Advanced search
Publication Cover
Expert Review of Obstetrics & Gynecology Volume 7, 2012 - Issue 6
Journal homepage
6
Views
1
CrossRef citations to date
0
Altmetric
Editorial

Cell-free fetal DNA: emerging applications and future obstacles

Kerry Oxenford Fetal Medicine Unit, University College London Hospitals NHS Foundation Trust, London, UK
,
Melissa Hill Fetal Medicine Unit, University College London Hospitals NHS Foundation Trust, London, UK
&
Lyn Chitty Fetal Medicine Unit, University College London Hospitals NHS Foundation Trust, London, UK and Clinical and Molecular Genetics, Institute of Child Health and Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK. [email protected]
Pages 513-515 | Published online: 10 Jan 2014

References

  • Hill M, Finning K, Martin P et al. Non-invasive prenatal determination of fetal sex: translating research into clinical practice. Clin. Genet. 80(1), 68–75 (2011).
  • Daniels G, Finning K, Martin P, Massey E. Noninvasive prenatal diagnosis of fetal blood group phenotypes: current practice and future prospects. Prenat. Diagn. 29(2), 101–107 (2009).
  • Hill M, Lewis C, Jenkins L, Allen S, Elles RG, Chitty LS. Implementing noninvasive prenatal fetal sex determination using cell-free fetal DNA in the United Kingdom. Expert Opin. Biol. Ther. 12(Suppl. 1), S119–S126 (2012).
  • Chitty LS, Griffin DR, Meaney C et al. New aids for the non-invasive prenatal diagnosis of achondroplasia: dysmorphic features, charts of fetal size and molecular confirmation using cell-free fetal DNA in maternal plasma. Ultrasound Obstet. Gynecol. 37(3), 283–289 (2011).
  • Finning K, Martin P, Summers J, Massey E, Poole G, Daniels G. Effect of high throughput RHD typing of fetal DNA in maternal plasma on use of anti-RhD immunoglobulin in RhD negative pregnant women: prospective feasibility study. BMJ 336(7648), 816–818 (2008).
  • Tsui NB, Kadir RA, Chan KC et al. Noninvasive prenatal diagnosis of hemophilia by microfluidics digital PCR analysis of maternal plasma DNA. Blood 117(13), 3684–3691 (2011).
  • Barrett AN, McDonnell TC, Chan KC, Chitty LS. Digital PCR analysis of maternal plasma for noninvasive detection of sickle cell anemia. Clin. Chem. 58(6), 1026–1032 (2012).
  • Lo YM, Chan KC, Sun H et al. Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus. Sci. Transl. Med. 2(61), 61ra91 (2010).
  • Bianchi DW, Platt LD, Goldberg JD, Abuhamad AZ, Sehnert AJ, Rava RP; Maternal Blood is Source to Accurately Diagnose Fetal Aneuploidy (MELISSA) Study Group. Genome-wide fetal aneuploidy detection by maternal plasma DNA sequencing. Obstet. Gynecol. 119(5), 890–901 (2012).
  • Palomaki GE, Kloza EM, Lambert-Messerlian GMH, Haddow JE et al. DNA sequencing of maternal plasma to detect Down syndrome: an international clinical validation. Genet. Med. 13(11), 913–920 (2011).
  • Benn P, Borrell A, Cuckle H et al. Prenatal detection of Down Syndrome using massively parallel sequencing (MPS): a rapid response statement from a committee on behalf of the Board of the International Society for Prenatal Diagnosis, 24 October 2011. Prenat. Diagn. 32(1), 1–2 (2012).
  • Palomaki GE, Deciu C, Kloza EM et al. DNA sequencing of maternal plasma reliably identifies trisomy 18 and trisomy 13 as well as Down syndrome: an international collaborative study. Genet. Med. 14(3), 296–305 (2012).
  • Norton ME, Brar H, Weiss J et al. Non-Invasive Chromosomal Evaluation (NICE) Study: results of a multicenter prospective cohort study for detection of fetal trisomy 21 and trisomy 18. Am. J. Obstet. Gynecol. 207(2), 137.e1–137.e8 (2012).
  • Sayres LC, Allyse M, Cho MK. Integrating stakeholder perspectives into the translation of cell-free fetal DNA testing for aneuploidy. Genome Med. 4(6), 49 (2012).
  • Lewis C, Hill M, Skirton H, Chitty LS. Fetal sex determination using cell-free fetal DNA: service users’ experiences of and preferences for service delivery. Prenat. Diagn. 32(8), 735–741 (2012).
  • Chitty LS, Hill M, White H, Wright D, Morris S. Non-invasive prenatal testing for aneuploidy-ready for prime time? Am. J. Obstet. Gynecol. 206(4), 269–275 (2012).
  • Sayres LC, Allyse M, Norton ME, Cho MK. Cell-free fetal DNA testing: a pilot study of obstetric healthcare provider attitudes toward clinical implementation. Prenat. Diagn. 31(11), 1070–1076 (2011).
  • Kelly SE, Farrimond HR. Non-invasive prenatal genetic testing: a study of public attitudes. Public Health Genomics 15(2), 73–81 (2012).
  • van den Heuvel A, Chitty L, Dormandy E et al. Is informed choice in prenatal testing universally valued? A population-based survey in Europe and Asia. BJOG 116(7), 880–885 (2009).
  • Fisher J. Supporting parents after disclosure of abnormal first trimester screening results. Curr. Opin. Obstet. Gynecol. 24(2), 109–113 (2012).

Websites

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.