49
Views
0
CrossRef citations to date
0
Altmetric
Editorials

PTEN mutations: help spot thyroid cancer before it occurs

&
Pages 251-254 | Published online: 10 Jan 2014

References

  • Kent WD, Hall SF, Isotalo PA, Houlden RL, George RL, Groome PA. Increased incidence of differentiated thyroid carcinoma and detection of subclinical disease. CMAJ 177(11), 1357–1361 (2007).
  • Davies L, Welch HG. Increasing incidence of thyroid cancer in the United States, 1973–2002. JAMA 295(18), 2164–2167 (2006).
  • Zbuk KM, Eng C. Cancer phenomics: RET and PTEN as illustrative models. Nat. Rev. Cancer 7(1), 35–45 (2007).
  • Kloos RT, Eng C, Evans DB et al.; American Thyroid Association Guidelines Task Force. Medullary thyroid cancer: management guidelines of the American Thyroid Association. Thyroid 19(6), 565–612 (2009).
  • Wells SA Jr, Gosnell JE, Gagel RF et al. Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer. J. Clin. Oncol. 28(5), 767–772 (2010).
  • Goldgar DE, Easton DF, Cannon-Albright LA, Skolnick MH. Systematic population-based assessment of cancer risk in first-degree relatives of cancer probands. J. Natl Cancer Inst. 86(21), 1600–1608 (1994).
  • Hemminki K, Eng C, Chen B. Familial risks for nonmedullary thyroid cancer. J. Clin. Endocrinol. Metab. 90(10), 5747–5753 (2005).
  • Ngeow J, Mester J, Rybicki LA, Ni Y, Milas M, Eng C. Incidence and clinical characteristics of thyroid cancer in prospective series of individuals with Cowden and Cowden-like syndrome characterized by germline PTEN, SDH, or KLLN alterations. J. Clin. Endocrinol. Metab. 96(12), E2063–E2071 (2011).
  • Ni Y, He X, Chen J et al. Germline SDHx variants modify breast and thyroid cancer risks in Cowden and Cowden-like syndrome via FAD/NAD-dependant destabilization of p53. Hum. Mol. Genet. 21(2), 300–310 (2012).
  • Ni Y, Zbuk KM, Sadler T et al. Germline mutations and variants in the succinate dehydrogenase genes in Cowden and Cowden-like syndromes. Am. J. Hum. Genet. 83(2), 261–268 (2008).
  • Bennett KL, Mester J, Eng C. Germline epigenetic regulation of KILLIN in Cowden and Cowden-like syndrome. JAMA 304(24), 2724–2731 (2010).
  • Tan MH, Mester JL, Ngeow J, Rybicki LA, Orloff MS, Eng C. Lifetime cancer risks in individuals with germline PTEN mutations. Clin. Cancer Res. 18(2), 400–407 (2012).
  • Bennett KL, Campbell R, Ganapathi S et al. Germline and somatic DNA methylation and epigenetic regulation of KILLIN in renal cell carcinoma. Genes. Chromosomes Cancer 50(8), 654–661 (2011).
  • Nagy R, Ganapathi S, Comeras I et al. Frequency of germline PTEN mutations in differentiated thyroid cancer. Thyroid 21(5), 505–510 (2011).
  • Tan MH, Mester J, Peterson C et al. A clinical scoring system for selection of patients for PTEN mutation testing is proposed on the basis of a prospective study of 3042 probands. Am. J. Hum. Genet. 88(1), 42–56 (2011).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.