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Combination therapy for patients with Type 2 diabetes: repaglinide in combination with metformin

Pages 331-342 | Published online: 10 Jan 2014

References

  • Campbell RK, Neumiller JJ, White J, Sisson E, Kuhn C. Type 2 diabetes: epidemiology and treatment, pathophysiology, new therapeutics, and the evolving role of the pharmacist [abstract]. J. Am. Pharm. Assoc.49(Suppl. 1), S2 (2009).
  • Milicevic Z, Raz I, Beattie SD et al. Natural history of cardiovascular disease in patients with diabetes: role of hyperglycemia. Diabetes Care31(Suppl. 2), S155–S160 (2008).
  • Tibaldi J. Importance of postprandial glucose levels as a target for glycemic control in Type 2 diabetes. South Med. J.102(1), 60–66 (2009).
  • Rodbard HW, Jellinger PS, Davidson JA et al. Statement by an American Association of Clinical Endocrinologists/American College of Endocrinology consensus panel on Type 2 diabetes mellitus: an algorithm for glycemic control. Endocr. Pract.15(6), 540–559 (2009).
  • American Diabetes Association. Standards of medical care in diabetes – 2009. Diabetes Care32(Suppl. 1), S13–S61 (2009).
  • Nathan DM, Buse JB, Davidson MB et al. Medical management of hyperglycaemia in Type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia52, 17–30 (2009).
  • Saaddine JB, Cadwell B, Gregg EW et al. Improvements in diabetes processes of care and intermediate outcomes: United States, 1988-2002. Ann. Intern. Med.144(7), 465–474 (2006).
  • Monnier L. Is postprandial glucose a neglected cardiovascular risk factor in Type 2 diabetes? Eur. J. Clin. Invest.30(Suppl. 2), 3–11 (2000).
  • Gale EA. Glucose control in the UKPDS: what did we learn? Diabet. Med.25(Suppl. 2), 9–12 (2008).
  • UK Prospective Diabetes Study Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with Type 2 diabetes (UKPDS 33). Lancet352(9131), 837–853 (1998).
  • Gaede P, Lund-Andersen H, Parving HH, Pedersen O. Effect of a multifactorial intervention on mortality in Type 2 diabetes. N. Engl. J. Med.358(6), 580–591 (2008).
  • Evans AJ, Krentz AJ. Insulin resistance and β-cell dysfunction as therapeutic targets in Type 2 diabetes. Diabetes Obes. Metab.3(4), 219–229 (2001).
  • Turner RC, Cull CA, Frighi V, Holman RR. Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with Type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). JAMA281(21), 2005–2012 (1999).
  • UK Prospective Diabetes Study Group. UKPDS 28: a randomized trial of efficacy of early addition of metformin in sulfonylurea-treated Type 2 diabetes. Diabetes Care21(1), 87–92 (1998).
  • UK Prospective Diabetes Study Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with Type 2 diabetes (UKPDS 34). Lancet352(9131), 854–865 (1998).
  • UK Prospective Diabetes Study Group. Overview of 6 years’ therapy of Type II diabetes: a progressive disease. Diabetes44(11), 1249–1258 (1995).
  • Raskin P. Oral combination therapy: repaglinide plus metformin for treatment of Type 2 diabetes. Diabetes Obes. Metab.10(12), 1167–1177 (2008).
  • Van Gaal LF, De Leeuw IH. Rationale and options for combination therapy in the treatment of Type 2 diabetes. Diabetologia46(Suppl. 1), M44–M50 (2003).
  • Hinnen D, Nielsen LL, Waninger A, Kushner P. Incretin mimetics and DPP-IV inhibitors: new paradigms for the treatment of Type 2 diabetes. J. Am. Board Fam. Med.19(6), 612–620 (2006).
  • Nathan DM. Finding new treatments for diabetes – how many, how fast... how good? N. Engl. J. Med.356(5), 437–440 (2007).
  • Del PS, Bianchi C, Marchetti P. β-cell function and anti-diabetic pharmacotherapy. Diabetes Metab. Res. Rev.23(7), 518–527 (2007).
  • Bailey CJ, Day C. Antidiabetic drugs. Br. J. Cardiol.10, 128–136 (2003).
  • van de Laar FA. α-glucosidase inhibitors in the early treatment of Type 2 diabetes. Vasc. Health Risk Manag.4(6), 1189–1195 (2008).
  • Krentz AJ, Bailey CJ. Oral antidiabetic agents: current role in Type 2 diabetes mellitus. Drugs65(3), 385–411 (2005).
  • Derosa G, Salvadeo SA, D’Angelo A et al. Metabolic effect of repaglinide or acarbose when added to a double oral antidiabetic treatment with sulphonylureas and metformin: a double-blind, cross-over, clinical trial. Curr. Med. Res. Opin.25(3), 607–615 (2009).
  • Delorme S, Chiasson JL. Acarbose in the prevention of cardiovascular disease in subjects with impaired glucose tolerance and Type 2 diabetes mellitus. Curr. Opin. Pharmacol.5(2), 184–189 (2005).
  • Schramm TK, Gislason G, Vaag A et al. Differences in risk of cardiovascular death according to type of oral glucose-lowering therapy in patients with diabetes: a nationwide study [abstract]. Diabetes58(Suppl. 1), A24 (2009).
  • Derosa G, Sibilla S. Optimizing combination treatment in the management of Type 2 diabetes. Vasc. Health Risk Manag.3(5), 665–671 (2007).
  • Black C, Donnelly P, McIntyre L, Royle PL, Shepherd JP, Thomas S. Meglitinide analogues for Type 2 diabetes mellitus. Cochrane Database Syst. Rev. (2), CD004654 (2007).
  • Johansen OE, Birkeland KI. Defining the role of repaglinide in the management of Type 2 diabetes mellitus: a review. Am. J. Cardiovasc. Drugs7(5), 319–335 (2007).
  • Fuhlendorff J, Rorsman P, Kofod H et al. Stimulation of insulin release by repaglinide and glibenclamide involves both common and distinct processes. Diabetes47(3), 345–351 (1998).
  • Kristensen JS, Frandsen KB, Bayer TH, Muller P. Repaglinide treatment is associated with significantly less severe hypoglycaemic events compared to sulphonylurea [abstract]. Diabetologia42(Suppl. 1), A4 (1999).
  • Bosi E. Metformin – the gold standard in Type 2 diabetes: what does the evidence tell us? Diabetes Obes. Metab.11(Suppl. 2), 3–8 (2009).
  • Nichols GA, Alexander CM, Girman CJ, Kamal-Bahl SJ, Brown JB. Treatment escalation and rise in HbA1c following successful initial metformin therapy. Diabetes Care29(3), 504–509 (2006).
  • Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. β-cell deficit and increased β-cell apoptosis in humans with Type 2 diabetes. Diabetes52(1), 102–110 (2003).
  • Hundal RS, Krssak M, Dufour S et al. Mechanism by which metformin reduces glucose production in Type 2 diabetes. Diabetes49(12), 2063–2069 (2000).
  • Hermann LS, Lindberg G, Lindblad U, Melander A. Efficacy, effectiveness and safety of sulphonylurea–metformin combination therapy in patients with Type 2 diabetes. Diabetes Obes. Metab.4(5), 296–304 (2002).
  • Evans JM, Ogston SA, Emslie-Smith A, Morris AD. Risk of mortality and adverse cardiovascular outcomes in Type 2 diabetes: a comparison of patients treated with sulfonylureas and metformin. Diabetologia49(5), 930–936 (2006).
  • Gulliford M, Latinovic R. Mortality in Type 2 diabetic subjects prescribed metformin and sulphonylurea drugs in combination: cohort study. Diabetes Metab. Res. Rev.20(3), 239–245 (2004).
  • Kahler KH, Rajan M, Rhoads GG et al. Impact of oral antihyperglycemic therapy on all-cause mortality among patients with diabetes in the Veterans Health Administration. Diabetes Care30(7), 1689–1693 (2007).
  • Rao AD, Kuhadiya N, Reynolds K, Fonseca VA. Is the combination of sulfonylureas and metformin associated with an increased risk of cardiovascular disease or all-cause mortality?: a meta-analysis of observational studies. Diabetes Care31(8), 1672–1678 (2008).
  • Lund SS, Tarnow L, Stehouwer CD et al. Impact of metformin versus repaglinide on non-glycaemic cardiovascular risk markers related to inflammation and endothelial dysfunction in non-obese patients with Type 2 diabetes. Eur. J. Endocrinol.158(5), 631–641 (2008).
  • Monami M, Luzzi C, Lamanna C et al. Three-year mortality in diabetic patients treated with different combinations of insulin secretagogues and metformin. Diabetes Metab. Res. Rev.22(6), 477–482 (2006).
  • Vilsboll T, Knop FK. Review: DPP IV inhibitors – current evidence and future directions. Br. J. Diab. Vasc. Dis.7, 69 (2009).
  • Lund SS, Tarnow L, Frandsen M et al. Impact of metformin versus the prandial insulin secretagogue, repaglinide, on fasting and postprandial glucose and lipid responses in non-obese patients with Type 2 diabetes. Eur. J. Endocrinol.158(1), 35–46 (2008).
  • Vila-Carriles WH, Zhao G, Bryan J. Defining a binding pocket for sulfonylureas in ATP-sensitive potassium channels. FASEB J.21(1), 18–25 (2007).
  • Ashcroft FM, Rorsman P. Electrophysiology of the pancreatic β-cell. Prog. Biophys. Mol. Biol.54(2), 87–143 (1989).
  • Malaisse WJ. Repaglinide, a new oral antidiabetic agent: a review of recent preclinical studies. Eur. J. Clin. Invest.29(Suppl. 2), 21–29 (1999).
  • Kofod H, Fuhlendorff J. Effect of repaglinide on insulin release in isolated islets of Labgerhans is unaffected by metabolic stress induced by dinitrophenol [abstract]. Eur. J. Endocrinol.132(Suppl. 1), 14 (1995).
  • Mannucci E, Tesi F, Bardini G et al. Effects of metformin on glucagon-like peptide-1 levels in obese patients with and without Type 2 diabetes. Diabetes Nutr. Metab.17(6), 336–342 (2004).
  • Strack T. Metformin: a review. Drugs Today (Barc. )44(4), 303–314 (2008).
  • Hatorp V. Clinical pharmacokinetics and pharmacodynamics of repaglinide. Clin. Pharmacokinet.41(7), 471–483 (2002).
  • Tronier B, Marbury TC, Damsbo P, Windfeld K. A new oral hypoglycemic agent, repaglinide minimizes risk of hypoglycemia in well controlled NIDDM patients [abstract]. Diabetes44(Suppl. 1), 70A (1995).
  • Hasslacher C, Multinational Repaglinide Renal Study Group. Safety and efficacy of repaglinide in Type 2 diabetic patients with and without impaired renal function. Diabetes Care26(3), 886–891 (2003).
  • Schumacher S, Abbasi I, Weise D et al. Single- and multiple-dose pharmacokinetics of repaglinide in patients with Type 2 diabetes and renal impairment. Eur. J. Clin. Pharmacol.57(2), 147–152 (2001).
  • Marbury TC, Ruckle JL, Hatorp V et al. Pharmacokinetic of repaglinide in subjects with renal impairment. Clin. Pharmacol. Ther.67(1), 7–15 (2000).
  • Hoelscher D, Chu PL, Lyness W. Fixed-dose combination tablet of repaglinide and metformin is bioequivalent to concomitantly administered individual tablets of repaglinide and metformin: randomized, single-blind, three-period crossover study in healthy subjects. Clin. Drug Invest.28(9), 573–582 (2008).
  • Sturis J, Elm T, Due AL, Carr R. Combination of repaglinide and metformin results in greater than additive (synergistic) effects on glucose tolerance in obese Zucker (fa/fa) rats [abstract]. Diabetes52(Suppl. 1), A457 (2003).
  • Hollingdal M, Sturis J, Gall MA et al. Repaglinide treatment amplifies first-phase insulin secretion and high-frequency pulsatile insulin release in Type 2 diabetes. Diabet. Med.22(10), 1408–1413 (2005).
  • Rudovich NN, Leyck Dieken MG, Rochlitz H, Pfeiffer AF. Enhancement of early- and late-phase insulin secretion and insulin sensitivity by the combination of repaglinide and metformin in Type 2 diabetes mellitus. Exp. Clin. Endocrinol. Diabetes112(7), 395–400 (2004).
  • Moses R. Repaglinide in combination therapy with metformin in Type 2 diabetes. Exp. Clin. Endocrinol. Diabetes107(Suppl. 4), S136–S139 (1999).
  • Setter SM, Iltz JL, Thams J, Campbell RK. Metformin hydrochloride in the treatment of Type 2 diabetes mellitus: a clinical review with a focus on dual therapy. Clin. Ther.25(12), 2991–3026 (2003).
  • Moses R, Slobodniuk R, Boyages S et al. Effect of repaglinide addition to metformin monotherapy on glycemic control in patients with Type 2 diabetes. Diabetes Care22(1), 119–124 (1999).
  • Raskin P, Klaff L, McGill J et al. Efficacy and safety of combination therapy: repaglinide plus metformin versus nateglinide plus metformin. Diabetes Care26(7), 2063–2068 (2003).
  • Soegondo S, Subekti I, Luthariana L. The efficacy of repaglinide monotherapy and in combination with metformin in Indonesian Type 2 diabetes mellitus patients. Acta Med. Indones.36(3), 142–147 (2004).
  • Shapiro MS, Abrams Z, Lieberman N. Clinical experience with repaglinide in patients with non-insulin-dependent diabetes mellitus. Isr. Med. Assoc. J.7(2), 75–77 (2005).
  • Reboussin DM, Goff DC Jr, Lipkin EW et al. The combination oral and nutritional treatment of late-onset diabetes mellitus (CONTROL DM) trial results. Diabet. Med.21(10), 1082–1089 (2004).
  • Jinagouda S. Combination therapy in Type 2 diabetes: repaglinide/metformin vs glyburide/metformin. Diabetes50(Suppl. 2), (2001) (Abstract A439).
  • Raskin P, Lewin A, Reinhardt R, Lyness W. Twice-daily dosing of a repaglinide/metformin fixed-dose combination tablet provides glycaemic control comparable to rosiglitazone/metformin tablet. Diabetes Obes. Metab.11(9), 865–873 (2009).
  • Marbury T, Huang WC, Strange P, Lebovitz H. Repaglinide versus glyburide: a one-year comparison trial. Diabetes Res. Clin. Pract.43(3), 155–166 (1999).
  • Wolffenbuttel BH, Landgraf R. A 1-year multicenter randomized double-blind comparison of repaglinide and glyburide for the treatment of Type 2 diabetes. Dutch and German Repaglinide Study Group. Diabetes Care22(3), 463–467 (1999).
  • Derosa G, Mugellini A, Ciccarelli L, Crescenzi G, Fogari R. Comparison of glycaemic control and cardiovascular risk profile in patients with Type 2 diabetes during treatment with either repaglinide or metformin. Diabetes Res. Clin. Pract.60(3), 161–169 (2003).
  • Kahn SE, Haffner SM, Heise MA et al. Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. N. Engl. J. Med.355(23), 2427–2443 (2006).
  • Bech P, Moses R, Gomis R. The effect of prandial glucose regulation with repaglinide on treatment satisfaction, wellbeing and health status in patients with pharmacotherapy naive Type 2 diabetes: a placebo-controlled, multicentre study. Qual. Life Res.12(4), 413–425 (2003).
  • Schatz H. Preclinical and clinical studies on safety and tolerability of repaglinide. Exp. Clin. Endocrinol. Diabetes107(Suppl. 4), S144–S148 (1999).
  • Hatorp V, Thomsen MS. Drug interaction studies with repaglinide: repaglinide on digoxin or theophylline pharmacokinetics and cimetidine on repaglinide pharmacokinetics. J. Clin. Pharmacol.40(2), 184–192 (2000).
  • Jovanovic L, Hassman DR, Gooch B et al. Treatment of Type 2 diabetes with a combination regimen of repaglinide plus pioglitazone. Diabetes Res. Clin. Pract.63(2), 127–134 (2004).
  • Kajosaari LI, Jaakkola T, Neuvonen PJ, Backman JT. Pioglitazone, an in vitro inhibitor of CYP2C8 and CYP3A4, does not increase the plasma concentrations of the CYP2C8 and CYP3A4 substrate repaglinide. Eur. J. Clin. Pharmacol.62(3), 217–223 (2006).
  • Hatorp V, Hansen KT, Thomsen MS. Influence of drugs interacting with CYP3A4 on the pharmacokinetics, pharmacodynamics, and safety of the prandial glucose regulator repaglinide. J. Clin. Pharmacol.43(6), 649–660 (2003).
  • Niemi M, Backman JT, Neuvonen M, Neuvonen PJ. Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics and pharmacodynamics of repaglinide: potentially hazardous interaction between gemfibrozil and repaglinide. Diabetologia46(3), 347–351 (2003).
  • Scheen AJ. Drug–drug and food–drug pharmacokinetic interactions with new insulinotropic agents repaglinide and nateglinide. Clin. Pharmacokinet.46(2), 93–108 (2007).
  • Palmer AJ, Roze S, Lammert M et al. Comparing the long-term cost-effectiveness of repaglinide plus metformin versus nateglinide plus metformin in Type 2 diabetes patients with inadequate glycaemic control: an application of the CORE diabetes model in Type 2 diabetes. Curr. Med. Res. Opin.20(Suppl. 1), S41–S51 (2004).
  • Bangalore S, Kamalakkannan G, Parkar S, Messerli FH. Fixed-dose combinations improve medication compliance: a meta-analysis. Am. J. Med.120(8), 713–719 (2007).

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