49
Views
9
CrossRef citations to date
0
Altmetric
Key Paper Evaluation

Weight loss as a cure for Type 2 diabetes: fact or fantasy?

, &
Pages 557-561 | Published online: 10 Jan 2014

References

  • Defronzo RA. Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of Type 2 diabetes mellitus. Diabetes58, 773–795 (2009).
  • Unger RH. Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome. Endocrinology144, 5159–5165 (2003).
  • Defronzo RA. Pathogenesis of Type 2 diabetes mellitus. Med. Clin. North Am.88, 787–835, ix (2004).
  • Vollmer K, Holst JJ, Baller B et al. Predictors of incretin concentrations in subjects with normal, impaired, and diabetic glucose tolerance. Diabetes57, 678–687 (2008).
  • Pi-Sunyer X, Blackburn G, Brancati FL et al. Reduction in weight and cardiovascular disease risk factors in individuals with Type 2 diabetes: one-year results of the look AHEAD trial. Diabetes Care30, 1374–1383 (2007).
  • Klein S, Sheard NF, Pi-Sunyer X et al. Weight management through lifestyle modification for the prevention and management of Type 2 diabetes: rationale and strategies: a statement of the American Diabetes Association, the North American Association for the Study of Obesity, and the American Society for Clinical Nutrition. Diabetes Care27, 2067–2073 (2004).
  • Camastra S, Manco M, Mari A et al. β-cell function in morbidly obese subjects during free living: long-term effects of weight loss. Diabetes54, 2382–2389 (2005).
  • Polonsky KS, Gumbiner B, Ostrega D, Griver K, Tager H, Henry RR. Alterations in immunoreactive proinsulin and insulin clearance induced by weight loss in NIDDM. Diabetes43, 871–877 (1994).
  • Pories WJ, Swanson MS, MacDonald KG et al. Who would have thought it? An operation proves to be the most effective therapy for adult-onset diabetes mellitus. Ann. Surg.222, 339–350 (1995).
  • Hofso D, Jenssen T, Bollerslev J et al. β cell function after weight loss: a clinical trial comparing gastric bypass surgery and intensive lifestyle intervention. Eur. J. Endocrinol.164, 231–238 (2011).
  • le Roux CW, Aylwin SJ, Batterham RL et al. Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters. Ann. Surg.243, 108–114 (2006).
  • Mingrone G, DeGaetano A, Greco AV et al. Reversibility of insulin resistance in obese diabetic patients: role of plasma lipids. Diabetologia40, 599–605 (1997).
  • Morinigo R, Vidal J, Lacy AM et al. Circulating peptide YY, weight loss, and glucose homeostasis after gastric bypass surgery in morbidly obese subjects. Ann. Surg.247, 270–275 (2008).
  • Kashyap SR, Daud S, Kelly KR et al. Acute effects of gastric bypass versus gastric restrictive surgery on β-cell function and insulinotropic hormones in severely obese patients with Type 2 diabetes. Int. J. Obes.34(3), 462–471 (2009).
  • Laferrere B, Teixeira J, McGinty J et al. Effect of weight loss by gastric bypass surgery versus hypocaloric diet on glucose and incretin levels in patients with Type 2 diabetes. J. Clin. Endocrinol. Metab.93, 2479–2485 (2008).
  • Dixon JB, O’Brien PE, Playfair J et al. Adjustable gastric banding and conventional therapy for Type 2 diabetes: a randomized controlled trial. J. Am. Med. Assoc.299, 316–323 (2008).
  • Korner J, Bessler M, Inabnet W, Taveras C, Holst JJ. Exaggerated glucagon-like peptide-1 and blunted glucose-dependent insulinotropic peptide secretion are associated with Roux-en-Y gastric bypass but not adjustable gastric banding. Surg. Obes. Relat. Dis.3, 597–601 (2007).
  • Laferrere B, Heshka S, Wang K et al. Incretin levels and effect are markedly enhanced 1 month after Roux-en-Y gastric bypass surgery in obese patients with Type 2 diabetes. Diabetes Care30, 1709–1716 (2007).
  • Goldfine AB, Mun EC, Devine E et al. Patients with neuroglycopenia after gastric bypass surgery have exaggerated incretin and insulin secretory responses to a mixed meal. J. Clin. Endocrinol. Metab.92, 4678–4685 (2007).
  • Bogardus C, Ravussin E, Robbins DC, Wolfe RR, Horton ES, Sims EA. Effects of physical training and diet therapy on carbohydrate metabolism in patients with glucose intolerance and non-insulin-dependent diabetes mellitus. Diabetes33, 311–318 (1984).
  • Dela F, von Linstow ME, Mikines KJ, Galbo H. Physical training may enhance β-cell function in Type 2 diabetes. Am. J. Physiol. Endocrinol. Metab.287, E1024–E1031 (2004).
  • Henry RR, Gumbiner B. Benefits and limitations of very-low-calorie diet therapy in obese NIDDM. Diabetes Care14, 802–823 (1991).
  • Kelley DE, Wing R, Buonocore C, Sturis J, Polonsky K, Fitzsimmons M. Relative effects of calorie restriction and weight loss in noninsulin-dependent diabetes mellitus. J. Clin. Endocrinol. Metab.77, 1287–1293 (1993).
  • Kelly KR, Brooks LM, Solomon TP, Kashyap S, O’Leary VB, Kirwan JP. The glucose-dependent insulinotropic polypeptide (GIP) and glucose-stimulated insulin response to exercise training and diet in obesity. Am. J. Physiol. Endocrinol. Metab. (2966), E1269–E1274 (2009).
  • Solomon TP, Haus JM, Kelly KR et al. Randomized trial on the effects of a 7-d low-glycemic diet and exercise intervention on insulin resistance in older obese humans. Am. J. Clin. Nutr.90, 1222–1229 (2009).
  • Solomon TP, Haus JM, Kelly KR et al. A low-glycemic index diet combined with exercise reduces insulin resistance, postprandial hyperinsulinemia, and glucose-dependent insulinotropic polypeptide responses in obese, prediabetic humans. Am. J. Clin. Nutr.92, 1359–1368 (2010).
  • Solomon TP, Haus JM, Kelly KR, Rocco M, Kashyap SR, Kirwan JP. Improved pancreatic β-cell function in Type 2 diabetic patients after lifestyle-induced weight loss is related to glucose-dependent insulinotropic polypeptide. Diabetes Care33, 1561–1566 (2010).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.