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Editorial

Does Kisspeptin signaling offer a new way to treat infertility?

, &
Pages 477-481 | Published online: 10 Jan 2014

References

  • Muir AI, Chamberlain L, Elsantibagy NA et al. AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1. J. Biol. Chem.276(31), 28969–28975 (2001).
  • Ohtaki T, Shintani Y, Honda S et al. Metastasis suppressor gene KISS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature411(6837), 613–617 (2001).
  • de Roux N, Genin E, Carel JC et al. Hypogonadotropic hypogonadism due to loss of function of the KISS1-derived peptide receptor GPR54. Proc. Natl Acad. Sci. USA100(19), 10972–10976 (2003).
  • Seminara SB, Messager S, Chatzidaki EE et al. The GPR54 gene as a regulator of puberty. N. Engl. J. Med.349(17), 1614–1627 (2003).
  • Lapatto R, Pallais JC, Zhang D et al.Kiss1-/- mice exhibit more variable hypogonadism than Gpr54-/- mice. Endocrinology148(10), 4927–4936 (2007).
  • d’Anglemont de Tassigny X, Fagg LA, Dixon JP et al. Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene. Proc. Natl Acad. Sci. USA104(25), 10714–10719 (2007).
  • Roseweir AK, Kauffman AS, Smith JT et al. Discovery of potent Kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation. J. Neurosci.29(12), 3920–3929 (2009).
  • Irwig MS, Fraley GS, Smith JT et al. Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of KISS-1 mRNA in the male rat. Neuroendocrinology80(4), 264–272 (2004).
  • Matsui H, Takatsu Y, Kumano S et al. Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat. Biochem. Biophys. Res. Commun.320(2), 383–388 (2004).
  • Navarro VM, Castellano JM, Fernandez-Fernandez R et al. Developmental and hormonally regulated messenger ribonucleic acid expression of KISS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KISS-1 peptide. Endocrinology145(10), 4565–4574 (2004).
  • Thompson EL, Patterson M, Murphy KG et al. Central and peripheral administration of Kisspeptin-10 stimulates the hypothalamic–pituitary–gonadal axis. J. Neuroendocrinol.16(10), 850–858 (2004).
  • Gottsch ML, Cunningham MJ, Smith JT et al. A role for Kisspeptins in the regulation of gonadotropin secretion in the mouse. Endocrinology145(9), 4073–4077 (2004).
  • Messager S, Chatzidaki EE, Ma D et al. Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. Proc. Natl Acad. Sci. USA102(5), 1761–1766 (2005).
  • Caraty A, Smith JT, Lomet D et al. Kisspeptin synchronizes preovulatory surges in cyclical ewes and causes ovulation in seasonally acyclic ewes. Endocrinology148(11), 5258–5267 (2007).
  • Arreguin-Arevalo JA, Lents CA, Farmerie TA et al. KISS-1 peptide induces release of LH by a direct effect on the hypothalamus of ovariectomized ewes. Anim. Reprod. Sci.101(3–4), 265–275 (2007).
  • Revel FG, Saboureau M, Masson-Pevet M et al. Kisspeptin mediates the photoperiodic control of reproduction in hamsters. Curr. Biol.16(17), 1730–1735 (2006).
  • Shahab M, Mastronardi C, Seminara SB et al. Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates. Proc. Natl Acad. Sci. USA102(6), 2129–2134 (2005).
  • Lents CA, Heidorn NL, Barb CR et al. Central and peripheral administration of Kisspeptin activates gonadotropin but not somatotropin secretion in prepubertal gilts. Reproduction135(6), 879–887 (2008).
  • Kadokawa H, Matsui M, Hayashi K et al. Peripheral administration of Kisspeptin-10 increases plasma concentrations of GH as well as LH in prepubertal Holstein heifers. J. Endocrinol.196(2), 331–334 (2008).
  • Dhillo WS, Chaudhri OB, Patterson M et al. Kisspeptin-54 stimulates the hypothalamic–pituitary–gonadal axis in human males. J. Clin. Endocrinol. Metab90(12), 6609–6615 (2005).
  • Dhillo WS, Chaudhri OB, Thompson EL et al. Kisspeptin-54 stimulates gonadotropin release most potently during the preovulatory phase of the menstrual cycle in women. J. Clin. Endocrinol. Metab92(10), 3958–3966 (2007).
  • Han SK, Gottsch ML, Lee KJ et al. Activation of gonadotropin-releasing hormone neurons by Kisspeptin as a neuroendocrine switch for the onset of puberty. J. Neurosci.25(49), 11349–11356 (2005).
  • Kotani M, Detheux M, Vandenbogaerde A et al. The metastasis suppressor gene KISS-1 encodes Kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J. Biol. Chem.276(37), 34631–34636 (2001).
  • Gutierrez-Pascual E, Martinez-Fuentes AJ, Pinilla L et al. Direct pituitary effects of Kisspeptin: activation of gonadotrophs and somatotrophs and stimulation of luteinising hormone and growth hormone secretion. J. Neuroendocrinol.19(7), 521–530 (2007).
  • Suzuki S, Kadokawa H, Hashizume T. Direct Kisspeptin-10 stimulation on luteinizing hormone secretion from bovine and porcine anterior pituitary cells. Anim. Reprod. Sci.103(3–4), 360–365 (2008).
  • Herbison AE. Multimodal influence of estrogen upon gonadotropin-releasing hormone neurons. Endocr. Rev.19(3), 302–330 (1998).
  • d’Anglemont de Tassigny X, Fagg LA, Carlton MB et al. Kisspeptin can stimulate gonadotropin-releasing hormone (GnRH) release by a direct action at GnRH nerve terminals. Endocrinology149(8), 3926–3932 (2008).
  • Rometo AM, Krajewski SJ, Voytko ML et al. Hypertrophy and increased Kisspeptin gene expression in the hypothalamic infundibular nucleus of postmenopausal women and ovariectomized monkeys. J. Clin. Endocrinol. Metab.92(7), 2744–2750 (2007).
  • Smith JT, Clay CM, Caraty A et al.KISS-1 messenger ribonucleic acid expression in the hypothalamus of the ewe is regulated by sex steroids and season. Endocrinology148(3), 1150–1157 (2007).
  • Smith JT, Popa SM, Clifton DK et al. Kiss1 neurons in the forebrain as central processors for generating the preovulatory luteinizing hormone surge. J. Neurosci.26(25), 6687–6694 (2006).
  • Smith JT, Dungan HM, Stoll EA et al. Differential regulation of KISS-1 mRNA expression by sex steroids in the brain of the male mouse. Endocrinology146(7), 2976–2984 (2005).
  • Herbison AE. Estrogen positive feedback to gonadotropin-releasing hormone (GnRH) neurons in the rodent: the case for the rostral periventricular area of the third ventricle (RP3V). Brain Res. Rev.57(2), 277–287 (2008).
  • Witkin JW, Xiao E, Popilskis S et al. FOS expression in the gonadotropin-releasing hormone (GnRH) neuron does not increase during the ovarian steroid-induced GnRH surge in the rhesus monkey. Endocrinology135(3), 956–961 (1994).
  • Jayasena CN, Chaudhri OB, Nijher GK et al. Kisspeptin potently increases reproductive hormone release in women with hypothalamic amenorrhoea: a potential novel therapy for infertility. Presented at: Society for Endocrinology BES 2009 Meeting. Harrogate, UK, 16–19 March 2009.
  • Horikoshi Y, Matsumoto H, Takatsu Y et al. Dramatic elevation of plasma metastin concentrations in human pregnancy: metastin as a novel placenta-derived hormone in humans. J. Clin. Endocrinol. Metab.88(2), 914–919 (2003).
  • Janneau JL, Maldonado-Estrada J, Tachdjian G et al. Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells. J. Clin. Endocrinol. Metab87(11), 5336–5339 (2002).
  • Mead EJ, Maguire JJ, Kuc RE et al. Kisspeptins are novel potent vasoconstrictors in humans, with a discrete localization of their receptor, G protein-coupled receptor 54, to atherosclerosis-prone vessels. Endocrinology148(1), 140–147 (2007).
  • Kadokawa H, Suzuki S, Hashizume T. Kisspeptin-10 stimulates the secretion of growth hormone and prolactin directly from cultured bovine anterior pituitary cells. Anim. Reprod. Sci.105(3–4), 404–408 (2008).
  • Whitlock BK, Daniel JA, Wilborn RR et al. Interaction of estrogen and progesterone on Kisspeptin-10-stimulated luteinizing hormone and growth hormone in ovariectomized cows. Neuroendocrinology88(3), 212–215 (2008).
  • Hauge-Evans AC, Richardson CC, Milne HM et al. A role for Kisspeptin in islet function. Diabetologia49(9), 2131–2135 (2006).
  • Arai AC, Xia YF, Suzuki E et al. Cancer metastasis-suppressing peptide metastin upregulates excitatory synaptic transmission in hippocampal dentate granule cells. J. Neurophysiol.94(5), 3648–3652 (2005).
  • Diedrich K, Felberbaum R. New approaches to ovarian stimulation. Hum. Reprod.13(Suppl. 3), 1–13 (1998).
  • Elchalal U, Schenker JG. The pathophysiology of ovarian hyperstimulation syndrome – views and ideas. Hum. Reprod.12(6), 1129–1137 (1997).
  • Niida A, Wang Z, Tomita K et al. Design and synthesis of downsized metastin (45–54) analogs with maintenance of high GPR54 agonistic activity. Bioorg. Med. Chem. Lett.16(1), 134–137 (2006).
  • Tomita K, Niida A, Oishi S et al. Structure–activity relationship study on small peptidic GPR54 agonists. Bioorg. Med. Chem.14(22), 7595–7603 (2006).
  • Kaiser U. Identification of small molecule agonists and antagonists of the G-protein-coupled receptor GPR54 by high throughput screening. Presented at: 1st World Conference on Kisspeptin Signalling in the Brain. Cordoba, Spain, 8–10 October (2008).
  • Seminara SB, Dipietro MJ, Ramaswamy S et al. Continuous human metastin 45–54 infusion desensitizes G protein-coupled receptor 54-induced gonadotropin-releasing hormone release monitored indirectly in the juvenile male Rhesus monkey (Macaca mulatta): a finding with therapeutic implications. Endocrinology147(5), 2122–2126 (2006).
  • Thompson EL, Murphy KG, Patterson M et al. Chronic subcutaneous administration of Kisspeptin-54 causes testicular degeneration in adult male rats. Am. J. Physiol. Endocrinol. Metab.291(5), E1074–E1082 (2006).
  • Makri A, Pissimissis N, Lembessis P et al. The Kisspeptin (KiSS-1)/GPR54 system in cancer biology. Cancer Treat. Rev.34(8), 682–692 (2008).
  • Kallman FJ, Schoenfeld WA, Barrera SE. The genetic aspects of primary eunuchoidism. Am. J. Ment. DefficiencyXLVII203–XLVII236 (1944).

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