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Toll-like receptors, triggering receptor expressed on myeloid cells family members and receptor for advanced glycation end-products in allergic airway inflammation

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Pages 171-184 | Received 26 Oct 2015, Accepted 14 Dec 2015, Published online: 20 Jan 2016

References

Papers of special note have been highlighted as

• of interest

•• of considerable interest

•Gives a comprehensive description of all toll-like receptors (TLRs), ligands and signaling pathways in the innate immune response.

•• Provides an in-depth review of TLRs, their ligands, cellular expression, signaling pathway and roles in antiviral immunity.

•• Comprehensive analysis of triggering receptor expressed on myeloid cell (TREM) family members in inflammatory diseases and potential therapeutic targets for future research.

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  • Liang Y, Hou C, Kong J, et al. HMGB1 binding to receptor for advanced glycation end products enhances inflammatory responses of human bronchial epithelial cells by activating p38 MAPK and ERK1/2. Mol Cell Biochem. 2015;405(1–2):63–71.
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•Most recent study highlighting the role of high-mobility group box -1 and receptor for advanced glycation end products (RAGE) in airway inflammation.

  • Akirav EM, Henegariu O, Preston-Hurlburt P, et al. The receptor for advanced glycation end products (RAGE) affects T cell differentiation in OVA induced asthma. PLoS One. 2014;9(4):e95678.
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  • Taniguchi A, Miyahara N, Waseda K, et al. Contrasting roles for the receptor for advanced glycation end-products on structural cells in allergic airway inflammation vs. airway hyperresponsiveness. Am J Physiol Lung Cell Mol Physiol. 2015;309(8):L789–800.
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  • Arts RJ, Joosten LA, van der Meer JW, et al. TREM-1: intracellular signaling pathways and interaction with pattern recognition receptors. J Leukoc Biol. 2013;93(2):209–215.

• Highlights shared interactions and signaling mechanisms of TLRs and TREM family members.

  • Hommes TJ, Hoogendijk AJ, Dessing MC, et al. Triggering receptor expressed on myeloid cells-1 (TREM-1) improves host defence in pneumococcal pneumonia. J Pathol. 2014;233(4):357–367.
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  • Buckland KF, Ramaprakash H, Murray LA, et al. Triggering receptor expressed on myeloid cells-1 (TREM-1) modulates immune responses to Aspergillus fumigatus during fungal asthma in mice. Immunol Invest. 2011;40(7–8):692–722.
  • Klesney-Tait J, Keck K, Li X, et al. Transepithelial migration of neutrophils into the lung requires TREM-1. J Clin Invest. 2013;123(1):138–149.
  • Wu K, Byers DE, Jin X, et al. TREM-2 promotes macrophage survival and lung disease after respiratory viral infection. J Exp Med. 2015;212(5):681–697.
  • Bouchon A, Hernandez-Munain C, Cella M, et al. A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells. J Exp Med. 2001;194(8):1111–1122.
  • Ito H, Hamerman JA. TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells. Eur J Immunol. 2012;42(1):176–185.
  • Turnbull IR, Gilfillan S, Cella M, et al. Cutting edge: TREM-2 attenuates macrophage activation. J Immunol. 2006;177(6):3520–3524.
  • Gao X, Dong Y, Liu Z, et al. Silencing of triggering receptor expressed on myeloid cells-2 enhances the inflammatory responses of alveolar macrophages to lipopolysaccharide. Mol Med Rep. 2013;7(3):921–926.
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  • Shi JX, Li JS, Hu R, et al. Diagnostic value of sTREM-1 in bronchoalveolar lavage fluid in ICU patients with bacterial lung infections: a bivariate meta-analysis. PLoS One. 2013;8(5):e65436.
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  • Bucova M, Suchankova M, Dzurilla M, et al. Inflammatory marker sTREM-1 reflects the clinical stage and respiratory tract obstruction in allergic asthma bronchiale patients and correlates with number of neutrophils. Mediators Inflamm. 2012;2012:628754.
  • Ibrahim ZA, Armour CL, Phipps S, et al. RAGE and TLRs: relatives, friends or neighbours? Mol Immunol. 2013;56(4):739–744.
  • Sakaguchi M, Murata H, Yamamoto K, et al. TIRAP, an adaptor protein for TLR2/4, transduces a signal from RAGE phosphorylated upon ligand binding. PLoS One. 2011;6(8):e23132.

•Study indicating a functional interaction between RAGE and TLRs in inflammation and the immune response.

  • Tadie JM, Bae HB, Jiang S, et al. HMGB1 promotes neutrophil extracellular trap formation through interactions with toll-like receptor 4. Am J Physiol Lung Cell Mol Physiol. 2013;304(5):L342–9.
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