298
Views
29
CrossRef citations to date
0
Altmetric
Drug Profile

Pharmacology of argatroban

, , , &
Pages 527-539 | Published online: 10 Jan 2014

References

  • Kobayashi W, Tazaki Y. Effect of the thrombin inhibitor argatroban in acute cerebral thrombosis. Semin. Thromb. Hemost.23, 531–534 (1997).
  • Ota K, Akizawa T, Hirasawa Y, Agishi T, Matsui N. Effects of argatroban as an anticoagulant for haemodialysis in patients with antithrombin III deficiency. Nephrol. Dial. Transplant.18, 1623–1630 (2003).
  • Miyata S, Yamamoto H, Kamei M et al. Heparin-induced thrombocytopenia clinical studies and the efficacy of argatroban in Japan. Semin. Thromb. Hemost.34(Suppl. 1), 37–47 (2008).
  • Ansell J, Hirsh J, Hylek E, Jacobson A, Crowther M, Palareti G. Pharmacology and management of the vitamin K antagonists. Chest133, S160–S198 (2008).
  • Duggan ST, Scott LJ, Plosker GL. Rivaroxaban: a review of its use for the prevention of venous thromboembolism after total hip or knee replacement surgery. Drugs69(13), 1829–1851 (2009).
  • Carreiro J, Ansell J. Apixaban, an oral direct Factor Xa inhibitor: awaiting the verdict. Expert Opin. Investig. Drugs17(12), 1937–1945 (2008).
  • Baetz BE, Spinler SA. Dabigatran etexilate: an oral direct thrombin inhibitor for prophylaxis and treatment of thromboembolic diseases. Pharmacotherapy28(11), 1354–1373 (2008).
  • Eriksson BI, Quinlan DJ, Weitz JI. Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor Xa inhibitors in development. Clin. Pharmacokinet.48(1), 1–22 (2009).
  • Bush LR. Argatroban, a selective, potent thrombin inhibitor. Cardiovasc. Drug Rev.9(3), 247–263 (1991).
  • Kikumoto R, Tamao Y, Tezuka T et al. Selective inhibition of thrombin by (2R, 4R)-4-methyl-1-[N2-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-l-arginyl)]-2-piperidinecarboxylic acid. Biochemistry23, 85–90 (1984).
  • Berry CN, Girardot C, Lecoffre C, Lunven C. Effects of th e synthetic thrombin inhibitor argatroban on fibrin-or clot-incorporated thrombin: comparison with heparin and recombinant hirudin. Thromb. Haemost.72, 381–386 (1994).
  • Hara H, Yoshikuni T, Kikumoto R. Effect of argatroban (MD-805) on platelet function. Jap. J. Pharm. Ther.14(Suppl. 1), 13–19 (1986).
  • Ueki Y, Matsumoto K, Kizaki Y et al. Argatroban increases nitric oxide levels in patients with peripheral arterial obstructive disease: placebo-controlled study. J. Thromb. Thrombolysis8(2), 131–137 (1999).
  • Rawson TE, Van Gorp KA, Yang J, Kogan TP. Separation of 21-(R)- and 21-(S)- argatroban: solubility and activity of the individual diastereoisomers. J. Pharm. Sci.82(6), 672–673 (1993).
  • Yeh R, Jang IK. Argatroban; update. Am. Heart J.151, 1131–1138 (2006).
  • Ansara AJ, Arif S, Warhurst RD. Weight-based argatroban dosing nomogram for treatment of heparin-induced-thrombocytopenia. Ann. Pharmacother.43(1), 9–18 (2009).
  • Ahsan A, Ahmad S, Iqbal O et al. Comparative studies on the biochemical and pharmacological properties of a major metabolite of argatroban (M1) [Abstract]. Thromb. Haemost.178(Suppl. 1), 92 (1997).
  • Hursting MJ, Alford KL, Becker JC et al. Novastan (brand of argatroban): a small-molecule, direct thrombin inhibitor. Semin. Thromb. Hemost.23, 503–516 (1997).
  • Hursting MJ, Murray PT. Argatroban anticoagulation in renal dysfunction: a literature analysis. Nephron109(2), 80–94 (2008).
  • Swan SK, Hursting MJ. The pharmacokinetics and pharmacodynamics of argatroban: effects of age, gender, and hepatic or renal dysfunction. Pharmacotherapy20, 318–329 (2000).
  • Guzzi LM, McCollum DA, Hursting MJ. Effect of renal function on argatroban therapy in heparin-induced thrombocytopenia. J. Thromb. Thrombolysis22(3), 169–176 (2006).
  • Husting MJ, Jang IK. Impact of renal function on argatroban therapy during percutaneous coronary intervention. J. Thromb. Thrombolysis29, 1–7 (2010).
  • Levine RL, Hursting MJ, McCollum D. Argatroban therapy in heparin-induced thrombocytopenia with hepatic dysfunction. Chest129(5), 1167–1175 (2006).
  • Hursting MJ, Dubb J, Verme-Gibboney CN. Argatroban anticoagulation in pediatric patients: a literature analysis. J. Pediatr. Hematol. Oncol.28(1), 4–10 (2006).
  • Hursting MJ, Jang IK. Effect of body mass index on argatroban therapy during percutaneous coronary intervention. J. Thromb. Thrombolysis25(3), 273–279 (2008).
  • Begelman SM, Baghdasarian SB, Singh IM, Militello MA, Hursting MJ, Bartholomew JR. Argatroban anticoagulation in intensive care patients: effects of heart failure and multiple organ system failure. J. Intensive Care Med.23(5), 313–320 (2008).
  • Keegan SP, Gallagher EM, Ernst NE, Young EJ, Mueller EW. Effects of critical illness and organ failure on therapeutic argatroban dosage requirements in patients with suspected or confirmed heparin-induced thrombocytopenia. Ann. Pharmacother.43, 19–27 (2009).
  • Warkentin TE, Greinacher A, Koster A, Lincoff AM. Treatment and prevention of heparin-induced thrombocytopenia. Chest133, S340–S380 (2008).
  • Clark RJ, Mayo G, Fitzgerald GA, Fitzgerald DJ. Combined administration of aspirin and a specific thrombin inhibitor in man. Circulation83, 1510–1518 (1991).
  • Tran JQ, DiCicco RA, Sheth SB. Assessment of the potential pharmacokinetic and pharmacodynamic interactions between erythromycin and argatroban. J. Clin. Pharmacol.39, 513–519 (1999).
  • Inglis AL, Sheth SB, Hursting MJ, Tenero DM, Graham AM, DiCicco RA. Investigation of interaction between argatroban and acetaminophen, lidocaine, or digoxin. Am. J. Health Syst. Pharm.59, 1258–1266 (2002).
  • Tamao Y, Yamamoto T, Hirata T, Kinusaga M, Kikumoto R. Effect of argatroban on blood coagulation. Jap. J. Pharm. Ther.14(5), 7–12 (1986).
  • Walenga JM, Ahmad S, Hoppensteadt D, Iqbal O, Hursting MJ, Lewis BE. Argatroban therapy does not generate antibodies that alter its anticoagulant activity in patients with heparin-induced thrombocytopenia. Thromb. Res.105, 401–405 (2002).
  • Jeske W, Walenga JM, Lewis BE, Fareed J. Pharmacology of argatroban. Expert Opin. Investig. Drugs8, 625–654 (1999).
  • Fareed J, Jeske WP. Small-molecule direct antithrombins: argatroban. Best Pract. Res. Clin. Haematol.17(1), 127–138 (2004).
  • Fareed J, Hoppensteadt D, Iqbal O, Tobu M, Lewis BE. Practical issues in the development of argatroban: a perspective. Pathophys. Haemost. Thromb.32(Suppl. 3), 56–65 (2002).
  • Weitz JI, Crowther MA. New anticoagulants; current status and future potential. Am. J. Cardiovasc. Drugs3, 201–209 (2003).
  • Lewis BE, Walenga JM, Hursting MJ. Argatroban anticoagulation in patients with heparin-induced thrombocytopenia. Cardiovasc. Rev. Rep.23(8), 445–454 (2002).
  • LaMonte MP, Brown PM, Hursting MJ. Alternative parenteral anticoagulation with argatroban, a direct thrombin inhibitor. Future Drugs3(1), 31–41 (2005).
  • Alving BM. How I treat heparin-induced thrombocytopenia and thrombosis. Blood101(1), 31–37 (2003).
  • Levine RL, Hursting MJ, Drexler A, Lewis BE, Francis JL. Heparin-induced thrombocytopenia in the emergency department. Ann. Emerg. Med.44(5), 511–515 (2004).
  • Hirsh J, Heddle N, Kelton JG. Treatment of heparin-induced thrombocytopenia. A critical review. Arch. Intern. Med.164, 361–369 (2004).
  • Hursting MJ, Soffer J. Reducing harm associated with anticoagulation: practical considerations of argatroban therapy in heparin-induced thrombocytopenia. Drug Saf.32(3), 203–218 (2009).
  • Lewis BE, Wallis DE, Berkowitz SD et al. Argatroban anticoagulant therapy in patients with heparin-induced thrombocytopenia. Circulation103, 1838–1843 (2001).
  • Lewis BE, Wallis DE, Leya F, Hursting MJ, Kelton JG; Argatroban-915 Investigators. Argatroban anticoagulation in patients with heparin-induced thrombocytopenia. Arch. Intern. Med.163, 1849–1856 (2003).
  • Matthai WH, Hursting MJ, Lewis BE, Kelton JG. Argatroban anticoagulation in patients with a history of heparin-induced thrombocytopenia. Thromb. Res.116(2), 121–126 (2005).
  • Greinacher A, Janssens U, Berg G et al.; for the Heparin-Associated Thrombocytopenia Study (HAT) Investigators. Lepirudin (recombinant hirudin) for parenteral anticoagulation in patients with heparin-induced thrombocytopenia. Circulation100(6), 587–593 (1999).
  • Greinacher A, Volpel H, Janssens U et al.; for the HIT Investigators Group. Recombinant hirudin (lepirudin) provides safe and effective anticoagulation in patients with heparin-induced thrombocytopenia: a prospective study. Circulation99, 73–80 (1999).
  • Veach SA, Franks AM, Allan MC. Severe anaphylactic reaction after repeated intermittent exposure to lepirudin. Pharmacotherapy27(5), 760–765 (2007).
  • Harenberg J, Jorg I, Fenyvesi T, Piazolo L. Treatment of patients with a history of heparin-induced thrombocytopenia and anti-lepirudin antibodies with argatroban. J. Thromb. Thrombolysis19(1), 65–69 (2005).
  • Kemkes-Matthes B, Walenga JM, Harenberg J, Fareed J. Argatroban treatment for patients with intolerance to heparin and hirudin. Clin. Appl. Thromb. Hemost.11(1), 99–103 (2005).
  • Smythe MA, Stephens JL, Koerber JM, Mattson JC. A comparison of lepirudin and argatroban outcomes. Clin. Appl. Thromb. Hemost.11(4), 371–374 (2005).
  • Bartholomew JR, Pietrangeli CE, Hursting MJ. Argatroban anticoagulation for heparin-induced thrombocytopenia in elderly patients. Drugs Aging24(6), 489–499 (2007).
  • Lewis BE, Matthai WH Jr, Cohen M et al. Argatroban anticoagulation during percutaneous coronary intervention in patients with heparin induced thrombocytopenia. Catheter Cardiovasc. Interv.57, 177–184 (2002).
  • Cruz-Gonzalez I, Sanchez-Ledesma M, Osakabe M et al. What is the optimal anticoagulation level with argatroban during percutaneous coronary intervention? Blood Coagul. Fibrinolysis19(5), 401–404 (2008).
  • Jang IK, Lewis BE, Matthai WH, Kleiman NS. Argatroban anticoagulation in conjunction with glycoprotein IIb/IIIa inhibition in patients undergoing percutaneous coronary intervention: an open-label, non-randomized trial. J. Thromb. Thrombolysis18(1), 31–37 (2004).
  • Cox DS, Kleiman NS, Boyle DA et al. Pharmacokinetics and pharmacodynamics of argatroban in combination with a platelet glycoprotein IIb/IIIa receptor antagonist in patients undergoing percutaneous coronary intervention. J. Clin. Pharm.44(9), 981–990 (2004).
  • Cruz-Gonzalez I, Sanchez-Ledesma M, Baron SJ et al. Efficacy and safety or argatroban with or without glycoprotein IIb/IIIa inhibitor in patients with heparin induced thrombocytopenia undergoing percutaneous coronary intervention for acute coronary syndrome. J. Thromb. Thrombolysis25(2), 214–218 (2008).
  • Hirahara T, Kubo N, Ohmura N et al. Prospective randomized study of argatroban versus heparin anticoagulation therapy after percutaneous coronary intervention for acute myocardial infarction. J. Cardiol.44(2), 47–52 (2004).
  • Itoh T, Nonogi H, Miyazaki S et al. Local delivery of argatroban for the prevention of restenosis after coronary balloon angioplasty: a prospective randomized pilot study. Circ. J.68(7), 615–622 (2004).
  • Roessig L, Genth-Zotz S, Rau M et al. Argatroban for elective percutaneous coronary intervention: the ARG-EO4 multi-center study. Int. J. Cardiol. DOI: 10.1016/j.ijcard.2010.02.044. (2010) (Epub ahead of print).
  • Cetta F, Graham LC, Wrona LL, Arruda MJ, Walenga JM. Argatroban use during pediatric interventional cardiac catheterization. Cath. Cardiovasc. Interv.61(1), 147–149 (2004).
  • Vermeer F, Vahanian A, Fels PW et al. Argatroban and alteplase in patients with acute myocardial infarction: the ARGAMI study. J. Thromb. Thrombolysis10, 233–240 (2000).
  • Nagatsuna T, Nomura S, Suehiro E, Fujisawa H, Koizumi H, Suzuki M. Systemic administration of argatroban reduces secondary brain damage in a rat model of intracerebral hemorrhage; histopathological assessment. Cerebrovasc. Dis.19(3), 192–200 (2005).
  • LaMonte MP, Nash ML, Wang DZ et al. Argatroban anticoagulation in patients with acute ischemic stroke (ARGIS-1): a randomized, placebo-controlled safety study. Stroke35(7), 1677–1682 (2004).
  • LaMonte MP, Brown PM, Hursting MJ. Stroke in patients with heparin-induced thrombocytopenia and the effect of argatroban therapy. Crit. Care Med.32(4), 976–980 (2004).
  • Murray PT, Reddy BV, Grossman EJ et al. A prospective comparison of three argatroban regimens during hemodialysis in end-stage renal disease. Kidney Int.66(6), 2446–2453 (2004).
  • Tang IY, Cox DS, Patel K et al. Argatroban and renal replacement therapy in patients with heparin-induced thrombocytopenia. Ann. Pharmacother.39(2), 231–236 (2005).
  • Young G, Yonekawa KE, Nakagawa P, Nugent DJ. Argatroban as an alternative to heparin in extracorporeal membrane oxygenation circuits. Perfusion19(5), 283–288 (2004).
  • Johnston N, Wait M, Huber L. Argatroban in adult extracorporeal membrane oxygenation. J. Extra Corpor. Technol.34, 281–284 (2002).
  • Kawada T, Kitagawa H, Hoson M, Okada Y, Shiomura J. Clinical application of argatroban as an alternative anticoagulant for extracorporeal circulation. Hematol. Oncol. Clin. N. Am.14, 4445–4457 (2000).
  • Mejak B, Giacomuzzi C, Heller E et al. Argatroban usage for anticoagulation for ECMO on a post-cardiac patient with heparin-induced thrombocytopenia. J. Extra Corpor. Technol.36(2), 178–181 (2004).
  • Kawada T, Mieda T, Abe H et al. Left heart bypass with the bio-medicus centrifugal pump by the use of an antithrombin agent, argatroban. Kyobu Geka47, 803–808 (1994).
  • Edwards JT, Hamby JK, Worrall NK. Successful use of argatroban as a heparin substitute during cardiopulmonary bypass: heparin-induced thrombocytopenia in a high-risk cardiac surgical patient. Ann.Thorac. Surg.75, 1622–1624 (2003).
  • Kamei M, Miyata S, Niwaya K et al. Successful argatroban anticoagulant management for left ventricular assist system implantation in two patients with heparin-induced thrombocytopenia type II. J. Thromb. Hemost.1(Suppl. 1), P1162 (2003).
  • Tokuda Y, Matsumoto M, Sugita T et al. Vascular surgery using argatroban in a patient with a history of heparin-induced thrombocytopenia. Circ. J.67, 899–890 (2003).
  • Malherbe S, Tsui BCH, Stobart K, Koller J. Argatroban as anticoagulant in cardiopulmonary bypass in an infant and attempted reversal with recombinant activated factor VII. Anesthesiology100, 443–445 (2004).
  • Dyke PC, Russo P, Mureebe L, Russo J, Tobias JD. Argatroban for anticoagulation during cardiopulmonary bypass in an infant. Paediatr. Anaesth.15, 328–333 (2005).
  • Mejak B, Giacomuzzi C, Shen I, Boshkov L, Ungerleider R. Cardiopulmonary bypass using argatroban as an anticoagulant for a 6.0‑kg pediatric patient. J. Extra. Corpor. Technol.37, 303–305 (2005).
  • Alsoufi B, Boshkov LK, Kirby A et al. Heparin-induced thrombocytopenia (HIT) in pediatric cardiac surgery: an emerging cause of morbidity and mortality. Semin. Thorac. Cardiovasc. Surg. Pediatr. Card. Surg. Ann.7, 155–171 (2004).
  • Kieta DR, McCammon AT, Holman WL, Nielsen VG. Hemostatic analysis of a patient undergoing off-pump coronary artery bypass surgery with argatroban anticoagulation. Anesth. Analg.96, 956–958 (2003).
  • Ohno H, Higashidate M, Yokosuka T. Argatroban as an alternative anticoagulant for patients with heparin allergy during coronary artery bypass. Heart Vessels18, 40–42 (2003).
  • Arnoletti JP, Whitman GJR. Heparin-induced thrombocytopenia in coronary bypass surgery. Ann. Thorac. Surg.68, 576–578 (1999).
  • Ide H, Fujiki T, Sato M, Endo H, Imamura K, Sudo K. Off-pump coronary artery bypass for a heparin-allergic patient. Jpn. J. Thorac. Cardiovasc. Surg.49, 250–254 (2001).
  • Cannon MA, Butterworth J, Riley RD, Hyland JM. Failure of argatroban anticoagulation during off-pump coronary artery bypass surgery. Ann. Thorac. Surg.77, 711–713 (2004).
  • Lubenow N, Selleng S, Wollert HG, Eichler P, Mullejans B, Greinacher A. Heparin-induced thrombocytopenia and cardiopulmonary bypass: perioperative argatroban use. Ann. Thorac. Surg.75(2), 577–579 (2003).
  • Hoffman WD, Czyz Y, McCollum DA, Hursting MJ. Reduced argatroban doses after coronary artery bypass graft surgery. Ann. Pharmacother.42(3), 309–316 (2008).
  • Hursting MJ, Verme-Gibboney CN. Risk factors for major bleeding in patients with heparin-induced thrombocytopenia treated with argatroban: a retrospective study. J. Cardiovasc. Pharm.52(6), 561–566 (2008).
  • Gray E, Harenberg J; on behalf of the ISTH Control of Anticoagulation SSC Working Group on Thrombin Inhibitors. Collaborative study on monitoring methods to determine direct thrombin inhibitors lepirudin and argatroban. J. Thromb. Haemost.3, 2096–2097 (2005).
  • Francis JL, Hursting MJ. Effect of argatroban on the activated partial thromboplastin time: a comparison of 21 commercial reagents. Blood Coagul. Fibrinolysis16, 251–257 (2005).
  • Iqbal O, Ahmad S, Lewis BE, Walenga JM, Rangel Y, Fareed J. Monitoring of argatroban in ARG310 study: potential recommendations for its use in interventional cardiology. Clin. Appl. Thromb. Hemost.8(3), 217–224 (2002).
  • Gosselin RC, Dager WE, King JH et al. Effect of direct thrombin inhibitors, bivalirudin, lepirudin and argatroban, on prothrombin time and INR values. Am. J. Clin. Pathol.121, 593–599 (2004).
  • Sheth SB, DiCicco RA, Hursting MJ, Montague T, Jorkasky DK. Interpreting the international normalized ratio (INR) in individuals receiving argatroban and warfarin. Thromb. Haemost.85, 435–440 (2001).
  • Harder S, Graff J, Klinkhardt U et al. Transition from argatroban to oral anticoagulation with phenprocoumon or acenocoumarol: effects on PT, aPTT and ecarin clotting time. Thromb. Haemost.91, 1137–1145 (2004).
  • Walenga JM, Drenth AF, Mayuga M et al. Transition from argatroban to oral anticoagulation with phenprocoumon or acenocoumarol: effect on coagulation factor testing. Clin. Appl. Thromb. Hemost.14(3), 325–331 (2008).
  • Hursting MJ, Lewis BE, Macfarlane DE. Transitioning from argatroban to warfarin therapy in patients with heparin-induced thrombocytopenia. Clin. Appl. Thromb. Hemost.11(3), 279–287 (2005).
  • Hirsh J, Bauer KA, Donati MB, Gould M, Samama MM, Weitz JI. Parenteral anticoagulants. Chest133, S141–S159 (2008).
  • Gosselin RC, Dager WE, King JH et al. Effect of direct thrombin inhibitors, bivalirudin, lepirudin, and argatroban, on prothrombin time and INR values. Am. J. Clin. Pathol.121, 593–599 (2004).
  • Gorman R, Gordan L, Zumberg M, Kitchens C. Successful use of argatroban as an anticoagulant in burn-related severe acquired antithrombin III deficiency after heparin failure. Thromb. Haemost.86, 1596–1597 (2001).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.