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Review

Role of omega-3 fatty acids in maternal, fetal, infant and child wellbeing

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Pages 125-138 | Published online: 10 Jan 2014

References

  • Simopoulos AP. Essential fatty acids in health and chronic disease. Am. J. Clin. Nutr.70(3 Suppl.), 560S–569S (1999).
  • Adams P, Lawson S, Sanigorski A, Sinclair A. Arachidonic acid to eicosapentaenoic acid ratio in blood correlates positively with clinical symptoms of depression. Lipids31(Suppl.), S157–S161 (1996).
  • Qiu C, Sanchez SE, Larrabure G, David R, Bralley JA, Williams MA. Erythrocyte omega-3 and omega-6 polyunsaturated fatty acids and preeclampsia risk in Peruvian women. Arch. Gynecol. Obstet.274(2), 97–103 (2006).
  • Shaikh SR, Edidin M. Polyunsaturated fatty acids, membrane organization, T cells, and antigen presentation. Am. J. Clin. Nutr.84(6), 1277–1289 (2006).
  • Koletzko B, Lien E, Agostoni C et al. The roles of long-chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of current knowledge and consensus recommendations. J. Perinat. Med.36(1), 5–14 (2008).
  • Weylandt KH, Kang JX. Rethinking lipid mediators. Lancet366(9486), 618–620 (2005).
  • Horrocks LA, Farooqui AA. Docosahexaenoic acid in the diet: its importance in maintenance and restoration of neural membrane function. Prostaglandins Leukot. Essent. Fatty Acids70(4), 361–372 (2004).
  • Maes M, Smith R. Fatty acids, cytokines, and major depression. Biol. Psychiatry43, 313–314 (1998).
  • Caughey G, Mantzioris E, Gibson R, Cleland L, James M. The effect on human tumor necrosis factor α and interleukin 1β production of diets enriched in n-3 fatty acids from vegetable oil or fish oil. Am. J. Clin. Nutr.63(1), 116–122 (1996).
  • James M, Gibson R, Cleland L. Dietary polyunsaturated fatty acids and inflammatory mediator production. Am. J. Clin. Nutr.71(Suppl.), 343S–348S (2000).
  • Ariel A, Serhan CN. Resolvins and protectins in the termination program of acute inflammation. Trends Immunol.28(4), 176–183 (2007).
  • Stillwell W, Wassall SR. Docosahexaenoic acid: membrane properties of a unique fatty acid. Chem. Phys. Lipids126(1), 1–27 (2003).
  • Innis SM. Dietary (n-3) fatty acids and brain development. J. Nutr.137(4), 855–859 (2007).
  • Schuchardt JP, Huss M, Stauss-Grabo M, Hahn A. Significance of long-chain polyunsaturated fatty acids (PUFAs) for the development and behaviour of children. Eur. J. Pediatr. DOI: 10.1007/s00431-009-1035-8 (2009).
  • Levant B, Ozias M, Carlson S. Specific brain regions of female rats are differentially depleted of docosahexaenoic acid by reproductive activity and an (n-3) fatty acid-deficient diet. J. Nutr.137(1), 130–134 (2007).
  • Cao D, Kevala K, Kim J et al. Docosahexaenoic acid promotes hippocampal neuronal development and synaptic function. J. Neurochem.111(2), 510–521 (2009).
  • Mukherjee PK, Marcheselli VL, Serhan CN, Bazan NG. From the cover: neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. PNAS101(22), 8491–8496 (2004).
  • Calandria JM, Marcheselli VL, Mukherjee PK et al. Selective survival rescue in 15-lipoxygenase-1-deficient retinal pigment epithelial cells by the novel docosahexaenoic acid-derived mediator, neuroprotectin D1. J. Biol. Chem.284(26), 17877–17882 (2009).
  • Sinha RA, Khare P, Rai A et al. Anti-apoptotic role of omega-3-fatty acids in developing brain: perinatal hypothyroid rat cerebellum as apoptotic model. Int. J. Dev. Neurosci.27(4), 377–383 (2009).
  • Bazan NG. Lipid signaling in neural plasticity, brain repair, and neuroprotection. Mol. Neurobiol.32(1), 89–103 (2005).
  • Siddiqui RA, Shaikh SR, Sech LA, Yount HR, Stillwell W, Zaloga GP. Omega 3-fatty acids: health benefits and cellular mechanisms of action. Mini Rev. Med. Chem.4(8), 859–871 (2004).
  • Yamagami T, Porada C, Pardini R, Zanjani E, Almeida-Porada G. Docosahexaenoic acid induces dose dependent cell death in an early undifferentiated subtype of acute myeloid leukemia cell line. Cancer Biol. Ther.8(4), 331–337 (2009).
  • Mehendale SS, Kilari Bams AS, Deshmukh CS, Dhorepatil BS, Nimbargi VN, Joshi SR. Oxidative stress-mediated essential polyunsaturated fatty acid alterations in female infertility. Hum. Fertil.12(1), 28–33 (2009).
  • Benson MK, Devi K. Influence of omega-6/omega-3 rich dietary oils on lipid profile and antioxidant enzymes in normal and stressed rats. Indian J. Exp. Biol.47(2), 98–103 (2009).
  • Hibbeln J. Seafood consumption, the DHA content of mothers’ milk and prevalence rates of postpartum depression: a cross-national, ecological analysis. J. Affect. Disord.69, 15–29 (2002).
  • Oken E, Kleinman K, Berland W, Simon S, Rich-Edwards J, Gillman M. Decline in fish consumption among pregnant women after a national mercury advisory. Obstet. Gynecol.102(2), 346–351 (2003).
  • Gochfeld M, Burger J. Good fish/bad fish: a composite benefit–risk by dose curve. Neurotoxicology26(4), 511–520 (2005).
  • Dovydaitis T. Fish consumption during pregnancy: an overview of the risks and benefits. J. Midwifery Women’s Health53(4), 325–330 (2008).
  • Debes F, Budtz-Jrgensen E, Weihe P, White R, Grandjean P. Impact of prenatal methylmercury exposure on neurobehavioral function at age 14 years. Neurotoxicol. Teratol.28(5), 536–547 (2006).
  • Davidson P, Myers G, Cox C et al. Methylmercury and neurodevelopment: longitudinal analysis of the Seychelles child development cohort. Neurotoxicol. Teratol.28(5), 529–535 (2006).
  • Jacobson J, Jacobson S. Prenatal exposure to polychlorinated biphenyls and attention at school age. J. Pediatr.143(6), 780–788 (2003).
  • Genuis SJ. To sea or not to sea: benefits and risks of gestational fish consumption. Reprod. Toxicol.26(2), 81–85 (2008).
  • Harper M. Randomized controlled trial of Omega-3 fatty acid supplementation for recurrent preterm birth prevention. Obstet. Gynecol.197(6 Suppl. 1), S2–S2 (2007).
  • Olsen SF, Hansen HS, Sorensen TI et al. Intake of marine fat, rich in (n-3)-polyunsaturated fatty acids, may increase birthweight by prolonging gestation. Lancet2(8503), 367–369 (1986).
  • Olsen SF, Joensen HD. High liveborn birth weights in the Faroes: a comparison between birth weights in the Faroes and in Denmark. J. Epid. Community Health39(1), 27–32 (1985).
  • Knudsen VK, Hansen HS, Osterdal ML, Mikkelsen TB, Mu H, Olsen SF. Fish oil in various doses or flax oil in pregnancy and timing of spontaneous delivery: a randomised controlled trial. BJOG113(5), 536–543 (2006).
  • Olsen S, Østerdal M, Salvig J et al. Duration of pregnancy in relation to seafood intake during early and mid pregnancy: prospective cohort. Eur. J. Epidemiol.21(10), 749–758 (2006).
  • Olsen SF, Secher NJ. Low consumption of seafood in early pregnancy as a risk factor for preterm delivery: prospective cohort study. BMJ324(7335), 447 (2002).
  • Thorsdottir I, Birgisdottir BE, Halldorsdottir S, Geirsson RT. Association of fish and fish liver oil intake in pregnancy with infant size at birth among women of normal weight before pregnancy in a fishing community. Am. J. Epidemiol.160(5), 460–465 (2004).
  • Rogers I, Emmett P, Ness A, Golding J. Maternal fish intake in late pregnancy and the frequency of low birth weight and intrauterine growth retardation in a cohort of British infants. J. Epid. Community Health58(6), 486–492 (2004).
  • Oken E, Kleinman KP, Olsen SF, Rich-Edwards JW, Gillman MW. Associations of seafood and elongated n-3 fatty acid intake with fetal growth and length of gestation: results from a US pregnancy cohort. Am. J. Epidemiol.160(8), 774–783 (2004).
  • Reece MS, McGregor JA, Allen KG, Harris MA. Maternal and perinatal long-chain fatty acids: possible roles in preterm birth. Am. J. Obstet. Gynecol.176(4), 907–914 (1997).
  • Olsen SF. The People’s League of Health trial. JRS Med.99(1), 44–45 (2006).
  • Olsen SF, Secher NJ. A possible preventive effect of low-dose fish oil on early delivery and pre-eclampsia: indications from a 50-year-old controlled trial. Br. J. Nutr.64(3), 599–609 (1990).
  • Makrides M, Duley L, Olsen SF. Marine oil, and other prostaglandin precursor, supplementation for pregnancy uncomplicated by pre-eclampsia or intrauterine growth restriction. Cochrane Database Syst. Rev. (3), CD003402 (2006).
  • Horvath A, Koletzko B, Szajewska H. Effect of supplementation of women in high-risk pregnancies with long-chain polyunsaturated fatty acids on pregnancy outcomes and growth measures at birth: a meta-analysis of randomized controlled trials. Br. J. Nutr.98(2), 253–259 (2007).
  • Szajewska H, Horvath A, Koletzko B. Effect of n-3 long-chain polyunsaturated fatty acid supplementation of women with low-risk pregnancies on pregnancy outcomes and growth measures at birth: a meta-analysis of randomized controlled trials. Am. J. Clin. Nutr.83(6), 1337–1344 (2006).
  • Olafsdottir AS, Magnusardottir AR, Thorgeirsdottir H, Hauksson A, Skuladottir GV, Steingrimsdottir L. Relationship between dietary intake of cod liver oil in early pregnancy and birthweight. BJOG112(4), 424–429 (2005).
  • Halldorsson TI, Meltzer HM, Thorsdottir I, Knudsen V, Olsen SF. Is High Consumption of Fatty Fish during Pregnancy a Risk Factor for Fetal Growth Retardation? A Study of 44,824 Danish Pregnant Women. Am. J. Epidemiol.166(6), 687–696 (2007).
  • Dyerberg J, Bang HO, Walters BNJ et al. Preeclampsia and prostaglandins. Lancet325(8440), 1267–1268 (1985).
  • Hosli I, Zanetti-Daellenbach R, Holzgreve W, Lapaire O. Role of omega 3-fatty acids and multivitamins in gestation. J. Perinat. Med.35(Suppl. 1), S19–S24 (2007).
  • Wang YP, Kay HH, Killam AP. Decreased levels of polyunsaturated fatty acids in preeclampsia. Am. J. Obstet. Gynecol.164(3), 812–818 (1991).
  • Williams MA, Zingheim RW, King IB, Zebelman AM. Omega-3 fatty acids in maternal erythrocytes and risk of preeclampsia. Epidemiology6(3), 232–237 (1995).
  • Kesmodel U, Olsen SF, Salvig JD. Marine n-3 fatty acid and calcium intake in relation to pregnancy induced hypertension, intrauterine growth retardation, and preterm delivery. A case–control study. Acta Obstet. Gynecol. Scand.76(1), 38–44 (1997).
  • Olafsdottir AS, Skuladottir GV, Thorsdottir I, Hauksson A, Thorgeirsdottir H, Steingrimsdottir L. Relationship between high consumption of marine fatty acids in early pregnancy and hypertensive disorders in pregnancy. BJOG113(3), 301–309 (2006).
  • Olsen S. Is supplementation with marine omega-3 fatty acids during pregnancy a useful tool in the prevention of preterm birth? Clin. Obstet. Gynecol.47(4), 768–774 (2004).
  • Olsen S, Secher N, Tabor A, Weber T, Walker J, Gluud C. Randomized clinical trials of fish oil supplementation in high risk pregnancies. Fish Oil Trials in Pregnancy (FOTIP) Team. BJOG107(3), 382–395 (2000).
  • Onwude J, Lilford R, Hjartardottir H, Staines A, Tuffnell D. A randomised double blind placebo controlled trial of fish oil in high risk pregnancy. Br. J. Obstet. Gynaecol.102(2), 95–100 (1995).
  • Hibbeln J, Salem N. Dietary polyunsaturated fatty acids and depression: when cholesterol does not satisfy. Am. J. Clin. Nutr.62(1), 1–15 (1995).
  • Timonen M, Horrobin D, Jokelainen J, Laitinen J, Herva A, Räsänen P. Fish consumption and depression: the Northern Finland 1966 birth cohort study. J. Affect. Disord.82(3), 447–452 (2004).
  • McNamara RK, Hahn CG, Jandacek R et al. Selective deficits in the omega-3 fatty acid docosahexaenoic acid in the postmortem orbitofrontal cortex of patients with major depressive disorder. Biol. Psychiatry62(1), 17–24 (2007).
  • Hulbert A, Turner N, Storlien L, Else P. Dietary fats and membrane function: implications for metabolism and disease. Biol. Rev. Camb. Philos. Soc.80(1), 155–169 (2005).
  • Levant B, Ozias M, Davis P et al. Decreased brain docosahexaenoic acid content produces neurobiological effects associated with depression: interactions with reproductive status in female rats. Psychoneuroendocrinology33(9), 1279–1292 (2008).
  • Otto S, de Groot R, Hornstra G. Increased risk of postpartum depressive symptoms is associated with slower normalization after pregnancy of the functional docosahexaenoic acid status. Prostaglandins Leukot. Essent. Fatty Acids69(4), 237–243 (2003).
  • Makrides M, Crowther C, Gibson R, Gibson R, Skeaff C. Docosahexaenoic acid and post-partum depression – is there a link? Asia Pac. J. Clin. Nutr.27(12 Suppl.), S37 (2003).
  • Llorente A, Jensen C, Voigt R, Fraley J, Berretta M, Heird W. Effect of maternal docasahexaenoic acid supplementation on postpartum depression and information processing. Am. J. Obstet. Gynecol.188(5), 1348–1353 (2003).
  • Marangell L, Martinez J, Zboyan H, Chong H, Puryear L. Omega-3 fatty acids for the prevention of postpartum depression: negative data from a preliminary, open-label pilot study. Depress. Anxiety19(1), 20–23 (2004).
  • Doornbos B, van Goor SA, Dijck-Brouwer DA, Schaafsma A, Korf J, Muskiet FA. Supplementation of a low dose of DHA or DHA+AA does not prevent peripartum depressive symptoms in a small population based sample. Prog. Neuropsychopharmacol. Biol. Psychiatry33(1), 49–52 (2009).
  • Freeman M, Hibbeln J, Wisner K, Brumbach B, Watchman M, Gelenberg A. Randomized dose-ranging pilot trial of omega-3 fatty acids for postpartum depression. Acta Psychiatr. Scand.113(1), 31–35 (2005).
  • Freeman M, Hibbeln J, Wisner K, Watchman M, Gelenberg A. An open trial of omega-3 fatty acids for depression in pregnancy. Acta Neuropsychiatrica18, 21–24 (2006).
  • Freeman MP. Omega-3 fatty acids and perinatal depression: a review of the literature and recommendations for future research. Prostaglandins Leukot. Essent. Fatty Acids75(4–5), 291–297 (2006).
  • Freeman MP, Davis M, Sinha P, Wisner KL, Hibbeln JR, Gelenberg AJ. Omega-3 fatty acids and supportive psychotherapy for perinatal depression: a randomized placebo-controlled study. J. Affect. Disord.110(1–2), 142–148 (2008).
  • Rees AM, Austin MP, Parker GB. Omega-3 fatty acids as a treatment for perinatal depression: randomized double-blind placebo-controlled trial. Aust. NZ J. Psych.42(3), 199–205 (2008).
  • Su KP, Huang SY, Chiu TH et al. Omega-3 fatty acids for major depressive disorder during pregnancy: results from a randomized, double-blind, placebo-controlled trial. J. Clin. Psychiatry69(4), 644–651 (2008).
  • Uauy R, Peirano P, Hoffman D, Mena P, Birch D, Birch E. Role of essential fatty acids in the function of the developing nervous system. Lipids31(Suppl.), S167–S176 (1996).
  • McNamara RK, Carlson SE. Role of omega-3 fatty acids in brain development and function: potential implications for the pathogenesis and prevention of psychopathology. Prostaglandins Leukot. Essent. Fatty Acids75(4–5), 329–349 (2006).
  • Hadders-Algra M, Bouwstra H, van Goor SA, Dijck-Brouwer DAJ, Muskiet FAJ. Prenatal and early postnatal fatty acid status and neurodevelopmental outcome. J. Perinat. Med.35(Suppl. 1), S28–S34 (2007).
  • Peterson BS, Vohr B, Staib LH et al. Regional brain volume abnormalities and long-term cognitive outcome in preterm infants. JAMA284(15), 1939–1947 (2000).
  • Hibbeln JR, Davis JM, Steer C et al. Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): an observational cohort study. Lancet369(9561), 578–585 (2007).
  • Helland IG, Smith L, Saarem K, Saugstad OD, Drevon CA. Maternal supplementation with very-long-chain n-3 fatty acids during pregnancy and lactation augments children’s IQ at 4 years of age. Pediatrics111(1), 39–44 (2003).
  • Colombo J, Kannass KN, Shaddy DJ et al. Maternal DHA and the development of attention in infancy and toddlerhood. Child Dev.75(4), 1254–1267 (2004).
  • Lauritzen L, Jorgensen MH, Olsen SF, Straarup EM, Michaelsen KF. Maternal fish oil supplementation in lactation: effect on developmental outcome in breast-fed infants. Reprod. Nutr. Dev.45(5), 535–547 (2005).
  • Simmer K, Patole S, Rao SC. Long chain polyunsaturated fatty acid supplementation in infants born at term. Cochrane Database Syst. Rev. (3), CD000376 (2007).
  • Simmer K, Schulzke S, Patole S. Longchain polyunsaturated fatty acid supplementation in preterm infants. Cochrane Database Syst. Rev. (3), CD000375 (2007).
  • Makrides M, Gibson R, McPhee A et al. Neurodevelopmental outcomes of preterm infants fed high-dose docosahexaenoic acid: a randomized controlled trial. JAMA301(2), 175–182 (2009).
  • McMillen IC, MacLaughlin SM, Muhlhausler BS, Gentili S, Duffield JL, Morrison JL. Developmental origins of adult health and disease: the role of periconceptional and foetal nutrition. Basic Clin. Pharmacol. Toxicol.102(2), 82–89 (2008).
  • Talge NM, Neal C, Glover V. Early Stress, Translational Research and Prevention Science Network Fetal and Neonatal Experience on Child and Adolescent Mental Health. Antenatal maternal stress and long-term effects on child neurodevelopment: how and why? J. Child Psychol. Psychiatry48(3–4), 245–261 (2007).
  • Li D, Weisinger HS, Weisinger RS et al. Omega 6 to omega 3 fatty acid imbalance early in life leads to persistent reductions in DHA levels in glycerophospholipids in rat hypothalamus even after long-term omega 3 fatty acid repletion. Prostaglandins Leuk. Essent. Fatty Acids74(6), 391–399 (2006).
  • Krabbendam L, Bakker E, Hornstra G, van Os J. Relationship between DHA status at birth and child problem behaviour at 7 years of age. Prostaglandins Leuk. Essent. Fatty Acids76(1), 29–34 (2007).
  • Chen J, Hsu S, Hsu C, Hwang L, Yang S. Dietary patterns and blood fatty acid composition in children with attention-deficit hyperactivity disorder in Taiwan. J. Nutr. Biochem.15(8), 467–472 (2004).
  • Brookes KJ, Chen W, Xu X, Taylor E, Asherson P. Association of fatty acid desaturase genes with attention-deficit/hyperactivity disorder. Biol. Psychiatry60(10), 1053–1061 (2006).
  • Blumer N, Renz H. Consumption of omega 3-fatty acids during perinatal life: role in immuno-modulation and allergy prevention. J. Perinat. Med.35(Suppl. 1), S12–S18 (2007).
  • Black PN, Sharpe S. Dietary fat and asthma: is there a connection? Eur. Respir. J.10(1), 6–12 (1997).
  • Oddy WH, de Klerk NH, Kendall GE, Mihrshahi S, Peat JK. Ratio of omega-6 to omega-3 fatty acids and childhood asthma. J. Asthma41(3), 319–326 (2004).
  • Calder PC, Krauss-Etschmann S, de Jong EC et al. Early nutrition and immunity – progress and perspectives. Br. J. Nutr.96(4), 774–790 (2006).
  • Dunstan JA, Mori TA, Barden A et al. Fish oil supplementation in pregnancy modifies neonatal allergen-specific immune responses and clinical outcomes in infants at high risk of atopy: a randomized, controlled trial. J. Allergy Clin. Immunol.112, 1178–1184 (2003).
  • Mihrshahi S, Peat JK, Webb K et al. Effect of omega-3 fatty acid concentrations in plasma on symptoms of asthma at 18 months of age. Pediatr. Allergy Immunol.15(6), 517–522 (2004).
  • Almqvist C, Garden F, Xuan W et al. Omega-3 and omega-6 fatty acid exposure from early life does not affect atopy and asthma at age 5 years. J. Allergy Clin. Immunol.119(6), 1438–1444 (2007).
  • Bays HE. Safety considerations with omega-3 fatty acid therapy. Am. J. Cardiol.99(6A), 35C–43C (2007).
  • Olsen S, Sorensen J, Secher N et al. Randomised controlled trial of effect of fish-oil supplementation on pregnancy duration. Lancet339, 1003–1007 (1992).
  • Mozaffarian D, Rimm EB. Fish intake, contaminants, and human health: evaluating the risks and the benefits. JAMA296(15), 1885–1899 (2006).
  • Bell IR. Diet and nutrition in Alzheimer’s disease and other dementias of late life. EXPLORE (NY)1(4), 299–301 (2005).
  • Mazza M, Pomponi M, Janiri L, Bria P, Mazza S. Omega-3 fatty acids and antioxidants in neurological and psychiatric diseases: an overview. Prog. Neuropsychopharmacol. Biol. Psychiatry31(1), 12–26 (2007).
  • Petridou E, Koussouri M, Toupadaki N et al. Diet during pregnancy and the risk of cerebral palsy. Br. J. Nutr.79(5), 407–412 (1998).
  • Berman DR, Mozurkewich E, Liu Y, Barks J. Docosahexaenoic acid pretreatment confers neuroprotection in a rat model of perinatal cerebral hypoxia–ischemia. Am. J. Obst. Gynecol.200(3), 305.e1–305.e6 (2009).

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