Controversies and evolving concepts in the diagnosis, classification and management of lentigo maligna

References

• Clark WH Jr, From L, Bernardino EA, Mihm MC. The histogenesis and biologic behavior of primary human malignant melanomas of the skin. Cancer Res. 29(3), 705–727 (1969).
   PubMed Web of Science ®Google Scholar
• McGovern VJ, Mihm MC Jr, Bailly C et al. The classification of malignant melanoma and its histologic reporting. Cancer 32(6), 1446–1457 (1973).
   PubMed Web of Science ®Google Scholar
• Weedon D. Malignant melanocytic lesions. In: Weedon’s Skin Pathology (3rd Edition). Elsevier, Amsterdam, The Netherlands, 734–754 (2010).
   Google Scholar
• Forman SB, Ferringer TC, Peckham SJ et al. Is superficial spreading melanoma still the most common form of malignant melanoma? J. Am. Acad. Dermatol. 58(6), 1013–1020 (2008).
   PubMed Web of Science ®Google Scholar
• Swetter SM, Boldrick JC, Jung SY, Egbert BM, Harvell JD. Increasing incidence of lentigo maligna melanoma subtypes: Northern California and national trends 1990–2000. J. Invest. Dermatol. 125(4), 685–691 (2005).
   PubMed Web of Science ®Google Scholar
• Hemminki K, Zhang H, Czene K. Incidence trends and familial risks in invasive and in situ cutaneous melanoma by sun-exposed body sites. Int. J. Cancer 104(6), 764–771 (2003).
   PubMed Web of Science ®Google Scholar
• McGovern VJ. The nature of melanoma. A critical review. J. Cutan. Pathol. 9(2), 61–81 (1982).
   PubMed Web of Science ®Google Scholar
• Hutchinson J. Senile freckles. Arch. Surg. 3, 319–322 (1892).
   Google Scholar
• Costello MJ, Fisher SB, Defeo CP. Melanotic freckle, lentigo maligna. Arch. Dermatol. 80, 753–771 (1959).
   PubMedGoogle Scholar
• Klauder JV, Beerman H. Melanotic freckle (Hutchinson), mélanose circonscrite précancéreuse (Dubreuilh). AMA. Arch. Derm. 71(1), 2–10 (1955).
   PubMedGoogle Scholar
• McGovern VJ, Shaw HM, Milton GW, Farago GA. Is malignant melanoma arising in a Hutchinson’s melanotic freckle a separate disease entity? Histopathology 4(3), 235–242 (1980).
   PubMed Web of Science ®Google Scholar
• English DR, Heenan PJ, Holman CD et al. Melanoma in Western Australia 1975–1976 to 1980–1981: trends in demographic and pathological characteristics. Int. J. Cancer 37(2), 209–215 (1986).
   PubMed Web of Science ®Google Scholar
• Hutchinson J. Lentigo-melanosis. A further report. Arch. Surg. 5, 252–256 (1894).
   Google Scholar
• Dubreuilh MW. De la mélanose circumscrite précancéreuse. Ann. Derm. 3(52), 129 (1912).
   Google Scholar
• Mishima Y. Melanosis circumscripta praecancerosa (Dubreuilh), a non-nevoid premelanoma distinct from junction nevus. J. Invest. Dermatol. 34, 361–375 (1960).
   PubMed Web of Science ®Google Scholar
• Becker SW. Dermatological investigations of melanin pigmentation. In: The Biology of Melanoma (Volume IV). Special Publications of the New York Academy of Sciences, New York, NY, USA, 82–125 (1948).
   Google Scholar
• Reed RJ. Acral lentiginous melanoma. In: New Concepts in Surgical Pathology of the Skin. Wiley, New York, NY, USA, 89–90 (1976).
   Google Scholar
• World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours. LeBoit PE, Burg G, Weedon D, Sarasain A (Eds). IARC Press, Lyon, France (2006).
   Google Scholar
• Kossard S. Atypical lentiginous junctional naevi of the elderly and melanoma. Australas. J. Dermatol. 43(2), 93–101 (2002).
   PubMedGoogle Scholar
• Elder DE, Xu X. The approach to the patient with a difficult melanocytic lesion. Pathology 36(5), 428–434 (2004).
   PubMed Web of Science ®Google Scholar
• Dubow BE, Ackerman AB. Ideas in pathology. Malignant melanoma in situ: the evolution of a concept. Mod. Pathol. 3(6), 734–744 (1990).
   PubMed Web of Science ®Google Scholar
• Holman CD, Mulroney CD, Armstrong BK. Epidemiology of pre-invasive and invasive malignant melanoma in Western Australia. Int. J. Cancer 25(3), 317–323 (1980).
   PubMed Web of Science ®Google Scholar
• English DR, Heenan PJ, Holman CD et al. Melanoma in Western Australia in 1980–1981: incidence and characteristics of histological types. Pathology 19(4), 383–392 (1987).
   PubMed Web of Science ®Google Scholar
• Newell GR, Sider JG, Bergfelt L, Kripke ML. Incidence of cutaneous melanoma in the United States by histology with special reference to the face. Cancer Res. 48(17), 5036–5041 (1988).
   PubMed Web of Science ®Google Scholar
• Levi F, Te VC, Randimbison L, La Vecchia C. Trends in incidence of various morphologies of malignant melanoma in Vaud and Neuchatel, Switzerland. Melanoma Res. 15(1), 73–75 (2005).
   PubMed Web of Science ®Google Scholar
• Golger A, Young DS, Ghazarian D, Neligan PC. Epidemiological features and prognostic factors of cutaneous head and neck melanoma: a population-based study. Arch. Otolaryngol. Head Neck Surg. 133(5), 442–447 (2007).
   PubMedGoogle Scholar
• Gillgren P, Månsson-Brahme E, Frisell J, Johansson H, Larsson O, Ringborg U. Epidemiological characteristics of cutaneous malignant melanoma of the head and neck – a population-based study. Acta Oncol. 38(8), 1069–1074 (1999).
   PubMed Web of Science ®Google Scholar
• Cox NH, Jones SK, MacKie RM. Malignant melanoma of the head and neck in Scotland: an eight-year analysis of trends in prevalence, distribution and prognosis. Q. J. Med. 64(244), 661–670 (1987).
   PubMedGoogle Scholar
• O’Brien CJ, Coates AS, Petersen-Schaefer K et al. Experience with 998 cutaneous melanomas of the head and neck over 30 years. Am. J. Surg. 162(4), 310–314 (1991).
   PubMed Web of Science ®Google Scholar
• Ringborg U, Afzelius LE, Lagerlöf B et al. Cutaneous malignant melanoma of the head and neck. Analysis of treatment results and prognostic factors in 581 patients: a report from the Swedish Melanoma Study Group. Cancer 71(3), 751–758 (1993).
   PubMed Web of Science ®Google Scholar
• Cox NH, Aitchison TC, Sirel JM, MacKie RM. Comparison between lentigo maligna melanoma and other histogenetic types of malignant melanoma of the head and neck. Scottish Melanoma Group. Br. J. Cancer 73(7), 940–944 (1996).
   PubMed Web of Science ®Google Scholar
• Elwood JM, Gallagher RP. Body site distribution of cutaneous malignant melanoma in relationship to patterns of sun exposure. Int. J. Cancer 78(3), 276–280 (1998).
   PubMed Web of Science ®Google Scholar
• Naldi L, Altieri A, Imberti GL, Gallus S, Bosetti C, La Vecchia C; Oncology Study Group of the Italian Group for Epidemiologic Research in Dermatology. Sun exposure, phenotypic characteristics, and cutaneous malignant melanoma. An analysis according to different clinico-pathological variants and anatomic locations (Italy). Cancer Causes Control 16(8), 893–899 (2005).
   PubMed Web of Science ®Google Scholar
• Elwood JM, Gallagher RP, Worth AJ, Wood WS, Pearson JC. Etiological differences between subtypes of cutaneous malignant melanoma: western Canada Melanoma Study. J. Natl Cancer Inst. 78(1), 37–44 (1987).
   PubMedGoogle Scholar
• Cohen HJ, Cox E, Manton K, Woodbury M. Malignant melanoma in the elderly. J. Clin. Oncol. 5(1), 100–106 (1987).
   PubMed Web of Science ®Google Scholar
• Kirkpatrick CS, Lee JA, White E. Melanoma risk by age and socio-economic status. Int. J. Cancer 46(1), 1–4 (1990).
   PubMed Web of Science ®Google Scholar
• Siskind V, Whiteman DC, Aitken JF, Martin NG, Green AC. An analysis of risk factors for cutaneous melanoma by anatomical site (Australia). Cancer Causes Control 16(3), 193–199 (2005).
   PubMed Web of Science ®Google Scholar
• Morris BT, Sober AJ. Cutaneous malignant melanoma in the older patient. Dermatol. Clin. 4(3), 473–480 (1986).
   PubMed Web of Science ®Google Scholar
• Goodson AG, Florell SR, Boucher KM, Grossman D. A decade of melanomas: identification of factors associated with delayed detection in an academic group practice. Dermatol. Surg. 37(11), 1620–1630 (2011).
   PubMed Web of Science ®Google Scholar
• Whiteman DC, Stickley M, Watt P, Hughes MC, Davis MB, Green AC. Anatomic site, sun exposure, and risk of cutaneous melanoma. J. Clin. Oncol. 24(19), 3172–3177 (2006).
   PubMed Web of Science ®Google Scholar
• Sina B, Samorodin C. Basal cell carcinoma surrounded by lentigo maligna. Cutis. 44(1), 81–82 (1989).
   PubMed Web of Science ®Google Scholar
• Burkhalter A, White WL. Malignant melanoma in situ colonizing basal cell carcinoma. A simulator of invasive melanoma. Am. J. Dermatopathol. 19(3), 303–307 (1997).
   PubMed Web of Science ®Google Scholar
• Florell SR, Zone JJ, Gerwels JW. Basal cell carcinomas are populated by melanocytes and Langerhans [correction of Langerhan’s] cells. Am. J. Dermatopathol. 23(1), 24–28 (2001).
   PubMed Web of Science ®Google Scholar
• Wang H, Benda PM, Piepkorn MW. Parasitism of basal cell carcinoma by lentigo maligna melanoma. J. Am. Acad. Dermatol. 48(Suppl. 5), S92–S94 (2003).
   Google Scholar
• Erickson LA, Myers JL, Mihm MC, Markovic SN, Pittelkow MR. Malignant basomelanocytic tumor manifesting as metastatic melanoma. Am. J. Surg. Pathol. 28(10), 1393–1396 (2004).
   PubMed Web of Science ®Google Scholar
• Rodriguez J, Nonaka D, Kuhn E, Reichel M, Rosai J. Combined high-grade basal cell carcinoma and malignant melanoma of the skin (‘malignant basomelanocytic tumor’): report of two cases and review of the literature. Am. J. Dermatopathol. 27(4), 314–318 (2005).
   PubMed Web of Science ®Google Scholar
• Belisle A, Gautier MS, Ghozali F, Plantier F, Wechsler J. A collision tumor involving basal cell carcinoma and lentigo maligna melanoma. Am. J. Dermatopathol. 27(4), 319–321 (2005).
   PubMed Web of Science ®Google Scholar
• Taibjee SM, Gee BC, Sanders DS, Smith A, Carr RA. Lentigo maligna involving the tumour nests and stroma of a nodular basal cell carcinoma. Br. J. Dermatol. 157(1), 184–188 (2007).
   PubMed Web of Science ®Google Scholar
• Rosen LB, Williams WD, Benson J, Rywlin AM. A malignant neoplasm with features of both squamous cell carcinoma and malignant melanoma. Am. J. Dermatopathol. 6, 213–219 (1984).
   PubMed Web of Science ®Google Scholar
• Hofer A, Kaddu S, Seidl H, Kerl H, Wolf P. Collision of squamous-cell carcinoma with melanoma in situ in a child with xeroderma pigmentosum. Dermatology (Basel) 203(1), 66–69 (2001).
   PubMed Web of Science ®Google Scholar
• Ahlgrimm-Siess V, Hofmann-Wellenhof R, Zalaudek I, Cerroni L, Kerl H. Collision of malignant melanoma (lentigo maligna type) with squamous cell carcinoma in solar-damaged skin of the face. Dermatol. Surg. 33(1), 122–124 (2007).
   PubMed Web of Science ®Google Scholar
• Forman SB, Vidmar DA, Ferringer TC. Collision tumor composed of Merkel cell carcinoma and lentigo maligna melanoma. J. Cutan. Pathol. 35(2), 203–206 (2008).
   PubMed Web of Science ®Google Scholar
• Holman CD, Armstrong BK. Cutaneous malignant melanoma and indicators of total accumulated exposure to the sun: an analysis separating histogenetic types. J. Natl Cancer Inst. 73(1), 75–82 (1984).
   PubMed Web of Science ®Google Scholar
• Holman CD, Armstrong BK, Heenan PJ. A theory of the etiology and pathogenesis of human cutaneous malignant melanoma. J. Natl Cancer Inst. 71(4), 651–656 (1983).
   PubMedGoogle Scholar
• Houghton AN, Viola MV. Solar radiation and malignant melanoma of the skin. J. Am. Acad. Dermatol. 5(4), 477–483 (1981).
   PubMed Web of Science ®Google Scholar
• Carey FA, Hogan JM. The relationship of sun exposure and solar elastosis to skin cancer in a high risk population. Ir. J. Med. Sci. 159(2), 44–47 (1990).
   PubMed Web of Science ®Google Scholar
• Holman CD, Armstrong BK, Heenan PJ. Relationship of cutaneous malignant melanoma to individual sunlight-exposure habits. J. Natl Cancer Inst. 76(3), 403–414 (1986).
   PubMed Web of Science ®Google Scholar
• Bataille V, Sasieni P, Grulich A et al. Solar keratoses: a risk factor for melanoma but negative association with melanocytic naevi. Int. J. Cancer 78(1), 8–12 (1998).
   PubMed Web of Science ®Google Scholar
• Kvaskoff M, Siskind V, Green AC. Risk factors for lentigo maligna melanoma compared with superficial spreading melanoma: a case–control study in Australia. Arch. Dermatol. 148(2), 164–170 (2012).
   PubMedGoogle Scholar
• Crowson AN, Magro CM, Sanchez-Carpintero I, Mihm MC Jr. The precursors of malignant melanoma. Recent Results Cancer Res. 160, 75–84 (2002).
   PubMedGoogle Scholar
• Olsen CM, Zens MS, Stukel TA et al. Nevus density and melanoma risk in women: a pooled analysis to test the divergent pathway hypothesis. Int. J. Cancer 124(4), 937–944 (2009).
   PubMed Web of Science ®Google Scholar
• Garbe C, Büttner P, Weiss J et al. Associated factors in the prevalence of more than 50 common melanocytic nevi, atypical melanocytic nevi, and actinic lentigines: multicenter case–control study of the Central Malignant Melanoma Registry of the German Dermatological Society. J. Invest. Dermatol. 102(5), 700–705 (1994).
   PubMed Web of Science ®Google Scholar
• Green A, Siskind V, Bain C, Alexander J. Sunburn and malignant melanoma. Br. J. Cancer 51(3), 393–397 (1985).
   PubMed Web of Science ®Google Scholar
• Lew RA, Sober AJ, Cook N, Marvell R, Fitzpatrick TB. Sun exposure habits in patients with cutaneous melanoma: a case–control study. J. Dermatol. Surg. Oncol. 9(12), 981–986 (1983).
   PubMedGoogle Scholar
• MacKie RM, Aitchison T. Severe sunburn and subsequent risk of primary cutaneous malignant melanoma in Scotland. Br. J. Cancer 46(6), 955–960 (1982).
   PubMed Web of Science ®Google Scholar
• Elwood JM, Gallagher RP, Davison J, Hill GB. Sunburn, suntan and the risk of cutaneous malignant melanoma – the Western Canada Melanoma study. Br. J. Cancer 51(4), 543–549 (1985).
   PubMed Web of Science ®Google Scholar
• Elwood JM, Gallagher RP, Hill GB, Pearson JC. Cutaneous melanoma in relation to intermittent and constant sun exposure – the Western Canada Melanoma study. Int. J. Cancer 35(4), 427–433 (1985).
   PubMed Web of Science ®Google Scholar
• Osterlind A, Tucker MA, Stone BJ, Jensen OM. The Danish case–control study of cutaneous malignant melanoma. II. Importance of UV-light exposure. Int. J. Cancer 42(3), 319–324 (1988).
   PubMed Web of Science ®Google Scholar
• Holly EA, Aston DA, Cress RD, Ahn DK, Kristiansen JJ. Cutaneous melanoma in women. I. Exposure to sunlight, ability to tan, and other risk factors related to ultraviolet light. Am. J. Epidemiol. 141(10), 923–933 (1995).
   PubMed Web of Science ®Google Scholar
• Lee EY, Williamson R, Watt P, Hughes MC, Green AC, Whiteman DC. Sun exposure and host phenotype as predictors of cutaneous melanoma associated with neval remnants or dermal elastosis. Int. J. Cancer 119(3), 636–642 (2006).
   PubMed Web of Science ®Google Scholar
• Gaudy-Marqueste C, Madjlessi N, Guillot B, Avril MF, Grob JJ. Risk factors in elderly people for lentigo maligna compared with other melanomas: a double case–control study. Arch. Dermatol. 145(4), 418–423 (2009).
   PubMedGoogle Scholar
• Siskind V, Hughes MC, Palmer JM et al. Nevi, family history, and fair skin increase the risk of second primary melanoma. J. Invest. Dermatol. 131(2), 461–467 (2011).
   PubMed Web of Science ®Google Scholar
• Lloyd KM. Multiple lentigo maligna melanomas: a preliminary report. Arch. Dermatol. 142(8), 1092 (2006).
   Google Scholar
• Whiteman DC, Parsons PG, Green AC. p53 expression and risk factors for cutaneous melanoma: a case–control study. Int. J. Cancer 77(6), 843–848 (1998).
   PubMed Web of Science ®Google Scholar
• Whiteman DC, Watt P, Purdie DM, Hughes MC, Hayward NK, Green AC. Melanocytic nevi, solar keratoses, and divergent pathways to cutaneous melanoma. J. Natl Cancer Inst. 95(11), 806–812 (2003).
   PubMedGoogle Scholar
• Ko JM, Velez NF, Tsao H. Pathways to melanoma. Semin. Cutan. Med. Surg. 29(4), 210–217 (2010).
   PubMed Web of Science ®Google Scholar
• Anderson WF, Pfeiffer RM, Tucker MA, Rosenberg PS. Divergent cancer pathways for early-onset and late-onset cutaneous malignant melanoma. Cancer 115(18), 4176–4185 (2009).
   PubMed Web of Science ®Google Scholar
• Heenan PJ. Cutaneous malignant melanoma in western Australia. Pathology 17(2), 321–327 (1985).
   PubMed Web of Science ®Google Scholar
• Weiss J, Bertz J, Jung EG. Malignant melanoma in southern Germany: different predictive value of risk factors for melanoma subtypes. Dermatologica 183(2), 109–113 (1991).
   PubMedGoogle Scholar
• Elwood JM, Gallagher RP, Hill GB, Spinelli JJ, Pearson JC, Threlfall W. Pigmentation and skin reaction to sun as risk factors for cutaneous melanoma: Western Canada Melanoma Study. Br. Med. J. (Clin. Res. Ed). 288(6411), 99–102 (1984).
   PubMed Web of Science ®Google Scholar
• Chi Z, Li S, Sheng X et al. Clinical presentation, histology, and prognoses of malignant melanoma in ethnic Chinese: a study of 522 consecutive cases. BMC Cancer 11, 85 (2011).
   PubMed Web of Science ®Google Scholar
• Milman T, Lambert WC, Mirani N, Langer PD. Lentigo maligna of the eyelid a rare finding in African Americans. Ophthalmology 114(7), 1409–1412 (2007).
   PubMed Web of Science ®Google Scholar
• Holman CD, Armstrong BK. Hutchinson’s melanotic freckle melanoma associated with non-permanent hair dyes. Br. J. Cancer 48(4), 599–601 (1983).
   PubMed Web of Science ®Google Scholar
• Holman CDJ, Armstrong BK. Hutchinson’s melanotic freckle melanoma and the use of non-permanent hair dyes. Br. J. Dermatol. 52, 135 (1985).
   Google Scholar
• Sawaya ME, Garland LD, Rothe MJ, Honig LS, Hsia SL. Oestrogen and progesterone receptors in lentigo maligna. Br. J. Dermatol. 118(1), 69–71 (1988).
   PubMed Web of Science ®Google Scholar
• Barnett JH, Lee FG, Rinsky MJ. Acral lentiginous melanoma and lentigo maligna occurring in Werner’s syndrome. Cutis. 32(3), 277–279, 283 (1983).
   PubMed Web of Science ®Google Scholar
• Greenwald G. Letter: lentigo maligna associated with porphyria cutanea tarda. Arch. Dermatol. 110(2), 298 (1974).
   PubMedGoogle Scholar
• Stoll DB, Ruschak P, Kauh Y, Martin J, Luscombe H. Lentigo maligna in a woman with oculocutaneous albinism. Arch. Dermatol. 117(6), 360–361 (1981).
   PubMedGoogle Scholar
• Proctor MS, Cox AJ, Grais LS. Lentigo maligna melanoma in a treated psoriatic plaque. Arch. Dermatol. 117(3), 149–150 (1981).
   PubMedGoogle Scholar
• Faghihi G, Radan M. Xeroderma pigmentosum and lentigo maligna in identical twins. J. Dermatolog. Treat. 17(4), 241–243 (2006).
   PubMed Web of Science ®Google Scholar
• Stern JB, Peck GL, Haupt HM, Hollingsworth HC, Beckerman T. Malignant melanoma in xeroderma pigmentosum: search for a precursor lesion. J. Am. Acad. Dermatol. 28(4), 591–594 (1993).
   PubMed Web of Science ®Google Scholar
• Fukuro S, Yamaguchi J, Mamada A, Kondo S, Satoh Y. Xeroderma pigmentosum group D patient bearing lentigo maligna without neurological symptoms. Dermatologica 181(2), 129–133 (1990).
   PubMedGoogle Scholar
• Farrell A, Burnett M, Bohjanen K. Hypomyopathic dermatomyositis associated with lentigo maligna melanoma. J. Am. Acad. Dermatol. 55(1), 164–165 (2006).
   PubMed Web of Science ®Google Scholar
• Dewan P, Jawad A, Goldsmith P, Harwood C, Cerio R. Melanoma in patients with rheumatoid arthritis treated with antitumour necrosis factor: cause or coincidence? Report of two cases. Br. J. Dermatol. 161(6), 1412–1414 (2009).
   PubMed Web of Science ®Google Scholar
• Hiscutt EL, Adams JR, Ryan JM, Langtry JA, Natarajan S. Atypical fibroxanthoma, lentigo maligna melanoma and squamous cell carcinoma arising in the site of a thermal burn treated with skin grafts. Br. J. Oral Maxillofac. Surg. 47(2), 157–158 (2009).
   PubMed Web of Science ®Google Scholar
• Kikuchi H, Nishida T, Kurokawa M, Setoyama M, Kisanuki A. Three cases of malignant melanoma arising on burn scars. J. Dermatol. 30(8), 617–624 (2003).
   PubMed Web of Science ®Google Scholar
• Ribero S, Grassi M, Caliendo V, Lauro D, Macripò G. Melanoma arising on a scar 10 years after a burn: management and review of the literature. Ann. Plast. Surg. 69(1), 27–29 (2012).
   PubMed Web of Science ®Google Scholar
• O’Dell BL, Jessen RT, Becker LE, Jackson RT, Smith EB. Diminished immune response in sun-damaged skin. Arch. Dermatol. 116(5), 559–561 (1980).
   PubMedGoogle Scholar
• Armstrong RB. Diminished immune response in sun-damaged skin. Arch. Dermatol. 117(3), 128–129 (1981).
   PubMedGoogle Scholar
• Donawho CK, Kripke ML. Lack of correlation between UV-induced enhancement of melanoma development and local suppression of contact hypersensitivity. Exp. Dermatol. 1(1), 20–26 (1992).
   PubMedGoogle Scholar
• Mishima Y, Tanay A. The effect of alpha-methyldopa and ultraviolet irradiation on melanogenesis. Dermatologica 136(2), 105–114 (1968).
   PubMedGoogle Scholar
• Zaidi MR, De Fabo EC, Noonan FP, Merlino G. Shedding light on melanocyte pathobiology in vivo. Cancer Res. 72(7), 1591–1595 (2012).
   PubMed Web of Science ®Google Scholar
• Atillasoy ES, Seykora JT, Soballe PW et al. UVB induces atypical melanocytic lesions and melanoma in human skin. Am. J. Pathol. 152(5), 1179–1186 (1998).
   PubMed Web of Science ®Google Scholar
• Hodis E, Watson IR, Kryukov GV et al. A landscape of driver mutations in melanoma. Cell 150(2), 251–263 (2012).
   PubMed Web of Science ®Google Scholar
• Black HS, deGruijl FR, Forbes PD et al. Photocarcinogenesis: an overview. J. Photochem. Photobiol. B, Biol. 40(1), 29–47 (1997).
   PubMed Web of Science ®Google Scholar
• Melnikova VO, Ananthaswamy HN. Cellular and molecular events leading to the development of skin cancer. Mutat. Res. 571(1–2), 91–106 (2005).
   PubMed Web of Science ®Google Scholar
• Purdue MP, From L, Kahn HJ et al. Etiologic factors associated with p53 immunostaining in cutaneous malignant melanoma. Int. J. Cancer 117(3), 486–493 (2005).
   PubMed Web of Science ®Google Scholar
• Hussein MR, Haemel AK, Wood GS. p53-related pathways and the molecular pathogenesis of melanoma. Eur. J. Cancer Prev. 12(2), 93–100 (2003).
   PubMed Web of Science ®Google Scholar
• Spatz A, Giglia-Mari G, Benhamou S, Sarasin A. Association between DNA repair-deficiency and high level of p53 mutations in melanoma of Xeroderma pigmentosum. Cancer Res. 61(6), 2480–2486 (2001).
   PubMed Web of Science ®Google Scholar
• Rünger TM, Kappes UP. Mechanisms of mutation formation with long-wave ultraviolet light (UVA). Photodermatol. Photoimmunol. Photomed. 24(1), 2–10 (2008).
   PubMed Web of Science ®Google Scholar
• Mitchell D, Fernandez A. The photobiology of melanocytes modulates the impact of UVA on sunlight-induced melanoma. Photochem. Photobiol. Sci. 11(1), 69–73 (2012).
   PubMed Web of Science ®Google Scholar
• Kowalczuk CI, Priestner MC, Pearson AJ, Saunders RD, Bouffler SD. Wavelength dependence of cellular responses in human melanocytes and melanoma cells following exposure to ultraviolet radiation. Int. J. Radiat. Biol. 82(11), 781–792 (2006).
   PubMed Web of Science ®Google Scholar
• Godar DE, Landry RJ, Lucas AD. Increased UVA exposures and decreased cutaneous Vitamin D(3) levels may be responsible for the increasing incidence of melanoma. Med. Hypotheses 72(4), 434–443 (2009).
   PubMed Web of Science ®Google Scholar
• Walter SD, Marrett LD, From L, Hertzman C, Shannon HS, Roy P. The association of cutaneous malignant melanoma with the use of sunbeds and sunlamps. Am. J. Epidemiol. 131(2), 232–243 (1990).
   PubMed Web of Science ®Google Scholar
• Autier P, Doré JF, Eggermont AM, Coebergh JW. Epidemiological evidence that UVA radiation is involved in the genesis of cutaneous melanoma. Curr. Opin. Oncol. 23(2), 189–196 (2011).
   PubMed Web of Science ®Google Scholar
• Kripke ML, Fisher MS. Immunologic parameters of ultraviolet carcinogenesis. J. Natl Cancer Inst. 57(1), 211–215 (1976).
   PubMed Web of Science ®Google Scholar
• Bevona C, Fewkes J, Liu V, Sober AJ. Prolonged evolution of a lentigo maligna. J. Am. Acad. Dermatol. 51(5), 830–835 (2004).
   PubMed Web of Science ®Google Scholar
• Ferrara G, Ligrone L, Zalaudek I, Mordente I, Argenziano G. Lentigo maligna in a young adult. Dermatology (Basel) 217(1), 66–68 (2008).
   PubMed Web of Science ®Google Scholar
• Durnick A, Stolz W, Landthaler M, Vogt T. Lentigo maligna and lentigo maligna melanoma in young adults. Dermatol. Surg. 30(5), 813–816 (2004).
   PubMed Web of Science ®Google Scholar
• Crucioli V, Stilwell J. The histogenesis of malignant melanoma in relation to pre-existing pigmented lesions. J. Cutan. Pathol. 9(6), 396–404 (1982).
   PubMed Web of Science ®Google Scholar
• Hoersch B, Leiter U, Garbe C. Is head and neck melanoma a distinct entity? A clinical registry-based comparative study in 5702 patients with melanoma. Br. J. Dermatol. 155(4), 771–777 (2006).
   PubMed Web of Science ®Google Scholar
• Cox NH, Aitchison TC, MacKie RM. Extrafacial lentigo maligna melanoma: analysis of 71 cases and comparison with lentigo maligna melanoma of the head and neck. Br. J. Dermatol. 139(3), 439–443 (1998).
   PubMed Web of Science ®Google Scholar
• Davidsson A, Hellquist HB, Villman K, Westman G. Malignant melanoma of the ear. J. Laryngol. Otol. 107(9), 798–802 (1993).
   PubMed Web of Science ®Google Scholar
• Papadopoulos T, Rasiah K, Thompson JF, Quinn MJ, Crotty KA. Melanoma of the nose. Br. J. Surg. 84(7), 986–989 (1997).
   PubMed Web of Science ®Google Scholar
• Jahn V, Breuninger H, Garbe C, Maassen MM, Moehrle M. Melanoma of the nose: prognostic factors, three-dimensional histology, and surgical strategies. Laryngoscope 116(7), 1204–1211 (2006).
   PubMed Web of Science ®Google Scholar
• Hicks C, Liu C, Hiranandani M, Garner A, Hungerford J. Conjunctival melanoma after excision of a lentigo maligna melanoma in the ipsilateral eyelid skin. Br. J. Ophthalmol. 78(4), 317–318 (1994).
   PubMed Web of Science ®Google Scholar
• Vaziri M, Buffam FV, Martinka M, Oryschak A, Dhaliwal H, White VA. Clinicopathologic features and behavior of cutaneous eyelid melanoma. Ophthalmology 109(5), 901–908 (2002).
   PubMed Web of Science ®Google Scholar
• Chan FM, O’Donnell BA, Whitehead K, Ryman W, Sullivan TJ. Treatment and outcomes of malignant melanoma of the eyelid: a review of 29 cases in Australia. Ophthalmology 114(1), 187–192 (2007).
   PubMed Web of Science ®Google Scholar
• Grossniklaus HE, McLean IW. Cutaneous melanoma of the eyelid. Clinicopathologic features. Ophthalmology 98(12), 1867–1873 (1991).
   PubMed Web of Science ®Google Scholar
• Naidoff MA, Bernardino VB, Clark WH. Melanocytic lesions of the eyelid skin. Am. J. Ophthalmol. 82(3), 371–382 (1976).
   PubMed Web of Science ®Google Scholar
• Rodriguez-Sains RS, Jakobiec FA, Iwamoto T. Lentigo maligna of the lateral canthal skin. Ophthalmology 88(12), 1186–1192 (1981).
   PubMed Web of Science ®Google Scholar
• Blodi FC, Widner RR. The melanotic freckle (Hutchinson) of the lids. Surv. Ophthalmol. 13(1), 23–30 (1968).
   PubMedGoogle Scholar
• Kroumpouzos G, Frank EW, Albertini JG et al. Lentigo maligna with spread onto oral mucosa. Arch. Dermatol. 138(9), 1216–1220 (2002).
   PubMedGoogle Scholar
• Davalbhakta A, Hamilton S, Grant JW, Lamberty BG. Spread of a recurrent lentigo maligna into a graft: a case for conservative treatment. Br. J. Plast. Surg. 54(3), 253–256 (2001).
   PubMedGoogle Scholar
• Cohen LM, McCall MW, Hodge SJ, Freedman JD, Callen JP, Zax RH. Successful treatment of lentigo maligna and lentigo maligna melanoma with Mohs’ micrographic surgery aided by rush permanent sections. Cancer 73(12), 2964–2970 (1994).
   PubMed Web of Science ®Google Scholar
• Dalton SR, Gardner TL, Libow LF, Elston DM. Contiguous lesions in lentigo maligna. J. Am. Acad. Dermatol. 52(5), 859–862 (2005).
   PubMed Web of Science ®Google Scholar
• Allan SJ, Dicker AJ, Tidman MJ, McLaren KM, Hunter JA. Amelanotic lentigo maligna and amelanotic lentigo maligna melanoma: a report of three cases mimicking intraepidermal squamous carcinoma. J. Eur. Acad. Dermatol. Venereol. 11(1), 78–81 (1998).
   PubMed Web of Science ®Google Scholar
• Powell AM, Russell-Jones R. Amelanotic lentigo maligna managed with topical imiquimod as immunotherapy. J. Am. Acad. Dermatol. 50(5), 792–796 (2004).
   PubMed Web of Science ®Google Scholar
• Abdulla FR, Kerns MJ, Mutasim DF. Amelanotic lentigo maligna: a report of three cases and review of the literature. J. Am. Acad. Dermatol. 62(5), 857–860 (2010).
   PubMed Web of Science ®Google Scholar
• Wasserman DI, Chang A, Lee D, Lee A, Finn D. Underlying amelanotic lentigo maligna melanoma uncovered after a severe blistering sunburn. Cutis. 86(2), 70–72 (2010).
   PubMed Web of Science ®Google Scholar
• Conrad N, Jackson B, Goldberg L. Amelanotic lentigo maligna melanoma: a unique case presentation. Dermatol. Surg. 25(5), 408–411 (1999).
   PubMed Web of Science ®Google Scholar
• Rocamora V, Puig L, Romaní J, de Moragas JM. Amelanotic lentigo maligna melanoma: report of a case and review of the literature. Cutis. 64(1), 53–56 (1999).
   PubMed Web of Science ®Google Scholar
• Kaufmann R, Nikelski K, Weber L, Sterry W. Amelanotic lentigo maligna melanoma. J. Am. Acad. Dermatol. 32(2 Pt 2), 339–342 (1995).
   PubMed Web of Science ®Google Scholar
• Herman KL, Shrager JD. Amelanotic lentigo maligna melanoma: a unique case and review of the literature. Cutis. 44(1), 45–48 (1989).
   PubMed Web of Science ®Google Scholar
• Borkovic SP, Schwartz RA. Amelanotic lentigo maligna melanoma manifesting as a dermatitis-like plaque. Arch. Dermatol. 119(5), 423–425 (1983).
   PubMedGoogle Scholar
• Kiene P, Christophers E. From melanotic to amelanotic lentigo maligna: an aggressive variant presenting as an inflammatory lesion. Int. J. Dermatol. 36(2), 123–125 (1997).
   PubMed Web of Science ®Google Scholar
• Ara M, Maillo C, Martín R, Grasa MP, Carapeto FJ. Recurrent lentigo maligna as amelanotic lentigo maligna melanoma. J. Eur. Acad. Dermatol. Venereol. 16(5), 506–510 (2002).
   PubMed Web of Science ®Google Scholar
• Su WP, Bradley RR. Amelanotic lentigo maligna. Arch. Dermatol. 116(1), 82–83 (1980).
   PubMedGoogle Scholar
• Kelly RI, Cook MG, Mortimer PS. Aggressive amelanotic lentigo maligna. Br. J. Dermatol. 131(4), 562–565 (1994).
   PubMed Web of Science ®Google Scholar
• Martires KJ, Capaldi L, Pattee SF, Maloney ME, Bordeaux JS. Failed treatment of amelanotic lentigo maligna with imiquimod followed by pigment production. Arch. Dermatol. 146(9), 1047–1048 (2010).
   PubMedGoogle Scholar
• Massi D, Nardini P, De Giorgi V, Carli P. Simultaneous occurrence of multiple melanoma in situ on sun-damaged skin (lentigo maligna), solar lentigo and labial melanosis: the value of dermoscopy in diagnosis. J. Eur. Acad. Dermatol. Venereol. 13(3), 193–197 (1999).
   PubMed Web of Science ®Google Scholar
• Moreno-Ramirez D, Ferrandiz L, Camacho FM. Are the ABCD signs useful for the management of solar lentigo? Br. J. Dermatol. 153(5), 1083–1084; author reply 1084 (2005).
   PubMed Web of Science ®Google Scholar
• Stante M, Giorgi V, Stanganelli I, Alfaioli B, Carli P. Dermoscopy for early detection of facial lentigo maligna. Br. J. Dermatol. 152(2), 361–364 (2005).
   PubMed Web of Science ®Google Scholar
• Stolz W, Schiffner R, Burgdorf WH. Dermatoscopy for facial pigmented skin lesions. Clin. Dermatol. 20(3), 276–278 (2002).
   PubMed Web of Science ®Google Scholar
• Sahin MT, Oztürkcan S, Ermertcan AT, Günes AT. A comparison of dermoscopic features among lentigo senilis/initial seborrheic keratosis, seborrheic keratosis, lentigo maligna and lentigo maligna melanoma on the face. J. Dermatol. 31(11), 884–889 (2004).
   PubMed Web of Science ®Google Scholar
• Robinson JK. Use of digital epiluminescence microscopy to help define the edge of lentigo maligna. Arch. Dermatol. 140(9), 1095–1100 (2004).
   PubMed Web of Science ®Google Scholar
• Slutsky JB, Marghoob AA. The zig-zag pattern of lentigo maligna. Arch. Dermatol. 146(12), 1444 (2010).
   PubMedGoogle Scholar
• Pralong P, Bathelier E, Dalle S, Poulalhon N, Debarbieux S, Thomas L. Dermoscopy of lentigo maligna melanoma: report of 125 cases. Br. J. Dermatol. 167(2), 280–287 (2012).
   PubMed Web of Science ®Google Scholar
• Kilinc-Karaarslan I, Akalin T, Ozdemir F. Lentigo maligna melanoma with folliculotropism: dermoscopic features during rapid progression. Arch. Dermatol. 145(6), 725–726 (2009).
   PubMedGoogle Scholar
• Akay BN, Kocyigit P, Heper AO, Erdem C. Dermatoscopy of flat pigmented facial lesions: diagnostic challenge between pigmented actinic keratosis and lentigo maligna. Br. J. Dermatol. 163(6), 1212–1217 (2010).
   PubMed Web of Science ®Google Scholar
• Tanaka M, Sawada M, Kobayashi K. Key points in dermoscopic differentiation between lentigo maligna and solar lentigo. J. Dermatol. 38(1), 53–58 (2011).
   PubMed Web of Science ®Google Scholar
• Shrestha B, Bishop J, Kam K et al. Detection of atypical texture features in early malignant melanoma. Skin Res. Technol. 16(1), 60–65 (2010).
   PubMed Web of Science ®Google Scholar
• Altamura D, Avramidis M, Menzies SW. Assessment of the optimal interval for and sensitivity of short-term sequential digital dermoscopy monitoring for the diagnosis of melanoma. Arch. Dermatol. 144(4), 502–506 (2008).
   PubMed Web of Science ®Google Scholar
• Schiffner R, Perusquia AM, Stolz W. One-year follow-up of a lentigo maligna: first dermoscopic signs of growth. Br. J. Dermatol. 151(5), 1087–1089 (2004).
   PubMed Web of Science ®Google Scholar
• Kelly JW. Following lentigo maligna may not prevent the development of life-threatening melanoma. Arch. Dermatol. 128(5), 657–660 (1992).
   PubMedGoogle Scholar
• Rosendahl C, Cameron A, Bulinska A, Williamson R, Kittler H. Dermatoscopy of a minute melanoma. Australas. J. Dermatol. 52(1), 76–78 (2011).
   PubMed Web of Science ®Google Scholar
• Cramer SF. Management of lentigo maligna. Arch. Dermatol. 129(1), 46 (1993).
   PubMedGoogle Scholar
• Rademaker M, Oakley A. Digital monitoring by whole body photography and sequential digital dermoscopy detects thinner melanomas. J. Prim. Health Care 2(4), 268–272 (2010).
   PubMedGoogle Scholar
• Tannous ZS, Mihm MC, Flotte TJ, González S. In vivo examination of lentigo maligna and malignant melanoma in situ, lentigo maligna type by near-infrared reflectance confocal microscopy: comparison of in vivo confocal images with histologic sections. J. Am. Acad. Dermatol. 46(2), 260–263 (2002).
   PubMed Web of Science ®Google Scholar
• Rajadhyaksha M, González S, Zavislan JM, Anderson RR, Webb RH. In vivo confocal scanning laser microscopy of human skin II: advances in instrumentation and comparison with histology. J. Invest. Dermatol. 113(3), 293–303 (1999).
   PubMed Web of Science ®Google Scholar
• Langley RG, Burton E, Walsh N, Propperova I, Murray SJ. In vivo confocal scanning laser microscopy of benign lentigines: comparison to conventional histology and in vivo characteristics of lentigo maligna. J. Am. Acad. Dermatol. 55(1), 88–97 (2006).
   PubMed Web of Science ®Google Scholar
• Ahlgrimm-Siess V, Massone C, Scope A et al. Reflectance confocal microscopy of facial lentigo maligna and lentigo maligna melanoma: a preliminary study. Br. J. Dermatol. 161(6), 1307–1316 (2009).
   PubMed Web of Science ®Google Scholar
• Wurm EM, Curchin CE, Lambie D, Longo C, Pellacani G, Soyer HP. Confocal features of equivocal facial lesions on severely sun-damaged skin: four case studies with dermatoscopic, confocal, and histopathologic correlation. J. Am. Acad. Dermatol. 66(3), 463–473 (2012).
   PubMed Web of Science ®Google Scholar
• Parasskevas LR, Halpem AC, Marghoob AA. Utility of the Wood’s light: five cases from a pigmented lesion clinic. Br. J. Dermatol. 152(5), 1039–1044 (2005).
   PubMed Web of Science ®Google Scholar
• Guitera P, Pellacani G, Crotty KA et al. The impact of in vivo reflectance confocal microscopy on the diagnostic accuracy of lentigo maligna and equivocal pigmented and nonpigmented macules of the face. J. Invest. Dermatol. 130(8), 2080–2091 (2010).
   PubMed Web of Science ®Google Scholar
• Chen CS, Elias M, Busam K, Rajadhyaksha M, Marghoob AA. Multimodal in vivo optical imaging, including confocal microscopy, facilitates presurgical margin mapping for clinically complex lentigo maligna melanoma. Br. J. Dermatol. 153(5), 1031–1036 (2005).
   PubMed Web of Science ®Google Scholar
• Curiel-Lewandrowski C, Williams CM, Swindells KJ et al. Use of in vivo confocal microscopy in malignant melanoma: an aid in diagnosis and assessment of surgical and nonsurgical therapeutic approaches. Arch. Dermatol. 140(9), 1127–1132 (2004).
   PubMedGoogle Scholar
• Erfan N, Kang HY, Cardot-Leccia N et al. Reflectance confocal microscopy for recurrent lentigo maligna. Dermatol. Surg. 37(10), 1519–1524 (2011).
   PubMed Web of Science ®Google Scholar
• Hinz T, Ehler LK, Voth H et al. Assessment of tumor thickness in melanocytic skin lesions: comparison of optical coherence tomography, 20-MHz ultrasound and histopathology. Dermatology (Basel) 223(2), 161–168 (2011).
   PubMed Web of Science ®Google Scholar
• Al-Niaimi F, Jury CS, McLaughlin S, Herd RM. Review of management and outcome in 65 patients with lentigo maligna. Br. J. Dermatol. 160(1), 211–213 (2009).
   PubMed Web of Science ®Google Scholar
• Farrahi F, Egbert BM, Swetter SM. Histologic similarities between lentigo maligna and dysplastic nevus: importance of clinicopathologic distinction. J. Cutan. Pathol. 32(6), 405–412 (2005).
   PubMed Web of Science ®Google Scholar
• Somach SC, Taira JW, Pitha JV, Everett MA. Pigmented lesions in actinically damaged skin. Histopathologic comparison of biopsy and excisional specimens. Arch. Dermatol. 132(11), 1297–1302 (1996).
   PubMedGoogle Scholar
• Green A, Little JH, Weedon D. The diagnosis of Hutchinson’s melanotic freckle (lentigo maligna) in Queensland. Pathology 15(1), 33–35 (1983).
   PubMed Web of Science ®Google Scholar
• Tannous ZS, Lerner LH, Duncan LM, Mihm MC Jr, Flotte TJ. Progression to invasive melanoma from malignant melanoma in situ, lentigo maligna type. Hum. Pathol. 31(6), 705–708 (2000).
   PubMed Web of Science ®Google Scholar
• Cohen LM. The starburst giant cell is useful for distinguishing lentigo maligna from photodamaged skin. J. Am. Acad. Dermatol. 35(6), 962–968 (1996).
   PubMed Web of Science ®Google Scholar
• Fallowfield ME, Cook MG. Pagetoid infiltration in primary cutaneous melanoma. Histopathology 20(5), 417–420 (1992).
   PubMed Web of Science ®Google Scholar
• Gerami P, Barnhill RL, Beilfuss BA, LeBoit P, Schneider P, Guitart J. Superficial melanocytic neoplasms with pagetoid melanocytosis: a study of interobserver concordance and correlation with FISH. Am. J. Surg. Pathol. 34(6), 816–821 (2010).
   PubMed Web of Science ®Google Scholar
• Tersteegen A, Steigleder GK. Is the involvement of the hair follicles and of the ducts of the sweat glands or the thickness of the epidermis a help in differential diagnosis between lentigo maligna melanoma (LMM) and superficial spreading melanoma in situ (SSM)? Z. Hautkr. 65(10), 941–942 (1990).
   PubMedGoogle Scholar
• Auslender S, Barzilai A, Goldberg I, Kopolovic J, Trau H. Lentigo maligna and superficial spreading melanoma are different in their in situ phase: an immunohistochemical study. Hum. Pathol. 33(10), 1001–1005 (2002).
   PubMed Web of Science ®Google Scholar
• Blake WE, Scurry J, Taylor GI, Bernard S. Melanoma lost in the freckle. ANZ J. Surg. 74(3), 180–182 (2004).
   PubMed Web of Science ®Google Scholar
• Jackson R. Elderly and sun-affected skin. Distinguishing between changes caused by aging and changes caused by habitual exposure to sun. Canadian Fam. Physician 41, 1237–1243 (2001).
   Google Scholar
• Larsen TE, Grude TH. A retrospective histological study of 669 cases of primary cutaneous malignant melanoma in clinical stage I. 6. The relation of dermal solar elastosis to sex, age and survival of the patient and to localization, histological type and level of invasion of the tumour. Acta Pathol. Microbiol. Scand. 87, 255–260 (1979).
   Google Scholar
• Bauer J, Büttner P, Murali R et al. BRAF mutations in cutaneous melanoma are independently associated with age, anatomic site of the primary tumor, and the degree of solar elastosis at the primary tumor site. Pigment Cell Melanoma Res. 24(2), 345–351 (2011).
   PubMed Web of Science ®Google Scholar
• Penneys NS. Microinvasive lentigo maligna melanoma. J. Am. Acad. Dermatol. 17(4), 675–680 (1987).
   PubMed Web of Science ®Google Scholar
• Dalton SR, Fillman EP, Altman CE et al. Atypical junctional melanocytic proliferations in benign lichenoid keratosis. Hum. Pathol. 34(7), 706–709 (2003).
   PubMed Web of Science ®Google Scholar
• Demitsu T, Sakakibara A, Kato T. Lentigo maligna. A unique case with pronounced nesting of atypical melanocytes seen at histologic examination. Int. J. Dermatol. 30(12), 879–880 (1991).
   PubMed Web of Science ®Google Scholar
• Ruiter DJ, van Dijk MC, Ferrier CM. Current diagnostic problems in melanoma pathology. Semin. Cutan. Med. Surg. 22(1), 33–41 (2003).
   PubMed Web of Science ®Google Scholar
• Martinka M, Bruecks AK, Trotter MJ. Histologic spectrum of melanocytic nevi removed from patients > 60 years of age. J. Cutan. Med. Surg. 11(5), 168–173 (2007).
   PubMed Web of Science ®Google Scholar
• Troxel DB. Medicolegal aspects of error in pathology. Arch. Pathol. Lab. Med. 130(5), 617–619 (2006).
   PubMed Web of Science ®Google Scholar
• Troxel DB. Trends in pathology malpractice claims. Am. J. Surg. Pathol. 36(1), e1–e5 (2012).
   PubMed Web of Science ®Google Scholar
• Fallowfield ME, Cook MG. Epidermal melanocytes adjacent to melanoma and the field change effect. Histopathology 17(5), 397–400 (1990).
   PubMed Web of Science ®Google Scholar
• Michaelsen C, Breuninger H, Rassner G, Dietz K. The subclinical portion in the periphery of lentigo maligna and lentigo maligna melanoma. Hautarzt. 41(3), 142–145 (1990).
   PubMed Web of Science ®Google Scholar
• Snell RS. The effect of ultraviolet irradiation on melanogenesis. J. Invest. Dermatol. 40, 127–132 (1963).
   PubMed Web of Science ®Google Scholar
• Scheibner A, Hollis DE, McCarthy WH, Milton GW. Effects of sunlight exposure on Langerhans cells and melanocytes in human epidermis. Photodermatol. 3(1), 15–25 (1986).
   PubMedGoogle Scholar
• Fallowfield ME, Curley RK, Cook MG. Melanocytic lesions and melanocyte populations in human epidermis. Br. J. Dermatol. 124(2), 130–134 (1991).
   PubMed Web of Science ®Google Scholar
• Hendi A, Wada DA, Jacobs MA et al. Melanocytes in nonlesional sun-exposed skin: a multicenter comparative study. J. Am. Acad. Dermatol. 65(6), 1186–1193 (2011).
   PubMed Web of Science ®Google Scholar
• Stolz W, Schmoeckel C, Ryckmanns F, Gross J, Braun-Falco O. Morphometric and ultrastructural analyses of melanocytes, nevus cells, and melanoma cells. Arch. Dermatol. Res. 279(3), 167–172 (1987).
   PubMed Web of Science ®Google Scholar
• Breathnach AS, Nazzaro-Porro M, Passi S, Picardo M. Ultrastructure of melanocytes in chronically sun-exposed skin of elderly subjects. Pigment Cell Res. 4(2), 71–79 (1991).
   PubMedGoogle Scholar
• Bleehen SS, Hartley L, Senior J. Proceedings: lentigo-maligna melanoma: an ultrastructural study. Br. J. Dermatol. 95(Suppl. 14), 14–15 (1976).
   PubMed Web of Science ®Google Scholar
• Miedema J, Marron JS, Niethammer M et al. Image and statistical analysis of melanocytic histology. Histopathology 61(3), 436–444 (2012).
   PubMed Web of Science ®Google Scholar
• Acker SM, Nicholson JH, Rust PF, Maize JC. Morphometric discrimination of melanoma in situ of sun-damaged skin from chronically sun-damaged skin. J. Am. Acad. Dermatol. 39(2 Pt 1), 239–245 (1998).
   PubMed Web of Science ®Google Scholar
• Black WH, Thareja SK, Blake BP, Chen R, Cherpelis BS, Glass LF. Distinction of melanoma in situ from solar lentigo on sun-damaged skin using morphometrics and MITF immunohistochemistry. Am. J. Dermatopathol. 33(6), 573–578 (2011).
   PubMed Web of Science ®Google Scholar
• Bowen AR, Thacker BN, Goldgar DE, Bowen GM. Immunohistochemical staining with Melan-A of uninvolved sun-damaged skin shows features characteristic of lentigo maligna. Dermatol. Surg. 37(5), 657–663 (2011).
   PubMed Web of Science ®Google Scholar
• Hendi A, Brodland DG, Zitelli JA. Melanocytes in long-standing sun-exposed skin: quantitative analysis using the MART-1 immunostain. Arch. Dermatol. 142(7), 871–876 (2006).
   PubMedGoogle Scholar
• Bowen GM, Bowen AR, Florell SR. Lentigo maligna: one size does not fit all. Arch. Dermatol. 147(10), 1211–1213 (2011).
   PubMedGoogle Scholar
• Weyers W, Bonczkowitz M, Weyers I, Bittinger A, Schill WB. Melanoma in situ versus melanocytic hyperplasia in sun-damaged skin. Assessment of the significance of histopathologic criteria for differential diagnosis. Am. J. Dermatopathol. 18(6), 560–566 (1996).
   PubMed Web of Science ®Google Scholar
• Wong CK. A study of melanocytes in the normal skin surrounding malignant melanomata. Dermatologica 141(3), 215–225 (1970).
   PubMedGoogle Scholar
• Barlow JO, Maize J Sr, Lang PG. The density and distribution of melanocytes adjacent to melanoma and nonmelanoma skin cancers. Dermatol. Surg. 33(2), 199–207 (2007).
   PubMed Web of Science ®Google Scholar
• Paul E, Gernand E. Increase of melanocytes around malignant melanoma. Arch. Dermatol. Forsch. 252(4), 275–283 (1975).
   PubMedGoogle Scholar
• Stretch JR, Scolyer RA. Surgical strategies and histopathologic issues in the management of lentigo maligna. Ann. Surg. Oncol. 16(6), 1456–1458 (2009).
   PubMed Web of Science ®Google Scholar
• Kocan P, Jurkovic I, Böör A et al. Immunohistochemical study of melanocytic differentiation antigens in cutaneous malignant melanoma. A comparison of six commercial antibodies and one non-commercial antibody in nodular melanoma, superficially spreading melanoma and lentigo maligna melanoma. Cesk. Patol. 40(2), 50–56 (2004).
   PubMedGoogle Scholar
• Wilson ML, Hossler EW, Ferringer TC, Elston DM. S100-negative junctional melanocytic proliferations. Am. J. Dermatopathol. 33(3), 327–329 (2011).
   PubMed Web of Science ®Google Scholar
• Megahed M, Schön M, Selimovic D, Schön MP. Reliability of diagnosis of melanoma in situ. Lancet 359(9321), 1921–1922 (2002).
   PubMed Web of Science ®Google Scholar
• Ribé A, McNutt NS. S100A protein expression in the distinction between lentigo maligna and pigmented actinic keratosis. Am. J. Dermatopathol. 25(2), 93–99 (2003).
   PubMed Web of Science ®Google Scholar
• Wiltz KL, Qureshi H, Patterson JW, Mayes DC, Wick MR. Immunostaining for MART-1 in the interpretation of problematic intra-epidermal pigmented lesions. J. Cutan. Pathol. 34(8), 601–605 (2007).
   PubMed Web of Science ®Google Scholar
• Helm K, Findeis-Hosey J. Immunohistochemistry of pigmented actinic keratoses, actinic keratoses, melanomas in situ and solar lentigines with Melan-A. J. Cutan. Pathol. 35(10), 931–934 (2008).
   PubMed Web of Science ®Google Scholar
• Lane H, O’Loughlin S, Powell F, Magee H, Dervan PA. A quantitative immunohistochemical evaluation of lentigo maligna and pigmented solar keratosis. Am. J. Clin. Pathol. 100(6), 681–685 (1993).
   PubMed Web of Science ®Google Scholar
• El Shabrawi-Caelen L, Kerl H, Cerroni L. Melan-A: not a helpful marker in distinction between melanoma in situ on sun-damaged skin and pigmented actinic keratosis. Am. J. Dermatopathol. 26(5), 364–366 (2004).
   PubMed Web of Science ®Google Scholar
• Kim J, Taube JM, McCalmont TH, Glusac EJ. Quantitative comparison of MiTF, Melan-A, HMB-45 and Mel-5 in solar lentigines and melanoma in situ. J. Cutan. Pathol. 38(10), 775–779 (2011).
   PubMed Web of Science ®Google Scholar
• Esclamado RM, Gown AM, Vogel AM. Unique proteins defined by monoclonal antibodies specific for human melanoma. Some potential clinical applications. Am. J. Surg. 152(4), 376–385 (1986).
   PubMed Web of Science ®Google Scholar
• Nybakken GE, Sargen M, Abraham R, Zhang PJ, Ming M, Xu X. MITF accurately highlights epidermal melanocytes in atypical intraepidermal melanocytic proliferations. Am. J. Dermatopathol. 35(1), 25–29 (2013).
   PubMed Web of Science ®Google Scholar
• Kimyai-Asadi A, Ayala GB, Goldberg LH, Vujevich J, Jih MH. The 20-minute rapid MART-1 immunostain for malignant melanoma frozen sections. Dermatol. Surg. 34(4), 498–500 (2008).
   PubMed Web of Science ®Google Scholar
• Cherpelis BS, Moore R, Ladd S, Chen R, Glass LF. Comparison of MART-1 frozen sections to permanent sections using a rapid 19-minute protocol. Dermatol. Surg. 35(2), 207–213 (2009).
   PubMed Web of Science ®Google Scholar
• Glass LF, Raziano RM, Clark GS et al. Rapid frozen section immunostaining of melanocytes by microphthalmia-associated transcription factor. Am. J. Dermatopathol. 32(4), 319–325 (2010).
   PubMed Web of Science ®Google Scholar
• Prieto VG, Argenyi ZB, Barnhill RL et al. Are en face frozen sections accurate for diagnosing margin status in melanocytic lesions? Am. J. Clin. Pathol. 120(2), 203–208 (2003).
   PubMed Web of Science ®Google Scholar
• Dinehart MS, Coldiron BM, Hiatt K, Breau RL. Concordance of frozen and permanent sections for the diagnosis of skin lesions. Dermatol. Surg. 36(7), 1111–1115 (2010).
   PubMed Web of Science ®Google Scholar
• Clark WH Jr, Mihm MC Jr. Lentigo maligna and lentigo-maligna melanoma. Am. J. Pathol. 55(1), 39–67 (1969).
   PubMed Web of Science ®Google Scholar
• Jackson R, Williamson GS, Beattie WG. Lentigo maligna and malignant melanoma. Can. Med. Assoc. J. 95(17), 846–851 (1966).
   PubMed Web of Science ®Google Scholar
• Coleman WP, Davis RS, Reed RJ, Krementz ET. Treatment of lentigo maligna and lentigo maligna melanoma in situ. Cancer 77, 888–892 (1996).
   PubMed Web of Science ®Google Scholar
• Clark WH Jr, Ainsworth AM, Bernardino EA, Yang CH, Mihm CM Jr, Reed RJ. The developmental biology of primary human malignant melanomas. Semin. Oncol. 2(2), 83–103 (1975).
   PubMedGoogle Scholar
• Knudsen EA, Thomsen HK. Malignant lentigo melanoma. Ugeskr. Laeg. 156(29), 4251–4252 (1994).
   PubMedGoogle Scholar
• McGovern VJ, Murad TM. Pathology of melanoma; an overview. Cutaneous Melanoma: Clinical Management and Treatment Results Worldwide. Balch CM, Milton GW (Eds). J.B. Lippincott Company, New York, NY, USA (1983).
   Google Scholar
• Wayte DM, Helwig EB. Melanotic freckle of Hutchinson. Cancer 21(5), 893–911 (1968).
   PubMed Web of Science ®Google Scholar
• Weinstock MA, Sober AJ. The risk of progression of lentigo maligna to lentigo maligna melanoma. Br. J. Dermatol. 116(3), 303–310 (1987).
   PubMed Web of Science ®Google Scholar
• Michalik EE, Fitzpatrick TB, Sober AJ. Rapid progression of lentigo maligna to deeply invasive lentigo maligna melanoma. Report of two cases. Arch. Dermatol. 119(10), 831–835 (1983).
   PubMedGoogle Scholar
• Liu W, Dowling JP, Murray WK et al. Rate of growth in melanomas: characteristics and associations of rapidly growing melanomas. Arch. Dermatol. 142(12), 1551–1558 (2006).
   PubMed Web of Science ®Google Scholar
• Knudsen EA, Osterlind AL. Malignant lentigo. Ugeskr. Laeg. 156(29), 4221–4223 (1994).
   PubMedGoogle Scholar
• Balch CM, Murad TM, Soong SJ, Ingalls AL, Halpern NB, Maddox WA. A multifactorial analysis of melanoma: prognostic histopathological features comparing Clark’s and Breslow’s staging methods. Ann. Surg. 188(6), 732–742 (1978).
   PubMed Web of Science ®Google Scholar
• Drzewiecki KT, Andersen PK. Survival with malignant melanoma: a regression analysis of prognostic factors. Cancer 49(11), 2414–2419 (1982).
   PubMed Web of Science ®Google Scholar
• Wanebo HJ, Cooper PH, Young DV, Harpole DH, Kaiser DL. Prognostic factors in head and neck melanoma. Effect of lesion location. Cancer 62(4), 831–837 (1988).
   PubMed Web of Science ®Google Scholar
• Huvos AG, Miké V, Donnellan MJ, Seemayer T, Strong EW. Prognostic factors in cutaneous melanoma of the head and neck. Am. J. Pathol. 71(1), 33–48 (1973).
   PubMed Web of Science ®Google Scholar
• Langford FP, Fisher SR, Molter DW, Seigler HF. Lentigo maligna melanoma of the head and neck. Laryngoscope 103(5), 520–524 (1993).
   PubMed Web of Science ®Google Scholar
• Koh HK, Michalik E, Sober AJ et al. Lentigo maligna melanoma has no better prognosis than other types of melanoma. J. Clin. Oncol. 2(9), 994–1001 (1984).
   PubMed Web of Science ®Google Scholar
• Lachiewicz AM, Berwick M, Wiggins CL, Thomas NE. Survival differences between patients with scalp or neck melanoma and those with melanoma of other sites in the Surveillance, Epidemiology, and End Results (SEER) program. Arch. Dermatol. 144(4), 515–521 (2008).
   PubMed Web of Science ®Google Scholar
• Barbe C, Hibon E, Vitry F, Le Clainche A, Grange F. Clinical and pathological characteristics of melanoma: a population-based study in a French regional population. J. Eur. Acad. Dermatol. Venereol. 26(2), 159–164 (2012).
   PubMed Web of Science ®Google Scholar
• Durbec F, Vitry F, Granel-Brocard F et al. The role of circumstances of diagnosis and access to dermatological care in early diagnosis of cutaneous melanoma: a population-based study in France. Arch. Dermatol. 146(3), 240–246 (2010).
   PubMedGoogle Scholar
• Urist MM, Balch CM, Soong S, Shaw HM, Milton GW, Maddox WA. The influence of surgical margins and prognostic factors predicting the risk of local recurrence in 3445 patients with primary cutaneous melanoma. Cancer 55(6), 1398–1402 (1985).
   PubMed Web of Science ®Google Scholar
• Schmid-Wendtner M-H, Baumert J, Eberele J, Plewig G, Volkenandt M, Sander CA. Disease progression in patients with thin cutaneous melanomas (tumour thickness ≤ 0.75 mm): clinical and epidemiological data from the Tumour Center Munich 1977–1998. British J. Dermatol. 149, 788–793 (2003).
   PubMed Web of Science ®Google Scholar
• Cramer SF, Kiehn CL. Sequential histologic study of evolving lentigo maligna melanoma. Arch. Pathol. Lab. Med. 106(3), 121–125 (1982).
   PubMed Web of Science ®Google Scholar
• Reed RJ, Leonard DD. Neurotropic melanoma. A variant of desmoplastic melanoma. Am. J. Surg. Pathol. 3(4), 301–311 (1979).
   PubMed Web of Science ®Google Scholar
• Su LD, Fullen DR, Lowe L et al. Desmoplastic and neurotropic melanoma: analysis of 33 patients with lymphatic mapping and sentinel lymph node biopsy. Cancer 100, 598–604 (2004).
   PubMed Web of Science ®Google Scholar
• Valensi QJ. Desmoplastic malignant melanoma: a report on two additional cases. Cancer 39(1), 286–292 (1977).
   PubMed Web of Science ®Google Scholar
• Labrecque PG, Hu CH, Winkelmann RK. On the nature of desmoplastic melanoma. Cancer 38(3), 1205–1213 (1976).
   PubMed Web of Science ®Google Scholar
• Conley J, Lattes R, Orr W. Desmoplastic malignant melanoma (a rare variant of spindle cell melanoma). Cancer 28(4), 914–936 (1971).
   PubMed Web of Science ®Google Scholar
• Carlson JA, Dickersin GR, Sober AJ, Barnhill RL. Desmoplastic neurotropic melanoma. A clinicopathologic analysis of 28 cases. Cancer 75(2), 478–494 (1995).
   PubMed Web of Science ®Google Scholar
• Anstey A, McKee P, Jones EW. Desmoplastic malignant melanoma: a clinicopathological study of 25 cases. Br. J. Dermatol. 129(4), 359–371 (1993).
   PubMed Web of Science ®Google Scholar
• Egbert B, Kempson R, Sagebiel R. Desmoplastic malignant melanoma. A clinicohistopathologic study of 25 cases. Cancer 62(9), 2033–2041 (1988).
   PubMed Web of Science ®Google Scholar
• Warner TF, Ford CN, Hafez GR. Neurotropic melanoma of the face invading the maxillary nerve. J. Cutan. Pathol. 12(6), 520–527 (1985).
   PubMed Web of Science ®Google Scholar
• McKenna JK, Florell SR, Goldman GD, Bowen GM. Lentigo maligna/lentigo maligna melanoma: current state of diagnosis and treatment. Dermatol. Surg. 32(4), 493–504 (2006).
   PubMed Web of Science ®Google Scholar
• Cohen LM. Lentigo maligna and lentigo maligna melanoma. J. Am. Acad. Dermatol. 33(6), 923–923; quiz 937 (1995).
   PubMed Web of Science ®Google Scholar
• Smalberger GJ, Siegel DM, Khachemoune A. Lentigo maligna. Dermatol. Ther. 21(6), 439–446 (2008).
   PubMed Web of Science ®Google Scholar
• Stevenson O, Ahmed I. Lentigo maligna: prognosis and treatment options. Am. J. Clin. Dermatol. 6(3), 151–164 (2005).
   PubMed Web of Science ®Google Scholar
• Gaspar ZS, Dawber RP. Treatment of lentigo maligna. Australas. J. Dermatol. 38(1), 1–6; quiz 7 (1997).
   PubMedGoogle Scholar
• Erickson C, Miller SJ. Treatment options in melanoma in situ: topical and radiation therapy, excision and Mohs surgery. Int. J. Dermatol. 49(5), 482–491 (2010).
   PubMed Web of Science ®Google Scholar
• Cohen LM, McCall MW, Zax RH. Mohs micrographic surgery for lentigo maligna and lentigo maligna melanoma. A follow-up study. Dermatol. Surg. 24(6), 673–677 (1998).
   PubMed Web of Science ®Google Scholar
• Ellis LZ, Cohen JL, High W, Stewart L. Melanoma in situ treated successfully using imiquimod after nonclearance with surgery: review of the literature. Dermatol. Surg. 38(6), 937–946 (2012).
   PubMed Web of Science ®Google Scholar
• Coory M, Baade P, Aitken J, Smithers M, McLeod GR, Ring I. Trends for in situ and invasive melanoma in Queensland, Australia, 1982–2002. Cancer Causes Control 17(1), 21–27 (2006).
   PubMed Web of Science ®Google Scholar
• Youl PH, Youlden DR, Baade PD. Changes in the site distribution of common melanoma subtypes in Queensland, Australia over time: implications for public health campaigns. Br. J. Dermatol. 168(1), 136–144 (2013).
   PubMed Web of Science ®Google Scholar
• Whiteman DC, Bray CA, Siskind V, Green AC, Hole DJ, Mackie RM. Changes in the incidence of cutaneous melanoma in the west of Scotland and Queensland, Australia: hope for health promotion? Eur. J. Cancer Prev. 17(3), 243–250 (2008).
   PubMed Web of Science ®Google Scholar
• Bonfá R, Bonamigo RR, Bonfá R, Duro KM, Furian RD, Zelmanowicz Ade M. Early diagnosis of cutaneous melanoma: an observation in southern Brazil. An. Bras. Dermatol. 86(2), 215–221 (2011).
   PubMed Web of Science ®Google Scholar
• Avilés-Izquierdo JA, Lázaro-Ochaita P, Suárez-Fernández R, Márquez-Rodas I, Parra-Blanco V, Escat-Cortés JL. [Epidemiological changes in cutaneous melanoma: retrospective study of 969 cases (1996–2010)]. Rev. Clin. Esp. 213(2), 81–87 (2012).
   PubMed Web of Science ®Google Scholar