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Expert Review of Clinical Immunology Volume 9, 2013 - Issue 2
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Editorial

EBV infection and anti-CD3 treatment for Type 1 diabetes: bad cop, good cop?

Denise L Faustman Immunobiology Labs, Massachusetts General Hospital and Harvard Medical School, Room 3602, MGH-East, Boston, MA 02129, USA. [email protected]
Pages 95-97 | Published online: 10 Jan 2014

References

  • Sherry N, Hagopian W, Ludvigsson J et al.; Protégé Trial Investigators. Teplizumab for treatment of Type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial. Lancet 378(9790), 487–497 (2011).
  • Keymeulen B, Vandemeulebroucke E, Ziegler AG et al. Insulin needs after CD3-antibody therapy in new-onset Type 1 diabetes. N. Engl. J. Med. 352(25), 2598–2608 (2005).
  • Herold KC, Hagopian W, Auger JA et al. Anti-CD3 monoclonal antibody in new-onset Type 1 diabetes mellitus. N. Engl. J. Med. 346(22), 1692–1698 (2002).
  • Ablamunits V, Bisikirska B, Herold KC. Acquisition of regulatory function by human CD8(+) T cells treated with anti-CD3 antibody requires TNF. Eur. J. Immunol. 40(10), 2891–2901 (2010).
  • Faustman D, Davis M. TNF receptor 2 pathway: drug target for autoimmune diseases. Nat. Rev. Drug Discov. 9(6), 482–493 (2010).
  • Dale E, Davis M, Faustman DL. A role for transcription factor NF-kappaB in autoimmunity: possible interactions of genes, sex, and the immune response. Adv. Physiol. Educ. 30(4), 152–158 (2006).
  • Ban L, Zhang J, Wang L, Kuhtreiber W, Burger D, Faustman DL. Selective death of autoreactive T cells in human diabetes by TNF or TNF receptor 2 agonism. Proc. Natl. Acad. Sci. U.S.A. 105(36), 13644–13649 (2008).
  • Faustman DL, Wang L, Okubo Y et al. Proof-of-concept, randomized, controlled clinical trial of Bacillus Calmette–Guérin for treatment of long-term Type 1 diabetes. PLoS One 7(8), e41756 (2012).
  • Cernea S, Herold KC. Monitoring of antigen-specific CD8 T cells in patients with Type 1 diabetes treated with antiCD3 monoclonal antibodies. Clin. Immunol. 134(2), 121–129 (2010).
  • Yan G, Fu Y, Faustman DL. Reduced expression of Tap1 and Lmp2 antigen-processing genes in the nonobese diabetic (NOD) mouse due to a mutation in their shared bidirectional promoter. J. Immunol. 159(6), 3068–3080 (1997).
  • Fu Y, Yan G, Shi L, Faustman D. Antigen processing and autoimmunity. Evaluation of mRNA abundance and function of HLA-linked genes. Ann. N. Y. Acad. Sci. 842, 138–155 (1998).
  • Hayashi T, Faustman D. NOD mice are defective in proteasome production and activation of NF-kappaB. Mol. Cell. Biol. 19(12), 8646–8659 (1999).
  • Hayashi T, Kodama S, Faustman DL. Reply to ‘LMP2 expression and proteasome activity in NOD mice’. Nat. Med. 6(10), 1065–1066 (2000).
  • Krause S, Kuckelkorn U, Dörner T, Burmester GR, Feist E, Kloetzel PM. Immunoproteasome subunit LMP2 expression is deregulated in Sjogren’s syndrome but not in other autoimmune disorders. Ann. Rheum. Dis. 65(8), 1021–1027 (2006).
  • Gregori G, Ravasio A, Murphy CD et al. Generation of scaled protogalactic seed magnetic fields in laser-produced shock waves. Nature 481(7382), 480–483 (2012).
  • Rahman MM, McFadden G. Modulation of tumor necrosis factor by microbial pathogens. PLoS Pathog. 2(2), e4 (2006).
  • Strachan DP. Hay-fever, hygiene, and household size. Br. Med. J. 299(6710), 1259–1260 (1989).

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