58
Views
23
CrossRef citations to date
0
Altmetric
Review

Radiation therapy in the management of Merkel cell carcinoma: current perspectives

, , &
Pages 395-404 | Published online: 10 Jan 2014

References

  • Hodgson NC. Merkel cell carcinoma: changing incidence trends. J. Surg. Oncol.89(1), 1–4 (2005).
  • Allen PJ, Bowne WB, Jaques DP, Brennan MF, Busam K, Coit DG. Merkel cell carcinoma: prognosis and treatment of patients from a single institution. J. Clin. Oncol.23(10), 2300–2309 (2005).
  • Agelli M, Clegg LX. Epidemiology of primary Merkel cell carcinoma in the United States. J. Am. Acad. Dermatol.49(5), 832–841 (2003).
  • Engels EA, Frisch M, Goedert JJ et al. Merkel cell carcinoma and HIV infection. Lancet359(9305), 497–498 (2002).
  • Lanoy E, Dores GM, Madeleine MM et al. Epidemiology of nonkeratinocytic skin cancers among persons with AIDS in the United States. AIDS23, 385–393 (2008).
  • Penn I, First MR. Merkel’s cell carcinoma in organ recipients: report of 41 cases. Transplantation68(11), 1717–1721 (1999).
  • Feng H, Shuda M, Chang Y et al. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science319(5866), 1096–1100 (2008).
  • Rockville Merkel Cell Carcinoma Group. Merkel cell carcinoma: recent progress and current priorities on etiology, pathogenesis, and clinical management. J. Clin. Oncol.27(24), 4021–4026 (2009).
  • Leonard JH, Ramsay JR, Kearsley JH et al. Radiation sensitivity of Merkel cell carcinoma cell lines. Int. J. Radiat. Oncol. Biol. Phys.32(5), 1401–1407 (1995).
  • Rao NG. Review of the role of radiation therapy in the management of Merkel cell carcinoma. Curr. Probl. Cancer34(1), 108–117 (2010).
  • Poulsen M, Round C, Keller J et al. Factors influencing relapse-free survival in Merkel cell carcinoma of the lower limb – a review of 60 cases. Int. J. Radiat. Oncol. Biol. Phys.76, 393–397 (2010).
  • American Joint Committee on Cancer. AJCC Cancer Staging Manual (7th Edition). Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A (Eds). Springer, NY, USA (2009).
  • Lemos BD, Storer BE, Iyer JG et al. Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging system. J. Am. Acad. Dermatol.63(5), 751–761 (2010).
  • Clark JR, Veness MJ, Gilbert R et al. Merkel cell carcinoma of the head and neck: is adjuvant radiotherapy necessary? Head Neck29(3), 249–257 (2007).
  • Lewis KG, Weinstock MA, Weaver AL et al. Adjuvant local irradiation for Merkel cell carcinoma. Arch. Dermatol.142(6), 693–700 (2006).
  • Mojica P, Smith D, Ellenhorn JD. Adjuvant radiation therapy is associated with improved survival in Merkel cell carcinoma of the skin. J. Clin. Oncol.25(9), 1043–1047 (2007).
  • Poulsen MG, Rischin D, Porter I et al. Does chemotherapy improve survival in high-risk stage I and II Merkel cell carcinoma of the skin? Int. J. Radiat. Oncol. Biol. Phys.64, 114–119 (2006).
  • McAfee WJ, Morris CG, Mendenhall CM et al. Merkel cell carcinoma: treatment and outcomes. Cancer104(8), 1761–1764 (2005).
  • Poulsen M, Harvey J. Is there a diminishing role for surgery for Merkel cell carcinoma of the skin? A review of current management. ANZ J. Surg.72(2), 142–146 (2002).
  • Mortier L, Mirabel X, Fournier C et al. Radiotherapy alone for primary Merkel cell carcinoma. Arch. Dermatol.139(12), 1587–1590 (2003).
  • Veness M, Foote M, Gebski V et al. The role of radiotherapy alone in patients with merkel cell carcinoma: reporting the Australian experience of 43 patients. Int. J. Radiat. Oncol. Biol. Phys.78(3), 703–709 (2010).
  • Koh CS, Veness MJ. Role of definitive radiotherapy in treating patients with inoperable Merkel cell carcinoma: the Westmead Hospital experience and a review of the literature Australas. J. Dermatol.50(4), 249–256 (2009).
  • Messina JL, Reintgen DS, Cruse CW et al. Selective lymphadenectomy in patients with Merkel cell (cutaneous neuroendocrine) carcinoma. Ann. Surg. Oncol.4(5), 389–395 (1997).
  • Hill AD, Brady MS, Coit DG. Intraoperative lymphatic mapping and sentinel lymph node biopsy for Merkel cell carcinoma. Br. J. Surg.86(4), 518–521 (1999).
  • Sian KU, Wagner JD, Sood R et al. Lymphoscintigraphy with sentinel lymph node biopsy in cutaneous Merkel cell carcinoma. Ann. Plast. Surg.42(6), 679–682 (1999).
  • Allen P, Busam K, Hill AD et al. Immunohistochemical analysis of sentinel lymph nodes from patients with Merkel cell carcinoma. Cancer.92(6), 1650–1655 (2001).
  • Schwartz JL, Griffith KA, Lowe L et al. Features predicting sentinel lymph node positivity in Merkel cell carcinoma. J. Clin. Oncol.29(8), 1036–1041 (2011).
  • Veness M, Howle J. Patients with clinically node negative extremity Merkel cell carcinoma: the importance of identifying and treating patients with microscopic nodal metastases. Australas. J. Dermatol.51(4), 274–278 (2010).
  • Fields RC, Busam KJ, Chou JF et al. Recurrence and survival in patients undergoing sentinel lymph node biopsy for Merkel cell carcinoma: analysis of 153 patients from a single institution. Ann. Surg. Oncol. DOI: 10.1245/s10434-011-1662-y (2011) (Epub ahead of print).
  • Fang LC, Lemos B, Douglas J et al. Radiation monotherapy as regional treatment for lymph node-positive Merkel cell carcinoma. Cancer116(7), 1783–1790 (2010).
  • Bichakjian CK, Coit DG, Wong SL. Radiation versus resection for Merkel cell carcinoma. Cancer116(7), 1620–1622 (2010).
  • Poulsen M, Rischin D, Walpole E et al. Trans-Tasman Radiation Oncology Group. High-risk Merkel cell carcinoma of the skin treated with synchronous carboplatin/etoposide and radiation: a Trans-Tasman Radiation Oncology Group Study – TROG 96:07. J. Clin. Oncol.21(23), 4371–4376 (2003).
  • Poulsen M, Walpole E, Harvey J et al. Weekly carboplatin reduces toxicity during synchronous chemoradiotherapy for Merkel cell carcinoma of skin. Int. J. Radiat. Oncol. Biol. Phys.72, 1070–1074 (2008).
  • Foote M, Harvey J, Porceddu S et al. Effect of radiotherapy dose and volume on relapse in Merkel cell cancer of the skin. Int. J. Radiat. Oncol. Biol. Phys.77(3), 677–684 (2010).
  • Cotter SE, Devlin PM, Sahni D et al. Treatment of cutaneous metastases of Merkel cell carcinoma with surface-mold computer-optimized high-dose-rate brachytherapy. J. Clin. Oncol.28(27), e464–e466 (2010).
  • Paulson KG, Iyer JG, Tegeder AR et al. Transcriptome-wide studies of Merkel cell carcinoma and validation of intratumoral CD8+ lymphocyte invasion as an independent predictor of survival. J. Clin. Oncol.29(12), 1539–1546 (2011).
  • Hui AC, Stillie AL, Seel M, Ainslie J. Merkel cell carcinoma: 27-year experience at the Peter MacCallum Cancer Centre. Int. J. Radiat. Oncol. Biol. Phys. DOI: 10.1016/j.ijrobp.2010.04.061 (2010) (Epub ahead of print).
  • Senchenkov A, Barnes SA, Moran SL. Predictors of survival and recurrence in the surgical treatment of Merkel cell carcinoma of the extremities. J. Surg. Oncol.95(3), 229–234 (2007).
  • Veness MJ, Perera L, McCourt J et al. Merkel cell carcinoma: improved outcome with adjuvant radiotherapy. ANZ J. Surg.75(5), 275–281 (2005).
  • Boyer JD, Zitelli JA, Brodland DG, D’Angelo G. Local control of primary Merkel cell carcinoma: review of 45 cases treated with Mohs micrographic surgery with and without adjuvant radiation. J. Am. Acad. Dermatol.47(6), 885–892 (2002).
  • Eich HT, Eich D, Staar S et al. Role of postoperative radiotherapy in the management of Merkel cell carcinoma. Am. J. Clin. Oncol.25(1), 50–56 (2002).
  • Gillenwater AM, Hessel AC, Morrison WH et al. Merkel cell carcinoma of the head and neck: effect of surgical excision and radiation on recurrence and survival. Arch. Otolaryngol. Head Neck Surg.127(2), 149–154 (2001).
  • Meeuwissen JA, Bourne RG, Kearsley JH. The importance of postoperative radiation therapy in the treatment of Merkel cell carcinoma. Int. J. Radiat. Oncol. Biol. Phys.31(2), 325–331 (1995).
  • Yiengpruksawan A, Coit DG, Thaler HT, Urmacher C, Knapper WK. Merkel cell carcinoma. Prognosis and management. Arch. Surg.126(12), 1514–1519 (1991).

Website

  • NCCN Merkel Cell Carcinoma Panel Members. NCCN Clinical Practice Guidelines: Merkel Cell Carcinoma. V.1.2010. National Comprehensive Cancer Network, PA, USA (2010) www.nccn.org/index.asp

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.