Diabetes associated with autoimmune pancreatitis: new insights into the mechanism of β-cell dysfunction

References

• Finkelberg DL, Sahani D, Deshpande V, Brugge WR. Autoimmune pancreatitis. N. Engl. J. Med.355(25), 2670–2676 (2006).
   PubMed Web of Science ®Google Scholar
• Sarles H, Sarles JC, Muratore R, Guien C. Chronic inflammatory sclerosis of the pancreas: an autonomous pancreatic disease. Am. J. Dig. Dis.6, 688–698 (1961).
   PubMedGoogle Scholar
• Yoshida K, Toki F, Takeuchi T, Watanabe S, Shiratori K, Hayashi N. Chronic pancreatitis caused by an autoimmune abnormality: proposal of the concept of autoimmune pancreatitis. Dig. Dis. Sci.40, 1561–1568 (1995).
   PubMed Web of Science ®Google Scholar
• Taniguchi T, Seko S, Okamoto M et al. Association of autoimmune pancreatitis and Type 1 diabetes: autoimmune exocrinopathy and endocrinopathy of the pancreas. Diabetes Care23(10), 1592–1594 (2000).
   Google Scholar
• Okazaki K, Uchida K, Fukui T. Recent advances in autoimmune pancreatitis: concept, diagnosis, and pathogenesis. J. Gastroenterol.43(6), 409–418 (2008).
   PubMed Web of Science ®Google Scholar
• Hamano H, Kawa S, Horiuchi A et al. High serum IgG4 concentrations in patients with sclerosing pancreatitis. N. Engl. J. Med.344(10), 732–738 (2001).
   PubMed Web of Science ®Google Scholar
• Muraki T, Hamano H, Ochi Y et al. Autoimmune pancreatitis and complement activation system. Pancreas32(1), 16–21 (2006).
   PubMed Web of Science ®Google Scholar
• Miyoshi H, Uchida K, Taniguchi T et al. Circulating naïve and CD4+CD25high regulatory T cells in patients with autoimmune pancreatitis. Pancreas36(2), 133–140 (2008).
   PubMed Web of Science ®Google Scholar
• Zen Y, Fujii T, Harada K et al. Th2 and regulatory immune reactions are increased in immunoglobin G4-related sclerosing pancreatitis and cholangitis. Hepatology45(6), 1538–1546 (2007).
   PubMed Web of Science ®Google Scholar
• Satoguina JS, Adjobimey T, Arndts K et al. Tr1 and naturally occurring regulatory T cells induce IgG4 in B cells through GITR/GITR-L interaction, IL-10 and TGF-β. Eur. J. Immunol.38(11), 3101–3113 (2008).
   PubMed Web of Science ®Google Scholar
• Inoue H, Miyatani H, Sawada Y, Yoshida Y. A case of pancreas cancer with autoimmune pancreatitis. Pancreas33(2), 208–209 (2006).
   Google Scholar
• Fukui T, Mitsuyama T, Takaoka M, Uchida K, Matsushita M, Okazaki K. Pancreatic cancer associated with autoimmune pancreatitis in remission. Intern. Med.47(3), 151–155 (2008).
   PubMed Web of Science ®Google Scholar
• Algül H, Treiber M, Lesina M, Schmid RM. Mechanisms of disease: chronic inflammation and cancer in the pancreas – a potential role for pancreatic stellate cells? Nat. Clin. Pract. Gastroenterol. Hepatol.4(8), 454–462 (2007).
   PubMedGoogle Scholar
• Kawaguchi K, Koike M, Tsuruta K, Okamoto A, Tabata I, Fujita N. Lympho-plasmacytic sclerosing pancreatitis with cholangitis: a variant of primary sclerosing cholangitis extensively involving pancreas. Hum. Pathol.22(4), 387–395 (1991).
   PubMed Web of Science ®Google Scholar
• Tanaka S, Kobayashi T, Nakanishi K et al. Corticosteroid-responsive diabetes mellitus associated with autoimmune pancreatitis. Lancet356(9233), 910–911 (2000).
   PubMed Web of Science ®Google Scholar
• Tanaka S, Kobayashi T, Nakanishi K et al. Evidence of primary β-cell destruction by T cells and β-cell differentiation from pancreatic ductal cells in diabetes associated with active autoimmune chronic pancreatitis. Diabetes Care24(9), 1661–1667 (2001).
   PubMedGoogle Scholar
• Tanaka S, Kobayashi T, Nakanishi K et al. Association of HLA-DQ genotype in autoantibody-negative and rapid-onset Type 1 diabetes. Diabetes Care25(12), 2302–2307 (2002).
   Google Scholar
• Kawa S, Ota M, Yoshizawa K et al. HLA DRB10405-DQB10401 haplotype is associated with autoimmune pancreatitis in the Japanese population. Gastroenterology122(5), 1264–1269 (2002).
   PubMed Web of Science ®Google Scholar
• Umemura T, Ota M, Hamano H, Katsuyama Y, Kiyosawa K, Kawa S. Genetic association of Fc receptor-like 3 polymorphisms with autoimmune pancreatitis in Japanese patients. Gut55(9), 1367–1368 (2006).
   PubMed Web of Science ®Google Scholar
• Chang MC, Chang YT, Tien YW et al. T-cell regulatory gene CTLA-4 polymorphism/haplotype association with autoimmune pancreatitis. Clin. Chem.53(9), 1700–1705 (2007).
   PubMed Web of Science ®Google Scholar
• Umemura T, Ota M, Hamano H et al. Association of autoimmune pancreatitis with cytotoxic T-lymphocyte antigen 4 gene polymorphisms in Japanese patients. Am. J. Gastroenterol.103(3), 588–594 (2008).
   PubMed Web of Science ®Google Scholar
• Ueda H, Howson JM, Esposito L et al. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 29, 423(6939), 506–511 (2003).
   PubMed Web of Science ®Google Scholar
• Kamisawa T, Yoshiike M, Egawa N, Nakajima H, Tsuruta K, Okamoto A. Treating patients with autoimmune pancreatitis: results from a long-term follow-up study. Pancreatology5(2–3), 234–238 (2005).
   PubMed Web of Science ®Google Scholar
• Nishimori I, Tamakoshi A, Kawa S et al. Research committee on intractable pancreatic diseases, the ministry of health and welfare of Japan. Influence of steroid therapy on the course of diabetes mellitus in patients with autoimmune pancreatitis: findings from a nationwide survey in Japan. Pancreas32(3), 244–248 (2006).
   PubMed Web of Science ®Google Scholar
• Uchida K, Yazumi S, Nishio A et al. Long-term outcome of autoimmune pancreatitis. J. Gastroenterol.44(7), 726–732 (2009).
   PubMed Web of Science ®Google Scholar
• Nishino T, Toki F, Oyama H, Shimizu K, Shiratori K. Long-term outcome of autoimmune pancreatitis after oral prednisolone therapy. Intern. Med.45(8), 497–501 (2006).
   PubMed Web of Science ®Google Scholar
• Takayama M, Hamano H, Ochi Y et al. Recurrent attacks of autoimmune pancreatitis result in pancreatic stone formation. Am. J. Gastroenterol.99(5), 932–937 (2004).
   PubMed Web of Science ®Google Scholar
• Ito T, Kawabe K, Arita Y et al. Evaluation of pancreatic endocrine and exocrine function in patients with autoimmune pancreatitis. Pancreas34(2), 254–259 (2007).
   PubMed Web of Science ®Google Scholar
• Davidson TS, Longnecker DS, Hickey WF. An experimental model of autoimmune pancreatitis in the rat. Am. J. Pathol.166(3), 729–736 (2005).
   Google Scholar
• Uchida K, Okazaki K, Nishi T et al. Experimental immune-mediated pancreatitis in neonatally thymectomized mice immunized with carbonic anhydrase II and lactoferrin. Lab. Invest.82(4), 411–424 (2002).
   PubMed Web of Science ®Google Scholar
• Guarneri F, Guarneri C, Benvenga S. Helicobacter pylori and autoimmune pancreatitis: role of carbonic anhydrase via molecular mimicry? J. Cell. Mol. Med.9(3), 741–744 (2005).
   Google Scholar
• Bhatia M. Molecular mimicry in autoimmune pancreatitis: an interesting idea. J. Cell. Mol. Med.9(3), 745 (2005).
   Google Scholar
• Kountouras J, Zavos C, Gavalas E, Tzilves D. Challenge in the pathogenesis of autoimmune pancreatitis: potential role of Helicobacter pylori infection via molecular mimicry. Gastroenterology133(1), 368–369(2007).
   Google Scholar
• Asada M, Nishio A, Uchida K et al. Identification of a novel autoantibody against pancreatic secretory trypsin inhibitor in patients with autoimmune pancreatitis. Pancreas33(1), 20–26 (2006).
   PubMed Web of Science ®Google Scholar
• Niki S, Oshikawa K, Mouri Y et al. Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice. J. Clin. Invest.116(5), 1292–1301 (2006).
   PubMed Web of Science ®Google Scholar
• Desilva MG, Lu J, Donadel G et al. Characterization and chromosomal localization of a new protein disulfide isomerase, PDIp, highly expressed in human pancreas. DNA Cell Biol.15(1), 9–16 (1996).
   Google Scholar
• Endo T, Takizawa S, Tanaka S et al. Amylase α-2A autoantibodies: novel marker of autoimmune pancreatitis and fulminant Type 1 diabetes. Diabetes58, 732–737, (2009).
   PubMed Web of Science ®Google Scholar
• Kobayashi T. Immunology and immunogenetics of Type 1 diabetes in Japan. IDF Bulletin35, 34–37 (1990).
   Google Scholar
• Imagawa A, Hanafusa T, Miyagawa J, Matsuzawa Y. A novel subtype of Type 1 diabetes mellitus characterized by a rapid onset and an absence of diabetes-related antibodies. Osaka IDDM study group. N. Engl. J. Med.342, 301–307 (2000).
   PubMedGoogle Scholar
• Imagawa A, Hanafusa T, Uchigata Y et al. Fulminant Type 1 diabetes: a nationwide survey in Japan. Diabetes Care26, 2345–2352 (2003).
   Google Scholar
• Tanaka S, Endo T, Aida K et al. Distinct diagnostic criteria of fulminant Type 1 diabetes based on serum C-peptide response and HbA1c levels at onset. Diabetes Care27, 1936–1941 (2004).
   Google Scholar
• Tanaka S, Kobayashi T, Momotsu T. A novel subtype of Type 1 diabetes mellitus. N. Engl. J. Med.342, 1835–1837 (2000).
   Google Scholar
• Sekine N et al. Rapid loss of insulin secretion in a patient with fulminant Type 1 diabetes mellitus and carbamazepine hypersensitivity syndrome. JAMA285, 1153–1154 (2001).
   Google Scholar
• Imagawa A et al. High titres of IgA antibodies to enterovirus in fulminant Type-1 diabetes. Diabetologia48, 290–293 (2005).
   Google Scholar
• Sano H, Terasaki J, Tsutsumi C, Imagawa A, Hanafusa T. A case of fulminant Type 1 diabetes mellitus after influenza B infection. Diabetes Res. Clin. Pract.79(3), E8–E9 (2008).
   Google Scholar
• Goto A, Takahashi Y, Kishimoto M et al. A case of fulminant Type 1 diabetes associated with significant elevation of mumps titers. Endocr. J.55(3), 561–564 (2008).
   Google Scholar
• Meagher C, Tang Q, Fife BT et al. Spontaneous development of a pancreatic exocrine disease in CD28-deficient NOD mice. J. Immunol.180(12), 7793–7803 (2008).
   PubMed Web of Science ®Google Scholar
• Takizawa S, Endo T, Wanjia X, Tanaka S, Takahashi M, Kobayashi T. HSP 10 is a new autoantigen in both autoimmune pancreatitis and fulminant Type 1 diabetes. Biochem Biophys Res Commun.386(1), 192–196 (2009).
   PubMed Web of Science ®Google Scholar
• Ohashi K, Burkart V, Flohe S, Kolb H, Cutting edge: heat shock protein 60 is a putative endogenous ligand of the Toll-like receptor-4 complex. J. Immunol.164(2), 558–561 (2000).
   PubMed Web of Science ®Google Scholar
• Johnson BJ, Le TT, Dobbin CA et al. Heat shock protein 10 inhibits lipopolysaccharide-induced inflammatory mediator production. J. Biol. Chem.280, 4037–4047 (2005).
   PubMed Web of Science ®Google Scholar
• Qu WM, Miyazaki T, Terada M et al. A novel autoimmune pancreatitis model in MRL mice treated with polyinosinic:polycytidylic acid. Clin. Exp. Immunol.129(1), 27–34 (2002).
   PubMed Web of Science ®Google Scholar
• Kawauchi Y, Suzuki K, Watanabe S et al. Role of IP-10/CXCL10 in the progression of pancreatitis-like injury in mice after murine retroviral infection. Am. J. Physiol. Gastrointest. Liver Physiol.291(2), G345–G354 (2006).
   Google Scholar
• Singh L, Bakshi DK, Majumdar S, Vasishta RK, Arora SK, Wig JD. Expression of interferon-γ-inducible protein-10 and its receptor CXCR3 in chronic pancreatitis. Pancreatology7(5–6), 479–490 (2007).
   Google Scholar
• Fitzner B, Holzhueter SA, Ibrahim S, Nizze H, Jaster R. Interferon-γ treatment accelerates and aggravates autoimmune pancreatitis in the MRL/Mp-mouse. Pancreatology9(3), 233–239 (2009).
   PubMedGoogle Scholar
• Sorg H, Lorch B, Jaster R et al. Early rise in inflammation and microcirculatory disorder determine the development of autoimmune pancreatitis in the MRL/Mp-mouse. Am. J. Physiol. Gastrointest. Liver Physiol.295(6), G1274–80 (2008).
   Google Scholar
• Klöppel G, Lüttges J, Sipos B, Capelli P, Zamboni G. Autoimmune pancreatitis: pathological findings. JOP6(1 Suppl.), 97–101 (2005).
   PubMedGoogle Scholar
• Arai S, Shimura H, Takizawa S et al. Amylase gene is expressed in pancreatic β-cell line and increased by Th1 cytokines. Diabetes57(Suppl. 1), A351 (2008).
   Google Scholar
• Wang J, Yoshida T, Nakaki F, Hiai H, Okazaki T, Honjo T. Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes. Proc. Natl Acad. Sci USA102(33), 11823–11828 (2005).
   PubMed Web of Science ®Google Scholar
• Kamisawa T. IgG4-positive plasma cells specifically infiltrate various organs in autoimmune pancreatitis. Pancreas29(2), 167–168 (2004).
   PubMedGoogle Scholar
• Gu D, Sarvetnick N. Epithelial cell proliferation and islet neogenesis in IFN-γ transgenic mice. Development118, 33–46 (1993).
   PubMed Web of Science ®Google Scholar
• Campbell IL, Hobbs MV, Dockter J, Oldstone MBA, Allison J. Islet inflammation and hyperplasia induced by the pancreatic islet-specific overexpression of interleukin-6 in transgenic mice. Am. J. Pathol.145, 157–166 (1994).
   PubMed Web of Science ®Google Scholar
• Higuchi Y, Herrera P, Muniesa P et al. Expression of a tumor necrosis factor a transgene in murine pancreatic β cells results in severe and permanent insulitis without evolution towards diabetes. J. Exp. Med.176, 1719–1731 (1992).
   PubMed Web of Science ®Google Scholar
• Kritzik MR, Jones E, Chen Z et al. PDX-1 and Msx-2 expression in the regenerating and developing Pancreas. J. Endocrinol.163, 523–530 (1999).
   PubMedGoogle Scholar
• Wiley JW, Pietropaolo M. Autoimmune pancreatitis: the emerging role of serologic biomarkers. Diabetes58(3), 520–522 (2009).
   Google Scholar