Skeletal muscle mitochondrial dysfunction in Type 2 diabetes

References

• Mokdad AH, Ford ES, Bowman BA et al. Prevalence of obesity, diabetes and obesity-related health risk factors. JAMA1, 76–79 (2003).
   Google Scholar
• Reaven GM. Pathophysiology of insulin resistance in human disease. Physiol. Rev.75, 473–486 (1995).
   PubMed Web of Science ®Google Scholar
• Befroy DE, Petersen KF, Dufour S et al. Impaired mitochondrial oxidation in muscle of insulin resistant offspring of Type 2 diabetic patients. Diabetes56, 1376–1381 (2007).
   PubMed Web of Science ®Google Scholar
• Hancock CR, Hancock CR, Han DH et al. High-fat diets cause insulin resistance despite an increase in muscle mitochondria. Proc. Natl Acad. Sci. USA105, 7815–7820 (2008).
   PubMed Web of Science ®Google Scholar
• Bonen A, Parolin ML, Steinberg GR et al. Triaglycerol accumulation in human obesity and Type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD 36. FASEB J.18, 1144–1146 (2004).
   PubMed Web of Science ®Google Scholar
• Koves TR, Ussher JR, Noland RC et al. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab.7, 45–56 (2008).
   PubMed Web of Science ®Google Scholar
• Hirabara SM, Curi R, Maechler P. Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells. J. Cell. Physiol.222, 187–194 (2010).
   PubMed Web of Science ®Google Scholar
• Kelly DE, He J, Menshikova EV, Ritov VB. Dysfunction of mitochondria in human skeletal muscle in Type 2 diabetes. Diabetes51, 2944–2950 (2002).
   Google Scholar
• Menshikova EV, Ritov VB, Toledo FG, Ferrell RE, Goodpaster BH, Kelly DE. Effects of weight loss and physical activity on skeletal muscle mitochondrial function in obesity. Am. J. Physiol. Endocrinol. Metab.288, E818–E825 (2005).
   PubMed Web of Science ®Google Scholar
• Ritov VB, Menshikova EV, Azuma K et al. Deficiency of electron transport chain in human skeletal muscle mitochondria in Type 2 diabetes mellitus and obesity. Am. J. Physiol. Endocrinol. Metab.298, E49–E58 (2010).
   PubMed Web of Science ®Google Scholar
• Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI. Impaired mitochondrial activity in the insulin resistant offspring of patients with Type 2 diabetes. N. Engl. J. Med.350, 664–671 (2004).
   PubMed Web of Science ®Google Scholar
• Boushel R, Gnaiger E, Schjerling P, Skovbro M, Krounsoe R, Dela F. Patients with Type 2 diabetes have normal mitochondrial function in skeletal muscle. Diabetologia50, 790–796 (2007).
   PubMed Web of Science ®Google Scholar
• Ortenblad N, Morgensen M, Petersen I et al. Reduced insulin mediated citrate synthase activity in cultured skeletal muscle cells from patients with Type 2 diabetes: evidence for an intrinsic oxidative enzyme defect. Biochim. Biophys. Acta1741, 2006–2214 (2005).
   Google Scholar
• Petersen KF, Dufour S, Shulman GI. Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of Type 2 diabetic parents. PLoS Med.2, E233 (2005).
   PubMed Web of Science ®Google Scholar
• Morino K, Petersen KF, Dufour S et al. Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin resistant offspring of Type 2 diabetic patients. J. Clin. Invest.15(21), 3587–3593 (2005).
   Google Scholar
• Szendroedi J, Schmid AI, Chmelik M et al. Muscle mitochondrial ATP synthesis and glucose transport/phosphorylation in Type 2 diabetes. PLoS Med.4, E154 (2007).
   Web of Science ®Google Scholar
• Patti ME, Butte AJ, Crunkhorn S et al. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes. Potential role of PGC1 and NRF1. Proc. Natl Acad. Sci. USA100, 8466–8471 (2003).
   PubMed Web of Science ®Google Scholar
• Toledo FG, Watkins S, Kelly DE et al. Changes induced by physical activity and weight loss in the morphology of intermyofibrillar mitochondria in obese men and women. J. Clin. Endocrinol. Metab.1, 3224–3227 (2006).
   Google Scholar
• Mogensen M, Sahlin K, Fernström M et al. Mitochondrial respiration is decreased in skeletal muscle of patients with Type 2 diabetes. Diabetes56, 1592–1599 (2007).
   PubMed Web of Science ®Google Scholar
• Phielix E, Schrauwen-Hinderling VB, Mensink M et al. Lower intrinsic ADP-stimulated mitochondrial respiration underlies in vivo mitochondrial dysfunction in muscles of male Type 2 diabetic patients. Diabetes57, 2943–2949 (2008).
   PubMed Web of Science ®Google Scholar
• Mensink M, Hesselink MK, Russel AP et al. Improved skeletal muscle oxidative enzyme activity and restoration of PGC-1 a and PPAR b/d gene expression upon rosiglitazone treatment in obese patients with Type 2 diabetes mellitus. Int. J. Obes.31, 1302–1310 (2007).
   PubMed Web of Science ®Google Scholar
• Hwang H, Bowen BP, Lefort N et al. Proteomics analysis of human skeletal muscle reveals novel abnormalities in obesity and Type 2 diabetes. Diabetes59, 33–42 (2010).
   PubMed Web of Science ®Google Scholar
• Bach D, Naon D, Pich S et al. Expression of Mfn2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 obesity, weight loss, and the regulatory role of tumor necrosis factor a and interleukin-6. Diabetes54, 2685–2693 (2005).
   PubMed Web of Science ®Google Scholar
• Toledo FG, Menshikova EV, Azuma K et al. Mitochondrial capacity in skeletal muscle is not stimulated by weight loss despite increase in insulin action and decreases in intermyocellular lipid content. Diabetes57, 987–994 (2008).
   PubMed Web of Science ®Google Scholar
• Meex RCR, Schrauwen-Hinderling VB, Moonen-Kornips E et al. Restoration of muscle mitochondrial function and metabolic flexibility in Type 2 diabetes by exercise training is paralleled by increased intramyocellular fat storage and improved insulin sensitivity. Diabetes59, 572–679 (2010).
   PubMed Web of Science ®Google Scholar
• Rabol R, Larsen S, Hojberg PM et al. Regionalanatomic differences in skeletal muscle mitochondrial respiration in Type 2 diabetes and obesity. J. Clin. Endocrinol. Metab.95, 857–863 (2010)
   Google Scholar
• Fagot-Campagna A, Pettit DJ, Engelgau MM et al. Type 2 diabetes among North American children and adolescents: an epidemiologic review and a public health perspective. J. Pediatr.136, 664–672 (2000).
   PubMed Web of Science ®Google Scholar
• McQuaid S, O’Gorman DJ, Yousif O et al. Early onset insulin-resistant diabetes in obese Caucasians has features of typical Type 2 diabetes, but 3 decades earlier. Diabetes Care28, 1216–1218 (2005).
   Google Scholar
• Hernandez-Alvarez MI, Thabit H, Burns N et al. Subjects with early onset Type 2 diabetes show defective activation of the skeletal muscle PGC-1a/mitofusin 2 regulatory pathway in response to physical activity. Diabetes Care33, 645–651 (2010).
   PubMed Web of Science ®Google Scholar