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Expert Review of Dermatology Volume 6, 2011 - Issue 1
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Drug Profile

Clinically relevant advances in acne management with adapalene 0.1%/benzoyl peroxide 2.5% gel

Jerry Tan Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, Canada. [email protected]; Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, Canada. [email protected]
&
Shaqil Peermohamed Faculty of Medicine, University of Calgary, Canada; Faculty of Medicine, University of Calgary, Canada
Pages 13-17 | Published online: 10 Jan 2014

References

  • Gollnick H, Cunliffe W, Berson D et al. Management of acne: a report from a Global Alliance to Improve Outcomes in Acne. J. Am. Acad. Dermatol.49(Suppl. 1), S1–S37 (2003).
  • Pariser D. Adapalene 0.1% and benzoyl peroxide 2.5% combination gel for the treatment of acne vulgaris. Expert Rev. Dermatol.5(4), 385–391 (2010).
  • Feldman SR, Tan J, Poulin Y et al. The efficacy of adapalene–benzoyl peroxide combination increases with number of acne lesions. J. Am. Acad. Dermatol. (2010) (In press).
  • Tan J, Gollnick H, Gold LS et al. Synergistic efficacy of adapalene 0.1% – benzoyl peroxide 2.5% in the treatment of 3855 acne vulgaris patients. J. Dermatol. Treat. DOI: 10.3109/09546631003681094 (2010) (Epub ahead of print).
  • Stein Gold L, Cruz A, Eichenfield L et al. Effective and safe combination therapy for severe acne vulgaris: a randomized vehicle-controlled, double-blind study of adapalene 0.1%–benzoyl peroxide 2.5% fixed dose combination gel with doxcycline hyclate 100 mg. Cutis85, 94–104 (2010).
  • Zouboulis CC, Fischer TC, Wohlrab J, Barnard J, Alió AB. Study of the efficacy, tolerability, and safety of 2 fixed-dose combination gels in the management of acne vulgaris. Cutis84, 223–229 (2009).
  • Thiboutot DM, Weiss J, Bucko A et al. Adapalene–benzoyl peroxide, a fixed-dose combination for the treatment of acne vulgaris: results of a multicenter, randomized double-blind controlled study. J. Am. Acad. Dermatol.57(5), 791–799 (2007).
  • Gold LS, Tan J, Cruz-Santana A et al. A North American study of adapalene–benzoyl peroxide combination gel in the treatment of acne. Cutis84(2), 110–116 (2009).
  • Gollnick HP, Draelos Z, Glenn MJ et al. Adapalene–benzoyl peroxide, a unique fixed-dose combination topical gel for the treatment of acne vulgaris: a transatlantic, randomized, double-blind, controlled study in 1670 patients. Br. J. Dermatol.161(5), 1180–1189 (2009).
  • Bikowski J. A new approach to comparing efficacy results from clinical trials of topical acne vulgaris treatments. J. Drugs Dermatol.6(7), 688–692 (2007).

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