Role of arginase in asthma: potential clinical applications

References

• Hamid Q, Tulic M. Immunobiology of asthma. Annu. Rev. Physiol.71, 489–507 (2009).
   PubMed Web of Science ®Google Scholar
• Maarsingh H, Zaagsma J, Meurs H. Arginine homeostasis in allergic asthma. Eur. J. Pharmacol.585(2–3), 375–384 (2008).
   PubMed Web of Science ®Google Scholar
• Ricciardolo FL, Sterk PJ, Gaston B, Folkerts G. Nitric oxide in health and disease of the respiratory system. Physiol. Rev.84(3), 731–765 (2004).
   PubMed Web of Science ®Google Scholar
• Smith AD, Cowan JO, Brassett KP, Herbison GP, Taylor DR. Use of exhaled nitric oxide measurements to guide treatment in chronic asthma. N. Engl. J. Med.352(21), 2163–2173 (2005).
   PubMed Web of Science ®Google Scholar
• Lara A, Khatri SB, Wang Z et al. Alterations of the arginine metabolome in asthma. Am. J. Respir. Crit. Care Med.178(7), 673–681 (2008).
   PubMed Web of Science ®Google Scholar
• Zimmermann N, King NE, Laporte J et al. Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. J. Clin. Invest.111(12), 1863–1874 (2003).
   PubMed Web of Science ®Google Scholar
• Morris CR, Poljakovic M, Lavrisha L, Machado L, Kuypers FA, Morris SM Jr. Decreased arginine bioavailability and increased serum arginase activity in asthma. Am. J. Respir. Crit. Care Med.170(2), 148–153 (2004).
   PubMed Web of Science ®Google Scholar
• Li H, Romieu I, Sienra-Monge JJ et al. Genetic polymorphisms in arginase I and II and childhood asthma and atopy. J. Allergy Clin. Immunol.117(1), 119–126 (2006).
   PubMed Web of Science ®Google Scholar
• Litonjua AA, Lasky-Su J, Schneiter K et al.ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts. Am. J. Respir. Crit. Care Med.178(7), 688–694 (2008).
   PubMed Web of Science ®Google Scholar
• Salam MT, Islam T, Gauderman WJ, Gilliland FD. Roles of arginase variants, atopy, and ozone in childhood asthma. J. Allergy Clin. Immunol.123(3), 596–602 E591–E598 (2009).
   PubMed Web of Science ®Google Scholar
• Bronte V, Zanovello P. Regulation of immune responses by L-arginine metabolism. Nat. Rev. Immunol.5(8), 641–654 (2005).
   PubMed Web of Science ®Google Scholar
• Munder M, Mollinedo F, Calafat J et al. Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity. Blood105(6), 2549–2556 (2005).
   PubMed Web of Science ®Google Scholar
• Zimmermann N, Rothenberg ME. The arginine–arginase balance in asthma and lung inflammation. Eur. J. Pharmacol.533(1–3), 253–262 (2006).
   PubMed Web of Science ®Google Scholar
• Maarsingh H, Pera T, Meurs H. Arginase and pulmonary diseases. Naunyn Schmiedebergs Arch. Pharmacol.378(2), 171–184 (2008).
   PubMed Web of Science ®Google Scholar
• Meurs H, McKay S, Maarsingh H et al. Increased arginase activity underlies allergen-induced deficiency of cNOS-derived nitric oxide and airway hyperresponsiveness. Br. J. Pharmacol.136(3), 391–398 (2002).
   PubMed Web of Science ®Google Scholar
• Yang M, Rangasamy D, Matthaei KI et al. Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness. J. Immunol.177(8), 5595–5603 (2006).
   PubMed Web of Science ®Google Scholar
• Maarsingh H, Tio MA, Zaagsma J, Meurs H. Arginase attenuates inhibitory nonadrenergic noncholinergic nerve-induced nitric oxide generation and airway smooth muscle relaxation. Respir. Res.6, 23 (2005).
   PubMedGoogle Scholar
• Maarsingh H, Leusink J, Bos IS, Zaagsma J, Meurs H. Arginase strongly impairs neuronal nitric oxide-mediated airway smooth muscle relaxation in allergic asthma. Respir. Res.7, 6 (2006).
   PubMed Web of Science ®Google Scholar
• Zhao A, Urban JF Jr, Anthony RM et al. Th2 cytokine-induced alterations in intestinal smooth muscle function depend on alternatively activated macrophages. Gastroenterology135(1), 217–225 e1 (2008).
   PubMed Web of Science ®Google Scholar
• Kitowska K, Zakrzewicz D, Konigshoff M et al. Functional role and species-specific contribution of arginases in pulmonary fibrosis. Am. J. Physiol. Lung Cell. Mol. Physiol.294(1), L34–L45 (2008).
   Web of Science ®Google Scholar
• Takemoto K, Ogino K, Shibamori M et al. Transiently, paralleled upregulation of arginase and nitric oxide synthase and the effect of both enzymes on the pathology of asthma. Am. J. Physiol. Lung Cell. Mol. Physiol.293(6), L1419–L1426 (2007).
   PubMed Web of Science ®Google Scholar
• Liu H, Drew P, Gaugler AC, Cheng Y, Visner GA. Pirfenidone inhibits lung allograft fibrosis through L-arginine-arginase pathway. Am. J. Transplant.5(6), 1256–1263 (2005).
   PubMed Web of Science ®Google Scholar
• Mabalirajan U, Aich J, Agrawal A, Ghosh B. Mepacrine inhibits subepithelial fibrosis by reducing the expression of arginase and TGF-β1 in an extended subacute mouse model of allergic asthma. Am. J. Physiol. Lung Cell. Mol. Physiol.297(3), L411–L419 (2009).
   Google Scholar
• Grasemann H, Schwiertz R, Matthiesen S, Racke K, Ratjen F. Increased arginase activity in cystic fibrosis airways. Am. J. Respir. Crit. Care Med.172(12), 1523–1528 (2005).
   PubMed Web of Science ®Google Scholar
• Lindemann D, Racke K. Glucocorticoid inhibition of interleukin-4 (IL-4) and interleukin-13 (IL-13) induced up-regulation of arginase in rat airway fibroblasts. Naunyn Schmiedebergs Arch. Pharmacol.368(6), 546–550 (2003).
   PubMed Web of Science ®Google Scholar
• Lee C, Kolesnik TB, Caminschi I et al. Suppressor of cytokine signalling 1 (SOCS1) is a physiological regulator of the asthma response. Clin. Exp. Allergy39(6), 897–907 (2009).
   PubMed Web of Science ®Google Scholar
• Mayer AK, Bartz H, Fey F, Schmidt LM, Dalpke AH. Airway epithelial cells modify immune responses by inducing an anti-inflammatory microenvironment. Eur. J. Immunol.38(6), 1689–1699 (2008).
   PubMed Web of Science ®Google Scholar
• Sharkhuu T, Matthaei KI, Forbes E et al. Mechanism of interleukin-25 (IL-17E)-induced pulmonary inflammation and airways hyper-reactivity. Clin. Exp. Allergy36(12), 1575–1583 (2006).
   PubMed Web of Science ®Google Scholar
• Holgate ST. Pathogenesis of asthma. Clin. Exp. Allergy38(6), 872–897 (2008).
   PubMed Web of Science ®Google Scholar
• Maarsingh H, Zuidhof AB, Bos IS et al. Arginase inhibition protects against allergen-induced airway obstruction, hyperresponsiveness, and inflammation. Am. J. Respir. Crit. Care Med.178(6), 565–573 (2008).
   PubMed Web of Science ®Google Scholar
• Ckless K, Lampert A, Reiss J et al. Inhibition of arginase activity enhances inflammation in mice with allergic airway disease, in association with increases in protein S-nitrosylation and tyrosine nitration. J. Immunol.181(6), 4255–4264 (2008).
   PubMed Web of Science ®Google Scholar
• Munder M, Schneider H, Luckner C et al. Suppression of T-cell functions by human granulocyte arginase. Blood108(5), 1627–1634 (2006).
   PubMed Web of Science ®Google Scholar
• Oberlies J, Watzl C, Giese T et al. Regulation of NK cell function by human granulocyte arginase. J. Immunol.182(9), 5259–5267 (2009).
   PubMed Web of Science ®Google Scholar
• Choi BS, Martinez-Falero IC, Corset C et al. Differential impact of L-arginine deprivation on the activation and effector functions of T cells and macrophages. J. Leukoc. Biol.85(2), 268–277 (2009).
   PubMed Web of Science ®Google Scholar
• Niese KA, Collier AR, Hajek AR et al. Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice. BMC Immunol.10, 33 (2009).
   PubMedGoogle Scholar
• North ML, Khanna N, Marsden PA, Grasemann H, Scott JA. Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma. Am. J. Physiol. Lung Cell. Mol. Physiol.296(6), L911–L920 (2009).
   PubMed Web of Science ®Google Scholar
• Kenyon NJ, Bratt JM, Linderholm AL, Last MS, Last JA. Arginases I and II in lungs of ovalbumin-sensitized mice exposed to ovalbumin: sources and consequences. Toxicol. Appl. Pharmacol.230(3), 269–275 (2008).
   PubMed Web of Science ®Google Scholar
• Chibana K, Trudeau JB, Mustovich AT et al. IL-13 induced increases in nitrite levels are primarily driven by increases in inducible l as compared with effects on arginases in human primary bronchial epithelial cells. Clin. Exp. Allergy38(6), 936–946 (2008).
   PubMed Web of Science ®Google Scholar
• Maarsingh H, Bossenga BE, Bos IS, Volders HH, Zaagsma J, Meurs H. L-arginine deficiency causes airway hyperresponsiveness after the late asthmatic reaction. Eur. Respir. J.34(1), 191–199 (2009).
   PubMed Web of Science ®Google Scholar
• Sapienza MA, Kharitonov SA, Horvath I, Chung KF, Barnes PJ. Effect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects. Thorax53(3), 172–175 (1998).
   PubMed Web of Science ®Google Scholar
• de Gouw HW, Verbruggen MB, Twiss IM, Sterk PJ. Effect of oral L-arginine on airway hyperresponsiveness to histamine in asthma. Thorax54(11), 1033–1035 (1999).
   PubMed Web of Science ®Google Scholar
• Schwedhelm E, Maas R, Freese R et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br. J. Clin. Pharmacol.65(1), 51–59 (2008).
   PubMed Web of Science ®Google Scholar