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Review

Hepatitis C and metabolic syndrome

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Pages 209-215 | Published online: 10 Jan 2014

References

  • Ge D, Fellay J, Thompson AJ et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature461(7262), 399–401 (2009).
  • Bressler BL, Guindi M, Tomlinson G, Heathcote J. High body mass index is an independent risk factor for nonresponse to antiviral treatment in chronic hepatitis C. Hepatology38(3), 639–644 (2003).
  • Tarantino G, Conca P, Sorrentino P, Ariello M. Metabolic factors involved in the therapeutic response of patients with hepatitis C virus-related chronic hepatitis. J. Gastroenterol. Hepatol.21, 1266–1268 (2006).
  • Elgouhari HM, Zein CO, Hanouneh I, Feldstein AE, Zein NN. Diabetes mellitus is associated with impaired response to antiviral therapy in chronic hepatitis C infection. Dig. Dis. Sci. DOI: 10.1007/s10620-008-0683-2 (2009) (Epub ahead of print).
  • Younossi ZM, McCullough AJ. Metabolic syndrome, non-alcoholic fatty liver disease and hepatitis C virus: impact on disease progression and treatment response. Liver Int.29(Suppl. 2), 3–12 (2009).
  • Tarantino G, Conca P, Ariello M, Mastrolia M. Does a lower insulin resistance affect antiviral therapy response in patients suffering from HCV related chronic hepatitis? Gut55(4), 585 (2006).
  • Butt AA, Wang X, Moore CG. Effect of hepatitis C virus and its treatment on survival. Hepatology50(2), 387–392 (2009).
  • Adinolfi LE, Utili R, Andreana A et al. Serum HCV RNA levels correlate with histological liver damage and concur with steatosis in progression of chronic hepatitis C. Dig. Dis. Sci.46(8), 1677–1683 (2001).
  • Tarantino G, Saldalamacchia G, Conca P, Arena A. Non-alcoholic fatty liver disease: further expression of the metabolic syndrome. J. Gastroenterol. Hepatol.22(3), 293–303 (2007).
  • Zekry A, McHutchison JG, Diehl AM. Insulin resistance and steatosis in hepatitis C virus infection. Gut54(7), 903–906 (2005).
  • Cammà C, Bruno S, Di Marco V et al. Insulin resistance is associated with steatosis in nondiabetic patients with genotype 1 chronic hepatitis C. Hepatology43(1), 64–71 (2006).
  • Qiang G, Yang L, Witek RP, Jhaveri R. Recombinant adenoviruses expressing steatosis-associated hepatitis C virus genotype 3 core protein produce intracellular lipid accumulation in cultured and primary hepatocytes. Virus Res.139(1), 127–130 (2009).
  • Sheikh MY, Choi J, Qadri I, Friedman JE, Sanyal AJ. Hepatitis C virus infection: molecular pathways to metabolic syndrome. Hepatology47(6), 2127–2133 (2008).
  • Grigorescu M, Radu C, Crişan D et al. Metabolic syndrome, insulin resistance and adiponectin level in patients with chronic hepatitis C. J. Gastrointestin. Liver Dis.17(2), 147–154 (2008).
  • Hourioux C, Patient R, Morin A et al. The genotype 3-specific hepatitis C virus core protein residue phenylalanine 164 increases steatosis in an in vitro cellular model. Gut56(9), 1302–1308 (2007).
  • Ong JP, Elariny H, Collantes R et al. Predictors of nonalcoholic steatohepatitis and advanced fibrosis in morbidly obese patients. Obes. Surg.15(3), 310–315 (2005).
  • Hui JM, Kench J, Farrell GC et al. Genotype-specific mechanisms for hepatic steatosis in chronic hepatitis C infection. J. Gastroenterol. Hepatol.17(8), 873–881 (2002).
  • Mehta SH, Brancati FL, Strathdee SA et al. Hepatitis C virus infection and incident Type 2 diabetes. Hepatology38(1), 50–56 (2003).
  • Ozdemir O, Arda K, Soylu M, Alyan O, Demir AD, Kütük E. Seroprevalence of hepatitis B and C in subjects admitted to a cardiology clinics in Turkey. Eur. J. Epidemiol.18(3), 255–258 (2003).
  • Hui CK, Belaye T, Montegrande K, Wright TL. A comparison in the progression of liver fibrosis in chronic hepatitis C between persistently normal and elevated transaminase. J. Hepatol.38(4), 511–517 (2003).
  • Cua IH, Hui JM, Kench JG, George J. Genotype-specific interactions of insulin resistance, steatosis, and fibrosis in chronic hepatitis C. Hepatology48(3), 723–731 (2008).
  • Moucari R, Asselah T, Cazals-Hatem D et al. Insulin resistance in chronic hepatitis C: association with genotypes 1 and 4, serum HCV RNA level, and liver fibrosis. Gastroenterology134(2), 416–423 (2008).
  • Almeda-Valdés P, Cuevas-Ramos D, Aguilar-Salinas CA. Metabolic syndrome and non-alcoholic fatty liver disease. Ann. Hepatol.8(Suppl. 1), S18–S24 (2009).
  • Day CP. The potential role of genes in nonalcoholic fatty liver disease. Clin. Liver Dis.8(3), 673–691 (2004).
  • Mason AL, Lau JY, Hoang N et al. Association of diabetes mellitus and chronic hepatitis C virus infection. Hepatology29(2), 328–333 (1999).
  • Chen HF, Li CY, Chen P, See TT, Lee HY. Seroprevalence of hepatitis B and C in Type 2 diabetic patients. J. Chin. Med. Assoc.69(4), 146–152 (2006).
  • Lecube A, Hernández C, Genescà J, Esteban JI, Jardí R, Simó R. High prevalence of glucose abnormalities in patients with hepatitis C virus infection: a multivariate analysis considering the liver injury. Diabetes Care27(5), 1171–1175 (2004).
  • Shintani Y, Fujie H, Miyoshi H et al. Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance. Gastroenterology126(3), 840–848 (2004).
  • Dharancy S, Malapel M, Perlemuter G et al. Impaired expression of the peroxisome proliferator-activated receptor α during hepatitis C virus infection. Gastroenterology128(2), 334–342 (2005).
  • Im SS, Kwon SK, Kim TH, Kim HI, Ahn YH. Regulation of glucose transporter type 4 isoform gene expression in muscle and adipocytes. IUBMB Life59(3), 134–145 (2007).
  • Petit JM, Minello A, Jooste V et al. Decreased plasma adiponectin concentrations are closely related to steatosis in hepatitis C virus-infected patients. J. Clin. Endocrinol. Metab.90(4), 2240–2243 (2005).
  • Kovac IP, Havlik RJ, Foley D et al. Linkage and association analyses of Type 2 diabetes/impaired glucose metabolism and adiponectin serum levels in Japanese Americans from Hawaii. Diabetes56(2), 537–540 (2007).
  • Sanyal AJ, Campbell-Sargent C et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology120(5), 1183–1192 (2001).
  • Machida K, Cheng KT, Lai CK, Jeng KS, Sung VM, Lai MM. Hepatitis C virus triggers mitochondrial permeability transition with production of reactive oxygen species, leading to DNA damage and STAT3 activation. J. Virol.80(14), 7199–7207 (2006).
  • Begriche K, Igoudjil A, Pessayre D, Fromenty B. Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it. Mitochondrion6(1), 1–28 (2006).
  • Jaeschke H. Reactive oxygen and mechanisms of inflammatory liver injury. J. Gastroenterol. Hepatol.15(7), 718–724 (2000).
  • Wellen KE, Hotamisligil GS. Obesity-induced inflammatory changes in adipose tissue. J. Clin. Invest.112(12), 1785–1788 (2003).
  • Bahcecioglu IH, Yalniz M, Ataseven H et al. Levels of serum hyaluronic acid, TNF-α and IL-8 in patients with nonalcoholic steatohepatitis. Gastroenterol. Hepatol.52(65), 1549–1553 (2005).
  • Cua IH, Hui JM, Bandara P et al. Insulin resistance and liver injury in hepatitis C is not associated with virus-specific changes in adipocytokines. Hepatology46(1), 66–73 (2007).
  • Cheung O, Puri P, Eicken C et al. Nonalcoholic steatohepatitis is associated with altered hepatic microRNA expression. Hepatology48(6), 1810–1820 (2008).
  • Chen XM. MicroRNA signatures in liver diseases. World J. Gastroenterol.15(14), 1665–1672 (2009).
  • Ura S, Honda M, Yamashita T et al. Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma. Hepatology49(4), 1098–1112 (2009).
  • Hui JM, Kench JG, Chitturi S et al. Long-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C. Hepatology38(2), 420–427 (2003).
  • Paradis V, Zalinski S, Chelbi E et al. Hepatocellular carcinomas in patients with metabolic syndrome often develop without significant liver fibrosis: a pathological analysis. Hepatology49(3), 851–859 (2009).
  • Browning JD, Szczepaniak LS, Dobbins R et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology40, 1387–1395 (2004).
  • Browning JD, Kumar KS, Saboorian MH, Thiele DL. Ethnic differences in the prevalence of cryptogenic cirrhosis. Am. J. Gastroenterol.99, 292–298 (2004).
  • Romeo S, Kozlitina J, Xing C et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat. Genet.40(12), 1461–1465 (2008).
  • Whitt K, Fleckenstein J. Hepatitis C in African Americans. Curr. Hepat. Rep.7(4), 139–144 (2008).
  • Conjeevaram HS, Fried MW, Jeffers LJ et al. Peginterferon and ribavirin treatment in African American and Caucasian American patients with hepatitis C genotype 1. Gastroenterology131(2), 470–477 (2006).
  • Neuschwander-Tetri BA. Fatty liver and the metabolic syndrome. Curr. Opin. Gastroenterol.23(2), 193–198 (2007).
  • Machado M, Cortez-Pinto H. Non-alcoholic steatohepatitis and metabolic syndrome. Curr. Opin. Clin. Nutr. Metab. Care.9(5), 637–642 (2006).
  • Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology43(2 Suppl. 1), S99–S112 (2006).
  • Collantes R, Ong JP, Younossi ZM. Nonalcoholic fatty liver disease and the epidemic of obesity. Cleve. Clin. J. Med.71(8), 657–664 (2004).
  • Ong JP, Younossi ZM. Epidemiology and natural history of NAFLD and NASH. Clin. Liver Dis.11(1), 1–16, vii (2007).
  • Rafiq N, Younossi ZM. Interaction of metabolic syndrome, nonalcoholic fatty liver disease and chronic hepatitis C. Expert Rev. Gastroenterol. Hepatol.2(2), 207–215 (2008).
  • Charlton MR, Pockros PJ, Harrison SA. Impact of obesity on treatment of chronic hepatitis C. Hepatology43(6), 1177–1186 (2006).
  • Chen W, Wong T, Tomlinson G, Krahn M, Heathcote EJ. Prevalence and predictors of obesity among individuals with positive hepatitis C antibody in a tertiary referral clinic. J. Hepatol.49(5), 711–717 (2008).
  • Puri P, Sanyal AJ. Role of obesity, insulin resistance, and steatosis in hepatitis C virus infection. Clin. Liver Dis.10(4), 793–819 (2006).
  • Glue P, Fang JWS, Rouzier-Panis R et al. Pegylated interferon-α2β: pharmacokinetics, pharmacodynamics, safety, and preliminary efficacy data. Hepatitis C Intervention Therapy group. Clin. Pharmacol. Ther.68, 556–567 (2000).
  • Lamb MW, Martin NE. Weight-based versus fixed dosing of peginterferon (40kDa) α-2a. Ann. Pharmacother.36, 933–935 (2002).
  • Mccullough AJ. Obesity and its nurturing effect on hepatitis C. Hepatology38, 557–559 (2003).
  • Jacobson IM, Brown RS, Freilich B et al. Weight-based ribavirin dosing increases sustained viral response in patients with chronic hepatitis C: final results of the WIN-R study, a US community based trial. Hepatology42(Suppl. 1), 749A (2005).
  • Jacobson IM, Brown RS Jr, McCone J et al. Impact of weight-based ribavirin with peginterferon α-2b in African Americans with hepatitis C virus genotype 1. Hepatology46(4), 982–990 (2007).
  • Baranova A, Gowder SJ, Schlauch K et al. Gene expression of leptin, resistin, and adiponectin in the white adipose tissue of obese patients with non-alcoholic fatty liver disease and insulin resistance. Obes. Surg.16(9), 1118–1125 (2006).
  • Schäffler A, Müller-Ladner U, Schölmerich J, Büchler C. Role of adipose tissue as an inflammatory organ in human diseases. Endocr. Rev.27(5), 449–467 (2006).
  • Lee SA, Kallianpur A, Xiang YB et al. Intra-individual variation of plasma adipokine levels and utility of single measurement of these biomarkers in population-based studies. Cancer Epidemiol. Biomarkers Prev.16(11), 2464–2470 (2007).
  • Estep JM, Baranova A, Hossain N et al. Expression of cytokine signaling genes in morbidly obese patients with non-alcoholic steatohepatitis and hepatic fibrosis. Obes. Surg.19(5), 617–624 (2009).
  • Pradhan A. Obesity, metabolic syndrome, and Type 2 diabetes: inflammatory basis of glucose metabolic disorders. Nutr. Rev.65(12 Pt 2), S152–S156 (2007).
  • Dyck DJ. Adipokines as regulators of muscle metabolism and insulin sensitivity. Appl. Physiol. Nutr. Metab.34(3), 396–402 (2009).
  • Park PH, Thakur V, Pritchard MT, McMullen MR, Nagy LE. Regulation of Kupffer cell activity during chronic ethanol exposure: role of adiponectin. J. Gastroenterol. Hepatol.21(Suppl. 3), S30–S33 (2006).
  • Kajikawa S, Harada T, Kawashima A, Imada K, Mizuguchi K. Suppression of hepatic fat accumulation by highly purified eicosapentaenoic acid prevents the progression of D-galactosamine-induced hepatitis in mice fed with a high-fat/high-sucrose diet. Biochim. Biophys. Acta1791(4), 281–288 (2009).
  • Akifusa S, Kamio N, Shimazaki Y, Yamaguchi N, Nishihara T, Yamashita Y. Globular adiponectin-induced RAW 264 apoptosis is regulated by a reactive oxygen species-dependent pathway involving Bcl-2. Free Radic. Biol. Med.46(9), 1308–1316 (2009).
  • Friedman SL. Mechanisms of hepatic fibrogenesis. Gastroenterology134(6), 1655–1669 (2008).
  • Romero-Gómez M, Del Mar Viloria M et al. Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients. Gastroenterology128(3), 636–641 (2005).
  • Lecube A, Hernández C, Simó R, Esteban JI, Genescà J. Glucose abnormalities are an independent risk factor for nonresponse to antiviral treatment in chronic hepatitis C. Am. J. Gastroenterol.102(10), 2189–2195 (2007).
  • Armstrong GL, Wasley A, Simard EP et al. The prevalence of hepatitis C virus infection in the United States, 1999 through 2002. Ann. Intern. Med.144, 705–714 (2006).
  • Haluzík M, Parízková J, Haluzík MM. Adiponectin and its role in the obesity-induced insulin resistance and related complications. Physiol. Res.53(2), 123–129 (2004).
  • Lecube A, Hernández C, Genescà J, Simó R. Proinflammatory cytokines, insulin resistance, and insulin secretion in chronic hepatitis C patients: a case–control study. Diabetes Care29(5), 1096–1101 (2006).
  • Bataller R, Paik YH, Lindquist JN, Lemasters JJ, Brenner DA. Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. Gastroenterology126, 529–540 (2004).
  • Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA285(19), 2486–2497 (2001).

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