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Review

Repair and regeneration of the human endometrium

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Pages 283-298 | Published online: 10 Jan 2014

References

  • Jabbour HN, Kelly RW, Fraser HM, Critchley HO. Endocrine regulation of menstruation. Endocr. Rev.27(1), 17–46 (2006).
  • Curry TE Jr, Osteen KG. Cyclic changes in the matrix metalloproteinase system in the ovary and uterus. Biol. Reprod.64(5), 1285–1296 (2001).
  • Marbaix E, Kokorine I, Moulin P, Donnez J, Eeckhout Y, Courtoy PJ. Menstrual breakdown of human endometrium can be mimicked in vitro and is selectively and reversibly blocked by inhibitors of matrix metalloproteinases. Proc. Natl Acad. Sci. USA93(17), 9120–9125 (1996).
  • Vassilev V, Pretto CM, Cornet PB et al. Response of matrix metalloproteinases and tissue inhibitors of metalloproteinases messenger ribonucleic acids to ovarian steroids in human endometrial explants mimics their gene- and phase-specific differential control in vivo. J. Clin. Endocrinol. Metab.90(10), 5848–5857 (2005).
  • Rodgers WH, Matrisian LM, Giudice LC et al. Patterns of matrix metalloproteinase expression in cycling endometrium imply differential functions and regulation by steroid hormones. J. Clin. Invest.94(3), 946–953 (1994).
  • Marbaix E, Kokorine I, Donnez J, Eeckhout Y, Courtoy PJ. Regulation and restricted expression of interstitial collagenase suggest a pivotal role in the initiation of menstruation. Hum. Reprod.11(Suppl. 2), 134–143 (1996).
  • Hornebeck W, Emonard H, Monboisse JC, Bellon G. Matrix-directed regulation of pericellular proteolysis and tumor progression. Semin. Cancer Biol.12(3), 231–241 (2002).
  • Critchley HO, Kelly RW, Brenner RM, Baird DT. Antiprogestins as a model for progesterone withdrawal. Steroids68(10–13), 1061–1068 (2003).
  • Hapangama DK, Critchley HO, Henderson TA, Baird DT. Mifepristone-induced vaginal bleeding is associated with increased immunostaining for cyclooxygenase-2 and decrease in prostaglandin dehydrogenase in luteal phase endometrium. J. Clin. Endocrinol. Metab.87(11), 5229–5234 (2002).
  • Catalano RD, Critchley HO, Heikinheimo O et al. Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol.Hum. Reprod.13(9), 641–654 (2007).
  • Milne SA, Jabbour HN. Prostaglandin (PG) F27alpha; receptor expression and signaling in human endometrium: role of PGF2alpha; in epithelial cell proliferation. J. Clin. Endocrinol. Metab.88(4), 1825–1832 (2003).
  • Milne SA, Perchick GB, Boddy SC, Jabbour HN. Expression, localization, and signaling of PGE2 and EP2/EP4 receptors in human nonpregnant endometrium across the menstrual cycle. J. Clin. Endocrinol. Metab.86(9), 4453–4459 (2001).
  • Smith OP, Jabbour HN, Critchley HO. Cyclooxygenase enzyme expression and E series prostaglandin receptor signalling are enhanced in heavy menstruation. Hum. Reprod.22(5), 1450–1456 (2007).
  • Baird DT, Cameron ST, Critchley HO et al. Prostaglandins and menstruation. Eur. J. Obstet. Gynecol. Reprod. Biol.70(1), 15–17 (1996).
  • Zhang J, Salamonsen LA. Expression of hypoxia-inducible factors in human endometrium and suppression of matrix metalloproteinases under hypoxic conditions do not support a major role for hypoxia in regulating tissue breakdown at menstruation. Hum. Reprod.17(2), 265–274 (2002).
  • Singer AJ, Clark RA. Cutaneous wound healing. N. Engl. J. Med.341(10), 738–746 (1999).
  • Lorenz HP, Longaker MT, Perkocha LA, Jennings RW, Harrison MR, Adzick NS. Scarless wound repair: a human fetal skin model. Development114(1), 253–259 (1992).
  • Longaker MT, Whitby DJ, Ferguson MW, Lorenz HP, Harrison MR, Adzick NS. Adult skin wounds in the fetal environment heal with scar formation. Ann. Surg.219(1), 65–72 (1994).
  • Kwon YB, Kim HW, Roh DH et al. Topical application of epidermal growth factor accelerates wound healing by myofibroblast proliferation and collagen synthesis in rat. J. Vet. Sci.7(2), 105–109 (2006).
  • McCallion RL, Ferguson MW. Fetal would healing and the development of antiscarring therapies for adult would healing. In: The Molecular and Cellular Biology of Wound Repair (Second Edition). Clark RAF (Ed.). Plenum Press, NY, USA (1996).
  • Moulin V, Lawny F, Barritault D, Caruelle JP. Platelet releasate treatment improves skin healing in diabetic rats through endogenous growth factor secretion. Cell. Mol. Biol. (Noisy-le-grand)44(6), 961–971 (1998).
  • De M, Wood GW. Influence of oestrogen and progesterone on macrophage distribution in the mouse uterus. J. Endocrinol.126(3), 417–424 (1990).
  • Tibbetts TA, Conneely OM, O’Malley BW. Progesterone via its receptor antagonizes the proinflammatory activity of estrogen in the mouse uterus. Biol. Reprod.60(5), 1158–1165 (1999).
  • Jones RL, Hannan NJ, Kaitu’u TJ, Zhang J, Salamonsen LA. Identification of chemokines important for leukocyte recruitment to the human endometrium at the times of embryo implantation and menstruation. J. Clin. Endocrinol. Metab.89(12), 6155–6167 (2004).
  • Salamonsen LA, Woolley DE. Menstruation: induction by matrix metalloproteinases and inflammatory cells. J. Reprod. Immunol.44(1–2), 1–27 (1999).
  • Salamonsen LA, Lathbury LJ. Endometrial leukocytes and menstruation. Hum. Reprod. Update6(1), 16–27 (2000).
  • Le Y, Zhou Y, Iribarren P, Wang J. Chemokines and chemokine receptors: their manifold roles in homeostasis and disease. Cell. Mol. Immunol.1(2), 95–104 (2004).
  • Leibovich SJ, Ross R. The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum. Am. J. Pathol.78(1), 71–100 (1975).
  • Bonatz G, Hansmann ML, Buchholz F, Mettler L, Radzun HJ, Semm K. Macrophage- and lymphocyte-subtypes in the endometrium during different phases of the ovarian cycle. Int. J. Gynaecol. Obstet.37(1), 29–36 (1992).
  • Kaitu’u-Lino TJ, Morison NB, Salamonsen LA. Neutrophil depletion retards endometrial repair in a mouse model. Cell Tissue Res.328(1), 197–206 (2007).
  • Wynn TA. Cellular and molecular mechanisms of fibrosis. J. Pathol.214(2), 199–210 (2008).
  • Rae MT, Niven D, Critchley HO, Harlow CR, Hillier SG. Antiinflammatory steroid action in human ovarian surface epithelial cells. J. Clin. Endocrinol. Metab.89(9), 4538–4544 (2004).
  • McDonald SE, Henderson TA, Gomez-Sanchez CE, Critchley HO, Mason JI. 11 β-hydroxysteroid dehydrogenases in human endometrium. Mol. Cell Endocrinol.248(1–2), 72–78 (2006).
  • Farombi EO, Surh YJ. Heme oxygenase-1 as a potential therapeutic target for hepatoprotection. J. Biochem. Mol. Biol.39(5), 479–491 (2006).
  • Tyrrell RM, Applegate LA, Tromvoukis Y. The proximal promoter region of the human heme oxygenase gene contains elements involved in stimulation of transcriptional activity by a variety of agents including oxidants. Carcinogenesis14(4), 761–765 (1993).
  • Motterlini R, Foresti R, Bassi R, Calabrese V, Clark JE, Green CJ. Endothelial heme oxygenase-1 induction by hypoxia. Modulation by inducible nitric-oxide synthase and S-nitrosothiols. J. Biol. Chem.275(18), 13613–13620 (2000).
  • Keyse SM, Tyrrell RM. Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite. Proc. Natl Acad. Sci. USA86(1), 99–103 (1989).
  • Fondevila C, Shen XD, Tsuchiyashi S et al. Biliverdin therapy protects rat livers from ischemia and reperfusion injury. Hepatology40(6), 1333–1341 (2004).
  • Pannen BH, Kohler N, Hole B, Bauer M, Clemens MG, Geiger KK. Protective role of endogenous carbon monoxide in hepatic microcirculatory dysfunction after hemorrhagic shock in rats. J. Clin. Invest.102(6), 1220–1228 (1998).
  • Cudmore M, Ahmad S, Al-Ani B et al. Negative regulation of soluble Flt-1 and soluble endoglin release by heme oxygenase-1. Circulation115(13), 1789–1797 (2007).
  • Yoshiki N, Kubota T, Aso T. Identification of heme oxygenase in human endometrium. J. Clin. Endocrinol. Metab.86(10), 5033–5038 (2001).
  • Ludwig H, Spornitz UM. Microarchitecture of the human endometrium by scanning electron microscopy: menstrual desquamation and remodeling. Ann. NY Acad. Sci.622, 28–46 (1991).
  • Heimark RL, Schwartz SM. The role of membrane–membrane interactions in the regulation of endothelial cell growth. J. Cell Biol.100(6), 1934–1940 (1985).
  • Kaitu’u-Lino TJ, Morison NB, Salamonsen LA. Estrogen is not essential for full endometrial restoration after breakdown: lessons from a mouse model. Endocrinology148(10), 5105–5111 (2007).
  • Nakamura T, Nishizawa T, Hagiya M et al. Molecular cloning and expression of human hepatocyte growth factor. Nature342(6248), 440–443 (1989).
  • Sugawara J, Fukaya T, Murakami T, Yoshida H, Yajima A. Hepatocyte growth factor stimulated proliferation, migration, and lumen formation of human endometrial epithelial cells in vitro. Biol. Reprod.57(4), 936–942 (1997).
  • Lindsey JS, Brenner RM. Novel hepatocyte growth factor/scatter factor isoform transcripts in the macaque endometrium and placenta. Mol. Hum. Reprod.8(1), 81–87 (2002).
  • Gaide Chevronnay HP, Cornet PB, Delvaux D et al. Opposite regulation of transforming growth factors-β2 and -β3 expression in the human endometrium. Endocrinology149(3), 1015–1025 (2008).
  • Dallas SL, Rosser JL, Mundy GR, Bonewald LF. Proteolysis of latent transforming growth factor-β (TGF-β)-binding protein-1 by osteoclasts. A cellular mechanism for release of TGF-β from bone matrix. J. Biol. Chem.277(24), 21352–21360 (2002).
  • Kane N, Jones M, Brosens JJ, Saunders PT, Kelly RW, Critchley HO. Transforming growth factor-β1 attenuates expression of both the progesterone receptor and dickkopf in differentiated human endometrial stromal cells. Mol. Endocrinol.22(3), 716–728 (2008).
  • Hou X, Tan Y, Li M, Dey SK, Das SK. Canonical Wnt signaling is critical to estrogen-mediated uterine growth. Mol. Endocrinol.18(12), 3035–3049 (2004).
  • Krummel TM, Michna BA, Thomas BL et al. Transforming growth factor β (TGF-β) induces fibrosis in a fetal wound model. J. Pediatr. Surg.23(7), 647–652 (1988).
  • Schrementi ME, Ferreira AM, Zender C, DiPietro LA. Site-specific production of TGF-β in oral mucosal and cutaneous wounds. Wound Repair Regen.16(1), 80–86 (2008).
  • Kim JP, Zhang K, Kramer RH, Schall TJ, Woodley DT. Integrin receptors and RGD sequences in human keratinocyte migration: unique anti-migratory function of α3β1 epiligrin receptor. J. Invest. Dermatol.98(5), 764–770 (1992).
  • Cao W, Mah K, Carroll RS, Slayden OD, Brenner RM. Progesterone withdrawal upregulates fibronectin and integrins during menstruation and repair in the rhesus macaque endometrium. Hum. Reprod.22(12), 3223–3231 (2007).
  • Mott JD, Werb Z. Regulation of matrix biology by matrix metalloproteinases. Curr. Opin. Cell Biol.16(5), 558–564 (2004).
  • Berton A, Selvais C, Lemoine P et al. Binding of matrilysin-1 to human epithelial cells promotes its activity. Cell. Mol. Life Sci.64(5), 610–620 (2007).
  • Dunsmore SE, Saarialho-Kere UK, Roby JD et al. Matrilysin expression and function in airway epithelium. J. Clin. Invest.102(7), 1321–1331 (1998).
  • Bigsby RM. Control of growth and differentiation of the endometrium: the role of tissue interactions. Ann. NY Acad. Sci.955, 110–117; discussion 118, 396–406 (2002).
  • Ferenczy A, Bertrand G, Gelfand MM. Proliferation kinetics of human endometrium during the normal menstrual cycle. Am. J. Obstet. Gynecol.133(8), 859–867 (1979).
  • Hantash BM, Zhao L, Knowles JA, Lorenz HP. Adult and fetal wound healing. Front. Biosci.13, 51–61 (2008).
  • Yuge A, Nasu K, Matsumoto H, Nishida M, Narahara H. Collagen gel contractility is enhanced in human endometriotic stromal cells: a possible mechanism underlying the pathogenesis of endometriosis-associated fibrosis. Hum. Reprod.22(4), 938–944 (2007).
  • Hellebrekers BW, Trimbos-Kemper TC, Trimbos JB, Emeis JJ, Kooistra T. Use of fibrinolytic agents in the prevention of postoperative adhesion formation. Fertil. Steril.74(2), 203–212 (2000).
  • Gleeson N, Devitt M, Sheppard BL, Bonnar J. Endometrial fibrinolytic enzymes in women with normal menstruation and dysfunctional uterine bleeding. Br. J. Obstet. Gynaecol.100(8), 768–771 (1993).
  • Nordengren J, Pilka R, Noskova V et al. Differential localization and expression of urokinase plasminogen activator (uPA), its receptor (uPAR), and its inhibitor (PAI-1) mRNA and protein in endometrial tissue during the menstrual cycle. Mol. Hum. Reprod.10(9), 655–663 (2004).
  • Gleeson NC, Buggy F, Sheppard BL, Bonnar J. The effect of tranexamic acid on measured menstrual loss and endometrial fibrinolytic enzymes in dysfunctional uterine bleeding. Acta Obstet. Gynecol. Scand.73(3), 274–277 (1994).
  • Markee JE. Menstruation in intraocular transplants in the rhesus monkey. Contributions to embryology of the Carnegie Institution. 177, 211–308 (1940).
  • Girling JE, Rogers PA. Recent advances in endometrial angiogenesis research. Angiogenesis8(2), 89–99 (2005).
  • Nayak NR, Brenner RM. Vascular proliferation and vascular endothelial growth factor expression in the rhesus macaque endometrium. J. Clin. Endocrinol. Metab.87(4), 1845–1855 (2002).
  • Gambino LS, Wreford NG, Bertram JF, Dockery P, Lederman F, Rogers PA. Angiogenesis occurs by vessel elongation in proliferative phase human endometrium. Hum. Reprod.17(5), 1199–1206 (2002).
  • Girling JE, Lederman FL, Walter LM, Rogers PA. Progesterone, but not estrogen, stimulates vessel maturation in the mouse endometrium. Endocrinology148(11), 5433–5441 (2007).
  • Asahara T, Murohara T, Sullivan A et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science275(5302), 964–967 (1997).
  • Rogers PA, Gargett CE. Endometrial angiogenesis. Angiogenesis2(4), 287–294 (1998).
  • Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr. Rev.25(4), 581–611 (2004).
  • Smith SK. Regulation of angiogenesis in the endometrium. Trends Endocrinol. Metab.12(4), 147–151 (2001).
  • Charnock-Jones DS, Sharkey AM, Rajput-Williams J et al. Identification and localization of alternately spliced mRNAs for vascular endothelial growth factor in human uterus and estrogen regulation in endometrial carcinoma cell lines. Biol. Reprod.48(5), 1120–1128 (1993).
  • Zhang L, Scott PA, Turley H et al. Validation of anti-vascular endothelial growth factor (anti-VEGF) antibodies for immunohistochemical localization of VEGF in tissue sections: expression of VEGF in the human endometrium. J. Pathol.185(4), 402–408 (1998).
  • Li XF, Gregory J, Ahmed A. Immunolocalisation of vascular endothelial growth factor in human endometrium. Growth Factors11(4), 277–282 (1994).
  • Gargett CE, Lederman FL, Lau TM, Taylor NH, Rogers PA. Lack of correlation between vascular endothelial growth factor production and endothelial cell proliferation in the human endometrium. Hum. Reprod.14(8), 2080–2088 (1999).
  • Gargett CE, Lederman F, Heryanto B, Gambino LS, Rogers PA. Focal vascular endothelial growth factor correlates with angiogenesis in human endometrium. Role of intravascular neutrophils. Hum. Reprod.16(6), 1065–1075 (2001).
  • Ma W, Tan J, Matsumoto H et al. Adult tissue angiogenesis: evidence for negative regulation by estrogen in the uterus. Mol. Endocrinol.15(11), 1983–1992 (2001).
  • Huang JC, Liu DY, Dawood MY. The expression of vascular endothelial growth factor isoforms in cultured human endometrial stromal cells and its regulation by 17β-oestradiol. Mol. Hum. Reprod.4(6), 603–607 (1998).
  • Albrecht ED, Babischkin JS, Lidor Y, Anderson LD, Udoff LC, Pepe GJ. Effect of estrogen on angiogenesis in co-cultures of human endometrial cells and microvascular endothelial cells. Hum. Reprod.18(10), 2039–2047 (2003).
  • Nayak NR, Critchley HO, Slayden OD et al. Progesterone withdrawal up-regulates vascular endothelial growth factor receptor type 2 in the superficial zone stroma of the human and macaque endometrium: potential relevance to menstruation. J. Clin. Endocrinol. Metab.85(9), 3442–3452 (2000).
  • Hyder SM, Huang JC, Nawaz Z et al. Regulation of vascular endothelial growth factor expression by estrogens and progestins. Environ. Health Perspect.108(Suppl. 5), 785–790 (2000).
  • Albrecht ED, Pepe GJ. Steroid hormone regulation of angiogenesis in the primate endometrium. Front. Biosci.8, d416–d429 (2003).
  • Green S, Walter P, Kumar V et al. Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature320(6058), 134–139 (1986).
  • Kuiper GG, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson JA. Cloning of a novel receptor expressed in rat prostate and ovary. Proc. Natl Acad. Sci. USA93(12), 5925–5930 (1996).
  • Critchley HO, Henderson TA, Kelly RW et al. Wild-type estrogen receptor (ERβ1) and the splice variant (ERβlcx/β2) are both expressed within the human endometrium throughout the normal menstrual cycle. J. Clin. Endocrinol. Metab.87(11), 5265–5273 (2002).
  • Lecce G, Meduri G, Ancelin M, Bergeron C, Perrot-Applanat M. Presence of estrogen receptor β in the human endometrium through the cycle: expression in glandular, stromal, and vascular cells. J. Clin. Endocrinol. Metab.86(3), 1379–1386 (2001).
  • Brosens JJ, Hayashi N, White JO. Progesterone receptor regulates decidual prolactin expression in differentiating human endometrial stromal cells. Endocrinology140(10), 4809–4820 (1999).
  • Wang H, Critchley HO, Kelly RW, Shen D, Baird DT. Progesterone receptor subtype B is differentially regulated in human endometrial stroma. Mol. Hum. Reprod.4(4), 407–412 (1998).
  • Semenza GL. HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J. Appl. Physiol.88(4), 1474–1480 (2000).
  • Krishnamachary B, Berg-Dixon S, Kelly B et al. Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. Cancer Res.63(5), 1138–1143 (2003).
  • Higgins DF, Biju MP, Akai Y, Wutz A, Johnson RS, Haase VH. Hypoxic induction of Ctgf is directly mediated by Hif-1. Am. J. Physiol. Renal Physiol.287(6), F1223–F1232 (2004).
  • Critchley HO, Osei J, Henderson TA et al. Hypoxia-inducible factor-1α expression in human endometrium and its regulation by prostaglandin E-series prostanoid receptor 2 (EP2). Endocrinology147(2), 744–753 (2006).
  • Gannon BJ, Carati CJ, Verco CJ. Endometrial perfusion across the normal human menstrual cycle assessed by laser Doppler fluxmetry. Hum. Reprod.12(1), 132–139 (1997).
  • Fan X, Krieg S, Kuo C et al. VEGF blockade inhibits angiogenesis and reepithelialization of endometrium. FASEB J.22(10), 3571–80 (2008).
  • Ottosen LD, Hindkaer J, Husth M, Petersen DE, Kirk J, Ingerslev HJ. Observations on intrauterine oxygen tension measured by fibre-optic microsensors. Reprod. Biomed. Online13(3), 380–385 (2006).
  • Marsh MM, Malakooti N, Taylor NH, Findlay JK, Salamonsen LA. Endothelin and neutral endopeptidase in the endometrium of women with menorrhagia. Hum. Reprod.12(9), 2036–2040 (1997).
  • Fukuda R, Kelly B, Semenza GL. Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1. Cancer Res.63(9), 2330–2334 (2003).
  • Haddad JJ, Land SC. A non-hypoxic, ROS-sensitive pathway mediates TNF-α-dependent regulation of HIF-1α. FEBS Lett.505(2), 269–274 (2001).
  • Blouin CC, Page EL, Soucy GM, Richard DE. Hypoxic gene activation by lipopolysaccharide in macrophages: implication of hypoxia-inducible factor 1α. Blood103(3), 1124–1130 (2004).
  • Critchley HO, Jones RL, Lea RG et al. Role of inflammatory mediators in human endometrium during progesterone withdrawal and early pregnancy. J. Clin. Endocrinol. Metab.84(1), 240–248 (1999).
  • Sales KJ, Maudsley S, Jabbour HN. Elevated prostaglandin EP2 receptor in endometrial adenocarcinoma cells promotes vascular endothelial growth factor expression via cyclic 3´,5´-adenosine monophosphate-mediated transactivation of the epidermal growth factor receptor and extracellular signal-regulated kinase 1/2 signaling pathways. Mol. Endocrinol.18(6), 1533–1545 (2004).
  • Gashaw I, Stiller S, Boing C, Kimmig R, Winterhager E. Premenstrual regulation of the pro-angiogenic factor CYR61 in human endometrium. Endocrinology149(5), 2261–2269 (2008).
  • Gargett CE. Uterine stem cells: what is the evidence? Hum. Reprod. Update13(1), 87–101 (2007).
  • Eckfeldt CE, Mendenhall EM, Verfaillie CM. The molecular repertoire of the ‘almighty’ stem cell. Nat. Rev. Mol. Cell Biol.6(9), 726–737 (2005).
  • Fuchs E, Segre JA. Stem cells: a new lease on life. Cell100(1), 143–155 (2000).
  • Fuchs E, Tumbar T, Guasch G. Socializing with the neighbors: stem cells and their niche. Cell116(6), 769–778 (2004).
  • Moore KA, Lemischka IR. Stem cells and their niches. Science311(5769), 1880–1885 (2006).
  • Tresserra F, Grases P, Ubeda A, Pascual MA, Grases PJ, Labastida R. Morphological changes in hysterectomies after endometrial ablation. Hum. Reprod.14(6), 1473–1477 (1999).
  • Wood C, Rogers P. A pregnancy after planned partial endometrial resection. Aust. NZ J. Obstet. Gynaecol.33(3), 316–318 (1993).
  • Meng X, Ichim TE, Zhong J et al. Endometrial regenerative cells: a novel stem cell population. J. Transl. Med.5, 57 (2007).
  • Padykula HA, Coles LG, Okulicz WC et al. The basalis of the primate endometrium: a bifunctional germinal compartment. Biol. Reprod.40(3), 681–690 (1989).
  • Mutter GL, Ince TA, Baak JP, Kust GA, Zhou XP, Eng C. Molecular identification of latent precancers in histologically normal endometrium. Cancer Res.61(11), 4311–4314 (2001).
  • Tanaka M, Kyo S, Kanaya T et al. Evidence of the monoclonal composition of human endometrial epithelial glands and mosaic pattern of clonal distribution in luminal epithelium. Am. J. Pathol.163(1), 295–301 (2003).
  • Chan RW, Schwab KE, Gargett CE. Clonogenicity of human endometrial epithelial and stromal cells. Biol. Reprod.70(6), 1738–1750 (2004).
  • Gargett CE, Zillwood R, Schwab KE. Characterising the stem cell activity of human endometrial cells. Hum. Reprod.20(Suppl. 1), i95 (2005).
  • Mints M, Jansson M, Sadeghi B et al. Endometrial endothelial cells are derived from donor stem cells in a bone marrow transplant recipient. Hum. Reprod.23(1), 139–143 (2008).
  • Taylor HS. Endometrial cells derived from donor stem cells in bone marrow transplant recipients. JAMA292(1), 81–85 (2004).
  • Fadini GP, de Kreutzenberg S, Albiero M et al. Gender differences in endothelial progenitor cells and cardiovascular risk profile: the role of female estrogens. Arterioscler. Thromb. Vasc. Biol.28(5), 997–1004 (2008).
  • Robb A, Mills N, Smith I et al. Influence of menstrual cycle on circulating endothelial progenitor cells. Hum. Reprod.24(3), 619–625 (2009).
  • Schwab KE, Gargett CE. Co-expression of two perivascular cell markers isolates mesenchymal stem-like cells from human endometrium. Hum. Reprod.22(11), 2903–2911 (2007).
  • Conboy MJ, Karasov AO, Rando TA. High incidence of non-random template strand segregation and asymmetric fate determination in dividing stem cells and their progeny. PLoS Biol.5(5), e102 (2007).
  • Chan RW, Gargett CE. Identification of label-retaining cells in mouse endometrium. Stem Cells24(6), 1529–1538 (2006).
  • Kiel MJ, He S, Ashkenazi R et al. Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU. Nature449(7159), 238–242 (2007).
  • Sasson IE, Taylor HS. Stem cells and the pathogenesis of endometriosis. Ann. NY Acad. Sci.1127, 106–115 (2008).
  • Giudice LC, Kao LC. Endometriosis. Lancet364(9447), 1789–1799 (2004).
  • Leyendecker G, Herbertz M, Kunz G, Mall G. Endometriosis results from the dislocation of basal endometrium. Hum. Reprod.17(10), 2725–2736 (2002).
  • Pardal R, Clarke MF, Morrison SJ. Applying the principles of stem-cell biology to cancer. Nat. Rev. Cancer.3(12), 895–902 (2003).
  • Prentice A. Health care implications of dysfunctional uterine bleeding. Baillieres Best Pract. Res. Clin. Obstet. Gynaecol.13(2), 181–188 (1999).

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