7
Views
4
CrossRef citations to date
0
Altmetric
Special Report

Novel therapies developed for the treatment of leg ulcers: focus on physical therapies

&
Pages 419-427 | Published online: 10 Jan 2014

References

  • Graham ID, Harrison MB, Nelson EA, Lorimer K, Fisher A. Prevalence of lower-limb ulceration: a systematic review of prevalence studies. Adv. Skin Wound Care 16(6), 305–316 (2003).
  • Robertson L, Evans C, Fowkes FG. Epidemiology of chronic venous disease. Phlebology 23(3), 103–111 (2008).
  • Price PE, Fagervik-Morton H, Mudge EJ et al. Dressing-related pain in patients with chronic wounds: an international patient perspective. Int. Wound J. 5(2), 159–171 (2008).
  • Schmidt S, Wollina U, Looks A, Elsner P, Strauss B. Quality of life and strategies of coping with disease in patients with chronic leg ulcers. Dermatol. Psychosomatics. 1, 27–34 (2000).
  • Vowden K, Vowden P, Posnett J. The resource costs of wound care in Bradford and Airedale primary care trust in the UK. J. Wound Care 18(3), 93–102 (2009).
  • Schultz GS, Barillo DJ, Mozingo DW, Chin GA; Wound Bed Advisory Board Members. Wound bed preparation and a brief history of TIME. Int. Wound J. 1(1), 19–32 (2004).
  • Uhlemann C, Heinig B, Wollina U. Therapeutic ultrasound in lower extremity wound management. Int. J. Low. Extrem. Wounds 2(3), 152–157 (2003).
  • Serena T, Lee SK, Lam K, Attar P, Meneses P, Ennis W. The impact of noncontact, nonthermal, low-frequency ultrasound on bacterial counts in experimental and chronic wounds. Ostomy. Wound. Manage. 55(1), 22–30 (2009).
  • Wollina U, Heinig B. Low-frequency ultrasound for the treatment of chronic wounds [German]. Z. Wundheilung. 14, 74–91 (2009).
  • Schmidt WD, Liebold K, Fassler D, Wollina U. Contact-free spectroscopy of leg ulcers: principle, technique, and calculation of spectroscopic wound scores. J. Invest. Dermatol. 116(4), 531–535 (2001).
  • Uhlemann C, Wollina U. Aspects of physiological effects of therapeutic ultrasound in wound management [German]. Phlebologie 32, 81–85 (2003).
  • Herberger K, Franzke N, Blome C, Kirsten N, Augustin M. Efficacy, tolerability and patient benefit of ultrasound-assisted wound treatment versus surgical debridement: a randomized clinical study. Dermatology (Basel) 222(3), 244–249 (2011).
  • Stanisic MM, Provo BJ, Larson DL, Kloth LC. Wound debridement with 25 kHz ultrasound. Adv. Skin Wound Care 18(9), 484–490 (2005).
  • Wollina U, Heinig B, Naumann G, Scheibe A, Schmidt WD, Neugebauer R. Effects of low-frequency ultrasound on microcirculation in venous leg ulcers. Indian J. Dermatol. 56(2), 174–179 (2011).
  • Bell AL, Cavorsi J. Noncontact ultrasound therapy for adjunctive treatment of nonhealing wounds: retrospective analysis. Phys. Ther. 88(12), 1517–1524 (2008).
  • Kavros SJ, Schenck EC. Use of noncontact low-frequency ultrasound in the treatment of chronic foot and leg ulcerations: a 51-patient analysis. J. Am. Podiatr. Med. Assoc. 97(2), 95–101 (2007).
  • Escandon J, Vivas AC, Perez R, Kirsner R, Davis S. A prospective pilot study of ultrasound therapy effectiveness in refractory venous leg ulcers. Int. Wound J. 9(5), 570–578(2012).
  • Ennis WJ, Valdes W, Gainer M, Meneses P. Evaluation of clinical effectiveness of MIST ultrasound therapy for the healing of chronic wounds. Adv. Skin Wound Care 19(8), 437–446 (2006).
  • Gehling ML, Samies JH. The effect of noncontact, low-intensity, low-frequency therapeutic ultrasound on lower-extremity chronic wound pain: a retrospective chart review. Ostomy. Wound. Manage. 53(3), 44–50 (2007).
  • Ramundo J, Gray M. Is ultrasonic mist therapy effective for debriding chronic wounds? J. Wound. Ostomy Continence Nurs. 35(6), 579–583 (2008).
  • Tan J, Abisi S, Smith A, Burnand KG. A painless method of ultrasonically assisted debridement of chronic leg ulcers: a pilot study. Eur. J. Vasc. Endovasc. Surg. 33(2), 234–238 (2007).
  • Schaden W, Thiele R, Kölpl C et al. Shock wave therapy for acute and chronic soft tissue wounds: a feasibility study. J. Surg. Res. 143(1), 1–12 (2007).
  • Saggini R, Figus A, Troccola A, Cocco V, Saggini A, Scuderi N. Extracorporeal shock wave therapy for management of chronic ulcers in the lower extremities. Ultrasound Med. Biol. 34(8), 1261–1271 (2008).
  • Wilkes R, Zhao Y, Cunningham K, Kieswetter K, Haridas B. 3D strain measurement in soft tissue: demonstration of a novel inverse finite element model algorithm on MicroCT images of a tissue phantom exposed to negative pressure wound therapy. J. Mech. Behav. Biomed. Mater. 2(3), 272–287 (2009).
  • Saxena V, Hwang CW, Huang S, Eichbaum Q, Ingber D, Orgill DP. Vacuum-assisted closure: microdeformations of wounds and cell proliferation. Plast. Reconstr. Surg. 114(5), 1086–1096; discussion 1097 (2004).
  • Labanaris AP, Polykandriotis E, Horch RE. The effect of vacuum-assisted closure on lymph vessels in chronic wounds. J. Plast. Reconstr. Aesthet. Surg. 62(8), 1068–1075 (2009).
  • Armstrong DG, Lavery LA; Diabetic Foot Study Consortium. Negative pressure wound therapy after partial diabetic foot amputation: a multicentre, randomised controlled trial. Lancet 366(9498), 1704–1710 (2005).
  • Ahearn C. Intermittent NPWT and lower negative pressures – exploring the disparity between science and current practice: a review. Ostomy. Wound. Manage. 55(6), 22–28 (2009).
  • Ubbink DT, Westerbos SJ, Evans D, Land L, Vermeulen H. Topical negative pressure for treating chronic wounds. Cochrane Database Syst. Rev. (3), CD001898 (2008).
  • Ubbink DT, Westerbos SJ, Nelson EA, Vermeulen H. A systematic review of topical negative pressure therapy for acute and chronic wounds. Br. J. Surg. 95(6), 685–692 (2008).
  • Augustin M, Herberger K. [Benefits and limitations of vacuum therapy in wounds]. Hautarzt. 58(11), 945–951 (2007).
  • Körber A, Franckson T, Grabbe S, Dissemond J. Vacuum assisted closure device improves the take of mesh grafts in chronic leg ulcer patients. Dermatology (Basel). 216(3), 250–256 (2008).
  • Mouës CM, van den Bemd GJ, Meerding WJ, Hovius SE. An economic evaluation of the use of TNP on full-thickness wounds. J. Wound Care 14(5), 224–227 (2005).
  • Gabriel A, Shores J, Bernstein B et al. A clinical review of infected wound treatment with vacuum assisted closure (V.A.C.) therapy: experience and case series. Int. Wound J. 6(Suppl. 2), 1–25 (2009).
  • Khashram M, Huggan P, Ikram R, Chambers S, Roake JA, Lewis DR. Effect of TNP on the microbiology of venous leg ulcers: a pilot study. J. Wound Care 18(4), 164–167 (2009).
  • Alvarez O, Patel M, Rogers R, Booker J. Effect of non-contact normothermic wound therapy on the healing of diabetic neuropathic foot ulcers. J. Tissue Viability 16(1), 8–11 (2006).
  • Leclère FM, Puechguiral IR, Rotteleur G, Thomas P, Mordon SR. A prospective randomized study of 980 nm diode laser-assisted venous ulcer healing on 34 patients. Wound Repair Regen. 18(6), 580–585 (2010).
  • Mercer JB, Nielsen SP, Hoffmann G. Improvement of wound healing by water-filtered infrared-A (WIRA) in patients with chronic venous stasis ulcers of the lower legs including evaluation using infrared thermography. Ger. Med. Sci. 6, Doc11 (2008).
  • Wehner H, von Ardenne A, Kaltofen S. Whole-body hyperthermia with water-filtered infrared radiation: technical-physical aspects and clinical experiences. Int. J. Hyperthermia 17(1), 19–30 (2001).
  • Zhang Y, Song S, Fong CC, Tsang CH, Yang Z, Yang M. cDNA microarray analysis of gene expression profiles in human fibroblast cells irradiated with red light. J. Invest. Dermatol. 120(5), 849–857 (2003).
  • Alexandratou E, Yova D, Handris P, Kletsas D, Loukas S. Human fibroblast alterations induced by low power laser irradiation at the single cell level using confocal microscopy. Photochem. Photobiol. Sci. 1(8), 547–552 (2002).
  • Saltmarche AE. Low level laser therapy for healing acute and chronic wounds – the extendicare experience. Int. Wound J. 5(2), 351–360 (2008).
  • Kopera D, Kokol R, Berger C, Haas J. Does the use of low-level laser influence wound healing in chronic venous leg ulcers? J. Wound Care 14(8), 391–394 (2005).
  • Lagan KM, McKenna T, Witherow A, Johns J, McDonough SM, Baxter GD. Low-intensity laser therapy/combined phototherapy in the management of chronic venous ulceration: a placebo-controlled study. J. Clin. Laser Med. Surg. 20(3), 109–116 (2002).
  • Taradaj J, Franek A, Cierpka L et al. Early and long-term results of physical methods in the treatment of venous leg ulcers: randomized controlled trial. Phlebology 26(6), 237–245 (2011).
  • Sobanko JF, Alster TS. Efficacy of low-level laser therapy for chronic cutaneous ulceration in humans: a review and discussion. Dermatol. Surg. 34(8), 991–1000 (2008).
  • Vinck EM, Cagnie BJ, Cornelissen MJ, Declercq HA, Cambier DC. Green light emitting diode irradiation enhances fibroblast growth impaired by high glucose level. Photomed. Laser Surg. 23(2), 167–171 (2005).
  • Lipovsky A, Nitzan Y, Lubart R. A possible mechanism for visible light-induced wound healing. Lasers Surg. Med. 40(7), 509–514 (2008).
  • Minatel DG, Frade MA, França SC, Enwemeka CS. Phototherapy promotes healing of chronic diabetic leg ulcers that failed to respond to other therapies. Lasers Surg. Med. 41(6), 433–441 (2009).
  • Kloth LC. Electrical stimulation for wound healing: a review of evidence from in vitro studies, animal experiments, and clinical trials. Int. J. Low. Extrem. Wounds 4(1), 23–44 (2005).
  • Daeschlein G, Assadian O, Kloth LC, Meinl C, Ney F, Kramer A. Antibacterial activity of positive and negative polarity low-voltage pulsed current (LVPC) on six typical Gram-positive and Gram-negative bacterial pathogens of chronic wounds. Wound Repair Regen. 15(3), 399–403 (2007).
  • Jünger M, Arnold A, Zuder D, Stahl HW, Heising S. Local therapy and treatment costs of chronic, venous leg ulcers with electrical stimulation (Dermapulse): a prospective, placebo controlled, double blind trial. Wound Repair Regen. 16(4), 480–487 (2008).
  • Young S, Hampton S, Tadej M. Study to evaluate the effect of low-intensity pulsed electrical currents on levels of oedema in chronic non-healing wounds. J. Wound Care 20(8), 368, 370–368, 373 (2011).
  • Jankovic A, Binic I. Frequency rhythmic electrical modulation system in the treatment of chronic painful leg ulcers. Arch. Dermatol. Res. 300(7), 377–383 (2008).
  • Houghton PE, Kincaid CB, Lovell M et al. Effect of electrical stimulation on chronic leg ulcer size and appearance. Phys. Ther. 83(1), 17–28 (2003).
  • Callaghan MJ, Chang EI, Seiser N et al. Pulsed electromagnetic fields accelerate normal and diabetic wound healing by increasing endogenous FGF-2 release. Plast. Reconstr. Surg. 121(1), 130–141 (2008).
  • Cañedo-Dorantes L, García-Cantú R, Barrera R, Méndez-Ramírez I, Navarro VH, Serrano G. Healing of chronic arterial and venous leg ulcers through systemic effects of electromagnetic fields [corrected]. Arch. Med. Res. 33(3), 281–289 (2002).
  • Strauch B, Herman C, Dabb R, Ignarro LJ, Pilla AA. Evidence-based use of pulsed electromagnetic field therapy in clinical plastic surgery. Aesthet. Surg. J. 29(2), 135–143 (2009).
  • Ravaghi H, Flemming K, Cullum N, Olyaee Manesh A. Electromagnetic therapy for treating venous leg ulcers. Cochrane Database Syst. Rev. (2), CD002933 (2006).
  • Sackett DL, Straus SE, Richardson WS, Rosenberg W, Haynes RB. Evidence-Based Medicine. How To Practice and Teach EBM (2nd Edition). Churchill Livingstone, Edinburgh, UK(2000).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.