Cancer prevention and treatment using combination therapy with plant- and animal-derived compounds

References

• Ketcham AS, Sindelar WF. Risk factors in breast cancer. Prog. Clin. Cancer 6, 99–114 (1975).
   PubMedGoogle Scholar
• DeVita VT Jr, Young RC, Canellos GP. Combination versus single agent chemotherapy: a review of the basis for selection of drug treatment of cancer. Cancer 35(1), 98–110 (1975).
   PubMed Web of Science ®Google Scholar
• Klippel JH. Winning the battle, losing the war? Another editorial about rheumatoid arthritis. J. Rheumatol. 17(9), 1118–1122 (1990).
   PubMed Web of Science ®Google Scholar
• Bartlett DL, Chu E. Can metastatic colorectal cancer be cured? Oncology (Williston Park, NY) 26(3), 266–275 (2012).
   PubMedGoogle Scholar
• Bode AM, Dong Z. Epigallocatechin 3-gallate and green tea catechins: united they work, divided they fail. Cancer Prev. Res. (Phila). 2(6), 514–517 (2009).
   PubMed Web of Science ®Google Scholar
• Hendrickx JF, Eger II EI, Sonner JM, Shafer SL. Is synergy the rule? a review of anesthetic interactions producing hypnosis and immobility. Anesth. Analg. 107(2), 494–506 (2008).
   PubMed Web of Science ®Google Scholar
• Ulrich-Merzenich G, Panek D, Zeitler H, Wagner H, Vetter H. New perspectives for synergy research with the ‘omic’-technologies. Phytomedicine 16, 495–508 (2009).
   PubMed Web of Science ®Google Scholar
• Tallarida RJ. Statistical analysis of drug combinations for synergism. Pain 49(1), 93–97 (1992).
   PubMed Web of Science ®Google Scholar
• Liu RH. Potential synergy of phytochemicals in cancer prevention: mechanism of action. J. Nutr. 134(Suppl. 12), S3479–S3485 (2004).
   PubMed Web of Science ®Google Scholar
• Soleas GJ, Diamandis EP, Goldberg DM. Resveratrol: a molecule whose time has come? And gone? Clin. Biochem. 30(2), 91–113 (1997).
   PubMed Web of Science ®Google Scholar
• Aggarwal BB, Bhardwaj A, Aggarwal RS, Seeram NP, Shishodia S, Takada Y. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res. 24(5A), 2783–2840 (2004).
   PubMed Web of Science ®Google Scholar
• Bishayee A, Politis T, Darvesh AS. Resveratrol in the chemoprevention and treatment of hepatocellular carcinoma. Cancer Treat. Rev. 36(1), 43–53 (2010).
   PubMed Web of Science ®Google Scholar
• Patel VB, Misra S, Patel BB, Majumdar AP. Colorectal cancer: chemopreventive role of curcumin and resveratrol. Nutr. Cancer 62(7), 958–967 (2010).
   PubMed Web of Science ®Google Scholar
• Qin W, Zhu W, Zhang K. Trans-resveratrol decreases breast proliferation and alters mammary promoter hypermethylation in women at increased risk for breast cancer. AACR Frontiers in Cancer Prev. Res. doi:10.1158/1940-6207 (2010) (Epub ahead of print).
   Google Scholar
• Jang M, Cai L, Udeani GO et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275(5297), 218–220 (1997).
   PubMed Web of Science ®Google Scholar
• Cottart CH, Nivet-Antoine V, Laguillier-Morizot C, Beaudeux JL. Resveratrol bioavailability and toxicity in humans. Mol. Nutr. Food Res. 54(1), 7–16 (2010).
   PubMed Web of Science ®Google Scholar
• Weng CJ, Yen GC. Chemopreventive effects of dietary phytochemicals against cancer invasion and metastasis: phenolic acids, monophenol, polyphenol, and their derivatives. Cancer Treat. Rev. 38(1), 76–87 (2012).
   PubMed Web of Science ®Google Scholar
• Wilken R, Veena MS, Wang MB, Srivatsan ES. Curcumin: a review of anticancer properties and therapeutic activity in head and neck squamous cell carcinoma. Mol. Cancer 10, 12 (2011).
   PubMed Web of Science ®Google Scholar
• Beecher GR. Overview of dietary flavonoids: nomenclature, occurrence and intake. J. Nutr. 133(10), S3248–S3254 (2003).
   PubMed Web of Science ®Google Scholar
• Lampe JW. Isoflavonoid and lignan phytoestrogens as dietary biomarkers. J. Nutr. 133(Suppl. 3), S956–S964 (2003).
   PubMed Web of Science ®Google Scholar
• Barnes S. The chemopreventive properties of soy isoflavonoids in animal models of breast cancer. Breast Cancer Res. Treat. 46(2-3), 169–179 (1997).
   PubMed Web of Science ®Google Scholar
• Virk-Baker MK, Nagy TR, Barnes S. Role of phytoestrogens in cancer therapy. Planta Med. 76(11), 1132–1142 (2010).
   PubMed Web of Science ®Google Scholar
• Weisburger JH. Tea and health: the underlying mechanisms. Proc. Soc. Exp. Biol. Med. 220(4), 271–275 (1999).
   PubMed Web of Science ®Google Scholar
• Manach C, Williamson G, Morand C, Scalbert A, Rémésy C. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am. J. Clin. Nutr. 81(Suppl. 1), S230–S242 (2005).
   PubMed Web of Science ®Google Scholar
• Chow HH, Hakim IA. Pharmacokinetic and chemoprevention studies on tea in humans. Pharmacol. Res. 64(2), 105–112 (2011).
   PubMed Web of Science ®Google Scholar
• Asano Y, Okamura S, Ogo T, Eto T, Otsuka T, Niho Y. Effect of (-)-epigallocatechin gallate on leukemic blast cells from patients with acute myeloblastic leukemia. Life Sci. 60(2), 135–142 (1997).
   PubMed Web of Science ®Google Scholar
• Paschka AG, Butler R, Young CY. Induction of apoptosis in prostate cancer cell lines by the green tea component, (-)-epigallocatechin-3-gallate. Cancer Lett. 130(1-2), 1–7 (1998).
   PubMed Web of Science ®Google Scholar
• Sah JF, Balasubramanian S, Eckert RL, Rorke EA. Epigallocatechin-3-gallate inhibits epidermal growth factor receptor signaling pathway. Evidence for direct inhibition of ERK1/2 and AKT kinases. J. Biol. Chem. 279(13), 12755–12762 (2004).
   PubMed Web of Science ®Google Scholar
• Lambert JD, Kennett MJ, Sang S, Reuhl KR, Ju J, Yang CS. Hepatotoxicity of high oral dose (-)-epigallocatechin-3-gallate in mice. Food Chem. Toxicol. 48(1), 409–416 (2010).
   PubMed Web of Science ®Google Scholar
• Lambert JD, Elias RJ. The antioxidant and pro-oxidant activities of green tea polyphenols: a role in cancer prevention. Arch. Biochem. Biophys. 501(1), 65–72 (2010).
   PubMed Web of Science ®Google Scholar
• Jimenez-Saenz M, Martinez-Sanchez Mdel C. Acute hepatitis associated with the use of green tea infusions. J. Hepatol. 44(3), 616–617 (2006).
   PubMed Web of Science ®Google Scholar
• Henning SM, Wang P, Heber D. Chemopreventive effects of tea in prostate cancer: green tea versus black tea. Mol. Nutr. Food Res. 55(6), 905–920 (2011).
   PubMed Web of Science ®Google Scholar
• Ikeda I, Tanaka K, Sugano M, Vahouny GV, Gallo LL. Inhibition of cholesterol absorption in rats by plant sterols. J. Lipid Res. 29(12), 1573–1582 (1988).
   PubMed Web of Science ®Google Scholar
• Raicht RF, Cohen BI, Fazzini EP, Sarwal AN, Takahashi M. Protective effect of plant sterols against chemically induced colon tumors in rats. Cancer Res. 40(2), 403–405 (1980).
   PubMed Web of Science ®Google Scholar
• Rabi T, Bishayee A. Terpenoids and breast cancer chemoprevention. Breast Cancer Res. Treat. 115(2), 223–239 (2009).
   PubMed Web of Science ®Google Scholar
• Phillips DR, Rasbery JM, Bartel B, Matsuda SP. Biosynthetic diversity in plant triterpene cyclization. Curr. Opin. Plant Biol. 9(3), 305–314 (2006).
   PubMed Web of Science ®Google Scholar
• Laszczyk MN. Pentacyclic triterpenes of the lupane, oleanane and ursane group as tools in cancer therapy. Planta Med. 75(15), 1549–1560 (2009).
   PubMed Web of Science ®Google Scholar
• Liby KT, Yore MM, Sporn MB. Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer. Nat. Rev. Cancer 7(5), 357–369 (2007).
   PubMed Web of Science ®Google Scholar
• Liu J. Oleanolic acid and ursolic acid: research perspectives. J. Ethnopharmacol. 100(1-2), 92–94 (2005).
   PubMed Web of Science ®Google Scholar
• Osbourn A, Goss RJ, Field RA. The saponins: polar isoprenoids with important and diverse biological activities. Nat. Prod. Rep. 28(7), 1261–1268 (2011).
   PubMed Web of Science ®Google Scholar
• Lü JM, Yao Q, Chen C. Ginseng compounds: an update on their molecular mechanisms and medical applications. Curr. Vasc. Pharmacol. 7(3), 293–302 (2009).
   PubMed Web of Science ®Google Scholar
• Kienle GS, Kiene H. Review article: influence of Viscum album L. (European mistletoe) extracts on quality of life in cancer patients: a systematic review of controlled clinical studies. Integr. Cancer Ther. 9(2), 142–157 (2010).
   PubMed Web of Science ®Google Scholar
• Weng JR, Omar HA, Kulp SK, Chen CS. Pharmacological exploitation of indole-3-carbinol to develop potent antitumor agents. Mini Rev. Med. Chem. 10(5), 398–404 (2010).
   PubMed Web of Science ®Google Scholar
• Tilton SC, Hendricks JD, Orner GA, Pereira CB, Bailey GS, Williams DE. Gene expression analysis during tumor enhancement by the dietary phytochemical, 3,3´-diindolylmethane, in rainbow trout. Carcinogenesis 28(7), 1589–1598 (2007).
   PubMed Web of Science ®Google Scholar
• Sarkar FH, Li Y. Harnessing the fruits of nature for the development of multi-targeted cancer therapeutics. Cancer Treat. Rev. 35(7), 597–607 (2009).
   PubMed Web of Science ®Google Scholar
• Mijatovic SA, Timotijevic GS, Miljkovic DM et al. Multiple antimelanoma potential of dry olive leaf extract. Int. J. Cancer 128(8), 1955–1965 (2011).
   PubMed Web of Science ®Google Scholar
• Ma D, Tremblay P, Mahngar K, Collins J, Hudlicky T, Pandey S. Selective cytotoxicity against human osteosarcoma cells by a novel synthetic C-1 analogue of 7-deoxypancratistatin is potentiated by curcumin. PLoS ONE 6(12), e28780 (2011).
   PubMed Web of Science ®Google Scholar
• Feldman D, Pike JW, Adams JS. Vitamin D (3rd Edition). Elsevier, London, UK (2011).
   Google Scholar
• Ross AC, Manson JE, Abrams SA et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J. Clin. Endocrinol. Metab. 96(1), 53–58 (2011).
   PubMed Web of Science ®Google Scholar
• Colston KW, Hansen CM. Mechanisms implicated in the growth regulatory effects of vitamin D in breast cancer. Endocr. Relat. Cancer 9(1), 45–59 (2002).
   PubMed Web of Science ®Google Scholar
• Coyle YM. The effect of environment on breast cancer risk. Breast Cancer Res. Treat. 84(3), 273–288 (2004).
   PubMed Web of Science ®Google Scholar
• Cui Y, Rohan TE. Vitamin D, calcium, and breast cancer risk: a review. Cancer Epidemiol. Biomarkers Prev. 15(8), 1427–1437 (2006).
   PubMed Web of Science ®Google Scholar
• Giovannucci E. The epidemiology of vitamin D and cancer incidence and mortality: a review (United States). Cancer Causes Control 16(2), 83–95 (2005).
   PubMed Web of Science ®Google Scholar
• Krishnan AV, Feldman D. Mechanisms of the anticancer and anti-inflammatory actions of vitamin D. Annu. Rev. Pharmacol. Toxicol. 51, 311–336 (2011).
   PubMed Web of Science ®Google Scholar
• Krishnan AV, Swami S, Peng L, Wang J, Moreno J, Feldman D. Tissue-selective regulation of aromatase expression by calcitriol: implications for breast cancer therapy. Endocrinology 151(1), 32–42 (2010).
   PubMed Web of Science ®Google Scholar
• Holick MF. Vitamin D: its role in cancer prevention and treatment. Prog. Biophys. Mol. Biol. 92(1), 49–59 (2006).
   PubMed Web of Science ®Google Scholar
• Institute of Medicine. Dietary Reference Intakes for Calcium and Vitamin D. The National Academies Press, Washington, DC, USA (2011).
   Google Scholar
• Chlebowski RT, Johnson KC, Kooperberg C et al.; Women’s Health Initiative Investigators. Calcium plus vitamin D supplementation and the risk of breast cancer. J. Natl Cancer Inst. 100(22), 1581–1591 (2008).
   PubMed Web of Science ®Google Scholar
• Holick MF. Evidence-based D-bate on health benefits of vitamin D revisited. Dermatoendocrinol. 4(2), 183–190 (2012).
   PubMedGoogle Scholar
• Bertone-Johnson ER, Chen WY, Holick MF et al. Plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D and risk of breast cancer. Cancer Epidemiol. Biomarkers Prev. 14(8), 1991–1997 (2005).
   PubMed Web of Science ®Google Scholar
• Beer TM, Ryan CW, Venner PM et al.; ASCENT Investigators. Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT Investigators. J. Clin. Oncol. 25(6), 669–674 (2007).
   PubMed Web of Science ®Google Scholar
• Deeb KK, Trump DL, Johnson CS. Vitamin D signalling pathways in cancer: potential for anticancer therapeutics. Nat. Rev. Cancer 7(9), 684–700 (2007).
   PubMed Web of Science ®Google Scholar
• Matthews D, LaPorta E, Zinser GM, Narvaez CJ, Welsh J. Genomic vitamin D signaling in breast cancer: insights from animal models and human cells. J. Steroid Biochem. Mol. Biol. 121(1–2), 362–367 (2010).
   PubMedGoogle Scholar
• Holick MF. The D-lemma: to screen or not to screen for 25-hydroxyvitamin D concentrations. Clin. Chem. 56(5), 729–731 (2010).
   PubMed Web of Science ®Google Scholar
• Richards JA, Brueggemeier RW. Prostaglandin E2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes. J. Clin. Endocrinol. Metab. 88(6), 2810–2816 (2003).
   PubMedGoogle Scholar
• Lands WE. Biosynthesis of prostaglandins. Annu. Rev. Nutr. 11, 41–60 (1991).
   PubMed Web of Science ®Google Scholar
• Ip C, Ip MM, Sylvester P. Relevance of trans fatty acids and fish oil in animal tumorigenesis studies. Prog. Clin. Biol. Res. 222, 283–294 (1986).
   PubMedGoogle Scholar
• Lim K, Han C, Dai Y, Shen M, Wu T. Omega-3 polyunsaturated fatty acids inhibit hepatocellular carcinoma cell growth through blocking 𝛃-catenin and cyclooxygenase-2. Mol. Cancer Ther. 8(11), 3046–3055 (2009).
   PubMed Web of Science ®Google Scholar
• Carroll KK, Braden LM, Bell JA, Kalamegham R. Fat and cancer. Cancer 58(Suppl. 8), 1818–1825 (1986).
   PubMed Web of Science ®Google Scholar
• Murff HJ, Shu XO, Li H et al. Dietary polyunsaturated fatty acids and breast cancer risk in Chinese women: a prospective cohort study. Int. J. Cancer 128(6), 1434–1441 (2011).
   PubMed Web of Science ®Google Scholar
• Chatterjee M, Janarthan M, Manivannan R, Rana A, Chatterjee M. Combinatorial effect of fish oil (Maxepa) and 1𝛂,25-dihydroxyvitamin D(3) in the chemoprevention of DMBA-induced mammary carcinogenesis in rats. Chem. Biol. Interact. 188(1), 102–110 (2010).
   PubMed Web of Science ®Google Scholar
• Fradet V, Cheng I, Casey G, Witte JS. Dietary omega-3 fatty acids, cyclooxygenase-2 genetic variation, and aggressive prostate cancer risk. Clin. Cancer Res. 15(7), 2559–2566 (2009).
   PubMed Web of Science ®Google Scholar
• Vincentini O, Quaranta MG, Viora M, Agostoni C, Silano M. Docosahexaenoic acid modulates in vitro the inflammation of celiac disease in intestinal epithelial cells via the inhibition of cPLA2. Clin. Nutr. 30(4), 541–546 (2011).
   PubMed Web of Science ®Google Scholar
• Cooper DA. Carotenoids in health and disease: recent scientific evaluations, research recommendations and the consumer. J. Plant. Nutr. 134(1), 221S–224S (2004).
   Google Scholar
• Pal D, Banerjee S, Ghosh AK. Dietary-induced cancer prevention: an expanding research arena of emerging diet related to healthcare system. J. Adv. Pharm. Technol. Res. 3(1), 16–24 (2012).
   PubMedGoogle Scholar
• Meyer F, Galan P, Douville P et al. Antioxidant vitamin and mineral supplementation and prostate cancer prevention in the SU.VI.MAX trial. Int. J. Cancer 116(2), 182–186 (2005).
   PubMed Web of Science ®Google Scholar
• Wu X, Patterson S, Hawk E. Chemoprevention – history and general principles. Best Pract. Res. Clin. Gastroenterol. 25(4-5), 445–459 (2011).
   PubMed Web of Science ®Google Scholar
• Taylor-Harding B, Agadjanian H, Nassanian H et al. Indole-3-carbinol synergistically sensitises ovarian cancer cells to bortezomib treatment. Br. J. Cancer 106(2), 333–343 (2012).
   PubMed Web of Science ®Google Scholar
• Ulrich-Merzenich G, Panek D, Zeitler H, Wagner H, Vetter H. New perspectives for synergy research with the ‘omic’-technologies. Phytomedicine 16(6–7), 495–508 (2009).
   PubMed Web of Science ®Google Scholar
• Fu LL, Zhou CC, Yao S, Yu JY, Liu B, Bao JK. Plant lectins: targeting programmed cell death pathways as antitumor agents. Int. J. Biochem. Cell Biol. 43(10), 1442–1449 (2011).
   PubMed Web of Science ®Google Scholar
• Siedlakowski P, McLachlan-Burgess A, Griffin C, Tirumalai SS, McNulty J, Pandey S. Synergy of pancratistatin and tamoxifen on breast cancer cells in inducing apoptosis by targeting mitochondria. Cancer Biol. Ther. 7(3), 376–384 (2008).
   PubMed Web of Science ®Google Scholar
• George J, Singh M, Srivastava AK et al. Resveratrol and black tea polyphenol combination synergistically suppress mouse skin tumors growth by inhibition of activated MAPKs and p53. PLoS ONE 6(8), e23395 (2011).
   PubMed Web of Science ®Google Scholar
• Whitsett TG Jr, Lamartiniere CA. Genistein and resveratrol: mammary cancer chemoprevention and mechanisms of action in the rat. Expert Rev. Anticancer Ther. 6(12), 1699–1706 (2006).
   PubMed Web of Science ®Google Scholar
• Kim JH, Chen C, Tony Kong AN. Resveratrol inhibits genistein-induced multi-drug resistance protein 2 (MRP2) expression in HepG2 cells. Arch. Biochem. Biophys. 512(2), 160–166 (2011).
   PubMed Web of Science ®Google Scholar
• Nakagawa H, Yamamoto D, Kiyozuka Y et al. Effects of genistein and synergistic action in combination with eicosapentaenoic acid on the growth of breast cancer cell lines. J. Cancer Res. Clin. Oncol. 126(8), 448–454 (2000).
   PubMed Web of Science ®Google Scholar
• Afaq F, Mukhtar H. Botanical antioxidants in the prevention of photocarcinogenesis and photoaging. Exp. Dermatol. 15(9), 678–684 (2006).
   PubMed Web of Science ®Google Scholar
• Iovine B, Iannella ML, Gasparri F, Monfrecola G, Bevilacqua MA. Synergic effect of genistein and daidzein on UVB-induced DNA damage: an effective photoprotective combination. J. Biomed. Biotechnol. 2011, 692846 (2011).
   PubMedGoogle Scholar
• Dias MC, Vieiralves NF, Gomes MI, Salvadori DM, Rodrigues MA, Barbisan LF. Effects of lycopene, synbiotic and their association on early biomarkers of rat colon carcinogenesis. Food Chem. Toxicol. 48(3), 772–780 (2010).
   PubMed Web of Science ®Google Scholar
• Krishnan AV, Swami S, Moreno J, Bhattacharyya RB, Peehl DM, Feldman D. Potentiation of the growth-inhibitory effects of vitamin D in prostate cancer by genistein. Nutr. Rev. 65(8 Pt 2), S121–S123 (2007).
   PubMed Web of Science ®Google Scholar
• Istfan NW, Person KS, Holick MF, Chen TC. 1𝛂,25-dihydroxy vitamin D and fish oil synergistically inhibit G1/S-phase transition in prostate cancer cells. J. Steroid Biochem. Mol. Biol. 103(3-5), 726–730 (2007).
   PubMed Web of Science ®Google Scholar
• Chiang KC, Persons KS, Istfan NW, Holick MF, Chen TC. Fish oil enhances the antiproliferative effect of 1𝛂,25-dihydroxyvitamin D3 on liver cancer cells. Anticancer Res. 29(9), 3591–3596 (2009).
   PubMed Web of Science ®Google Scholar
• Dyck MC, Ma DW, Meckling KA. The anticancer effects of Vitamin D and omega-3 PUFAs in combination via cod-liver oil: one plus one may equal more than two. Med. Hypotheses 77(3), 326–332 (2011).
   PubMed Web of Science ®Google Scholar