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Review

Mucositis in malignant hematology

Pages 57-65 | Published online: 10 Jan 2014

References

  • Sonis ST. Mucositis: the impact, biology and therapeutic opportunities of oral mucositis. Oral Oncol.45(12), 1015–1020 (2009).
  • Niscola P, Romani C, Cupelli L et al. Mucositis in patients with hematologic malignancies: an overview. Haematologica92(2), 222–231 (2007).
  • Sonis ST. The pathobiology of mucositis. Nat. Rev.30, 277 (2004).
  • Logan RM, Stringer AM, Bowen JM, Gibson RJ, Sonis ST, Keefe DM. Is the pathobiology of chemotherapy-induced alimentary tract mucositis influenced by the type of mucotoxic drug administered? Cancer Chemother. Pharmacol.63(2), 239–251 (2009).
  • Kaplan JR, Wolf JS Jr. Efficacy and survival associated with cystoscopy and clot evacuation for radiation or cyclophosphamide induced hemorrhagic cystitis. J. Urol.181(2), 641–646 (2009).
  • Matteucci P, Carlo-Stella C, Di Nicola M et al. Topical prophylaxis of conjunctivitis induced by high-dose cytosine arabinoside. Haematologica91(2), 255–257 (2006).
  • Niscola P, Romani C, Scaramucci L et al. Pain syndromes in the setting of haematopoietic stem cell transplantation for haematological malignancies. Bone Marrow Transplant.41(9), 757–764 (2008).
  • Ramírez-Amador V, Anaya-Saavedra G, Crespo-Solís E, Camacho EI, González-Ramírez I, Ponce-de-León S. Prospective evaluation of oral mucositis in acute leukemia patients receiving chemotherapy. Support Care Cancer DOI: 10.1007/s00520-009-0708-1 (2009) (Epub ahead of print).
  • Sonis ST, Oster G, Fuchs H et al. Oral mucositis and the clinical and economic outcomes of hematopoietic stem-cell transplantation. J. Clin. Oncol.19(8), 2201–2205 (2001).
  • Logan RM, Stringer AM, Bowen JM, Gibson RJ, Sonis ST, Keefe DM. Serum levels of NF-κB and pro-inflammatory cytokines following administration of mucotoxic drugs. Cancer Biol. Ther.7(7), 1139–1145 (2008).
  • Logan RM, Gibson RJ, Sonis ST, Keefe DM. Nuclear factor-κB (NF-κB) and cyclooxygenase-2 (COX-2) expression in the oral mucosa following cancer chemotherapy. Oral Oncol.43(4), 395–401 (2007).
  • Hwang D, Popat R, Bragdon C, O’Donnell KE, Sonis ST. Effects of ceramide inhibition on experimental radiation-induced oral mucositis. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.100(3), 321–329 (2005).
  • Al-Dasooqi N, Gibson RJ, Bowen JM, Keefe DM. Matrix metalloproteinases: key regulators in the pathogenesis of chemotherapy-induced mucositis? Cancer Chemother. Pharmacol.64(1), 1–9 (2009).
  • Bowen JM, Gibson RJ, Cummins AG, Keefe DM. Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage. Support Care Cancer14(7), 713–731 (2006).
  • Keefe DM. Intestinal mucositis: mechanisms and management. Curr. Opin. Oncol.19(4), 323–327 (2007).
  • Stringer AM, Gibson RJ, Bowen JM, Keefe DM. Chemotherapy-induced modifications to gastrointestinal microflora: evidence and implications of change. Curr. Drug Metab.10(1), 79–83 (2009).
  • Barasch A, Peterson DE. Risk factors for ulcerative oral mucositis in cancer patients: unanswered questions. Oral Oncol.9, 91–100 (2003).
  • Sonis ST, Elting LS, Keefe D et al. Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer100(9 Suppl.), 1995–2025 (2004).
  • Keefe D, Anthony L. Tyrosine kinase inhibitors and gut toxicity: a new era in supportive care. Curr. Opin. Support Palliat. Care2(1), 19–21 (2008).
  • Gerson SL, Bhalla KN, Grant S, Creger RJ, Bahlis NJ. Pharmacology and molecular mechanisms of antineoplastic agents for hematologic malignancies. In: Hematology, Basic Principles and Practice. (Fourth Edition) Hoffman R, Benz EJ Jr, Shattil SJ et al. (Eds). Elsevier, Churchill Livingstone, PA, USA 955–1017 (2005).
  • Robien K, Schubert MM, Chay T et al. Methylenetetrahydrofolate reductase and thymidylate synthase genotypes modify oral mucositis severity following hematopoietic stem cell transplantation. Bone Marrow Transplant.37(8), 799–800 (2006).
  • Gemmati D, Ongaro A, Tognazzo S et al. Methylenetetrahydrofolate reductase C677T and A1298C gene variants in adult non-Hodgkin’s lymphoma patients: association with toxicity and survival. Haematologica92(4), 478–485 (2007).
  • Salavaggione OE, Wang L, Wiepert M, Yee VC, Weinshilboum RM. Thiopurine S-methyltransferase pharmacogenetics: variant allele functional and comparative genomics. Pharmacogenet. Genomics15, 801–815 (2005).
  • Coiffier B, Lepage E, Briere J et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. N. Engl. J. Med.346(4), 235–242 (2002).
  • Johnson PW, Radford JA, Cullen MH et al. Comparison of ABVD and alternating or hybrid multidrug regimens for the treatment of advanced Hodgkin’s lymphoma: results of the United Kingdom Lymphoma group LY09 Trial (ISRCTN97144519). J. Clin. Oncol.23(36), 9208–9218 (2005).
  • Friedenberg WR, Miller HJ, Marx JJ Jr et al. The treatment of older adult patients with acute myeloid leukemia by triple infusion chemotherapy. Am. J. Clin. Oncol.18(2), 105–110 (1995).
  • Pea F, Russo D, Michieli M et al. M. Disposition of liposomal daunorubicin during cotreatment with cytarabine in patients with leukaemia. Clin Pharmacokinet.42(9), 851–862 (2003).
  • Ferrara F, Palmieri S, Pocali B et al.De novo acute myeloid leukemia with multilineage dysplasia: treatment results and prognostic evaluation from a series of 44 patients treated with fludarabine, cytarabine and G-CSF (FLAG). Eur. J. Haematol.68(4), 203–209 (2002).
  • Pastore D, Specchia G, Carluccio P et al. FLAG-IDA in the treatment of refractory/relapsed acute myeloid leukemia: single-center experience. Ann. Hematol.82(4), 231–235 (2003).
  • Girmenia C, Lo Coco F, Breccia M et al. Infectious complications in patients with acute promyelocytic leukaemia treated with the AIDA regimen. Leukemia17(5), 925–930 (2003).
  • Wang EH, Chen YA, Corringham S et al. High-dose CEB vs BEAM with autologous stem cell transplant in lymphoma. Bone Marrow Transplant.34(7), 581–587 (2004).
  • Blijlevens N, Schwenkglenks M, Bacon P et al. Prospective oral mucositis audit: oral mucositis in patients receiving high-dose melphalan or BEAM conditioning chemotherapy – European Blood and Marrow Transplantation Mucositis Advisory group. J. Clin. Oncol.26(9), 1519–1525 (2008).
  • Ozturk M, Komurcu S, Kilic S et al. Self-reported experience of mucositis in cancer patients who underwent conditioning regimen and stem cell transplantation. Support Care Cancer17(10), 1295–1299 (2009).
  • Ferrara F, Palmieri S, De Simone M et al. High-dose idarubicin and busulphan as conditioning to autologous stem cell transplantation in adult patients with acute myeloid leukaemia. Br. J. Haematol.128(2), 234–241 (2005).
  • Ferrara F, Palmieri S, Pedata M et al. Autologous stem cell transplantation for elderly patients with acute myeloid leukaemia conditioned with continuous infusion idarubicin and busulphan. Hematol. Oncol.27(1), 40–45 (2009).
  • Kröger N, Zabelina T, Krüger W et al. Comparison of total body irradiation vs busulfan in combination with cyclophosphamide as conditioning for unrelated stem cell transplantation in CML patients. Bone Marrow Transplant.27(4), 349–354 (2001).
  • Moreau P, Facon T, Attal M et al. Comparison of 200 mg/m(2) melphalan and 8 Gy total body irradiation plus 140 mg/m(2) melphalan as conditioning regimens for peripheral blood stem cell transplantation in patients with newly diagnosed multiple myeloma: final analysis of the Intergroupe Francophone du Myélome 9502 randomized trial. Blood99(3), 731–735 (2002).
  • Palumbo A, Bringhen S, Petrucci MT et al. Intermediate-dose melphalan improves survival of myeloma patients aged 50 to 70:results of a randomized controlled trial. Blood104(10), 3052–3057 (2004).
  • Bolwell BJ, Kalaycio M, Sobecks R et al. A multivariable analysis of factors influencing mucositis after autologous progenitor cell transplantation. Bone Marrow Transplant.30(9), 587–591 (2002).
  • Wardley AM, Jayson GC, Swindell R et al. Prospective evaluation of oral mucositis in patients receiving myeloablative conditioning regimens and haemopoietic progenitor rescue. Br. J. Haematol.110(2), 292–299 (2000).
  • Robien K, Schubert MM, Bruemmer B, Lloid ME, Potter JD, Ulrich CM. Predictors of oral mucositis in patients receiving hematopoietic cell transplants for chronic myelogenous leukemia. J. Clin. Oncol.22, 1268–1275 (2004).
  • Cutler C, Li S, Kim HT et al. Mucositis after allogeneic hematopoietic stem cell transplantation: a cohort study of methotrexate- and non-methotrexate-containing graft-versus-host disease prophylaxis regimens. Biol. Blood Marrow Transplant.11(5), 383–388 (2005).
  • Takahashi K, Soga Y, Murayama Y et al. Oral mucositis in patients receiving reduced-intensity regimens for allogeneic hematopoietic cell transplantation: comparison with conventional regimen. Support Care Cancer DOI: 10.1007/s00520-009-0637-z (2009) (Epub ahead of print).
  • Quinn B, Potting CM, Stone R et al. Guidelines for the assessment of oral mucositis in adult chemotherapy, radiotherapy and haematopoietic stem cell transplant patients. Eur. J. Cancer44(1), 61–72 (2008).
  • WCCNR. Assessing stomatitis: refinement of the Western Consortium for Cancer Nursing Research (WCCNR) stomatitis staging system. Can. Oncol. Nurs. J.8, 160–165 (1998).
  • Cella D, Pulliam J, Fuchs H et al. Evaluation of pain associated with oral mucositis during the acute period after administration of high-dose chemotherapy. Cancer98(2), 406–412 (2003).
  • Bellm LA, Epstein JB, Rose-Ped A, Martin P, Fuchs HJ. Patient reports of complications of bone marrow transplantation. Support Care Cancer8(1), 33–39 (2000).
  • van der Velden WJ, Blijlevens NM, Feuth T, Donnelly JP. Febrile mucositis in haematopoietic SCT recipients. Bone Marrow Transplant.43(1), 55–60 (2009).
  • Woo SB, Sonis ST, Monopoli MM, Sonis AL. A longitudinal study of oral ulcerative mucositis in bone marrow transplant recipients. Cancer72, 1612–1617 (1993).
  • Miaskowski C. Biology of mucosal pain. J. Natl Cancer Inst. Monographs29, 37–40 (2001).
  • Triantafyllou K, Dervenoulas J, Tsirigotis P, Ladas SD. The nature of small intestinal mucositis: a video-capsule endoscopy study. Support Care Cancer16(10), 1173–1178 (2008).
  • Blijlevens NM, Donnelly JP, Yakar D, van Die CE, de Witte T. Determining mucosal barrier injury to the oesophagus using CT scan. Support Care Cancer15(9), 1105–1108 (2007).
  • Canaud G, Vasiliu V, Suarez F. Clinical challenges and images in GI. Esophageal mucosa expulsion after high-dose chemotherapy. Gastroenterology136(5), 1508, 1847 (2009).
  • Davila ML. Neutropenic enterocolitis. Curr. Opin. Gastroenterol.22(1), 44–47 (2006).
  • Siniscalchi A, Tendas A, Ales M et al. Bortezomib-related colon mucositis in a multiple myeloma patient. Support Care Cancer17(4), 325–327 (2009).
  • Rubenstein EB, Peterson DE, Schubert M et al. Clinical practice guidelines for the prevention and treatment of cancer therapy-induced oral and gastrointestinal mucositis. Cancer100(9 Suppl.), 2026–2046 (2004).
  • Keefe DM, Schubert MM, Elting LS et al. Updated clinical practice guidelines for the prevention and treatment of mucositis. Cancer109(5), 820–831 (2007).
  • Bensinger W, Schubert M, Ang KK et al. NCCN Task Force Report: prevention and management of mucositis in cancer care. J. Natl Compr. Canc. Netw.6(Suppl. 1), S1–21 (2008).
  • Hensley ML, Hagerty KL, Kewalramani T et al. American Society of Clinical Oncology 2008 clinical practice guideline update: use of chemotherapy and radiation therapy protectants. J. Clin. Oncol.27(1), 127–145 (2009).
  • Lövenich H, Schütt-Gerowitt H, Keulertz C et al. Failure of anti-infective mouth rinses and concomitant antibiotic prophylaxis to decrease oral mucosal colonization in autologous stem cell transplantation. Bone Marrow Transplant.35(10), 997–1001 (2005).
  • von Bültzingslöwen I, Brennan MT, Spijkervet FK et al. Growth factors and cytokines in the prevention and treatment of oral and gastrointestinal mucositis. Support Care Cancer14(6), 519–527 (2006).
  • Potting CM, Uitterhoeve R, Op Reimer WS, Van Achterberg T. The effectiveness of commonly used mouthwashes for the prevention of chemotherapy-induced oral mucositis: a systematic review. Eur. J. Cancer Care (Engl.)15(5), 431–439 (2006).
  • Vokurka S, Bystrická E, Koza V et al. The comparative effects of povidone-iodine and normal saline mouthwashes on oral mucositis in patients after high-dose chemotherapy and APBSCT – results of a randomized multicentre study. Support Care Cancer13(7), 554–558 (2005).
  • Lockhart PB, Brennan MT, Kent ML et al. Randomized controlled trial of pilocarpine hydrochloride for the moderation of oral mucositis during autologous blood stem cell transplantation. Bone Marrow Transplant.35(7), 713–720 (2005).
  • Elad S, Ackerstein A, Bitan M et al. A prospective, double-blind Phase II study evaluating the safety and efficacy of a topical histamine gel for the prophylaxis of oral mucositis in patients post hematopoietic stem cell transplantation. Bone Marrow Transplant.37(8), 757–762 (2006).
  • Sironi M, Milanese C, Vecchi A et al. Benzydamine inhibits the release of tumor necrosis factor-α and monocyte chemotactic protein-1 by Candida albicans-stimulated human peripheral blood cells. Int. J. Clin. Lab. Res.27(2), 118–122 (1997).
  • Thieblemont C, Dumontet C, Saad H et al. Amifostine reduces mucosal damage after high-dose melphalan conditioning and autologous peripheral blood progenitor cell transplantation for patients with multiple myeloma. Bone Marrow Transplant.30(11), 769–775 (2002).
  • Crowther M, Avenell A, Culligan DJ. Systematic review and meta-analyses of studies of glutamine supplementation in haematopoietic stem cell transplantation. Bone Marrow Transplant.44(7), 413–425 (2009).
  • Lalla RV, Schubert MM, Bensadoun RJ, Keefe D. Anti-inflammatory agents in the management of alimentary mucositis. Support Care Cancer14, 558–565 (2006).
  • Migliorati CA, Oberle-Edwards L, Schubert M. The role of alternative and natural agents, cryotherapy, and/or laser for management of alimentary mucositis. Support Care Cancer14, 533–540 (2006).
  • Spielberger R, Stiff P, Bensinger W et al. Palifermin for oral mucositis after intensive therapy for hematologic cancers. N. Engl. J. Med. 16, 351(25), 2590–2598 (2004).
  • Niscola P, Scaramucci L, Giovannini M et al. Palifermin in the management of mucositis in hematological malignancies: current evidences and future perspectives. Cardiovasc. Hematol. Agents Med. Chem.7(4), 305–312 (2009).
  • Epstein JB, Schubert MM. Managing pain in mucositis. Semin. Oncol. Nurs.20, 30–37 (2004).
  • Cerchietti LC, Navigante AH, Körte MW et al. Potential utility of the peripheral analgesic properties of morphine in stomatitis-related pain: a pilot study. Pain105(1–2), 265–273 (2003).
  • Epstein JB, Epstein JD, Epstein MS, Oien H, Truelove EL. Doxepin rinse for management of mucositis pain in patients with cancer: one week follow-up of topical therapy. Spec. Care Dentist.28(2), 73–77 (2008).
  • Keefe DM. Mucositis guidelines: what have they achieved, and where to from here? Support Care Cancer14(6), 489–491 (2006).
  • Bowen JM, Keefe DM. New pathways for alimentary mucositis. J. Oncol. 907892 (2008).
  • Keefe DM, Sonis ST, Bowen JM. Emerging drugs for chemotherapy-induced mucositis. Expert Opin Emerg. Drugs.13(3), 511–522 (2008).
  • Evans WE, McLeod HL. Pharmacogenomics; drug disposition, drug targets, and side effects. N. Engl. J. Med.348, 538–549 (2003).
  • Chung HM, Lyckholm LJ, Smith TJ. Palliative care in BMT. Bone Marrow Transplant.43(4), 265–273 (2009).

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