Merkel cell carcinoma: what we know now

References

• Briggaman RA, Wheeler CE Jr. The epidermal–dermal junction. J. Invest. Dermatol.65(1), 71–84 (1975).
   PubMed Web of Science ®Google Scholar
• Miettinen M, Lehto VP, Virtanen I, Asko-Seljavaara S, Pitkanen J, Dahl D. Neuroendocrine carcinoma of the skin (Merkel cell carcinoma): ultrastructural and immunohistochemical demonstration of neurofilaments. Ultrastruct. Pathol.4(2–3), 219–225 (1983).
   PubMed Web of Science ®Google Scholar
• Sadahira Y, Nakamoto S, Mori M, Hsueh CL, Awai M. Merkel cell tumor coexpressing cytokeratin and neurofilament proteins. Acta Pathol. Jpn.37(2), 331–337 (1987).
   PubMedGoogle Scholar
• Vaigot P, Pisani A, Darmon YM, Ortonne JP. The majority of epidermal Merkel cells are non-proliferative: a quantitative immunofluorescence analysis. Acta Derm. Venereol.67(6), 517–520 (1987).
   PubMed Web of Science ®Google Scholar
• Moll I, Zieger W, Schmelz M. Proliferative Merkel cells were not detected in human skin. Arch Dermatol. Res.288(4), 184–187 (1996).
   PubMed Web of Science ®Google Scholar
• Smith PD, Patterson JW. Merkel cell carcinoma (neuroendocrine carcinoma of the skin). Am. J. Clin. Pathol.115(Suppl.), S68–S78 (2001).
   Google Scholar
• Gould E, Albores-Saavedra J, Dubner B, Smith W, Payne CM. Eccrine and squamous differentiation in Merkel cell carcinoma. An immunohistochemical study. Am. J. Surg. Pathol.12(10), 768–772 (1988).
   PubMed Web of Science ®Google Scholar
• Saeb-Lima M, Montante-Montes de Oca D, Albores-Saavedra J. Merkel cell carcinoma with eccrine differentiation: a clinicopathologic study of 7 cases. Ann. Diagn. Pathol.12(6), 410–414 (2008).
   PubMed Web of Science ®Google Scholar
• Toker C. Trabecular carcinoma of the skin. Arch. Derm.105(1), 107–110 (1972).
   PubMed Web of Science ®Google Scholar
• Tang CK, Toker C. Trabecular carcinoma of the skin: an ultrastructural study. Cancer42(5), 2311–2321 (1978).
   PubMed Web of Science ®Google Scholar
• Johannessen JV, Gould VE. Neuroendocrine skin carcinoma associated with calcitonin production: a Merkel cell carcinoma? Hum. Pathol.11(5 Suppl.), 586–588 (1980).
   PubMed Web of Science ®Google Scholar
• Heath M, Jaimes N, Lemos B et al. Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features. J. Am. Acad. Dermatol.58(3), 375–381 (2008).
   PubMed Web of Science ®Google Scholar
• Allen PJ, Bowne WB, Jaques DP, Brennan MF, Busam K, Coit DG. Merkel cell carcinoma: prognosis and treatment of patients from a single institution. J. Clin. Oncol.23(10), 2300–2309 (2005).
   PubMed Web of Science ®Google Scholar
• Konno A, Nagata M, Nanko H. Immunohistochemical diagnosis of a Merkel cell tumor in a dog. Vet. Pathol.35(6), 538–540 (1998).
   PubMed Web of Science ®Google Scholar
• Glick AD, Holscher MA, Crenshaw JD. Neuroendocrine carcinoma of the skin in a dog. Vet. Pathol.20(6), 761–763 (1983).
   PubMed Web of Science ®Google Scholar
• Patnaik AK, Post GS, Erlandson RA. Clinicopathologic and electron microscopic study of cutaneous neuroendocrine (Merkel cell) carcinoma in a cat with comparisons to human and canine tumors. Vet. Pathol.38(5), 553–556 (2001).
   PubMed Web of Science ®Google Scholar
• Miller RW, Rabkin CS. Merkel cell carcinoma and melanoma: etiological similarities and differences. Cancer Epidemiol. Biomarkers Prev.8(2), 153–158 (1999).
   PubMed Web of Science ®Google Scholar
• Penn I, First MR. Merkel’s cell carcinoma in organ recipients: report of 41 cases. Transplantation68(11), 1717–1721 (1999).
   PubMed Web of Science ®Google Scholar
• Bordea C, Wojnarowska F, Millard PR, Doll H, Welsh K, Morris PJ. Skin cancers in renal-transplant recipients occur more frequently than previously recognized in a temperate climate. Transplantation77(4), 574–579 (2004).
   PubMed Web of Science ®Google Scholar
• Koljonen V, Kukko H, Tukiainen E et al. Incidence of Merkel cell carcinoma in renal transplant recipients. Nephrol. Dial. Transplant.24(10), 3231–3235 (2009).
   PubMed Web of Science ®Google Scholar
• Buell JF, Trofe J, Hanaway MJ et al. Immunosuppression and Merkel cell carcinoma. Transplant. Proc.34, 1780–1781 (2002).
   PubMed Web of Science ®Google Scholar
• Koljonen V, Kukko H, Pukkala E et al. Chronic lymphocytic leukaemia patients have a high risk of Merkel-cell polyomavirus DNA-positive Merkel-cell carcinoma. Br. J. Cancer101(8), 1444–1447 (2009).
   PubMed Web of Science ®Google Scholar
• Lawenda BD, Thiringer JK, Foss RD, Johnstone PA. Merkel cell carcinoma arising in the head and neck: optimizing therapy. Am. J. Clin. Oncol.24(1), 35–42 (2001).
   PubMed Web of Science ®Google Scholar
• Popp S, Waltering S, Herbst C, Moll I, Boukamp P. UV-B-type mutations and chromosomal imbalances indicate common pathways for the development of Merkel and skin squamous cell carcinomas. Int. J. Cancer99(3), 352–360 (2002).
   PubMed Web of Science ®Google Scholar
• Tai PT, Yu E, Winquist E et al. Chemotherapy in neuroendocrine/Merkel cell carcinoma of the skin: case series and review of 204 cases. J. Clin. Oncol.18(12), 2493–2499 (2000).
   PubMed Web of Science ®Google Scholar
• Altman LK. Virus is Linked to a Powerful Skin Cancer. New York Times, 18 January (2008).
   Google Scholar
• Feng H, Shuda M, Chang Y, Moore PS. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science319(5866), 1096–1100 (2008).
   PubMed Web of Science ®Google Scholar
• Shuda M, Arora R, Kwun HJ et al. Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors. Int. J. Cancer125(6), 1243–1249 (2009).
   PubMed Web of Science ®Google Scholar
• Shuda M, Feng H, Kwun HJ et al. T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus. Proc. Natl Acad. Sci. USA105(42), 16272–16277 (2008).
   PubMed Web of Science ®Google Scholar
• Sihto H, Kukko H, Koljonen V, Sankila R, Bohling T, Joensuu H. Clinical factors associated with Merkel cell polyomavirus infection in Merkel cell carcinoma. J. Natl Cancer Inst.101(13), 938–945 (2009).
   PubMedGoogle Scholar
• Kassem A, Schopflin A, Diaz C et al. Frequent detection of Merkel cell polyomavirus in human Merkel cell carcinomas and identification of a unique deletion in the VP1 gene. Cancer Res.68(13), 5009–5013 (2008).
   PubMed Web of Science ®Google Scholar
• Andres C, Belloni B, Puchta U, Sander CA, Flaig MJ. Prevalence of MCPyV in Merkel cell carcinoma and non-MCC tumors. J. Cutan. Pathol. DOI: 10.1111/j.1600-0560.2009.01352.x (2009) (Epub ahead of print).
   Google Scholar
• Becker JC, Houben R, Ugurel S, Trefzer U, Pfohler C, Schrama D. MC polyomavirus is frequently present in Merkel cell carcinoma of European patients. J. Invest. Dermatol.129(1), 248–250 (2009).
   PubMed Web of Science ®Google Scholar
• Garneski KM, Warcola AH, Feng Q, Kiviat NB, Leonard JH, Nghiem P. Merkel cell polyomavirus is more frequently present in North American than Australian Merkel cell carcinoma tumors. J. Invest. Dermatol.129(1), 246–248 (2009).
   PubMed Web of Science ®Google Scholar
• Ridd K, Yu S, Bastian BC. The presence of polyomavirus in non-melanoma skin cancer in organ transplant recipients is rare. J. Invest. Dermatol.129(1), 250–252 (2009).
   PubMed Web of Science ®Google Scholar
• Foulongne V, Dereure O, Kluger N, Moles JP, Guillot B, Segondy M. Merkel cell polyomavirus DNA detection in lesional and nonlesional skin from patients with Merkel cell carcinoma or other skin diseases. Br. J. Dermatol.162(1), 59–63 (2009).
   PubMed Web of Science ®Google Scholar
• Duncavage EJ, Zehnbauer BA, Pfeifer JD. Prevalence of Merkel cell polyomavirus in Merkel cell carcinoma. Mod. Pathol.22(4), 516–521 (2009).
   PubMed Web of Science ®Google Scholar
• Sastre-Garau X, Peter M, Avril MF et al. Merkel cell carcinoma of the skin: pathological and molecular evidence for a causative role of MCV in oncogenesis. J. Pathol.218(1), 48–56 (2009).
   PubMed Web of Science ®Google Scholar
• Wetzels CT, Hoefnagel JG, Bakkers JM, Dijkman HB, Blokx WA, Melchers WJ. Ultrastructural proof of polyomavirus in Merkel cell carcinoma tumor cells and its absence in small cell carcinoma of the lung. PLoS ONE, 4(3), e4958 (2009).
   Google Scholar
• Varga E, Kiss M, Szabo K, Kemeny L. Detection of Merkel cell polyomavirus DNA in Merkel cell carcinomas. Br. J. Dermatol.161(4), 930–932 (2009).
   PubMed Web of Science ®Google Scholar
• Touze A, Gaitan J, Maruani A et al. Merkel cell polyomavirus strains in patients with merkel cell carcinoma. Emerg. Infect. Dis.15(6), 960–962 (2009).
   PubMed Web of Science ®Google Scholar
• Bhatia K, Goedert JJ, Modali R, Preiss L, Ayers LW. Merkel cell carcinoma subgroups by merkel cell polyomavirus DNA relative abundance and oncogene expression. Int. J. Cancer126(9), 2240–2246 (2009).
   Web of Science ®Google Scholar
• Carter JJ, Paulson KG, Wipf GC et al. Association of Merkel cell polyomavirus-specific antibodies with Merkel cell carcinoma. J. Natl Cancer Inst.101(21), 1510–1522 (2009).
   PubMedGoogle Scholar
• Leonard JH, Bell JR, Kearsley JH. Characterization of cell lines established from Merkel-cell (‘small-cell’) carcinoma of the skin. Int. J. Cancer55(5), 803–810 (1993).
   PubMed Web of Science ®Google Scholar
• Helmbold P, Lahtz C, Herpel E, Schnabel PA, Dammann RH. Frequent hypermethylation of RASSF1A tumor suppressor gene promoter and presence of Merkel cell polyomavirus in small cell lung cancer. Eur. J. Cancer45(12), 2207–2211 (2009).
   PubMed Web of Science ®Google Scholar
• Bluemn EG, Paulson KG, Higgins EE, Sun Y, Nghiem P, Nelson PS. Merkel cell polyomavirus is not detected in prostate cancers, surrounding stroma, or benign prostate controls. J. Clin. Virol.44(2), 164–166 (2009).
   PubMed Web of Science ®Google Scholar
• Kassem A, Technau K, Kurz AK et al. Merkel cell polyomavirus sequences are frequently detected in nonmelanoma skin cancer of immunosuppressed patients. Int. J. Cancer125(2), 356–361 (2009).
   PubMed Web of Science ®Google Scholar
• Dworkin AM, Tseng SY, Allain DC, Iwenofu OH, Peters SB, Toland AE. Merkel cell polyomavirus in cutaneous squamous cell carcinoma of immunocompetent individuals. J. Invest. Dermatol.129(12), 2868–2874 (2009).
   PubMed Web of Science ®Google Scholar
• Tarkkanen M, Knuutila S. The diagnostic use of cytogenetic and molecular genetic techniques in the assessment of small round cell tumours. Curr. Diagn. Pathol.8(5), 338–348 (2002).
   Google Scholar
• Pisick E, Skarin AT, Salgia R. Recent advances in the molecular biology, diagnosis and novel therapies for various small blue cell tumors. Anticancer Res.23(4), 3379–3396 (2003).
   PubMed Web of Science ®Google Scholar
• Bialasiewicz S, Lambert SB, Whiley DM, Nissen MD, Sloots TP. Merkel cell polyomavirus DNA in respiratory specimens from children and adults. Emerg. Infect. Dis.15(3), 492–494 (2009).
   PubMed Web of Science ®Google Scholar
• Goh S, Lindau C, Tiveljung-Lindell A, Allander T. Merkel cell polyomavirus in respiratory tract secretions. Emerg. Infect. Dis.15(3), 489–491 (2009).
   PubMed Web of Science ®Google Scholar
• Kantola K, Sadeghi M, Lahtinen A et al. Merkel cell polyomavirus DNA in tumor-free tonsillar tissues and upper respiratory tract samples: implications for respiratory transmission and latency. J. Clin. Virol.45(4), 292–295 (2009).
   PubMed Web of Science ®Google Scholar
• Loyo M, Guerrero-Preston R, Brait M et al. Quantitative detection of merkel cell virus in human tissues and possible mode of transmission. Int. J. Cancer126(12), 2991–2996 (2010).
   PubMed Web of Science ®Google Scholar
• Tolstov YL, Pastrana DV, Feng H et al. Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays. Int. J. Cancer125(6), 1250–1256 (2009).
   PubMed Web of Science ®Google Scholar
• Van Gele M, Kaghad M, Leonard JH et al. Mutation analysis of P73 and TP53 in Merkel cell carcinoma. Br. J. Cancer82(4), 823–826 (2000).
   PubMed Web of Science ®Google Scholar
• Koljonen V, Tukiainen E, Haglund C, Bohling T. Cell cycle control by p21, p27 and p53 in Merkel cell carcinoma. Anticancer Res.26(3B), 2209–2212 (2006).
   PubMed Web of Science ®Google Scholar
• Van Gele M, Leonard JH, Van Roy N, Cook AL, De Paepe A, Speleman F. Frequent allelic loss at 10q23 but low incidence of PTEN mutations in Merkel cell carcinoma. Int. J. Cancer92(3), 409–413 (2001).
   PubMed Web of Science ®Google Scholar
• Liu S, Daa T, Kashima K, Kondoh Y, Yokoyama S. The Wnt-signaling pathway is not implicated in tumorigenesis of Merkel cell carcinoma. J. Cutan. Pathol.34(1), 22–26 (2007).
   PubMedGoogle Scholar
• Swick BL, Ravdel L, Fitzpatrick JE, Robinson WA. Merkel cell carcinoma: evaluation of KIT (CD117) expression and failure to demonstrate activating mutations in the C-KIT proto-oncogene – implications for treatment with imatinib mesylate. J. Cutan. Pathol.34(4), 324–329 (2007).
   PubMed Web of Science ®Google Scholar
• Brunner M, Thurnher D, Pammer J et al. Expression of VEGF-A/C, VEGF-R2, PDGF-α/β, c-kit, EGFR, Her-2/Neu, Mcl-1 and Bmi-1 in Merkel cell carcinoma. Mod. Pathol.21(7), 876–884 (2008).
   PubMed Web of Science ®Google Scholar
• Houben R, Michel B, Vetter-Kauczok CS et al. Absence of classical MAP kinase pathway signalling in Merkel cell carcinoma. J. Invest. Dermatol.126(5), 1135–1142 (2006).
   PubMed Web of Science ®Google Scholar
• Kennedy MM, Blessing K, King G, Kerr KM. Expression of bcl-2 and p53 in Merkel cell carcinoma. An immunohistochemical study. Am. J. Dermatopathol.18(3), 273–277 (1996).
   PubMed Web of Science ®Google Scholar
• Plettenberg A, Pammer J, Tschachler E. Merkel cells and Merkel cell carcinoma express the BCL-2 proto-oncogene. Exp. Dermatol.5(3), 183–188 (1996).
   PubMedGoogle Scholar
• Tucci MG, Lucarini G, Giangiacomi M et al. Immunohistochemical study of apoptosis markers and involvement of chemokine CXCR4 in skin Merkel cell carcinoma. J. Eur. Acad. Dermatol. Venereol.20(10), 1220–1225 (2006).
   PubMed Web of Science ®Google Scholar
• Coleman NM, Smith-Zagone MJ, Tanyi J et al. Primary neuroendocrine carcinoma of the vagina with Merkel cell carcinoma phenotype. Am. J. Surg. Pathol.30(3), 405–410 (2006).
   PubMed Web of Science ®Google Scholar
• Sur M, Alardati H, Ross C, Alowami S. TdT expression in Merkel cell carcinoma: potential diagnostic pitfall with blastic hematological malignancies and expanded immunohistochemical analysis. Mod. Pathol.20(11), 1113–1120 (2007).
   PubMed Web of Science ®Google Scholar
• Schlagbauer-Wadl H, Klosner G, Heere-Ress E et al. Bcl-2 antisense oligonucleotides (G3139) inhibit Merkel cell carcinoma growth in SCID mice. J. Invest. Dermatol.114(4), 725–730 (2000).
   PubMed Web of Science ®Google Scholar
• Shah MH, Varker KA, Collamore M et al. G3139 (Genasense) in patients with advanced merkel cell carcinoma. Am. J. Clin. Oncol.32(2), 174–179 (2009).
   PubMed Web of Science ®Google Scholar
• Hodgson NC. Merkel cell carcinoma: changing incidence trends. J. Surg. Oncol.89(1), 1–4 (2005).
   PubMed Web of Science ®Google Scholar
• Landis SH, Murray T, Bolden S, Wingo PA. Cancer statistics, 1998. CA Cancer J. Clin.48(1), 6–29 (1998).
   PubMed Web of Science ®Google Scholar
• Howard RA, Dores GM, Curtis RE, Anderson WF, Travis LB. Merkel cell carcinoma and multiple primary cancers. Cancer Epidemiol. Biomarkers Prev.15(8), 1545–1549 (2006).
   PubMed Web of Science ®Google Scholar
• Schmid C, Beham A, Feichtinger J, Aubock L, Dietze O. Recurrent and subsequently metastasizing Merkel cell carcinoma in a 7-year-old girl. Histopathology20(5), 437–439 (1992).
   PubMed Web of Science ®Google Scholar
• Albores-Saavedra J, Batich K, Chable-Montero F, Sagy N, Schwartz AM, Henson DE. Merkel cell carcinoma demographics, morphology, and survival based on 3870 cases: a population based study. J. Cutan. Pathol. 10.1111/j.1600-0560.2009.01370.x (2009) (Epub ahead of print).
   PubMedGoogle Scholar
• Lanoy E, Dores GM, Madeleine MM, Toro JR, Fraumeni JF Jr, Engels EA. Epidemiology of nonkeratinocytic skin cancers among persons with AIDS in the United States. AIDS23(3), 385–393 (2009).
   PubMed Web of Science ®Google Scholar
• Gupta SG, Wang LC, Penas PF, Gellenthin M, Lee SJ, Nghiem P. Sentinel lymph node biopsy for evaluation and treatment of patients with Merkel cell carcinoma: the Dana-Farber experience and meta-analysis of the literature. Arch. Dermatol.142(6), 685–690 (2006).
   PubMedGoogle Scholar
• Poulsen M. Merkel cell carcinoma of skin: diagnosis and management strategies. Drugs Aging22(3), 219–229 (2005).
   PubMed Web of Science ®Google Scholar
• Dancey AL, Rayatt SS, Soon C, Ilchshyn A, Brown I, Srivastava S. Merkel cell carcinoma: a report of 34 cases and literature review. J. Plast. Reconstr. Aesthet. Surg.59(12), 1294–1299 (2006).
   PubMed Web of Science ®Google Scholar
• Walsh NM. Primary neuroendocrine (Merkel cell) carcinoma of the skin: morphologic diversity and implications thereof. Hum. Pathol.32(7), 680–689 (2001).
   PubMed Web of Science ®Google Scholar
• Brenner B, Sulkes A, Rakowsky E et al. Second neoplasms in patients with Merkel cell carcinoma. Cancer91(7), 1358–1362 (2001).
   PubMed Web of Science ®Google Scholar
• Ziprin P, Smith S, Salerno G, Rosin RD. Two cases of merkel cell tumor arising in patients with chronic lymphocytic leukaemia. Br. J. Dermatol.142(3), 525–528 (2000).
   PubMed Web of Science ®Google Scholar
• Sinclair N, Mireskandari K, Forbes J, Crow J. Merkel cell carcinoma of the eyelid in association with chronic lymphocytic leukaemia. Br. J. Ophthalmol.87(2), 240 (2003).
   PubMedGoogle Scholar
• Bedane C, Clavere P, Lavignac C, Labrousse F, Olivier JP, Bonnetbalnc JM. [Neuroendocrine primary cutaneous carcinoma. Therapeutic aspects in 13 patients]. Ann. Dermatol. Venereol.123(8), 443–446 (1996).
   PubMed Web of Science ®Google Scholar
• Cerroni L, Kerl H. Primary cutaneous neuroendocrine (Merkel cell) carcinoma in association with squamous- and basal-cell carcinoma. Am. J. Dermatopathol.19(6), 610–613 (1997).
   PubMed Web of Science ®Google Scholar
• Moll I, Bladt U, Jung EG. Presence of Merkel cells in sun-exposed and not sun-exposed skin: a quantitative study. Arch. Dermatol. Res.282(4), 213–216 (1990).
   PubMed Web of Science ®Google Scholar
• Hartschuh W, Schulz T. Merkel cell hyperplasia in chronic radiation-damaged skin: its possible relationship to fibroepithelioma of Pinkus. J. Cutan. Pathol.24(8), 477–483 (1997).
   PubMed Web of Science ®Google Scholar
• Vieites B, Suarez-Penaranda JM, Delgado V, Vazquez-Veiga H, Varela J, Forteza J. Merkel cell carcinoma associated with in situ and invasive squamous cell carcinoma. Acta Derm. Venereol.89(2), 184–186 (2009).
   PubMed Web of Science ®Google Scholar
• Johansson L, Tennvall J, Akerman M. Immunohistochemical examination of 25 cases of Merkel cell carcinoma: a comparison with small cell carcinoma of the lung and oesophagus, and a review of the literature. APMIS98(8), 741–752 (1990).
   PubMed Web of Science ®Google Scholar
• Moll R, Lowe A, Laufer J, Franke WW. Cytokeratin 20 in human carcinomas. A new histodiagnostic marker detected by monoclonal antibodies. Am. J. Pathol.140(2), 427–447 (1992).
   PubMed Web of Science ®Google Scholar
• Ralston J, Chiriboga L, Nonaka D. MASH1: a useful marker in differentiating pulmonary small cell carcinoma from Merkel cell carcinoma. Mod. Pathol.21(11), 1357–1362 (2008).
   PubMed Web of Science ®Google Scholar
• Yiengpruksawan A, Coit DG, Thaler HT, Urmacher C, Knapper WK. Merkel cell carcinoma. Prognosis and management. Arch. Surg.126(12), 1514–1519 (1991).
   PubMedGoogle Scholar
• Van Gele M, Boyle GM, Cook AL et al. Gene-expression profiling reveals distinct expression patterns for classic versus variant Merkel cell phenotypes and new classifier genes to distinguish Merkel cell from small-cell lung carcinoma. Oncogene23(15), 2732–2742 (2004).
   PubMed Web of Science ®Google Scholar
• Anderson SE, Beer KT, Banic A et al. MRI of merkel cell carcinoma: histologic correlation and review of the literature. AJR Am. J. Roentgenol.185(6), 1441–1448 (2005).
   PubMed Web of Science ®Google Scholar
• Tsang G, O’Brien P, Robertson R, Hamilton C, Wratten C, Denham J. All delays before radiotherapy risk progression of Merkel cell carcinoma. Australas. Radiol.48(3), 371–375 (2004).
   PubMedGoogle Scholar
• Swann MH, Yoon J. Merkel cell carcinoma. Semin. Oncol.34(1), 51–56 (2007).
   PubMed Web of Science ®Google Scholar
• Pectasides D, Pectasides M, Economopoulos T. Merkel cell cancer of the skin. Ann. Oncol.17(10), 1489–1495 (2006).
   PubMed Web of Science ®Google Scholar
• Agelli M, Clegg LX. Epidemiology of primary Merkel cell carcinoma in the United States. J. Am. Acad. Dermatol.49(5), 832–841 (2003).
   PubMed Web of Science ®Google Scholar
• Fernandez-Figueras MT, Puig L, Musulen E et al. Expression profiles associated with aggressive behavior in Merkel cell carcinoma. Mod. Pathol.20(1), 90–101 (2007).
   PubMed Web of Science ®Google Scholar
• Kim J, McNiff JM. Nuclear expression of survivin portends a poor prognosis in Merkel cell carcinoma. Mod. Pathol.21(6), 764–769 (2008).
   PubMed Web of Science ®Google Scholar
• Koljonen V, Tukiainen E, Haglund C, Bohling T. Proliferative activity detected by Ki67 correlates with poor outcome in Merkel cell carcinoma. Histopathology49(5), 551–553 (2006).
   PubMedGoogle Scholar
• Asioli S, Righi A, Volante M, Eusebi V, Bussolati G. p63 expression as a new prognostic marker in Merkel cell carcinoma. Cancer110(3), 640–647 (2007).
   PubMed Web of Science ®Google Scholar
• Poulsen M. Merkel-cell carcinoma of the skin. Lancet Oncol.5(10), 593–599 (2004).
   PubMed Web of Science ®Google Scholar
• Medina-Franco H, Urist MM, Fiveash J, Heslin MJ, Bland KI, Beenken SW. Multimodality treatment of Merkel cell carcinoma: case series and literature review of 1024 cases. Ann. Surg. Oncol.8(3), 204–208 (2001).
   PubMed Web of Science ®Google Scholar
• Stokes JB, Graw KS, Dengel LT et al. Patients with Merkel cell carcinoma tumors < or = 1.0 cm in diameter are unlikely to harbor regional lymph node metastasis. J. Clin. Oncol.27(23), 3772–3777 (2009).
   PubMed Web of Science ®Google Scholar
• Andea AA, Coit DG, Amin B, Busam KJ. Merkel cell carcinoma: histologic features and prognosis. Cancer113(9), 2549–2558 (2008).
   PubMed Web of Science ®Google Scholar
• Ng L, Beer TW, Murray K. Vascular density has prognostic value in Merkel cell carcinoma. Am. J. Dermatopathol.30(5), 442–445 (2008).
   PubMed Web of Science ®Google Scholar
• Beer TW, Ng LB, Murray K. Mast cells have prognostic value in Merkel cell carcinoma. Am. J. Dermatopathol.30(1), 27–30 (2008).
   PubMed Web of Science ®Google Scholar
• Goldberg SR, Neifeld JP, Frable WJ. Prognostic value of tumor thickness in patients with merkel cell carcinoma. J. Surg. Oncol.95(8), 618–622 (2007).
   PubMed Web of Science ®Google Scholar
• Sandel HD 4th, Day T, Richardson MS, Scarlett M, Gutman KA. Merkel cell carcinoma: does tumor size or depth of invasion correlate with recurrence, metastasis, or patient survival? Laryngoscope116(5), 791–795 (2006).
   PubMed Web of Science ®Google Scholar
• Zhan FQ, Packianathan VS, Zeitouni NC. Merkel cell carcinoma: a review of current advances. J. Natl Compr. Canc. Netw.7(3), 333–339 (2009).
   PubMed Web of Science ®Google Scholar
• Ruan JH, Reeves M. A Merkel cell carcinoma treatment algorithm. Arch. Surg.144(6), 582–585 (2009).
   PubMedGoogle Scholar
• Migliano E, Monarca C, Rizzo MI, Bucher S. Merkel cell carcinoma: our therapeutic algorithm: treatment of Merkel cell carcinoma. Ann. Surg. Oncol.16(11), 3211–3213 (2009).
   PubMed Web of Science ®Google Scholar
• Koljonen V, Bohling T, Granhroth G, Tukiainen E. Merkel cell carcinoma: a clinicopathological study of 34 patients. Eur. J. Surg. Oncol.29(7), 607–610 (2003).
   PubMedGoogle Scholar
• Bajetta E, Celio L, Platania M et al. Single-institution series of early-stage Merkel cell carcinoma: long-term outcomes in 95 patients managed with surgery alone. Ann. Surg. Oncol.16(11), 2985–2993 (2009).
   PubMed Web of Science ®Google Scholar
• Mehrany K, Otley CC, Weenig RH, Phillips PK, Roenigk RK, Nguyen TH. A meta-analysis of the prognostic significance of sentinel lymph node status in Merkel cell carcinoma. Dermatol. Surg.28(2), 113–117 (2002).
   PubMed Web of Science ®Google Scholar
• Koljonen V, Suominen S. Sentinel node biopsy in local anaesthesia in patients with head and neck Merkel cell carcinoma. Eur. J. Plast. Surg.30(5), 205–210 (2008).
   Google Scholar
• Allen PJ, Busam K, Hill AD, Stojadinovic A, Coit DG. Immunohistochemical analysis of sentinel lymph nodes from patients with Merkel cell carcinoma. Cancer92(6), 1650–1655 (2001).
   PubMed Web of Science ®Google Scholar
• Rodrigues LK, Leong SP, Kashani-Sabet M, Wong JH. Early experience with sentinel lymph node mapping for Merkel cell carcinoma. J. Am. Acad. Dermatol.45(2), 303–308 (2001).
   PubMed Web of Science ®Google Scholar
• Pan D, Narayan D, Ariyan S. Merkel cell carcinoma: five case reports using sentinel lymph node biopsy and a review of 110 new cases. Plast. Reconstr. Surg.110(5), 1259–1265 (2002).
   PubMed Web of Science ®Google Scholar
• Schmalbach CE, Lowe L, Teknos TN, Johnson TM, Bradford CR. Reliability of sentinel lymph node biopsy for regional staging of head and neck Merkel cell carcinoma. Arch. Otolaryngol. Head Neck Surg.131(7), 610–614 (2005).
   PubMedGoogle Scholar
• Maza S, Trefzer U, Hofmann M et al. Impact of sentinel lymph node biopsy in patients with Merkel cell carcinoma: results of a prospective study and review of the literature. Eur. J. Nucl. Med. Mol. Imaging33(4), 433–440 (2006).
   PubMed Web of Science ®Google Scholar
• Shnayder Y, Weed DT, Arnold DJ et al. Management of the neck in Merkel cell carcinoma of the head and neck: University of Miami experience. Head Neck30, 1559–1565 (2008).
   PubMed Web of Science ®Google Scholar
• Warner RE, Quinn MJ, Hruby G, Scolyer RA, Uren RF, Thompson JF. Management of Merkel cell carcinoma: the roles of lymphoscintigraphy, sentinel lymph node biopsy and adjuvant radiotherapy. Ann. Surg. Oncol.15(9), 2509–2518 (2008).
   PubMed Web of Science ®Google Scholar
• Pozo L, Sanchez-Carrillo JJ, Martinez A, Blanes A, Diaz-Cano SJ. Differential kinetic features by tumor topography in cutaneous small-cell neuroendocrine (Merkel cell) carcinomas. J. Eur. Acad. Dermatol. Venereol.21(9), 1220–1228 (2007).
   PubMed Web of Science ®Google Scholar
• Poulsen M, Round C, Keller J, Tripcony L, Veness M. Factors influencing relapse-free survival in Merkel cell carcinoma of the lower limb – a review of 60 cases. Int. J. Radiat. Oncol. Biol. Phys.76(2), 393–397 (2009).
   PubMed Web of Science ®Google Scholar
• Poulsen MG, Rischin D, Porter I et al. Does chemotherapy improve survival in high-risk stage I and II Merkel cell carcinoma of the skin? Int. J. Radiat. Oncol. Biol. Phys.64(1), 114–119 (2006).
   PubMed Web of Science ®Google Scholar