2,132
Views
24
CrossRef citations to date
0
Altmetric
Editorial

Novel therapeutics in the field of capsaicin and pain

References

  • Holzer P. Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. Pharmacol Rev 1991;43:143-201
  • Holzer P. Role of visceral afferent neurons in mucosal inflammation and defense. Curr Opin Pharmacol 2007;7:563-9
  • Caterina MJ, Schumacher MA, Tominaga M, et al. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 1997;389:816-24
  • Evangelista S. Capsaicin receptor as target of calcitonin gene-related peptide in the gut. Prog Drug Res 2014;68:259-67
  • Gomtsyan A, Brederson JD. Clinical and preclinical experience with TRPV1 antagonists as potential analgesic agents. In: Szallasi A, editor. TRP channels as therapeutic targets: from basic science to clinical use. Elsevier, London, UK; 2015. 129-45
  • Szolcsányi J, Pintér E. Transient receptor potential vanilloid 1 as a therapeutic target in analgesia. Expert Opin Ther Targets 2013;17:641-57
  • Hammer J, Hammer HF, Eherer AJ, et al. Intraluminal capsaicin does not affect fluid and electrolyte absorption in the human jejunum but does cause pain. Gut 1998;43:252-5
  • Schmidt B, Hammer J, Holzer P, et al. Chemical nociception in the jejunum induced by capsaicin. Gut 2004;53:1109-16
  • Fuhrer M, Vogelsang H, Hammer J. A placebo-controlled trial of an oral capsaicin load in patients with functional dyspepsia. Neurogastroenterol Motil 2011;23:918-e397
  • Rodriguez-Stanley S, Collings KL, Robinson M, et al. The effects of capsaicin on reflux, gastric emptying and dyspepsia. Aliment Pharmacol Ther 2000;14:129-34
  • Gonzalez R, Dunkel R, Koletzko B, et al. Effect of capsaicin-containing red pepper sauce suspension on upper gastrointestinal motility in healthy volunteers. Dig Dis Sci 1998;43:1165-71
  • Agarwal MK, Bhalia SJ, Desai SA, et al. Effect of red chilies on small bowel and colonic transit and rectal sensitivity in men with irritable bowel syndrome. Ind J Gastroenterol 2002;21:179-82
  • Aniwan S, Gonlachanvit S. Effects of chili treatment on gastrointestinal and rectal sensation in diarrhea-predominant irritable bowel syndrome: a randomized, double-blinded, crossover study. J Neurogastroenterol Motil 2014;20:400-6
  • Chan CLH, Facer P, Davis JB, et al. Sensory fibres expressing capsaicin receptor TRPV-1 in patients with rectal hypersensitivity and faecal urgency. Lancet 2003;361:385-91
  • Akbar A, Yiangou Y, Facer P, et al. Increased capsaicin receptor TRPV-1 expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain. Gut 2008;57:923-9
  • Akbar A, Yiangou Y, Facer P, et al. Expression of the TRPV-1 receptor differs in quiescent inflammatory bowel disease with or without abdominal pain. Gut 2010;59:767-74
  • Jones RC3rd, Otsuka E, Wagstrom E, et al. Short-term sensitization of colon mechanoreceptors is associated with long-term hypersensitivity to colon distention in the mouse. Gastroenterology 2007;133:184-94
  • Bortolotti M, Porta S. Effect of red pepper on symptoms of irritable bowel syndrome: preliminary study. Dig Dis Sci 2011;56:3288-95
  • Fuhrer M, Hammer J. Effect of repeated, long term capsaicin ingestion on intestinal chemo- and mechanosensation in healthy volunteers. Neurogastroenterol Motil 2009;21:521-e7
  • Bortolotti M, Coccia G, Grossi G, et al. The treatment of functional dyspepsia with red pepper. Aliment Pharmacol Ther 2002;16:1075-82

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.