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Expert Review of Obstetrics & Gynecology Volume 6, 2011 - Issue 1
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Review

Stillbirth: issues and new insights

Fabio Facchinetti Mother–Infant Department, University of Modena and Reggio Emilia, Italy; Unit of Obstetrics, Azienda Ospedaliero Universitaria, Via del Pozzo 71, 41100 Modena, Italy. [email protected]; Unit of Obstetrics, Azienda Ospedaliero Universitaria, Via del Pozzo 71, 41100 Modena, Italy. [email protected]
,
Francesca Ferrari Mother–Infant Department, University of Modena and Reggio Emilia, Italy; Mother–Infant Department, University of Modena and Reggio Emilia, Italy
,
Francesca Monari Mother–Infant Department, University of Modena and Reggio Emilia, Italy; Mother–Infant Department, University of Modena and Reggio Emilia, Italy
&
Isabella Neri Mother–Infant Department, University of Modena and Reggio Emilia, Italy; Mother–Infant Department, University of Modena and Reggio Emilia, Italy
Pages 93-108 | Published online: 10 Jan 2014

References

  • Walsh CA, McMenamin MB, Foley ME, Daly SF, Robson MS, Geary MP. Trends in intrapartum fetal death, 1979–2003. Am. J. Obstet. Gynecol.198, 47.e1–e47 (2008).
  • WHO. Neonatal and Perinatal Mortality – Country, Regional and Global Estimates. Department of Making Pregnancy Safer, WHO, Geneva, Switzerland (2006).
  • Mathers CD, Bernard C, Iburg K et al. Global Burden of Disease in 2002, data sources, methods and results. WHO, Geneva, Switzerland (2003).
  • WHO. Neonatal and Perinatal Mortality – Country, Regional and Global Estimates 2004. Department of Making Pregnancy Safer, WHO, Geneva, Switzerland (2007).
  • Stanton C, Lawn JE, Rahman H, Wilczynska-Ketende K, Hill K. Stillbirth rates, delivering estimates in 190 countries. Lancet367, 1487–1494 (2006).
  • Kramer MS, Liu S, Luo Z et al. Analysis of perinatal mortality and its components, time for a change? Am. J. Epidemiol.156, 493–497 (2002).
  • Lawn JE, McCarthy B, Ross SR. The healthy newborn, a reference guide for program managers. CDC and CARE, Atlanta, GA, USA (2001).
  • Chen LM, Sun CA, Wu DM et al. Underregistration of neonatal deaths, an empirical study of the accuracy of infantile vital statistics in Taiwan. J. Epidemiol. Community Health52, 289–292 (1998).
  • WHO. ICD-10, International Statistical Classification of Diseases and Related Health Problems – Instruction Manual. WHO, Geneva, Switzerland, Report No. 2 (2004).
  • Chu SY, Kim SY, Lau JL et al. Maternal obesity and risk of stillbirth, a metaanalysis. Review. Am. J. Obstet. Gynecol.197(3), 223–228 (2007).
  • Stephansson O, Dickman PW, Johansson A, Cnattingius S. Maternal weight, pregnancy weight gain, and the risk of antepartum stillbirth. Am. J. Obstet. Gynecol.184, 463–469 (2001).
  • Cnattingius S, Lambe M. Trends in smoking and overweight during pregnancy, prevalence, risks of pregnancy complications, and adverse pregnancy outcomes. Semin. Perinatol.26, 286–295 (2002).
  • Cadergren MI. Maternal morbid obesity and the risk of adverse pregnancy outcome. Obstet. Gynecol.103, 219–224 (2004).
  • Nohr EA, Bech BH, Davies MJ et al. Pregnancy obesity and fetal death, a study within then Danish National Birth Cohort. Obstet. Gynaecol.106, 250–259 (2005).
  • Kristensen J. Vestergaard M, Wisborg K et al. Pre-pregnancy weight and the risk of stillbirth and neonatal death. BJOG112, 403–408 (2005).
  • Cnattingius S, The epidemiology of smoking during pregnancy, smoking prevalence, maternal characteristics and pregnancy outcomes. Nicotine Tob. Res.6, S125–S140 (2004).
  • Wisborg K, Kesmodel U, Henriksen TB et al. Exposure to tabacco smoke in utero and the risk of stillbirth and death in the first year of life. Am. J. Epidemiol.154, 322–327 (2001).
  • Wisborg K, Henriksen TB, Secher NJ. A prospective intervention study of stopping smoking in pregnancy in a routine antenatal care setting. Br. J. Obstet. Gynaecol.105, 1171–1176 (1998).
  • Ananth CV, Smulian JC, Demissie K, Vintzileos AM, Knuppel RA. Placental abruption among singleton and twin births in the United States, risk factor profiles. Am. J. Epidemiol.153, 771–778 (2006).
  • Odegard RA, Vatten LI, Nilsen ST et al. Risk factors and clinical manifestations of pre-eclampsia. BJOG107, 1410–1416 (2000).
  • Cnattingius LB, Signorello G, Anneren B et al. Caffeine intake and the risk of first trimestre spontaneous abortion. N. Engl. J. Med.343, 1839–1845 (2000).
  • Grosso LM, Bracken MB. Caffeine metabolism, genetics and perinatal outcomes, a review of exposure assessment considerations during pregnancy. Ann. Epidemiol.15, 460–466 (2005).
  • Kesmodel U, Wisborg K, Olsen SF, Henriksen TB, Secher NJ. Moderate alcohol intake during pregnancy and the risk of stillbirth and death in the first year of life. Am. J. Epidemiol.155(4), 305–312 (2002).
  • US Preventive Service Task Force. Screening and behavioral counselling intervention in primary care to reduce alcohol misure, recommendation statement. Ann. Intern. Med.140, 554–556 (2004).
  • Huang L, Sauve R, Birkett N et al. Maternal age and the risk of stillbirth, a systematic review. CMAJ178, 165–172 (2008).
  • Nybo Andersen AM, Wohlfahrt J et al. Maternal age and fetal loss, population based register linkage study. Br. Med. J.320, 1708–1712 (2000).
  • Guildea ZE, Fone DL, Dunstan FD, Sibert JR, Cartlidge PH. Social deprivation and the causes of stillbirth and infant mortality. Arch. Dis. Child.84, 307–310 (2001).
  • Saastad E, Vangen S, Frøen JF. Suboptimal care in stillbirth – a retrospective audit study. Acta Obstet. Gynaecol. Scand.86, 444–450 (2007).
  • Salihu HM, Kinninburgh BA, Aliyu MH et al. Racial disparity in stillbirth among singleton, twin and triplets gestations in the United States. Obstet. Gynaecol.104, 734–740 (2004).
  • Sharma PP, Salihu HM, Oyelese Y, Ananth CV, Kirby RS. Is race a determinant of stillbirth recurrence? Obstet. Gynaecol.107, 391–397 (2006).
  • Smith GC, Pell JP, Dobbie R. Cesarean section and risk of unexplained stillbirth in subsequent pregnancy. Lancet362, 1779–1784 (2003).
  • Salihu HM, Sharma PP, Aliyu HM et al. Is small for gestational age a marker of future fetal survival in utero? Obstet. Gynaecol.107, 851–856 (2006).
  • Facchinetti F, Marozio L, Frusca T et al. Maternal thrombophilia and the risk of recurrence of preeclampsia. Am. J. Obstet. Gynaecol.200(1), 46.e1–5 (2009).
  • Glinianaia SV, Rankin J, Bell R et al. Does particulate air pollution contribute to infant death? A systematic review. Environ. Health Perspect.112, 1365–1371 (2004).
  • Toledano MB, Nieuwenhuijsen MJ, Best N et al. Relation of trihalomethane concentrations in public water supplies to stillbirth and birth weight in three water regions of England. Environ. Health Perspect.113, 225–232 (2005).
  • von Ehrenstein OS, Guha Mazumder DN, Hira-Smith M et al. Pregnancy outcomes, infant mortality and arsenic drinking water in West Bengal, India. Am. Epidemiol.163, 662–669 (2006).
  • Parker L, Pearce MS, Dickinson HO et al. Stillbirths among offspring of male radiation workers at Sellafield nuclear reprocessing plant. Lancet354, 1407–1414 (1999).
  • Fretts RC, Elkin EB, Myers et al. Should offer women have antepartum testing to prevent unexplained stillbirth? Obstet. Gynaecol.104, 56–56 (2004).
  • Stephansson O, Dickman PW, Johansson AL, Cnattingius S. The influence of socioeconomic status on stillbirth risk in Sweden. Int. Epidemiol.30, 1296–1301 (2001).
  • Robson S, Chan A, Keane RJ, Luke CG. Subsequent birth outcomes after an unexplained stillbirth, preliminary population-based retrospective cohort study. Aust. N. Z. J. Obstet. Gynaecol.4, 29–35 (2001).
  • Ngoc HTN, Merialdi M, Abdel-Aleem H et al. Causes of stillbirths and early neonatal deaths, data from 7993 pregnancies in six developing countries. Bull. WHO84, 699–705 (2006).
  • Rosser J. Confidential Enquiry into Stillbirths and Deaths in Infancy (CESDI). Highlights of the 6th Annual Report. Part 4. Pract. Midwife3(1), 11 (2000).
  • Heazell AE, Froen JF. Methods of fetal movement counting and detection of fetal compromise. J. Obstet. Gynaecol.28, 147–154 (2008).
  • Salihu HS, Aliyu MH, Rouse DJ et al. Potentially preventable excess mortality among higher-order multiples. Obstet. Gynecol.102, 679–684 (2003).
  • Donald J. Dudley, MD. Diabetic-associated stillbirth, incidence, pathophysiology, and prevention. Clin. Perinatol.34, 611–626 (2007).
  • Alfirevic Z, Devane D, Gyte GM. Continuous cardiotography (CTG) as a form of electronic fetal monitoring for fetal assessment during labor. Cochrane Database Syst. Rev.3, CD006066 (2006).
  • Barton JR, Sibai BM. Prediction and prevention of recurrent preeclampsia. Obstet. Gynaecol.112, 359–372 (2008).
  • Makrides M, Duley L, Olsen SF. Marine oil, and other prostaglandin precursor, supplementation for pregnancy uncomplicated by preeclampsia or intrauterine growth restriction (review). The Cochrane Library, Issue 2 (2007).
  • Rumbold A, Crowther CA. Vitamin E supplementation in pregnancy (review). The Cochrane Library, Issue 2 (2007).
  • Rumbold A, Crowther CA. Vitamin C supplementation in pregnancy (review). The Cochrane Library, Issue 2 (2007).
  • Abalos E, Duley L, Steyn DW, Henderson-Smart DJ. Antihypertensive drug therapy for mild to moderate hypertension during pregnancy. Cochrane Database Syst. Rev.1, CD002252 (2007).
  • Hofmeyr GJ, Atallah AN, Duley L. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems (review). The Cochrane Library, Issue 2 (2007).
  • Duley L, Henderson-Smart DJ, Meher S, King JF. Antiplatelet agents for preventing pre-eclampsia and its complications (review). The Cochrane Library, Issue 4 (2008).
  • De Groot PG, Derksen RH. The antiphospholipid syndrome, clinical carachteristics, laboratory features and pathogenesis. Curr. Opin. Infect. Dis.18, 205–210 (2005).
  • Derksen RH, Khamashta M, Branch DW. Management of the obstetric antiphospholipid syndrome. Arthritis Rheum.50, 1028–1039 (2004).
  • Bloomenthal D, Von Dadelszen P, Liston R, Magee L, Tsang P. The effect of Factor V Leiden carriage on maternal and fetal health. CMAJ167, 48–54 (2002).
  • Duhl AJ, Paidas MJ, Ural SH et al. Antithrombotic therapy and pregnancy, consensus report and recommendations for prevention and treatment of venous thromboembolism and adverse pregnancy outcome. Am. J. Obstet. Gynecol.197, 457.e1–e21 (2007).
  • Froen JF, Gardosi J, Thurmann A, Francis A, Stray-Pedersen B. Restricted fetal growth in sudden intrauterine unexplained death. Acta Obstet. Gynecol. Scand.83, 801–807 (2004).
  • American College of Obstetricians and Gynaecologists. Intrautherine growth restriction. ACOG Practice Bulletin 12 (2000).
  • Reddy U. Prediction and prevention of recurrent stillbirth. Obstet. Gynaecol.110, 1151–1164 (2007).
  • Smith GCS, Fretts RC. Stillbirth. Lancet370, 1715–1725 (2007).
  • Smith GCS. Life-table analysis of the risk of perinatal death at term and post term in singleton pregnancies. Am. J. Obstet. Gynaecol.184, 489–496 (2001).
  • Silver RM, Varner MW, Reddy U et al. Work-up of stillbirth, a review of the evidence. Am. J. Obstet. Gynecol.196, 433–444 (2007).
  • Petersson K. Diagnostic evaluation of fetal death with special reference to intrauterine infections. Karolinska Institutet, Department of Clinical Science, Division of Obstetrics and Gynecology, Stockholm, Sweden (2002).
  • Horn LC, Langner A, Stiehl P, Wittekind C, Faber R. Identification of the causes of intrauterine death during 310 consecutive autopsies. Eur. J. Obstet. Gynecol. Reprod. Biol.113, 134–138 (2004).
  • Pauli RM, Reiser CA. Wisconsin Stillbirth Service Program, II. Analysis of diagnoses and diagnostic categories in the first 1,000 referrals. Am. J. Med. Genet.50, 135–153 (1994).
  • Flenady V, Koopmans L et al. Modifiable risk factors for stillbirth: a systematic review and meta-analysis. Presented at: International Stillbirth Alliance Congress. Oslo, Norway, 5–7 November 2008.
  • NSW Health Department. Guidelines for investigation of a stillbirth. Electronic/circular. Sydney, NSW Health Department; 1997 27/10/1997. Report No., 97/107, Nursing and Midwifery Sub-group SZCSN. Antepartum haemorrhage, Southern Zone Maternity Procedural Guidelines. 104–108 (2003).
  • Emery CL, Morway LF, Chung-Park M, Wyatt-Ashmead J, Sawady J, Beddow TD. The Kleihauer–Betke test. Clinical utility, indication, and correlation in patients with placental abruption and cocaine use. Arch. Pathol. Lab. Med.119(11), 1032–1037 (1995).
  • Korteweg FJ, Bouman K, Erwich JJ et al. Cytogenetic analysis after evaluation of 750 fetal deaths, proposal for diagnostic workup. Obstet. Gynecol.111(4), 865–874 (2008).
  • Ahlenius I, Floberg J, Thomassen P. Sixty-six cases of intrauterine fetal death. A prospective study with an extensive test protocol. Acta Obstet. Gynecol. Scand.74(2), 109–117 (1995).
  • Khong TY. From delivery suite to laboratory, optimizing returns from placental examination in medico-legal defence. Aust. N. Z. J. Obstet. Gynaecol.37, 1–5 (1997).
  • Korteweg FJ, Bouman K, Erwich JJ et al. Cytogenetic analysis after evaluation of 750 fetal deaths, proposal for diagnostic workup. Obstet. Gynecol.111(4), 865–874 (2008).
  • Christiaens GC, Vissers J, Poddighe PJ, de Pater JM. Comparative genomic hybridization for cytogenetic evaluation of stillbirth. Obstet. Gynecol.96(2), 281–286 (2000).
  • Pauli RM, Reiser CA, Lebovitz RM et al. Wisconsin Stillbirth Service Program: I. Establishment and assessment of a community-based program for etiologic investigation of intrauterine deaths. Am. J. Med. Genet. Review50(2), 116–134 (1994).
  • Faye-Petersen DA, Guinn, Wenstrom KD. Value of perinatal autopsy. Obstet. Gynecol.94, 915–920 (1999).
  • Moore C, Negrusz A, Lewis D. Determination of drugs of abuse in meconium. J. Chromatogr. B Biomed. Sci. Appl.713, 137–146 (1998).
  • Sachs H, Kintz P. Testing for drugs in hair, critical review of chromatographic procedures since 1992. J. Chromatogr. B. Biomed. Sci. Appl.713, 147–161 (1998).
  • Parfitt VJ, Clark JD, Turner GM, Hartog M. Use of fructosamine and glycated haemoglobin to verify self blood glucose monitoring data in diabetic pregnancy. Diabet. Med.10(2), 162–166 (1993).
  • Moise K. Hemolytic disease of the fetus and newborn. In: Maternal–Fetal Medicine, Principles and Practice (5th Edition). Creasy RK, Resnik R (Eds). Saunders, PA, USA, 537–561 (2004).
  • Moise KJ. Red blood cell alloimmunization in pregnancy. Semin. Hematol.42(3), 169–78 (2005).
  • Baird D, Walker J, Thomson AM. The causes and prevention of stillbirths and first week deaths. III. A classification of deaths by clinical cause; the effect of age, parity and length of gestation on death rates by cause. J. Obstet. Gynaecol. Br. Emp.61, 433–448 (1954).
  • Flenady V, Frøen JF, Pinar H et al. An evaluation of classification systems for stillbirth. BMC Pregnancy Childbirth9, 24 (2009).
  • de Galan-Roosen AE, Kuijpers JC, van der Straaten PJ, Merkus JM. Fundamental classification of perinatal death. Validation of a new classification system of perinatal death. Eur. J. Obstet. Gynecol. Reprod. Biol.103, 30–36 (2002).
  • Gardosi J, Mul T, Mongelli M, Fagan D. Analysis of birth-weight and gestational age in ante-partum stillbirths. Br. J. Obstet. Gynaecol.105, 524–530 (1998).
  • Gardosi J, Kady SM, McGeown P, Francis A, Tonks A. Classification of stillbirth by relevant condition at death (ReCoDe), population based cohort study. Br. Med. J.331, 1113–1117 (2005).
  • McClure EM, Goldenberg LR, Bann CM. Maternal mortality, stillbirth and measures of obstetric care in developing and developed countries. Int. J. Gynaecol. Obstet.96, 139–146 (2007).
  • Arnestad M, Crotti L, Rognum TO et al. Prevalence of long-QT syndrome gene variants in sudden infant death syndrome. Circulation115, 361–367 (2007).
  • Schwartz PJ. Stillbirths, sudden infant deaths, and long-QT syndrome, puzzle or mosaic, the pieces of the Jigsaw are being fitted together. Circulation109, 2930–2932 (2004).
  • Crotti L, Spazzolini C, Schwartz PJ et al. The common long-QT syndrome mutation KCNQ1/A341V causes unusually severe clinical manifestations in patients with different ethnic backgrounds: toward a mutation-specific risk stratification. Circulation116(21), 2366–2375 (2007).
  • Kinney HC, Filiano JJ, Sleeper LA, Mandell F, Valdes-Dapena M, White WF. Decreased muscarinic receptor binding in the arcuate nucleus in sudden infant death syndrome. Science269, 1446–1450 (1995).
  • Matturri L, Minoli I, Lavezzi AM, Cappellini A, Ramos S, Rossi L. Hypoplasia of medullary arcuate nucleus in unexpected late fetal death (stillborn infants), a pathologic study. Pediatrics109, E43 (2002).
  • Kupferminc MJ, Eldor A, Steiman N et al. Increased frequency of genetic thrombophilia in women with complications of pregnancy. N. Eng. J. Med.340, 9–13 (1999).
  • Rey E, Kahn SR, Dvid M, Shrier I. Thrombophilic disorders and fetal loss, a meta-analysis. Lancet361, 901–908 (2003).
  • Ariel I, Anteby E, Hamani Y, Redline RW. Placental pathology in fetal thrombophilia. Hum. Pathol.35, 729–733 (2004).
  • Tranquilli AL, Emanuelli M. The thrombophilic fetus. Med. Hypotheses67, 1226–1229 (2006).
  • Wapner RJ, Lewis D. Genetics and metabolic causes of stillbirth. Semin. Perinatol.26, 70–74 (2002).
  • McPherson TA, Garver KL, Turner JH, Diggans GR, Marchese SG, Poole GC. Predicting in vitro tissue culture growth for cytogenetic evaluation of stillborn fetuses. Eur. J. Obstet. Gynecol. Reprod. Biol.19, 167–174 (1985).
  • Shinawi M, Cheung SW. The array CGH and its clinical applications. Drug Discov. Today13(17–18), 760–770 (2008).
  • Kallioniemi, Kallioniemi OP, Sudar D et al. Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science258, 818–821 (1992).
  • Cheung SW, Shaw CA, Yu W et al. Development and validation of a CGH microarray for clinical cytogenetic diagnosis. Genet. Med.7, 422–432 (2005).

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