteroid responsiveness and clinical characteristics in childhood difficult asthma. Eur Respir J 2009;34:1052-9
   PubMed Web of Science ®Google Scholar
• Moore KW, de Waal Malefyt R, Coffman RL, O’Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 2001;19:683-765
   PubMed Web of Science ®Google Scholar
• Lim S, Crawley E, Woo P, et al. Haplotype associated with low interleukin-10 production in patients with severe asthma. Lancet 1998;352:113
   PubMed Web of Science ®Google Scholar
• Hawrylowicz C, Richards D, Loke TK, et al. A defect in corticosteroid-induced IL-10 production in T lymphocytes from corticosteroid-resistant asthmatic patients. J Allergy Clin Immunol 2002;109:369-70
   PubMed Web of Science ®Google Scholar
• Bush A, Zar HJ. WHO universal definition of severe asthma. Curr Opin Allergy Clin Immunol 2011;11:115-21
   PubMed Web of Science ®Google Scholar
• Gupta A, Dimeloe S, Richards DF, et al. Defective IL-10 expression and in vitro steroid-induced IL-17A in paediatric severe therapy-resistant asthma. Thorax 2014;69(6):508-15
   PubMed Web of Science ®Google Scholar
• Gupta A, Sjoukes A, Richards D, et al. Relationship between serum vitamin D, disease severity, and airway remodeling in children with asthma. Am J Respir Crit Care Med 2011;184(12):1342-9
   PubMed Web of Science ®Google Scholar
• Pietinalho A, Pelkonen A, Rytilä P. Linkage between smoking and asthma. Allergy 2009;64(12):1722-7
   PubMed Web of Science ®Google Scholar
• Lazarus SC, Chinchilli VM, Rollings NJ, et al. National Heart Lung and Blood Institute’s Asthma Clinical Research Network. Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma. Am J Respir Crit Care Med 2007;175(8):783-90
   PubMed Web of Science ®Google Scholar
• Murahidy A, Ito M, Adcock IM, et al. Reduction is histone deacetylase expression and activity in smoking asthmatics: A mechanism of steroid resistance. Proc Am Thorac Soc 2005;2(2):A889
   Google Scholar
• Kobayashi Y, Bossley C, Gupta A, et al. Passive smoking impairs histone deacetylase-2 in children with severe asthma. Chest 2014;145(2):305-12
   PubMed Web of Science ®Google Scholar
• Denning DW, Pashley C, Hartl D, et al. Fungal allergy in asthma-state of the art and research needs. Clin Transl Allergy 2014;4:14
   PubMed Web of Science ®Google Scholar
• Vicencio AG, Santiago MT, Tsirilakis K, et al. Fungal sensitization in childhood persistent asthma is associated with disease severity. Pediatr Pulmonol 2014;49(1):8-14
   PubMed Web of Science ®Google Scholar
• Denning DW, O’Driscoll BR, Hogaboam CM, et al. The link between fungi and severe asthma: a summary of the evidence. Eur Respir J 2006;27(3):615-26
   PubMed Web of Science ®Google Scholar
• Castanhinha S, Sherburn R, Walker S, et al. Pediatric severe asthma with fungal sensitization is mediated by steroid-resistant IL-33. J Allergy Clin Immunol 2015;pii:S0091-6749(15):00106-2
   Google Scholar
• Iikura M, Hojo M, Koketsu R, et al. The importance of bacterial and viral infections associated with adult asthma exacerbations in clinical practice. PLoS ONE 2015;10(4):e0123584
   Google Scholar
• Szefler SJ, Chmiel JF, Fitzpatrick AM, et al. Asthma across the ages: knowledge gaps in childhood asthma. J Allergy Clin Immunol 2014;133(1):3-13
   PubMed Web of Science ®Google Scholar
• Jackson DJ, Makrinioti H, Rana BM, et al. IL-33-dependent type 2 inflammation during rhinovirus-induced asthma exacerbations in vivo. Am J Respir Crit Care Med 2014;190(12):1373-82
   PubMed Web of Science ®Google Scholar
• Beale J, Jayaraman A, Jackson DJ, et al. Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation. Sci Transl Med 2014;6(256):256ra134
   PubMed Web of Science ®Google Scholar
• Petersen BC, Budelsky AL, Baptist AP, et al. Interleukin-25 induces type 2 cytokine production in a steroid-resistant interleukin-17RB+ myeloid population that exacerbates asthmatic pathology. Nat Med 2012;18(5):751-8
   PubMed Web of Science ®Google Scholar
• Panickar JR, Grigg J. Controversies in the management of preschool viral wheeze. Paediatr Respir Rev 2006;7(4):293-8
   Google Scholar
• Bacharier LB, Phillips BR, Zeiger RS, et al. CARE Network. Episodic use of an inhaled coricosteroid or leukotriene receptor antagonist in preschool children with moderate-to-severe intermittent wheezing. J Allergy Clin Immunol 2008;122(6):1127-35
   PubMed Web of Science ®Google Scholar
• Webster Marketon JI, Corry J, Teng MN. The respiratory syncytial virus (RSV) nonstructural proteins mediate RSV suppression of glucocorticoid receptor transactivation. Virology 2014;449:62-9
   Google Scholar
• Hinzey A, Alexander J, Corry J, et al. Respiratory syncytial virus represses glucocorticoid receptor-mediated gene activation. Endocrinology 2011;152(2):483-94
   PubMed Web of Science ®Google Scholar
• Lloyd CM, Saglani S. Epithelial cytokines and pulmonary allergic inflammation. Curr Opin Immunol 2015;34:52-8
   PubMed Web of Science ®Google Scholar
• Brusselle GG, Maes T, Bracke KR. Eosinophils in the spotlight: Eosinophilic airway inflammation in nonallergic asthma. Nat Med 2013;19(8):977-9
   PubMed Web of Science ®Google Scholar
• Christianson CA, Goplen NP, Zafar I, et al. Persistence of asthma requires multiple feedback circuits involving type 2 innate lymphoid cells and IL-33. J Allergy Clin Immunol 2015. [Epub ahead of print]
   Google Scholar
• Ortega HG, Liu MC, Pavord ID, et al. MENSA Investigators. Mepolizumab treatment in patients with severe eosinophilic asthma. N Engl J Med 2014;371(13):1198-207
   PubMed Web of Science ®Google Scholar
• Corren J, Lemanske RF, Hanania NA, et al. Lebrikizumab treatment in adults with asthma. N Engl J Med 2011;365(12):1088-98
   PubMed Web of Science ®Google Scholar