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Review

Lactogens and estrogens in breast cancer chemoresistance

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Pages 411-422 | Published online: 10 Jan 2014

References

  • Coley HM. Mechanisms and strategies to overcome chemotherapy resistance in metastatic breast cancer. Cancer Treat. Rev.34, 378–390 (2008).
  • Yager JD, Davidson NE. Estrogen carcinogenesis in breast cancer. N. Engl. J. Med.354, 270–282 (2006).
  • Clevenger CV, Gadd SL, Zheng J. New mechanisms for PRLr action in breast cancer. Trends Endocrinol. Metab.20, 223–229 (2009).
  • Lapensee EW, Ben-Jonathan N. Novel roles of prolactin and estrogens in breast cancer: resistance to chemotherapy. Endocr. Relat. Cancer17, R91–R107 (2010).
  • Carver KC, Arendt LM, Schuler LA. Complex prolactin crosstalk in breast cancer: new therapeutic implications. Mol. Cell Endocrinol.307, 1–7 (2009).
  • Sui M, Huang Y, Park BH, Davidson NE, Fan W. Estrogen receptor α mediates breast cancer cell resistance to paclitaxel through inhibition of apoptotic cell death. Cancer Res.67, 5337–5344 (2007).
  • Ben-Jonathan N, Mershon JL, Allen DL, Steinmetz RW. Extrapituitary prolactin: distribution, regulation, functions, and clinical aspects. Endocr. Rev.17, 639–669 (1996).
  • Kimura AP, Sizova D, Handwerger S, Cooke NE, Liebhaber SA. Epigenetic activation of the human growth hormone gene cluster during placental cytotrophoblast differentiation. Mol. Cell Biol.27, 6555–6568 (2007).
  • Harvey S. Extrapituitary growth hormone. Endocrine38, 335–359 (2010).
  • Keeler C, Dannies PS, Hodsdon ME. The tertiary structure and backbone dynamics of human prolactin. J. Mol. Biol.328, 1105–1121 (2003).
  • Ben-Jonathan N, Lapensee CR, Lapensee EW. What can we learn from rodents about prolactin in humans? Endocr. Rev.29, 1–41 (2008).
  • Xu J, Zhang Y, Berry PA et al. Growth hormone signaling in human T47D breast cancer cells: potential role for a growth hormone receptor-prolactin receptor complex. Mol. Endocrinol.25(4), 597–610 (2011).
  • Bernichtein S, Touraine P, Goffin V. New concepts in prolactin biology. J. Endocrinol.206, 1–11 (2010).
  • Zinger M, McFarland M, Ben-Jonathan N. Prolactin expression and secretion by human breast glandular and adipose tissue explants. J. Clin. Endocrinol. Metab.88, 689–696 (2003).
  • Ben-Jonathan N, Liby K, McFarland M, Zinger M. Prolactin as an autocrine/paracrine growth factor in human cancer. Trends Endocrinol. Metab.13, 245–250 (2002).
  • Scotti ML, Langenheim JF, Tomblyn S, Springs AE, Chen WY. Additive effects of a prolactin receptor antagonist, G129R, and herceptin on inhibition of HER2-overexpressing breast cancer cells. Breast Cancer Res. Treat.111, 241–250 (2008).
  • Howell SJ, Anderson E, Hunter T, Farnie G, Clarke RB. Prolactin receptor antagonism reduces the clonogenic capacity of breast cancer cells and potentiates doxorubicin and paclitaxel cytotoxicity. Breast Cancer Res.10, R68 (2008).
  • Perry JK, Mohankumar KM, Emerald BS, Mertani HC, Lobie PE. The contribution of growth hormone to mammary neoplasia. J. Mammary Gland Biol. Neoplasia13, 131–145 (2008).
  • Kleinberg DL, Wood TL, Furth PA, Lee AV. Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions. Endocr. Rev.30, 51–74 (2009).
  • Perry JK, Emerald BS, Mertani HC, Lobie PE. The oncogenic potential of growth hormone. Growth Horm. IGF Res.16, 277–289 (2006).
  • Mojarrad M, Momeny M, Mansuri F et al. Autocrine human growth hormone expression leads to resistance of MCF-7 cells to tamoxifen. Med. Oncol.27, 474–480 (2010).
  • Chhabra Y, Waters MJ, Brooks AJ. Role of the growth hormone-IGF-1 axis in cancer. Exp. Rev. Endocrinol. Metab.6, 71–84 (2011).
  • Raccurt M, Lobie PE, Moudilou E et al. High stromal and epithelial human GH gene expression is associated with proliferative disorders of the mammary gland. J. Endocrinol.175, 307–318 (2002).
  • Zatelli MC, Minoia M, Mole D et al. Growth hormone excess promotes breast cancer chemoresistance. J. Clin. Endocrinol. Metab.94, 3931–3938 (2009).
  • Handwerger S. New insights into the regulation of human cytotrophoblast cell differentiation. Mol. Cell Endocrinol.323, 94–104 (2010).
  • Horne CH, Reid IN, Milne GD. Prognostic significance of inappropriate production of pregnancy proteins by breast cancers. Lancet2, 279–282 (1976).
  • Sheth NA, Suraiya JN, Sheth AR, Ranadive KJ, Jussawalla DJ. Ectopic production of human placental lactogen by human breast tumors. Cancer39, 1693–1699 (1977).
  • Latham C, Zhang A, Nalbanti A et al. Frequent co-amplification of two different regions on 17q in aneuploid breast carcinomas. Cancer Genet. Cytogenet.127, 16–23 (2001).
  • Duffy MJ. Serum tumor markers in breast cancer: are they of clinical value? Clin. Chem.52, 345–351 (2006).
  • Butler SA, Iles RK. Ectopic human chorionic gonadotropin β secretion by epithelial tumors and human chorionic gonadotropin β-induced apoptosis in Kaposi’s sarcoma: is there a connection? Clin. Cancer Res.9, 4666–4673 (2003).
  • Hu ZZ, Zhuang L, Dufau ML. Prolactin receptor gene diversity: structure and regulation. Trends Endocrinol. Metab.9, 94–102 (1998).
  • Swaminathan G, Varghese B, Fuchs SY. Regulation of prolactin receptor levels and activity in breast cancer. J. Mammary Gland Biol. Neoplasia13, 81–91 (2008).
  • Ginsburg E, Alexander S, Lieber S et al. Characterization of ductal and lobular breast carcinomas using novel prolactin receptor isoform specific antibodies. BMC Cancer10, 678 (2010).
  • Tran-Thanh D, Arneson NC, Pintilie M et al. Amplification of the prolactin receptor gene in mammary lobular neoplasia. Breast Cancer Res. Treat. DOI: 10.1007/s10549-010-1025-6 (2010) (Epub ahead of print).
  • Teilum K, Hoch JC, Goffin V, Kinet S, Martial JA, Kragelund BB. Solution structure of human prolactin. J. Mol. Biol.351, 810–823 (2005).
  • Jomain JB, Tallet E, Broutin I et al. Structural and thermodynamic bases for the design of pure prolactin receptor antagonists: x-ray structure of Del1-9-G129R-hPRL. J. Biol. Chem.282, 33118–33131 (2007).
  • Voorhees JL, Brooks CL. Obligate ordered binding of human lactogenic cytokines. J. Biol. Chem.285, 20022–20030 (2010).
  • Utama FE, Tran TH, Ryder A, LeBaron MJ, Parlow AF, Rui H. Insensitivity of human prolactin receptors to nonhuman prolactins: relevance for experimental modeling of prolactin receptor-expressing human cells. Endocrinology150, 1782–1790 (2009).
  • Acosta JJ, Munoz RM, Gonzalez L et al. Src mediates prolactin-dependent proliferation of T47D and MCF7 cells via the activation of focal adhesion kinase/Erk1/2 and phosphatidylinositol 3-kinase pathways. Mol. Endocrinol.17, 2268–2282 (2003).
  • Piazza TM, Lu JC, Carver KC, Schuler LA. SRC family kinases accelerate prolactin receptor internalization, modulating trafficking and signaling in breast cancer cells. Mol. Endocrinol.23, 202–212 (2009).
  • Fresno Vara JA, Carretero MV, Geronimo H, Ballmer-Hofer K, Martin-Perez J. Stimulation of c-Src by prolactin is independent of Jak2. Biochem. J.345(Pt 1), 17–24 (2000).
  • Gutzman JH, Nikolai SE, Rugowski DE, Watters JJ, Schuler LA. Prolactin and estrogen enhance the activity of activating protein 1 in breast cancer cells: role of extracellularly regulated kinase 1/2-mediated signals to c-fos. Mol. Endocrinol.19, 1765–1778 (2005).
  • Fox EM, Andrade J, Shupnik MA. Novel actions of estrogen to promote proliferation: integration of cytoplasmic and nuclear pathways. Steroids74, 622–627 (2009).
  • Gonzalez L, Zambrano A, Lazaro-Trueba I et al. Activation of the unliganded estrogen receptor by prolactin in breast cancer cells. Oncogene28, 1298–1308 (2009).
  • Pharoah PD, Antoniou AC, Easton DF, Ponder BA. Polygenes, risk prediction, and targeted prevention of breast cancer. N. Engl. J. Med.358, 2796–2803 (2008).
  • Ahmed S, Thomas G, Ghoussaini M et al. Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nat. Genet.41, 585–590 (2009).
  • Wheeler DA, Srinivasan M, Egholm M et al. The complete genome of an individual by massively parallel DNA sequencing. Nature452, 872–876 (2008).
  • Levy S, Sutton G, Ng PC et al. The diploid genome sequence of an individual human. PLoS Biol.5, e254 (2007).
  • Anghel A, Narita D, Seclaman E, Popovici E, Anghel M, Tamas L. Estrogen receptor α polymorphisms and the risk of malignancies. Pathol. Oncol. Res.16, 485–496 (2010).
  • Giess M, Lattrich C, Springwald A, Goerse R, Ortmann O, Treeck O. GPR30 gene polymorphisms are associated with progesterone receptor status and histopathological characteristics of breast cancer patients. J. Steroid Biochem. Mol. Biol.118, 7–12 (2010).
  • Canbay E, Degerli N, Gulluoglu BM, Kaya H, Sen M, Bardakci F. Could prolactin receptor gene polymorphism play a role in pathogenesis of breast carcinoma? Curr. Med. Res. Opin.20, 533–540 (2004).
  • Bogorad RL, Courtillot C, Mestayer C et al. Identification of a gain-of-function mutation of the prolactin receptor in women with benign breast tumors. Proc. Natl Acad. Sci. USA105, 14533–14538 (2008).
  • Courtillot C, Chakhtoura Z, Bogorad R et al. Characterization of two constitutively active prolactin receptor variants in a cohort of 95 women with multiple breast fibroadenomas. J. Clin. Endocrinol. Metab.95, 271–279 (2010).
  • Lee SA, Haiman CA, Burtt NP et al. A comprehensive analysis of common genetic variation in prolactin (PRL) and PRL receptor (PRLR) genes in relation to plasma prolactin levels and breast cancer risk: the multiethnic cohort. BMC Med. Genet.8, 72 (2007).
  • Vaclavicek A, Hemminki K, Bartram CR et al. Association of prolactin and its receptor gene regions with familial breast cancer. J. Clin. Endocrinol. Metab.91, 1513–1519 (2006).
  • Hinds DA, Stuve LL, Nilsen GB et al. Whole-genome patterns of common DNA variation in three human populations. Science307, 1072–1079 (2005).
  • Tworoger SS, Hankinson SE. Prolactin and breast cancer etiology: an epidemiologic perspective. J. Mammary Gland Biol. Neoplasia13, 41–53 (2008).
  • Lissoni P, Vaghi M, Ardizzoia A et al. Efficacy of monochemotherapy with docetaxel (taxotere) in relation to prolactin secretion in heavily pretreated metastatic breast cancer. Neuro. Endocrinol. Lett.22, 27–29 (2001).
  • Lissoni P, Bucovec R, Malugani F et al. A clinical study of taxotere versus taxotere plus the antiprolactinemic agent bromocriptine in metastatic breast cancer pretreated with anthracyclines. Anticancer Res.22, 1131–1134 (2002).
  • Ramamoorthy P, Sticca R, Wagner TE, Chen WY. In vitro studies of a prolactin antagonist, hPRL-G129R n human breast cancer cells. Int. J. Oncol.18, 25–32 (2001).
  • Perks CM, Keith AJ, Goodhew KL, Savage PB, Winters ZE, Holly JM. Prolactin acts as a potent survival factor for human breast cancer cell lines. Br. J. Cancer91, 305–311 (2004).
  • Chakravarti P, Henry MK, Quelle FW. Prolactin and heregulin override DNA damage-induced growth arrest and promote phosphatidylinositol-3 kinase-dependent proliferation in breast cancer cells. Int. J. Oncol.26, 509–514 (2005).
  • Lapensee EW, Schwemberger SJ, Lapensee CR, Bahassi EM, Afton SE, Ben-Jonathan N. Prolactin confers resistance against cisplatin in breast cancer cells by activating glutathione-S-transferase. Carcinogenesis30, 1298–1304 (2009).
  • Decatris MP, Sundar S, O’Byrne KJ. Platinum-based chemotherapy in metastatic breast cancer: current status. Cancer Treat. Rev.30, 53–81 (2004).
  • Kelland L. The resurgence of platinum-based cancer chemotherapy. Nat. Rev. Cancer7, 573–584 (2007).
  • Townsend DM, Findlay VL, Tew KD. Glutathione S-transferases as regulators of kinase pathways and anticancer drug targets. Methods Enzymol.401, 287–307 (2005).
  • Ambrosone CB, Sweeney C, Coles BF et al. Polymorphisms in glutathione S-transferases (GSTM1 and GSTT1) and survival after treatment for breast cancer. Cancer Res.61, 7130–7135 (2001).
  • Peirce SK, Chen WY. Human prolactin and its antagonist, hPRL-G129R, regulate bax and bcl-2 gene expression in human breast cancer cells and transgenic mice. Oncogene23, 1248–1255 (2004).
  • Jongen VH, Hollema H, Van Der Zee AG, Heineman MJ. Aromatase in the context of breast and endometrial cancer. A review. Minerva Endocrinol.31, 47–60 (2006).
  • Suzuki T, Miki Y, Nakamura Y et al. Sex steroid-producing enzymes in human breast cancer. Endocr. Relat. Cancer12, 701–720 (2005).
  • Pasqualini JR, Chetrite G, Blacker C et al. Concentrations of estrone, estradiol, and estrone sulfate and evaluation of sulfatase and aromatase activities in pre- and postmenopausal breast cancer patients. J. Clin. Endocrinol. Metab.81, 1460–1464 (1996).
  • Santen RJ, Santner SJ, Pauley RJ et al. Estrogen production via the aromatase enzyme in breast carcinoma: which cell type is responsible? J. Steroid Biochem. Mol. Biol.61, 267–271 (1997).
  • Nabholtz JM, Mouret-Reynier MA, Durando X et al. Comparative review of anastrozole, letrozole and exemestane in the management of early breast cancer. Expert Opin. Pharmacother.10, 1435–1447 (2009).
  • Gray J, Evans N, Taylor B, Rizzo J, Walker M. State of the evidence: the connection between breast cancer and the environment. Int. J. Occup. Environ. Health15, 43–78 (2009).
  • Wolff MS. Endocrine disruptors: challenges for environmental research in the 21st Century. Ann. NY Acad. Sci.1076, 228–238 (2006).
  • Holloway AC, Anger DA, Crankshaw DJ, Wu M, Foster WG. Atrazine-induced changes in aromatase activity in estrogen sensitive target tissues. J. Appl. Toxicol.28, 260–270 (2008).
  • Falconer IR. Are endocrine disrupting compounds a health risk in drinking water? Int. J. Environ. Res. Public Health3, 180–184 (2006).
  • Mense SM, Hei TK, Ganju RK, Bhat HK. Phytoestrogens and breast cancer prevention: possible mechanisms of action. Environ. Health Perspect.116, 426–433 (2008).
  • Martin JH, Crotty S, Nelson PN. Phytoestrogens: perpetrators or protectors? Future Oncol.3, 307–318 (2007).
  • Heldring N, Pike A, Andersson S et al. Estrogen receptors: how do they signal and what are their targets. Physiol. Rev.87, 905–931 (2007).
  • Nilsson S, Makela S, Treuter E et al. Mechanisms of estrogen action. Physiol. Rev.81, 1535–1565 (2001).
  • Gertler A, Grosclaude J, Strasburger CJ, Nir S, Djiane J. Real-time kinetic measurements of the interactions between lactogenic hormones and prolactin-receptor extracellular domains from several species support the model of hormone-induced transient receptor dimerization. J. Biol. Chem.271, 24482–24491 (1996).
  • Bai Z, Gust R. Breast cancer, estrogen receptor and ligands. Arch. Pharm.342, 133–149 (2009).
  • Van Den Bemd GJ, Kuiper GG, Pols HA, Van Leeuwen JP. Distinct effects on the conformation of estrogen receptor α and β by both the antiestrogens ICI 164,384 and ICI 182,780 leading to opposite effects on receptor stability. Biochem. Biophys. Res. Commun.261, 1–5 (1999).
  • Normanno N, Di MM, De ME et al. Mechanisms of endocrine resistance and novel therapeutic strategies in breast cancer. Endocr. Relat. Cancer12, 721–747 (2005).
  • Khan SA, Bhandare D, Chatterton RT Jr. The local hormonal environment and related biomarkers in the normal breast. Endocr. Relat. Cancer12, 497–510 (2005).
  • Bjornstrom L, Sjoberg M. Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes. Mol. Endocrinol.19, 833–842 (2005).
  • Manavathi B, Kumar R. Steering estrogen signals from the plasma membrane to the nucleus: two sides of the coin. J. Cell Physiol.207, 594–604 (2006).
  • Song RX, Fan P, Yue W, Chen Y, Santen RJ. Role of receptor complexes in the extranuclear actions of estrogen receptor alpha in breast cancer. Endocr. Relat. Cancer13(Suppl. 1), S3–S13 (2006).
  • Watson CS, Bulayeva NN, Wozniak AL, Alyea RA. Xenoestrogens are potent activators of nongenomic estrogenic responses. Steroids72, 124–134 (2007).
  • Prossnitz ER, Arterburn JB, Smith HO, Oprea TI, Sklar LA, Hathaway HJ. Estrogen signaling through the transmembrane G protein-coupled receptor GPR30. Annu. Rev. Physiol.70, 165–190 (2008).
  • Filardo EJ, Thomas P. GPR30: a seven-transmembrane-spanning estrogen receptor that triggers EGF release. Trends Endocrinol. Metab.16, 362–367 (2005).
  • Filardo EJ, Graeber CT, Quinn JA et al. Distribution of GPR30, a seven membrane-spanning estrogen receptor, in primary breast cancer and its association with clinicopathologic determinants of tumor progression. Clin. Cancer Res.12, 6359–6366 (2006).
  • Thomas P, Pang Y, Filardo EJ, Dong J. Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology146, 624–632 (2005).
  • Rodrik V, Zheng Y, Harrow F, Chen Y, Foster DA. Survival signals generated by estrogen and phospholipase D in MCF-7 breast cancer cells are dependent on Myc. Mol. Cell Biol.25, 7917–7925 (2005).
  • Huang Y, Ray S, Reed JC et al. Estrogen increases intracellular p26Bcl-2 to p21Bax ratios and inhibits taxol-induced apoptosis of human breast cancer MCF-7 cells. Breast Cancer Res. Treat.42, 73–81 (1997).
  • Teixeira C, Reed JC, Pratt MA. Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 proto-oncogene expression in human breast cancer cells. Cancer Res.55, 3902–3907 (1995).
  • Lagadec C, Adriaenssens E, Toillon RA et al. Tamoxifen and TRAIL synergistically induce apoptosis in breast cancer cells. Oncogene27, 1472–1477 (2008).
  • Lapensee EW, Lapensee CR, Fox S, Schwemberger S, Afton S, Ben-Jonathan N. Bisphenol A and estradiol are equipotent in antagonizing cisplatin-induced cytotoxicity in breast cancer cells. Cancer Lett.290, 167–173 (2010).
  • Razandi M, Pedram A, Levin ER. Plasma membrane estrogen receptors signal to antiapoptosis in breast cancer. Mol. Endocrinol.14, 1434–1447 (2000).
  • Zampieri L, Bianchi P, Ruff P, Arbuthnot P. Differential modulation by estradiol of P-glycoprotein drug resistance protein expression in cultured MCF7 and T47D breast cancer cells. Anticancer Res.22, 2253–2259 (2002).
  • Welshons WV, Nagel SC, vom Saal FS. Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure. Endocrinology147, S56–S69 (2006).
  • Kang JH, Kondo F, Katayama Y. Human exposure to bisphenol A. Toxicology226, 79–89 (2006).
  • Le HH, Carlson EM, Chua JP, Belcher SM. Bisphenol A is released from polycarbonate drinking bottles and mimics the neurotoxic actions of estrogen in developing cerebellar neurons. Toxicol. Lett.176, 149–156 (2008).
  • Fernandez MF, Arrebola JP, Taoufiki J et al. Bisphenol-A and chlorinated derivatives in adipose tissue of women. Reprod. Toxicol.24, 259–264 (2007).
  • Yi B, Kim C, Yang M. Biological monitoring of bisphenol A with HLPC/FLD and LC/MS/MS assays. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci.878, 2606–2610 (2010).
  • Vandenberg LN, Maffini MV, Sonnenschein C, Rubin BS, Soto AM. Bisphenol-A and the great divide: a review of controversies in the field of endocrine disruption. Endocr. Rev.30, 75–95 (2009).
  • Ben-Jonathan N, Hugo ER, Brandebourg TD. Effects of bisphenol A on adipokine release from human adipose tissue: implications for the metabolic syndrome. Mol. Cell Endocrinol.304, 49–54 (2009).
  • Singleton DW, Feng Y, Chen Y et al. Bisphenol-A and estradiol exert novel gene regulation in human MCF-7 derived breast cancer cells. Mol. Cell Endocrinol.221, 47–55 (2004).
  • Li X, Zhang S, Safe S. Activation of kinase pathways in MCF-7 cells by 17β-estradiol and structurally diverse estrogenic compounds. J. Steroid Biochem. Mol. Biol.98, 122–132 (2006).
  • Walsh DE, Dockery P, Doolan CM. Estrogen receptor independent rapid non-genomic effects of environmental estrogens on [Ca2+]i in human breast cancer cells. Mol. Cell Endocrinol.230, 23–30 (2005).
  • Kuiper GG, Lemmen JG, Carlsson B et al. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β. Endocrinology139, 4252–4263 (1998).
  • Watson CS, Bulayeva NN, Wozniak AL, Finnerty CC. Signaling from the membrane via membrane estrogen receptor-α: estrogens, xenoestrogens, and phytoestrogens. Steroids70, 364–371 (2005).
  • Hugo ER, Brandebourg TD, Woo JG, Loftus J, Alexander JW, Ben-Jonathan N. Bisphenol A at environmentally relevant doses inhibits adiponectin release from human adipose tissue explants and adipocytes. Environ. Health Perspect.116, 1642–1647 (2008).
  • Safe SH, Pallaroni L, Yoon K, Gaido K, Ross S, McDonnell D. Problems for risk assessment of endocrine-active estrogenic compounds. Environ. Health Perspect.110(Suppl. 6), 925–929 (2002).
  • Ariazi EA, Jordan VC. Estrogen-related receptors as emerging targets in cancer and metabolic disorders. Curr. Top. Med. Chem.6, 203–215 (2006).
  • Okada H, Tokunaga T, Liu X, Takayanagi S, Matsushima A, Shimohigashi Y. Direct evidence revealing structural elements essential for the high binding ability of bisphenol A to human estrogen-related receptor-γ. Environ. Health Perspect.116, 32–38 (2008).
  • Ariazi EA, Clark GM, Mertz JE. Estrogen-related receptor α and estrogen-related receptor γ associate with unfavorable and favorable biomarkers, respectively, in human breast cancer. Cancer Res.62, 6510–6518 (2002).
  • Lapensee EW, Tuttle TR, Fox SR, Ben-Jonathan N. Bisphenol A at low nanomolar doses confers chemoresistance in estrogen receptor-α-positive and -negative breast cancer cells. Environ. Health Perspect.117, 175–180 (2009).
  • Goffin V, Bernichtein S, Touraine P, Kelly PA. Development and potential clinical uses of human prolactin receptor antagonists. Endocr. Rev.26, 400–422 (2005).
  • Jacobson EM, Hugo ER, Tuttle TR, Papoian R, Ben-Jonathan N. Unexploited therapies in breast and prostate cancer: blockade of the prolactin receptor. Trends Endocrinol. Metab.21, 691–698 (2010).

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