Immunosuppression-free transplantation reconsidered from a regenerative medicine perspective

References

• Orlando G, Hematti P, Stratta RJ et al. Clinical operational tolerance after renal transplantation: current status and future challenges. Ann. Surg.252(6), 915–928 (2010).
   PubMed Web of Science ®Google Scholar
• Orlando G, Soker S, Wood KJ. Clinical operational tolerance after liver Transplantation J. Hepatol.50(6), 1247–1257 (2009).
   PubMed Web of Science ®Google Scholar
• Orlando G. Finding the right time for weaning off immunosuppression in solid organ transplant recipients. Expert Rev. Clin. Immunol.6(6), 879–892 (2010).
   PubMed Web of Science ®Google Scholar
• Kirk AD. Clinical tolerance 2008. Transplantation87(7), 953–955 (2009).
   PubMedGoogle Scholar
• Orlando G, Wood KJ, Soker S et al. How regenerative medicine may contribute to the achievement of an immunosuppression-free state. Transplantation92(8), e36–e38 (2011).
   PubMed Web of Science ®Google Scholar
• Orlando G. Transplantation as a subfield of regenerative medicine. Expert Rev. Clin. Immunol.7(2), 137–141 (2011).
   PubMed Web of Science ®Google Scholar
• Brasile L, Glowacki P, Stubenitsky BM. Bioengineered skin allografts: a new method to prevent humoral response. ASAIO J.57(3), 239–243 (2011).
   PubMed Web of Science ®Google Scholar
• Brasile L, Glowacki P, Castracane J et al. Pretransplant kidney-specific treatment to eliminate the need for systemic immunosuppression. Transplantation90(12), 1294–1298 (2010).
   PubMed Web of Science ®Google Scholar
• Poznansky MC, Evans RH, Foxall RB et al. Efficient generation of human T cells from a tissue-engineered thymic organoid. Nat. Biotechnol.18(7), 729–734 (2000).
   PubMed Web of Science ®Google Scholar
• Suematsu S, Watanabe T. Generation of a synthetic lymphoid tissue-like organoid in mice. Nat. Biotechnol.22(12), 1539–1545 (2004).
   PubMed Web of Science ®Google Scholar
• Clark RA, Yamanaka K, Bai M et al. Human skin cells support thymus-independent T cell development. J. Clin. Invest.115(11), 3239–3249 (2005).
   PubMed Web of Science ®Google Scholar
• Marshall D, Bagley J, Le P et al. T cell generation including positive and negative selection ex vivo in a three-dimensional matrix. J. Hematother. Stem Cell Res.12(5), 565–574 (2003).
   PubMedGoogle Scholar
• Vianello F, Poznansky MC. Generation of a tissue-engineered thymic organoid. Methods Mol. Biol.380, 163–170 (2007).
   PubMedGoogle Scholar
• Orlando G, Wood KJ, Stratta RJ et al. Regenerative medicine and organ transplantation: past, present, and future. Transplantation91(12), 1310–1317 (2011).
   PubMed Web of Science ®Google Scholar
• Orlando G, Baptista P, Birchall M et al. Regenerative medicine as applied to solid organ transplantation: current status and future challenges. Transpl. Int.24(3), 223–232 (2010).
   PubMedGoogle Scholar
• Orlando G, Wood KJ, De Coppi P et al. Regenerative medicine as applied to general surgery. Ann. Surg. (2012) (In Press).
   Google Scholar
• Shinoka T, Imai Y, Ikada Y. Transplantation of a tissue-engineered pulmonary artery. N. Engl. J. Med.344(7), 532–533 (2001).
   PubMed Web of Science ®Google Scholar
• Shinoka T, Matsumura G, Hibino N et al. Midterm clinical result of tissue-engineered vascular autografts seeded with autologous bone marrow cells. J. Thorac. Cardiovasc. Surg.129(6), 1330–1338 (2005).
   PubMed Web of Science ®Google Scholar
• Hibino N, McGillicuddy E, Matsumura G et al. Late-term results of tissue-engineered vascular grafts in humans. J. Thorac. Cardiovasc. Surg.139(2), 431–436 (2010).
   PubMed Web of Science ®Google Scholar
• Naito Y, Shinoka T, Duncan D et al. Vascular tissue engineering: towards the next generation vascular grafts. Adv. Drug Deliv. Rev.63(4–5), 312–323 (2011).
   PubMed Web of Science ®Google Scholar
• McAllister TN, Maruszewski M, Garrido SA et al. Effectiveness of haemodialysis access with an autologous tissue-engineered vascular graft: a multicentre cohort study. Lancet373(9673), 1440–1446 (2009).
   PubMed Web of Science ®Google Scholar
• L’Heureux N, McAllister TN, de la Fuente LM. Tissue-engineered blood vessel for adult arterial revascularization. N. Engl. J. Med.357(14), 1451–1453 (2007).
   PubMed Web of Science ®Google Scholar
• L’Heureux N, Dusserre N, Konig G et al. Human tissue-engineered blood vessels for adult arterial revascularization. Nat. Med.12(3), 361–365 (2006).
   PubMed Web of Science ®Google Scholar
• Dahl SL, Kypson AP, Lawson JH et al. Readily available tissue-engineered vascular grafts. Sci. Transl. Med.3(68), 68ra9 (2011).
   PubMed Web of Science ®Google Scholar
• Atala A, Bauer SB, Soker S et al. Tissue-engineered autologous bladders for patients needing cystoplasty. Lancet367(9518), 1241–1246 (2006).
   PubMed Web of Science ®Google Scholar
• Folkman J, Hochberg M. Self-regulation of growth in three dimensions. J. Exp. Med.138(4), 745–753 (1973).
   PubMed Web of Science ®Google Scholar
• Macchiarini P, Jungebluth P, Go T et al. Clinical transplantation of a tissue-engineered airway. Lancet372(9655), 2023–2030 (2008).
   PubMed Web of Science ®Google Scholar
• Baiguera S, Birchall MA, Macchiarini P. Tissue-engineered tracheal transplantation. Transplantation89(5), 485–491 (2010).
   PubMed Web of Science ®Google Scholar
• Baiguera S, Gonfiotti A, Jaus M et al. Development of bioengineered human larynx. Biomaterials32(19), 4433–4442 (2011).
   PubMed Web of Science ®Google Scholar
• Raya-Rivera A, Esquiliano DR, Yoo JJ et al. Tissue-engineered autologous urethras for patients who need reconstruction: an observational study. Lancet377(9772), 1175–1182 (2011).
   PubMed Web of Science ®Google Scholar
• Song JJ, Kim SS, Liu Z et al. Enhanced in vivo function of bioartificial lungs in rats. Ann. Thorac. Surg.92(3), 998–1006 (2011).
   PubMed Web of Science ®Google Scholar
• Wang Y, Cui CB, Yamauchi M et al. Lineage restriction of human hepatic stem cells to mature fates is made efficient by tissue-specific biomatrix scaffolds. Hepatology53(1), 293–305 (2011).
   PubMed Web of Science ®Google Scholar
• Mertsching H, Schanz J, Steger V et al. Generation and transplantation of an autologous vascularized bioartificial human tissue. Transplantation88(2), 203–210 (2009).
   PubMedGoogle Scholar
• Orlando G, Stratta RJ, Light J. Pancreas transplantation for type 2 diabetes mellitus. Curr. Opin. Organ. Transplant. doi: 10.1097/MOT.0b013e3283424d1f (2010) (Epub ahead of print).
   Google Scholar
• Cravedi P, van der Meer IM, Cattaneo S et al. Successes and disappointments with clinical islet transplantation. Adv. Exp. Med. Biol.654, 749–769 (2010).
   PubMedGoogle Scholar
• Vaithilingam V, Tuch BE. Islet transplantation and encapsulation: an update on recent developments. Rev. Diabet. Stud.8(1), 63–79 (2011).
   Google Scholar
• Bach JF, Chatenoud L. Organ transplantation and autoimmunity: common mechanisms common therapies. Semin. Immunol.23(3), 155–156 (2011).
   PubMedGoogle Scholar
• Teramura Y, Iwata H. Bioartificial pancreas. Microencapsulation and conformal coating of islet of Langerhans. Adv. Drug Del. Rev.62(2010), 827–840 (2010).
   PubMed Web of Science ®Google Scholar
• Lechler RI, Sykes M, Thomson AW et al. Organ transplantation – how much of the promise has been realized? Nat. Med.11(6), 605–613 (2005).
   PubMed Web of Science ®Google Scholar
• Giraldo JA, Weaver JD, Stabler CL. Tissue engineering approaches to enhancing clinical islet transplantation through tissue engineering strategies. J. Diabetes. Sci. Technol.4(5), 1238–1247 (2010).
   PubMedGoogle Scholar
• De Carlo E, Baiguera S, Conconi MT et al. Pancreatic acellular matrix supports islet survival and function in a synthetic tubular device: in vitro and in vivo studies. Int. J. Mol. Med.25(2), 195–202 (2010).
   PubMed Web of Science ®Google Scholar
• Brasile L, Glowacki P, Castracane J, Stubenitsky BM. Pretransplant kidney-specific treatment to eliminate the need for systemic immunosuppression. Transplantation90(12), 1294–1298 (2010).
   PubMed Web of Science ®Google Scholar
• Stubenitsky BM, Brasile L, Rebellato LM et al. Delayed skin allograft rejection following matrix membrane pretreatment. J. Plast. Reconstr. Aesthet. Surg.62(4), 520–525 (2009).
   PubMed Web of Science ®Google Scholar
• Scott MD, Murad KL, Koumpouras F et al. Chemical camouflage of antigenic determinants: stealth erythrocytes. Proc. Natl Acad. Sci. USA94(14), 7566–7571 (1997).
   PubMed Web of Science ®Google Scholar
• Scott MD, Murad KL. Cellular camouflage: fooling the immune system with polymers. Curr. Pharm. Des.4(6), 423–438 (1998).
   PubMed Web of Science ®Google Scholar
• Murad KL, Mahany KL, Brugnara C et al. Structural and functional consequences of antigenic modulation of red blood cells with methoxypoly(ethylene glycol). Blood93(6), 2121–2127 (1999).
   PubMed Web of Science ®Google Scholar
• Chen AM, Scott MD. Current and future applications of immunological attenuation via pegylation of cells and tissue. BioDrugs5(12), 833–847 (2001).
   Google Scholar
• Chen AM, Scott MD. Immunocamouflage: prevention of transfusion-induced graft-versus-host disease via polymer grafting of donor cells. J. Biomed. Mater. Res. A.67(2), 626–636 (2003).
   PubMedGoogle Scholar
• Rossi NA, Constantinescu I, Kainthan RK et al. Red blood cell membrane grafting of multi-functional hyperbranched polyglycerols. Biomaterials31(14), 4167–4178 (2010).
   PubMed Web of Science ®Google Scholar
• Le Y, Scott MD. Immunocamouflage: the biophysical basis of immunoprotection by grafted methoxypoly(ethylene glycol) (mPEG). Acta Biomater.6(7), 2631–2641 (2010).
   PubMedGoogle Scholar
• Wang D, Kyluik DL, Murad KL et al. Polymer-mediated immunocamouflage of red blood cells: effects of polymer size on antigenic and immunogenic recognition of allogeneic donor blood cells. Sci. China Life Sci.54(7), 589–598 (2011).
   PubMedGoogle Scholar
• Wang D, Toyofuku WM, Chen AM et al. Induction of immunotolerance via mPEG grafting to allogeneic leukocytes. Biomaterials32(35), 9494–9503 (2011).
   PubMedGoogle Scholar
• Sutton TC, Scott MD. The effect of grafted methoxypoly(ethylene glycol) chain length on the inhibition of respiratory syncytial virus (RSV) infection and proliferation. Biomaterials31(14), 4223–4230 (2010).
   PubMedGoogle Scholar
• Seach N, Layton D, Lim J et al. Thymic generation and regeneration: a new paradigm for establishing clinical tolerance of stem cell-based therapies. Curr. Opin. Biotechnol.18(5), 441–447 (2007).
   PubMedGoogle Scholar
• Yamada K, Gianello PR, Ierino FL et al. Role of the thymus in transplantation tolerance in miniature swine. I. Requirement of the thymus for rapid and stable induction of tolerance to class I-mismatched renal allografts. J. Exp. Med.186(3), 497–506 (1997).
   PubMedGoogle Scholar
• Nobori S, Samelson-Jones E, Shimizu A et al. Long-term acceptance of fully allogeneic cardiac grafts by cotransplantation of vascularized thymus in miniature swine. Transplantation81(1), 26–35 (2006).
   PubMedGoogle Scholar
• Nobori S, Shimizu A, Okumi M et al. Thymic rejuvenation and the induction of tolerance by adult thymic grafts. Proc. Natl Acad. Sci. USA103(50), 19081–19086 (2006).
   PubMedGoogle Scholar
• Yamada K, Shimizu A, Ierino FL et al. Thymic transplantation in miniature swine. I. Development and function of the ‘thymokidney’. Transplantation68(11), 1684–1692 (1999).
   PubMedGoogle Scholar
• Yamada K, Shimizu A, Utsugi R et al. Thymic transplantation in miniature swine. II. Induction of tolerance by transplantation of composite thymokidneys to thymectomized recipients. J. Immunol.164(6), 3079–3086 (2000).
   PubMedGoogle Scholar
• Yamada K, Vagefi PA, Utsugi R et al. Thymic transplantation in miniature swine: III. Induction of tolerance by transplantation of composite thymokidneys across fully major histocompatibility complex-mismatched barriers. Transplantation76(3), 530–536 (2003).
   PubMedGoogle Scholar
• Vagefi PA, Ierino FL, Gianello PR et al. Role of the thymus in transplantation tolerance in miniature swine: IV. The thymus is required during the induction phase, but not the maintenance phase, of renal allograft tolerance. Transplantation77(7), 979–985 (2004).
   PubMedGoogle Scholar
• Suematsu S, Watanabe T. Generation of a synthetic lymphoid tissue-like organoid in mice. Nat. Biotechnol.22(12), 1539–1545 (2004).
   PubMed Web of Science ®Google Scholar