Does the intrauterine growth-restricted fetus benefit from antenatal glucocorticoids?

References

• Laws PJ, Hilder L. Australia’s mothers and babies 2006. Perinatal Statistics Series (AIHW cat. no. PER 46), 1–104 (2008).
   Google Scholar
• Moss TJ, Doherty DA, Nitsos I, Sloboda DM, Harding R, Newnham JP. Effects into adulthood of single or repeated antenatal corticosteroids in sheep. Am. J. Obstet. Gynecol.192(1), 146–152 (2005).
   PubMed Web of Science ®Google Scholar
• St John EB, Nelson KG, Cliver SP, Bishnoi RR, Goldenberg RL. Cost of neonatal care according to gestational age at birth and survival status. Am. J. Obstet. Gynecol.182(1 Pt 1), 170–175 (2000).
   PubMed Web of Science ®Google Scholar
• Gilbert WM, Danielsen B. Pregnancy outcomes associated with intrauterine growth restriction. Am. J. Obstet. Gynecol.188(6), 1596–1599; discussion 1599–1601 (2003).
   PubMed Web of Science ®Google Scholar
• Liggins GC. Premature delivery of foetal lambs infused with glucocorticoids. Endocrinology45, 515–523 (1969).
   Web of Science ®Google Scholar
• Crowley PA. Antenatal corticosteroid therapy: a meta-analysis of the randomized trials, 1972 to 1994. Am. J. Obstet. Gynecol.173(1), 322–335 (1995).
   PubMed Web of Science ®Google Scholar
• Elimian A, Verma U, Canterino J, Shah J, Visintainer P, Tejani N. Effectiveness of antenatal steroids in obstetric subgroups. Obstet. Gynecol.93(2), 174–179 (1999).
   PubMed Web of Science ®Google Scholar
• National Institutes of Health Consensus Development Panel. Antenatal Corticosteroids Revisited: Repeat Courses – National Institutes of Health Consensus Development Conference Statement, August 17–18, 2000. Obstet. Gynecol.98(1), 144–150 (2001).
   PubMed Web of Science ®Google Scholar
• Bernstein IM, Horbar JD, Badger GJ, Ohlsson A, Golan A. Morbidity and mortality among very-low-birth-weight neonates with intrauterine growth restriction. The Vermont Oxford Network. Am. J. Obstet. Gynecol.182(1 Pt 1), 198–206 (2000).
   PubMed Web of Science ®Google Scholar
• Ikegami M, Polk D, Jobe A. Minimum interval from fetal β-methasone treatment to postnatal lung responses in preterm lambs. Am. J. Obstet. Gynecol.174(5), 1408–1413 (1996).
   PubMed Web of Science ®Google Scholar
• Jobe AH, Ikegami M. Lung development and function in preterm infants in the surfactant treatment era. Annu. Rev. Physiol.62(1), 825–846 (2000).
   PubMed Web of Science ®Google Scholar
• Modi N, Lewis H, Al-Naqeeb N, Ajayi-Obe M, Dore CJ, Rutherford M. The effects of repeated antenatal glucocorticoid therapy on the developing brain. Pediatr. Res.50(5), 581–585 (2001).
   PubMed Web of Science ®Google Scholar
• Brocklehurst P, Gates S, McKenzie-McHarg K, Alfirevic Z, Chamberlain G. Are we prescribing multiple courses of antenatal corticosteroids? A survey of practice in the UK. Br. J. Obstet. Gynaecol.106(9), 977–979 (1999).
   PubMedGoogle Scholar
• Quinlivan JA, Evans SF, Dunlop SA, Beazley LD, Newnham JP. Use of corticosteroids by Australian obstetricians – a survey of clinical practice. Aust. N. Z. J. Obstet. Gynaecol.38(1), 1–7 (1998).
   PubMed Web of Science ®Google Scholar
• Crowther CA, Haslam RR, Hiller JE, Doyle LW, Robinson JS. Neonatal respiratory distress syndrome after repeat exposure to antenatal corticosteroids: a randomised controlled trial. Lancet367(9526), 1913–1919 (2006).
   PubMed Web of Science ®Google Scholar
• Roberts D, Dalziel S. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst. Rev.3, CD004454 (2006).
   PubMed Web of Science ®Google Scholar
• Crowther CA, Harding J. Repeat doses of prenatal corticosteroids for women at risk of preterm birth for preventing neonatal respiratory disease. Cochrane Database Syst. Rev. (3), CD003935 (2003).
   Google Scholar
• Murphy KE, Hannah ME, Willan AR et al. Multiple courses of antenatal corticosteroids for preterm birth (MACS): a randomised controlled trial. Lancet372(9656), 2143–2151 (2008).
   PubMed Web of Science ®Google Scholar
• Polglase GR, Nitsos I, Jobe AH, Newnham JP, Moss TJ. Maternal and intra-amniotic corticosteroid effects on lung morphometry in preterm lambs. Pediatr. Res.62(1), 32–36 (2007).
   PubMed Web of Science ®Google Scholar
• Ueda T, Ikegami M, Polk D, Mizuno K, Jobe A. Effects of fetal corticosteroid treatments on postnatal surfactant function in preterm lambs. J. Appl. Physiol.79, 846–851 (1995).
   PubMed Web of Science ®Google Scholar
• Ballard PL, Ning Y, Polk D, Ikegami M, Jobe AH. Glucocorticoid regulation of surfactant components in immature lambs. Am. J. Physiol.273(5 Pt 1), L1048–L1057 (1997).
   PubMed Web of Science ®Google Scholar
• Willet KE, Jobe AH, Ikegami M, Kovar J, Sly PD. Lung morphometry after repetitive antenatal glucocorticoid treatment in preterm sheep. Am. J. Respir. Crit. Care Med.163(6), 1437–1443 (2001).
   PubMed Web of Science ®Google Scholar
• Walfisch A, Hallak M, Mazor M. Multiple courses of antenatal steroids: risks and benefits. Obstet. Gynecol.98(3), 491–497 (2001).
   PubMed Web of Science ®Google Scholar
• Schaap AH, Wolf H, Bruinse HW, Smolders-De Haas H, Van Ertbruggen I, Treffers PE. Effects of antenatal corticosteroid administration on mortality and long-term morbidity in early preterm, growth-restricted infants. Obstet. Gynecol.97(6), 954–960 (2001).
   PubMed Web of Science ®Google Scholar
• Schwab M, Roedel M, Anwar MA et al. Effects of bmethasone administration to the fetal sheep in late gestation on fetal cerebral blood flow. J. Physiol.528(Pt 3), 619–632 (2000).
   PubMed Web of Science ®Google Scholar
• Huang WL, Harper CG, Evans SF, Newnham JP, Dunlop SA. Repeated prenatal corticosteroid administration delays myelination of the corpus callosum in fetal sheep. Int. J. Dev. Neurosci.19(4), 415–425 (2001).
   PubMed Web of Science ®Google Scholar
• Sloboda DM, Newnham JP, Challis JR. Effects of repeated maternal β-methasone administration on growth and hypothalamic–pituitary–adrenal function of the ovine fetus at term. J. Endocrinol.165(1), 79–91 (2000).
   PubMed Web of Science ®Google Scholar
• Sloboda DM, Newnham JP, Challis JR. Repeated maternal glucocorticoid administration and the developing liver in fetal sheep. J. Endocrinol.175(2), 535–543 (2002).
   PubMed Web of Science ®Google Scholar
• Baud O, Sola A. Corticosteroids in perinatal medicine: how to improve outcomes without affecting the developing brain? Semin. Fetal Neonatal Med.12(4), 273–279 (2007).
   PubMed Web of Science ®Google Scholar
• Schwab M, Coksaygan T, Nathanielsz PW. bmethasone effects on ovine uterine and umbilical placental perfusion at the dose used to enhance fetal lung maturation. Am. J. Obstet. Gynecol.194(2), 572–579 (2006).
   PubMed Web of Science ®Google Scholar
• Huang WL, Beazley LD, Quinlivan JA, Evans SF, Newnham JP, Dunlop SA. Effect of corticosteroids on brain growth in fetal sheep. Obstet. Gynecol.94(2), 213–218 (1999).
   PubMed Web of Science ®Google Scholar
• Anwar MA, Schwab M, Poston L, Nathanielsz PW. bmethasone-mediated vascular dysfunction and changes in hematological profile in the ovine fetus. Am. J. Physiol.276(4 Pt 2), H1137–H1143 (1999).
   Google Scholar
• Edwards LJ, Simonetta G, Owens JA, Robinson JS, McMillen IC. Restriction of placental and fetal growth in sheep alters fetal blood pressure responses to angiotensin II and captopril. J. Physiol.515(Pt 3), 897–904 (1999).
   PubMed Web of Science ®Google Scholar
• Economides DL, Nicolaides KH. Blood glucose and oxygen tension levels in small-for-gestational-age fetuses. Am. J. Obstet. Gynecol.160(2), 385–389 (1989).
   PubMed Web of Science ®Google Scholar
• Owens JA, Kind KL, Carbone F, Robinson JS, Owens PC. Circulating insulin-like growth factors-I and -II and substrates in fetal sheep following restriction of placental growth. J. Endocrinol.140(1), 5–13 (1994).
   PubMed Web of Science ®Google Scholar
• Morrison JL, Botting KJ, Dyer JL et al.Restriction of placental function alters heart development in the sheep fetus. Am. J. Physiol. Regul. Integr. Comp. Physiol.293(1), R306–R313 (2007).
   PubMed Web of Science ®Google Scholar
• Economides DL, Nicolaides KH, Linton EA, Perry LA, Chard T. Plasma cortisol and adrenocorticotropin in appropriate and small for gestational age fetuses. Fetal Ther.3(3), 158–164 (1988).
   PubMedGoogle Scholar
• Phillips ID, Simonetta G, Owens JA, Robinson JS, Clarke IJ, McMillen IC. Placental restriction alters the functional development of the pituitary–adrenal axis in the sheep fetus during late gestation. Pediatr. Res.40(6), 861–866 (1996).
   PubMed Web of Science ®Google Scholar
• Lipsett J, Tamblyn M, Madigan K et al. Restricted fetal growth and lung development: a morphometric analysis of pulmonary structure. Pediatr. Pulmonol.41(12), 1138–1145 (2006).
   PubMed Web of Science ®Google Scholar
• Rees S, Ng J, Dickson K, Nicholas T, Harding R. Growth retardation and the development of the respiratory system in fetal sheep. Early Hum. Dev.26(1), 13–27 (1991).
   PubMed Web of Science ®Google Scholar
• Braems GA, Yao LJ, Inchley K et al. Ovine surfactant protein cDNAs: use in studies on fetal lung growth and maturation after prolonged hypoxemia. Am. J. Physiol.278(4), L754–L764 (2000).
   Google Scholar
• Gagnon R, Langridge J, Inchley K, Murotsuki J, Possmayer F. Changes in surfactant-associated protein mRNA profile in growth-restricted fetal sheep. Am. J. Physiol.276(3 Pt 1), L459–L465 (1999).
   Google Scholar
• Nardo L, Zhao L, Green L, Possmayer F, Richardson BS, Bocking AD. The effect of repeated umbilical cord occlusions on pulmonary surfactant protein mRNA levels in the ovine fetus. J. Soc. Gynecol. Investig.12(7), 510–517 (2005).
   PubMedGoogle Scholar
• Morrison JL. Sheep models of intrauterine growth restriction: fetal adaptations and consequences. Clin. Exp. Pharmacol. Physiol.35(7), 730–743 (2008).
   PubMed Web of Science ®Google Scholar
• McMillen IC, Adams MB, Ross JT et al. Fetal growth restriction: adaptations and consequences. Reproduction122(2), 195–204 (2001).
   PubMed Web of Science ®Google Scholar
• Orgeig S, Crittenden TA, Marchant C, McMillen IC, Morrison JL. Intrauterine growth restriction delays surfactant protein maturation in the sheep fetus. Am. J. Physiol. Lung Cell. Mol. Physiol. (2010) (Epub ahead of print).
   PubMed Web of Science ®Google Scholar
• Saini Y, Harkema JR, LaPres JJ. HIF1a is essential for normal intrauterine differentiation of alveolar epithelium and surfactant production in the newborn lung of mice. J. Biol. Chem.283(48), 33650–33657 (2008).
   PubMed Web of Science ®Google Scholar
• Ginouves A, Ilc K, Macias N, Pouyssegur J, Berra E. PHDs overactivation during chronic hypoxia ‘desensitizes’ HIFα and protects cells from necrosis. Proc. Natl Acad. Sci. USA105(12), 4745–4750 (2008).
   PubMed Web of Science ®Google Scholar
• Nathanielsz PW, Hanson MA. The fetal dilemma: spare the brain and spoil the liver. J. Physiol.548(Pt 2), 333 (2003).
   PubMed Web of Science ®Google Scholar
• Dubiel M, Gunnarsson GO, Gudmundsson S. Blood redistribution in the fetal brain during chronic hypoxia. Ultrasound Obstet. Gynecol.20(2), 117–121 (2002).
   PubMed Web of Science ®Google Scholar
• Cheema R, Dubiel M, Gudmundsson S. Fetal brain sparing is strongly related to the degree of increased placental vascular impedance. J. Perinat. Med.34(4), 318–322 (2006).
   PubMed Web of Science ®Google Scholar
• Miller SL, Chai M, Loose J et al. The effects of maternal β-methasone administration on the intrauterine growth-restricted fetus. Endocrinology148(3), 1288–1295 (2007).
   PubMed Web of Science ®Google Scholar
• Nozaki AM, Francisco RP, Fonseca ES, Miyadahira S, Zugaib M. Fetal hemodynamic changes following maternal bmethasone administration in pregnancies with fetal growth restriction and absent end-diastolic flow in the umbilical artery. Acta Obstet. Gynecol. Scand.88(3), 350–354 (2009).
   PubMed Web of Science ®Google Scholar