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Review

Pharmacological treatment of attention-deficit/hyperactivity disorder: assessing outcomes

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References

  • Polanczyk G, de Lima MS, Horta BL, et al. The worldwide prevalence of ADHD: a systematic review and metaregression analysis. Am J Psychiat 2007;164(6):942-8
  • Swensen A, Birnbaum HG, Ben Hamadi R, et al. Incidence and costs of accidents among attention-deficit/hyperactivity disorder patients. J Adoles Health 2004;35(4):346.e1-9
  • Barkley RA, Fischer M. The unique contribution of emotional impulsiveness to impairment in major life activities in hyperactive children as adults. J Am Acad Child Adoles Psych 2010;49(5):503-13
  • Kessler RC, Adler L, Barkley R, et al. The prevalence and correlates of adult ADHD in the united states: results from the national comorbidity survey replication. Am J Psychiat 2006;163(4):716-23
  • Dalsgaard S, Ostergaard SD, Leckman JF, et al. Mortality in children, adolescents, and adults with attention deficit hyperactivity disorder: a nationwide cohort study. Lancet 2015. [Epub ahead of print]
  • Fischer M, Barkley RA, Smallish L, Fletcher K. Hyperactive children as young adults: driving abilities, safe driving behavior, and adverse driving outcomes. Accid Anal Prev 2007;39(1):94-105
  • Cortese S, Ramos Olazagasti MA, Klein RG, et al. Obesity in men with childhood ADHD: a 33-year controlled, prospective, follow-up study. Pediatrics 2013;131(6):e1731-8
  • Klein RG, Mannuzza S, Olazagasti MA, et al. Clinical and functional outcome of childhood attention-deficit/hyperactivity disorder 33 years later. Arch Gen Psychiatry 2012;69(12):1295-303
  • Ramos Olazagasti MA, Klein RG, Mannuzza S, et al. Does childhood attention-deficit/hyperactivity disorder predict risk-taking and medical illnesses in adulthood? J Am Acad Child Adolesc Psychiatry 2013;52(2):153-162.e4
  • Coghill D, Markarian M, Seth S. Effective management of attention-deficit/hyperactivity disorder (ADHD) through structured re-assessment: the Dundee ADHD clinical care pathway. Child and Adolesc Psychiatry Mental Health; in press
  • Langley K, Fowler T, Ford T, et al. Adolescent clinical outcomes for young people with attention-deficit hyperactivity disorder. Br J Psychiatry 2010;196(3):235-40
  • Fredriksen M, Halmoy A, Faraone SV, Haavik J. Long-term efficacy and safety of treatment with stimulants and atomoxetine in adult ADHD: a review of controlled and naturalistic studies. Eur Neuropsychopharmacol 2013;23(6):508-27
  • Bihlar Muld B, Jokinen J, Bolte S, Hirvikoski T. Long-term outcomes of pharmacologically treated versus non-treated adults with ADHD and substance use disorder: a naturalistic study. J Subst Abuse Treat 2015;51:82-90
  • Lichtenstein P, Halldner L, Zetterqvist J, et al. Medication for attention deficit-hyperactivity disorder and criminality. N Eng J Med 2012;367(21):2006-14
  • Man KK, Chan EW, Coghill D, et al. Methylphenidate and the risk of trauma. Pediatrics 2015;135(1):40-8
  • Raman SR, Marshall SW, Haynes K, et al. Stimulant treatment and injury among children with attention deficit hyperactivity disorder: an application of the self-controlled case series study design. Inj Prev 2013;19(3):164-70
  • Dalsgaard S, Nielsen HS, Simonsen M. Consequences of ADHD medication use for children’s outcomes. J Health Econ 2014;37:137-51
  • MTA Cooperative Group. A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. The MTA cooperative group. multimodal treatment study of children with ADHD. Arch Gen Psychiatry 1999;56(12):1073-86
  • Hanwella R, Senanayake M, de Silva V. Comparative efficacy and acceptability of methylphenidate and atomoxetine in treatment of attention deficit hyperactivity disorder in children and adolescents: a meta-analysis. BMC Psychiatry 2011;11:176
  • Wilens TE. Effects of methylphenidate on the catecholaminergic system in attention-deficit/hyperactivity disorder. J Clin Psychopharmacol 2008;28(3):S46-53
  • Coghill D, Banaschewski T, Lecendreux M, et al. European, randomized, phase 3 study of lisdexamfetamine dimesylate in children and adolescents with attention-deficit/hyperactivity disorder. Eur Neuropsychopharmacol 2013;23(10):1208-18
  • Schwartz S, Correll CU. Efficacy and safety of atomoxetine in children and adolescents with attention-deficit/hyperactivity disorder: results from a comprehensive meta-analysis and metaregression. J Am Acad Child Adolesc Psychiatry 2014;53(2):174-87
  • Savill NC, Buitelaar JK, Anand E, et al. The efficacy of atomoxetine for the treatment of children and adolescents with attention-deficit/hyperactivity disorder: a comprehensive review of over a decade of clinical research. CNS Drugs 2015;29(2):131-51
  • Ruggiero S, Clavenna A, Reale L, et al. Guanfacine for attention deficit and hyperactivity disorder in pediatrics: a systematic review and meta-analysis. Eur Neuropsychopharmacol 2014;24(10):1578-90
  • Kollins SH, Jain R, Brams M, et al. Clonidine extended-release tablets as add-on therapy to psychostimulants in children and adolescents with pediatrics. ADHD 2011;127(6):e1406-13
  • Childress AC. Guanfacine extended release as adjunctive therapy to psychostimulants in children and adolescents with attention-deficit/hyperactivity disorder. Adv Ther 2012;29(5):385-400
  • Faraone SV, Buitelaar J. Comparing the efficacy of stimulants for ADHD in children and adolescents using meta-analysis. Eur Child Adolesc Psychiatry 2010;19(4):353-64
  • Hirota T, Schwartz S, Correll CU. Alpha-2 agonists for attention-deficit/hyperactivity disorder in youth: a systematic review and meta-analysis of monotherapy and add-on trials to stimulant therapy. J Am Acad Child Adolesc Psychiatry 2014;53(2):153-73
  • Banaschewski T, Coghill D, Santosh P, et al. Long-acting medications for the hyperkinetic disorders. A systematic review and European treatment guideline. Eur Child Adolesc Psychiatry 2006;15(8):476-95
  • Castells X, Ramos-Quiroga JA, Rigau D, et al. Efficacy of methylphenidate for adults with attention-deficit hyperactivity disorder: a meta-regression analysis. CNS Drugs 2011;25(2):157-69
  • Faraone SV, Spencer T, Aleardi M, et al. Meta-analysis of the efficacy of methylphenidate for treating adult attention-deficit/hyperactivity disorder. J Clin Psychopharmacol 2004;24(1):24-9
  • Coghill D. The impact of medications on quality of life in attention-deficit hyperactivity disorder: a systematic review. CNS Drugs 2010;24(10):843-66
  • Buitelaar JK, Wilens TE, Zhang S, et al. Comparison of symptomatic versus functional changes in children and adolescents with ADHD during randomized, double-blind treatment with psychostimulants, atomoxetine, or placebo. J Child Psychol Psychiatry 2009;50(3):335-42
  • O’Connor BC, Garner AA, Peugh JL, et al. Improved but still impaired: symptom-impairment correspondence among youth with attention-deficit hyperactivity disorder receiving community-based care. J Dev Behav Pediatr 2015;36(2):106-14
  • Epstein JN, Langberg JM, Lichtenstein PK, et al. Attention-deficit/hyperactivity disorder outcomes for children treated in community-based pediatric settings. Arch Pediatr Adolesc Med 2010;164(2):160-5
  • Steele M, Jensen PS, Quinn DM. Remission versus response as the goal of therapy in ADHD: a new standard for the field? Clin Therapeut 2006;28(11):1892-908
  • Greenhill LL, Shockey E, Davies M, et al. Review of safety assessment methods used in pediatric psychopharmacology. J Am Acad Child Adolesc Psychiatry 2003;42(6):627-33
  • Graham J, Coghill D. Adverse effects of pharmacotherapies for attention-deficit hyperactivity disorder: epidemiology, prevention and management. CNS Drugs 2008;22(3):213-37
  • Coghill DR, Seth S, Pedroso S, et al. Effects of methylphenidate on cognitive functions in children and adolescents with attention-deficit/hyperactivity disorder: evidence from a systematic review and a meta-analysis. Biol Psychiatry 2014;76(8):603-15
  • Advokat C. What are the cognitive effects of stimulant medications? Emphasis on adults with attention-deficit/hyperactivity disorder (ADHD). Neurosci Biobehav Rev 2010;34(8):1256-66
  • Coghill D. Editorial: Acknowledging complexity and heterogeneity in causality--implications of recent insights into neuropsychology of childhood disorders for clinical practice. J Child Psychol Psychiatry 2014;55(7):737-40
  • Coghill DR, Hayward D, Rhodes SM, et al. A longitudinal examination of neuropsychological and clinical functioning in boys with attention deficit hyperactivity disorder (ADHD): improvements in executive functioning do not explain clinical improvement. Psychol Med 2014;44(5):1087-99
  • Coghill DR, Seth S, Matthews K. A comprehensive assessment of memory, delay aversion, timing, inhibition, decision making and variability in attention deficit hyperactivity disorder: advancing beyond the three-pathway models. Psychol Med 2014;44(9):1989-2001
  • Nigg JT, Willcutt EG, Doyle AE, Sonuga-Barke EJ. Causal heterogeneity in attention-deficit/hyperactivity disorder: do we need neuropsychologically impaired subtypes? Biol Psychiatry 2005;57(11):1224-30
  • Willcutt EG, Doyle AE, Nigg JT, et al. Validity of the executive function theory of attention-deficit/hyperactivity disorder: a meta-analytic review. Biol Psychiatry 2005;57(11):1336-46
  • Sonuga-Barke E, Bitsakou P, Thompson M. Beyond the dual pathway model: evidence for the dissociation of timing, inhibitory, and delay-related impairments in attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 2010;49(4):345-55
  • Conners CK. Conners’ rating scales-revised user’s manual. Multi-Health Systems. Multi-Health Systems, Inc., North Tonawanda, NY; 1997
  • Wolraich ML, Lambert W, Doffing MA, et al. Psychometric properties of the Vanderbilt ADHD diagnostic parent rating scale in a referred population. J Pediatr Psychol 2003;28(8):559-67
  • Wolraich ML, Feurer ID, Hannah JN, et al. Obtaining systematic teacher reports of disruptive behavior disorders utilizing DSM-IV. J Abnorm Child Psychol 1998;26(2):141-52
  • DuPaul GJ. ADHD Rating Scale-IV: Checklists, Norms, and Clinical Interpretation. 1998: Guilford Press
  • Swanson JM, Nolan W, Pelham WE. The SNAP-IV rating scale. 1992. Available from: http://www.adhd.net
  • DuPaul GJ, Barkley RA. Situational variability of attention problems: psychometric properties of the revised home and school situations questionnaires. J Clin Child Psychol 1992;21(2):178-88
  • Collett BR, Ohan JL, Myers KM. Ten-year review of rating scales. V: scales assessing attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 2003;42(9):1015-37
  • Pelham WEJr, Fabiano GA, Massetti GM. Evidence-based assessment of attention deficit hyperactivity disorder in children and adolescents. J Clin Child Adolesc Psychol 2005;34(3):449-76
  • Weckerly J, Aarons GA, Leslie LK, et al. Attention on inattention: the differential effect of caregiver education on endorsement of ADHD symptoms. J Dev Behav Pediatr 2005;26(3):201-8
  • European Medicines Agency (EMA). C.f.M.P.f.H.U.C. Guideline on the clinical investigation of medicinal products for the treatment of attention deficit hyperactivity disorder (ADHD). 2009
  • European Medicines Agency (EMA). C.f.M.P.f.H.U.C, Guideline on clinical investigation of medicinal products, including depot preparations, in the treatment of schizophrenia. 2012
  • European Medicines Agency (EMA). C.f.M.P.f.H.U.C, Guideline on clinical investigation of medicinal products in the treatment of depression. 2013
  • European Medicines Agency (EMA). C.f.M.P.f.H.U.C, Draft concept paper on the development of medicinal products for the treatment of autism spectrum disorder. 2013
  • Döpfner M, Steinhausen HC, Coghill D, et al. Cross-cultural reliability and validity of ADHD assessed by the ADHD Rating Scale in a pan-European study. Eur Child Adolesc Psychiatry 2006;15(1):i46-55
  • Group, MC. A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. The MTA cooperative group. multimodal treatment study of children with ADHD. Arch Gen Psychiatry 1999;56(12):1073-86
  • Valo S, Tannock R. Diagnostic instability of DSM–IV ADHD subtypes: effects of informant source, instrumentation, and methods for combining symptom reports. J Clin Child Adolesc Psychol 2010;39(6):749-60
  • Shemmassian SK, Lee SS. Comparing four methods of integrating parent and teacher symptom ratings of attention-deficit/hyperactivity disorder (ADHD). J Psychopathol Behav Assess 2012;34(1):1-10
  • Conners CK. Rating scales in attention-deficit/hyperactivity disorder: use in assessment and treatment monitoring. J Clin Psychiatry 1998;59(7):24-30
  • Waschbusch DA, Pelham WEJr, Waxmonsky J, Johnston C. Are there placebo effects in the medication treatment of children with attention-deficit hyperactivity disorder? J Dev Behav Pediatr 2009;30(2):158-68
  • Pelham WE, Waxmonsky JG, Schentag J, et al. Efficacy of a methylphenidate transdermal system versus t.i.d. methylphenidate in a laboratory setting. J Atten Disord 2011;15(1):28-35
  • Swanson JM, Lerner M, Wigal T, et al. The use of a laboratory school protocol to evaluate concepts about efficacy and side effects of new formulations of stimulant medications. J Atten Disord 2002;6(Suppl 1):S73-88
  • Swanson J, Wigal S, Greenhill L, et al. Objective and subjective measures of the pharmacodynamic effects of Adderall in the treatment of children with ADHD in a controlled laboratory classroom setting. Psychopharmacol Bull 1998;34(1):55-60
  • Wigal SB, Gupta S, Guinta D, Swanson JM. Reliability and validity of the SKAMP rating scale in a laboratory school setting. Psychopharmacol Bull 1998;34(1):47-53
  • Dalsgaard S, Mortensen PB, Frydenberg M, Thomsen PH. Conduct problems, gender and adult psychiatric outcome of children with attention-deficit hyperactivity disorder. Br J Psychiatry 2002;181:416-21
  • Coghill D, Spiel G, Baldursson G, et al. Which factors impact on clinician-rated impairment in children with ADHD? Eur Child Adolesc Psychiatry 2006;15(1):I30-7
  • Breuer D, Gortz-Dorten A, Rothenberger A, Dopfner M. Assessment of daily profiles of ADHD and ODD symptoms, and symptomatology related to ADHD medication, by parent and teacher ratings. Eur Child Adolesc Psychiatry 2011;20(Suppl 2):S289-96
  • Childress AC, Arnold V, Adeyi B, et al. The effects of lisdexamfetamine dimesylate on emotional lability in children 6 to 12 years of age with ADHD in a double-blind placebo-controlled trial. J Atten Disord 2014;18(2):123-32
  • Rosler M, Retz W, Fischer R, et al. Twenty-four-week treatment with extended release methylphenidate improves emotional symptoms in adult ADHD. World J Biol Psychiatry 2010;11(5):709-18
  • Stringaris A, Goodman R, Ferdinando S, et al. The Affective Reactivity Index: a concise irritability scale for clinical and research settings. J Child Psychol Psychiatry 2012;53(11):1109-17
  • De Crescenzo F, Armando M, Mazzone L, et al. The use of actigraphy in the monitoring of methylphenidate versus placebo in ADHD: a meta-analysis. Atten Defic Hyperact Disord 2014;6(1):49-58
  • Tabori-Kraft J, Sorensen MJ, Kaergaard M, et al. Is OPTAx useful for monitoring the effect of stimulants on hyperactivity and inattention? A brief report. Eur Child Adolesc Psychiatry 2007;16(5):347-51
  • Ramos-Quiroga JA, Casas M. Achieving remission as a routine goal of pharmacotherapy in attention-deficit hyperactivity disorder. CNS Drugs 2011;25(1):17-36
  • Jacobson NS, Truax P. Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. J Cons Clin Psychol 1991;59(1):12-19
  • Dittmann RW, Cardo E, Nagy P, et al. Treatment response and remission in a double-blind, randomized, head-to-head study of lisdexamfetamine dimesylate and atomoxetine in children and adolescents with attention-deficit hyperactivity disorder. CNS Drugs 2014;28(11):1059-69
  • Soutullo C, Banaschewski T, Lecendreux M, et al. A post hoc comparison of the effects of lisdexamfetamine dimesylate and osmotic-release oral system methylphenidate on symptoms of attention-deficit hyperactivity disorder in children and adolescents. CNS Drugs 2013;27(9):743-51
  • Erder MH, Xie J, Signorovitch JE, et al. Cost effectiveness of guanfacine extended-release versus atomoxetine for the treatment of attention-deficit/hyperactivity disorder: application of a matching-adjusted indirect comparison. Appl Health Econ Health Policy 2012;10(6):381-95
  • Coghill DR, Rhodes SM, Matthews K. The neuropsychological effects of chronic methylphenidate on drug-naive boys with attention-deficit/hyperactivity disorder. Biol Psychiatry 2007;62(9):954-62
  • Coghill DR, Banaschewski T, Lecendreux M, et al. Maintenance of efficacy of lisdexamfetamine dimesylate in children and adolescents with attention-deficit/hyperactivity disorder: randomized-withdrawal study design. J Am Acad Child Adolesc Psychiatry 2014;53(6):647-657 e1
  • Arnold LE, Lindsay RL, Conners CK, et al. A double-blind, placebo-controlled withdrawal trial of dexmethylphenidate hydrochloride in children with attention deficit hyperactivity disorder. J Child Adolesc Psychopharmacol 2004;14(4):542-54
  • Buitelaar JK, Michelson D, Danckaerts M, et al. A randomized, double-blind study of continuation treatment for attention-deficit/hyperactivity disorder after 1 year. Biol Psychiatry 2007;61(5):694-9
  • Michelson D, Buitelaar JK, Danckaerts M, et al. Relapse prevention in pediatric patients with ADHD treated with atomoxetine: a randomized, double-blind, placebo-controlled study. J Am Acad Child Adolesc Psychiatry 2004;43(7):896-904
  • Epstein JN, Weiss MD. Assessing treatment outcomes in attention-deficit/hyperactivity disorder: a narrative review. Prim Care Companion CNS Disord 2012;14(6):11r01336
  • European Medicines Agency (EMA). C.f.M.P.f.H.u.C. Guideline on the clinical investigation of medicinal products for the treatment of attention deficit hyperactivity disorder (ADHD). 2010. Available from: www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2010/08/WC500095686.pdf
  • Kaufman J, Birmaher B, Brent D, et al. Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 1997;36(7):980-8
  • Berk M, Ng F, Dodd S, et al. The validity of the CGI severity and improvement scales as measures of clinical effectiveness suitable for routine clinical use. J Eval Clin Pract 2008;14(6):979-83
  • Shaffer D, Gould MS, Brasic J, et al. A children’s global assessment scale (CGAS). Arch Gen Psychiatry 1983;40(11):1228-31
  • Bird HR, Canino G, Rubio-Stipec M, Ribera JC. Further measures of the psychometric properties of the children’s global assessment scale. Arch Gen Psychiatry 1987;44(9):821-4
  • Bird HR, Shaffer D, Fisher P, et al. The Columbia Impairmenr Scale (CIS): pilot findings on a measure of global impairment for children and adolescents. J Method Psychiatr Res 1993;3:167-76
  • Bird HR, Andrews H, Schwab-Stone M, et al. Global measures of impairment for epidemiologic and clinical use with children and adolescents. J Method Psychiatr Res 1996;6:295-307
  • Hodges K, Doucette-Gates A, Liao Q. The relationship between the child and adolescent functional assessment scale (CAFAS) and indicators of functioning. J Child Family Stud 1999;8:108-22
  • Maziade M, Rouleau N, Lee B, et al. Atomoxetine and neuropsychological function in children with attention-deficit/hyperactivity disorder: results of a pilot study. J Child Adolesc Psychopharmacol 2009;19(6):709-18
  • Stein MA, Waldman ID, Charney E, et al. Dose effects and comparative effectiveness of extended release dexmethylphenidate and mixed amphetamine salts. J Child Adolesc Psychopharmacol 2011;21(6):581-8
  • (CADDRA), C.A.D.H.D.R.A. Canadian ADHD Practice Guidelines. 3rd editon, ed. CADDRA, Toronto; 2011
  • Fuentes J, Danckaerts M, Cardo E, et al. Long-term quality-of-life and functioning comparison of atomoxetine versus other standard treatment in pediatric attention-deficit/hyperactivity disorder. J Clin Psychopharmacol 2013;33(6):766-74
  • Banaschewski T, Soutullo C, Lecendreux M, et al. Health-related quality of life and functional outcomes from a randomized, controlled study of lisdexamfetamine dimesylate in children and adolescents with attention deficit hyperactivity disorder. CNS Drugs 2013;27(10):829-40
  • Landgraf JM, Rich M, Rappaport L. Measuring quality of life in children with attention-deficit/hyperactivity disorder and their families: development and evaluation of a new tool. Arch Pediatr Adolesc Med 2002;156(4):384-91
  • Surman CB, Hammerness PG, Pion K, Faraone SV. Do stimulants improve functioning in adults with ADHD? A review of the literature. Eur Neuropsychopharmacol 2013;23(6):528-33
  • Riley AW, Lyman LM, Spiel G, et al. The family strain index (FSI). Reliability, validity, and factor structure of a brief questionnaire for families of children with ADHD. Eur Child Adolesc Psychiatry 2006;15(Suppl 1):I72-8
  • Saylor K, Buermeyer C, Sutton V, et al. The life participation scale for attention-deficit/hyperactivity disorder–child version: psychometric properties of an adaptive change instrument. J Child Adolesc Psychopharmacol 2007;17(6):831-42
  • Kelsey DK, Sumner CR, Casat CD, et al. Once-daily atomoxetine treatment for children with attention-deficit/hyperactivity disorder, including an assessment of evening and morning behavior: a double-blind, placebo-controlled trial. Pediatrics 2004;114(1):e1-8
  • Hoza B, Pelham WEJr, Dobbs J, et al. Do boys with attention-deficit/hyperactivity disorder have positive illusory self-concepts? J Abnorm Psychol 2002;111(2):268-78
  • Shaffer D, Fisher P, Lucas CP, et al. NIMH Diagnostic Interview Schedule for Children Version IV (NIMH DISC-IV): description, differences from previous versions, and reliability of some common diagnoses. J Am Acad Child Adolesc Psychiatry 2000;39(1):28-38
  • Danckaerts M, Sonuga-Barke EJ, Banaschewski T, et al. The quality of life of children with attention deficit/hyperactivity disorder: a systematic review. Eur Child Adolesc Psychiatry 2010;19(2):83-105
  • WHO. The world health organization quality of life assessment (WHOQOL): position paper from the world health organization. Soc Sci Med 1995;41(10):1403-9
  • Rentz AM, Matza LS, Secnik K, et al. Psychometric validation of the child health questionnaire (CHQ) in a sample of children and adolescents with attention-deficit/hyperactivity disorder. Qual Life Res 2005;14(3):719-34
  • Varni JW, Burwinkle TM. The PedsQL as a patient-reported outcome in children and adolescents with Attention-Deficit/Hyperactivity Disorder: a population-based study. Health Qual Life Outcomes 2006;4:26
  • Varni JW, Seid M, Kurtin PS. PedsQL 4.0: reliability and validity of the Pediatric Quality of Life Inventory version 4.0 generic core scales in healthy and patient populations. Med Care 2001;39(8):800-12
  • Escobar R, Soutullo CA, Hervas A, et al. Worse quality of life for children with newly diagnosed attention-deficit/hyperactivity disorder, compared with asthmatic and healthy children. Pediatrics 2005;116(3):e364-9
  • Coghill D, Hodgkins P. Health-related quality of life of children with attention-deficit/hyperactivity disorder versus children with diabetes and healthy controls. Eur Child Adolesc Psychiatry 2009; in press
  • Riley AW, Coghill D, Forrest CB, et al. Validity of the health-related quality of life assessment in the ADORE study: parent report form of the CHIP-Child Edition. Eur Child Adolesc Psychiatry 2006;15(Suppl 1):I63-71
  • Kamp-Becker I, Schroder J, Muehlan H, et al. Health-related quality of life in children and adolescents with autism spectrum disorder. Z Kinder Jugendpsychiatr Psychother 2011;39(2):123-31
  • Cavanna AE, David K, Bandera V, et al. Health-related quality of life in Gilles de la Tourette syndrome: a decade of research. Behav Neurol 2013;27(1):83-93
  • Jardine J, Glinianaia SV, McConachie H, et al. Self-reported quality of life of young children with conditions from early infancy: a systematic review. Pediatrics 2014;134(4):e1129-48
  • Lin YF, Chung HH. Parenting stress and parents’ willingness to accept treatment in relation to behavioral problems of children with attention-deficit hyperactive disorder. J Nurs Res 2002;10(1):43-56
  • Xiang YT, Luk ES, Lai KY. Health-related quality of life in children and adolescents with autism spectrum disorder. Z Kinder Jugendpsychiatr Psychother 2011;43(8):731-8
  • Riley AW, Spiel G, Coghill D, et al. Factors related to health-related quality of life (HRQoL) among children with ADHD in Europe at entry into treatment. Eur Child Adolesc Psychiatry 2006;15(1):I38-45
  • Marques JC, Oliveira JA, Goulardins JB, et al. Comparison of child self-reports and parent proxy-reports on quality of life of children with attention deficit hyperactivity disorder. Health Qual Life Outcomes 2013;11:186
  • Coghill D. Pragmatic measures in paediatric psychopharmacology-are we getting it right? Eur Neuropsychopharmacol 2011;21(8):571-83
  • Banaschewski T, Johnson M, Lecendreux M, et al. Health-related quality of life and functional outcomes from a randomized-withdrawal study of long-term lisdexamfetamine dimesylate treatment in children and adolescents with attention-deficit/hyperactivity disorder. CNS Drugs 2014;28(12):1191-203
  • Childress AC, Cutler AJ, Saylor K, et al. Participant-perceived quality of life in a long-term, open-label trial of lisdexamfetamine dimesylate in adolescents with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol 2014;24(4):210-17
  • Altin M, El-Shafei AA, Yu M, et al. Pharmacological treatment for attention deficit hyperactivity disorder: functional outcomes in children and adolescents from non-Western countries. Drugs Context 2013;2013:212260
  • Ghanizadeh A, Sayyari Z, Mohammadi MR. Effect of methylphenidate and folic Acid on ADHD symptoms and quality of life and aggression: a randomized double blind placebo controlled clinical trial. Iran J Psychiatry 2013;8(3):108-12
  • Haertling F, Mueller BO. Bilke-hentsch, effectiveness and safety of a long-acting, once-daily, two-phase release formulation of methylphenidate (Ritalin LA) in school children under daily practice conditions. Atten Defic Hyperact Disord 2014. [Epub ahead of print]
  • Brod M, Adler LA, Lipsius S, et al. Validation of the adult attention-deficit/hyperactivity disorder quality-of-life scale in European patients: comparison with patients from the USA. Atten Defic Hyperact Disord 2015 [Epub ahead of print]
  • Faraone SV, Biederman J, Morley CP, Spencer TJ. Effect of stimulants on height and weight: a review of the literature. J Am Acad Child Adolesc Psychiatry 2008;47(9):994-1009
  • Dalsgaard S, Kvist AP, Leckman JF, et al. Cardiovascular safety of stimulants in children with Attention-Deficit/Hyperactivity Disorder: A nationwide prospective cohort study. J Child Adolesc Psychopharmacol 2014;24(6):302-10
  • Cooper WO, Habel LA, Sox CM, et al. ADHD drugs and serious cardiovascular events in children and young adults. N Eng J Med 2011;365(20):1896-904
  • Cortese S, Holtmann M, Banaschewski T, et al. European ADHD Guidelines Group, Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents. J Child Psychol Psychiatry 2013;54(3):227-46
  • Graham J, Banaschewski T, Buitelaar J, et al. European guidelines on managing adverse effects of medication for ADHD. Eur Child Adolesc Psychiatry 2011;20(1):17-37
  • Hammerness PG, Perrin JM, Shelley-Abrahamson R, Wilens TE. Cardiovascular risk of stimulant treatment in pediatric attention-deficit/hyperactivity disorder: update and clinical recommendations. J Am Acad Child Adolesc Psychiatry 2011;50(10):978-90
  • Brown EG, Wood L, Wood S. The medical dictionary for regulatory activities (MedDRA). Drug Saf 1999;20(2):109-17
  • Mullins D, Pfefferbaum B, Schultz H, Overall JE. Brief psychiatric rating scale for children: quantitative scoring of medical records. Psychiatry Res 1986;19(1):43-9
  • Overall JE, Gorham DR. The brief psychiatric rating scale (BPRS): recent developments in ascertainment and scaling. Psychopharmacol Bull 1988;24:97-9
  • Levine J, Schooler NR. SAFTEE: a technique for the systematic assessment of side effects in clinical trials. Psychopharmacol Bull 1986;22(2):343-81
  • Barkley RA, McMurray MB, Edelbrock CS, Robbins K. Side effects of methylphenidate in children with attention deficit hyperactivity disorder: a systemic, placebo-controlled evaluation. Pediatrics 1990;86(2):184-92
  • Sonuga-Barke EJ, Coghill D, Wigal T, et al. Adverse reactions to methylphenidate treatment for attention-deficit/hyperactivity disorder: structure and associations with clinical characteristics and symptom control. J Child Adolesc Psychopharmacol 2009;19(6):683-90
  • Frazier TW, Demaree HA, Youngstrom EA. Meta-analysis of intellectual and neuropsychological test performance in attention-deficit/hyperactivity disorder. Neuropsychology 2004;18(3):543-55
  • Jepsen JR, Fagerlund B, Mortensen EL. Do attention deficits influence IQ assessment in children and adolescents with ADHD? J Atten Disord 2009;12(6):551-62
  • Gimpel GA, Collett BR, Veeder MA, et al. Effects of stimulant medication on cognitive performance of children with ADHD. Clin Pediatr 2005;44(5):405-11
  • Gillberg C, Melander H, von Knorring AL, et al. Long-term stimulant treatment of children with attention-deficit hyperactivity disorder symptoms. A randomized, double-blind, placebo-controlled trial. Arch Gen Psychiatry 1997;54(9):857-64
  • Tsai CS, Huang YS, Wu CL, et al. Long-term effects of stimulants on neurocognitive performance of Taiwanese children with attention-deficit/hyperactivity disorder. BMC Psychiatry 2013;13:330
  • van Lieshout M, Luman M, Buitelaar J, et al. Does neurocognitive functioning predict future or persistence of ADHD? A systematic review. Clin Psychol Rev 2013;33(4):539-60
  • Biederman J, Monuteaux MC, Doyle AE, et al. Impact of executive function deficits and attention-deficit/hyperactivity disorder (ADHD) on academic outcomes in children. J Cons Clin Psychol 2004;72(5):757-66
  • Wahlstedt C, Thorell LB, Bohlin G. Heterogeneity in ADHD: neuropsychological pathways, comorbidity and symptom domains. J Abnorm Child Psychol 2009;37(4):551-64
  • Gualtieri C.T, Johnson LG. Medications do not necessarily normalize cognition in ADHD patients. J Atten Disord 2008;11(4):459-69
  • Bedard AC, Stein MA, Halperin JM, et al. Differential impact of methylphenidate and atomoxetine on sustained attention in youth with attention-deficit/hyperactivity disorder. J Child Psychol Psychiatry 2015;56(1):40-8
  • Cortese S, Ferrin M, Brandeis D, et al. Cognitive training for attention-deficit/hyperactivity disorder: meta-analysis of clinical and neuropsychological outcomes from randomized controlled trials. J Am Acad Child Adolesc Psychiatry 2015;54(3):164-74
  • Morris RC, Evendon JL, Sahakian BJ, Robbins TW. In cognitive neurochemistry. In: Stahl SM, Iverson SD, Goodman EC, Computer-aided assessment of dementia: comparative studies of neuropsychological deficits in Alzheimer-type dementia and Parkinson’s disease. Oxford University Press, Oxford; 1987. pp 21-36
  • Gioia GA, Isquith PK, Guy SC, et al. BRIEF: behavior rating inventory of executive function: professional manual. Psychol Assess Res 2000
  • Brown TE, Landgraf JM. Improvements in executive function correlate with enhanced performance and functioning and health-related quality of life: evidence from 2 large, double-blind, randomized, placebo-controlled trials in ADHD. Postgrad Med 2010;122(5):42-51
  • Findling RL, Adeyi B, Dirks B, et al. Parent-reported executive function behaviors and clinician ratings of attention-deficit/hyperactivity disorder symptoms in children treated with lisdexamfetamine dimesylate. J Child Adolesc Psychopharmacol 2013;23(1):28-35
  • Volkow ND, Wang GJ, Fowler JS, et al. Evidence that methylphenidate enhances the saliency of a mathematical task by increasing dopamine in the human brain. Am J Psychiatry 2004;161(7):1173-80
  • Douglas VI, Barr RG, Desilets J, Sherman E. Do high doses of stimulants impair flexible thinking in attention-deficit hyperactivity disorder? J Am Acad Child Adolesc Psychiatry 1995;34(7):877-85
  • Andersen SL, Napierata L, Brenhouse HC, Sonntag KC. Juvenile methylphenidate modulates reward-related behaviors and cerebral blood flow by decreasing cortical D3 receptors. Eur J Neurosci 2008;27(11):2962-72
  • Sprague RL, Sleator EK. Methylphenidate in hyperkinetic children: differences in dose effects on learning and social behavior. Science 1977;198(4323):1274-6
  • Tannock R, Schachar R. Methylphenidate and cognitive perseveration in hyperactive children. J Child Psychol Psychiatry 1992;33(7):1217-28
  • Funk JB, Chessare JB, Weaver MT, Exley AR. Attention deficit hyperactivity disorder, creativity, and the effects of methylphenidate. Pediatrics 1993;91(4):816-19

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