References
- Papers of special note have been highlighted as:
- * of interest
- ** of considerable interest
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**Discovery of phenotypes on the degree of Th2 inflammation.
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**An interesting and complete overview on known and potential biomarkers of omalizumab effects in severe asthma management.
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**Authors identified for the first time neutrophilic inflammation in mild asthmatics and found an association between clinical variables and different amounts of eosinophilic inflammation.
- Gibson PG, Simpson JL, Hankin R, et al. Relationship between induced sputum eosinophils and the clinical pattern of childhood asthma. Thorax. 2003;58:116–121.
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**An intresting study on phenotypic differences between early-onset severe asthma as compared with late-onset disease.
- Moore WC, Meyers DA, Wenzel SE, et al. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med. 2010;181:315–323. 37.
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**This study began the concept of molecular phenotyping.
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**High serum periostin identified as predicting biomarkers of lebrikizumab treatment outcome.
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*Effectiveness of anti-IL4Ralpha on Th2 inflammation and pulmonary function.
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