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Review

Time-lapse technology: evaluation of embryo quality and new markers for embryo selection

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Pages 175-190 | Published online: 10 Jan 2014

References

  • Shoukir Y, Campana A, Farley T, Sakkas D. Early cleavage of in vitro fertilized human embryos to the 2-cell stage: a novel indicator of embryo quality and viability. Hum. Reprod.12(7), 1531–1536 (1997).
  • Sakkas D, Shoukir Y, Chardonnens D, Bianchi P, Campana A. Early cleavage of human embryos to the two-cell stage after intracytoplasmic sperm injection as an indicator of embryo viability. Hum. Reprod.13(1), 182–187 (1998).
  • Kline D, Kline JT. Repetitive calcium transients and the role of calcium exocytosis and cell cycle activation in the mouse egg. Dev. Biol.149, 80–89 (1992).
  • Comizzoli P, Marquant-Le Guienne B, Heyman Y, Renard JP. Onset of the first S-phase is determined by a paternal effect during the G1-phase in the bovine zygotes. Biol. Reprod.62, 1677–1684 (2000).
  • Schabronath J, Gartner K. Paternal influence on timing of pronuclear DNA synthesis in naturally ovulated and fertilized mouse eggs. Biol. Reprod.38, 744–749 (1988).
  • Schultz RM, Kopf GS. Molecular basis of mammalian egg activation. Curr. Topics Dev. Biol.30, 21–62 (1995).
  • Herbert M, Gillespie JI, Murdoch AP. Development of calcium signaling mechanisms during maturation of human oocytes. Mol. Hum. Reprod.3, 965–973 (1997).
  • Goldbard SB, Warner CM. Genes affect the timing of early mouse embryo development. Biol. Reprod.27, 419–424 (1982).
  • Stroynowski I. Molecules related to class-I major histocompatibility complex antigens. Annu. Rev. Immunol.8, 501–530 (1990).
  • Jurisicova A, Casper RF, MacLusky NJ, Mills G, Librach C. HLA-G expression during preimplantation human embryo development. Proc. Natl Acad. Sci. USA93, 161–165 (1996).
  • Palermo G, Joris H, Devroey P, Van Steirteghem AC. Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte. Lancet340, 17–18 (1992).
  • Payne D, Flaherty SP, Barry MF, Matthews CD. Preliminary observations on polar body extrusion and pronuclear formation in human oocytes using time-lapse video cinematography. Hum. Reprod.12(3), 532–541 (1997).
  • Nagy ZP, Liu J, Joris H, Devroey P, Van Steirteghem A. Time-course of oocyte activation, pronucleus formation and cleavage in human oocytes fertilized by intracytoplasmic sperm injection. Hum. Reprod.9, 1743–1748 (1994).
  • Plachot M. Fertilization. Hum. Reprod.15(Suppl. 4), 19–30 (2000).
  • Edwards RG, Fishel SB, Cohen J et al. Factors influencing the success of in vitro fertilization for alleviating human infertility. J. In Vitro Fert. Embryo Transf.1, 3–23 (1984).
  • Bos-Mikich A, Mattos AL, Ferrari AN. Early cleavage of human embryos: an effective method for predicting successful IVF/ICSI outcome. Hum. Reprod.16, 2658–2661 (2001).
  • Neuber E, Rinaudo P, Trimarchi JR, Sakkas D. Sequential assessment of individually cultured human embryos as an indicator of subsequent good quality blastocyst development. Hum. Reprod.18, 1307–1312 (2003).
  • Sakkas D, Percival G, D’Arcy Y, Sharif K, Afnan M. Assessment of early clearing in vitro fertilized human embryos at the 2-cell stage before transfer improves embryo selection. Fertil. Steril.76, 1150–1156 (2001).
  • Wharf E, Dimitrakopulos A, Khalaf Y, Pickering S. Early embryo development is an indicator of implantation potential. Reprod. Biomed. Online2, 212–218 (2004).
  • Van Montfoort AP, Dumoulin JC, Kester AD, Evers JL. Early cleavage is a valuable addition to existing embryo selection parameters: a study using single embryo transfers. Hum. Reprod.19, 2103–2108 (2004).
  • Lundin K, Bergh C, Hardarson T. Early embryo cleavage is a strong indicator of embryo quality in human IVF. Hum. Reprod.16, 2652–2657 (2001).
  • Salumets A, Hyden-Granskog C, Mäkinen S, Suikkari A, Tiitinen A, Tuuri T. Early cleavage predicts the viability of human embryos in elective single embryo transfers procedures. Hum. Reprod.18, 821–825 (2003).
  • Tsai YC, Chung MT, Sung YH, Tsai TF, Tsai YT, Lin LY. Clinical value of early cleavage embryo. Int. J. Gynaecol. Obstet.76, 293–297 (2002).
  • Fenwick J, Platteau P, Murdoch AP, Herbert M. Time from insemination to first cleavage predicts developmental competence of human preimplantation embryos in vitro. Hum. Reprod.17(2), 407–412 (2002).
  • Bavister BD. Culture of preimplantation embryos: facts and artifacts. Hum. Reprod.1(2), 91–148 (1995).
  • Inoué S. Video Microscopy. Plenum Press, New York, NY, USA (1986).
  • Salmon ED. VE-DIC light microscopy and the discovery of kinesin. Trends Cell Biol.5, 154–158 (1995).
  • Inoué S, Spring K. Video Microscopy, 2nd Edition. Plenum Press, New York, NY, USA (1997).
  • Wolf D. Digital microscopy (Volume 72, second edition). A Second Edition of Video Microscopy (Methods in Cell Biology). Sluder G (Ed.). Academic Press, MO, USA (2003).
  • Cole RJ. Cinemicrographic observations on the trophoblast and zona pellucida of the mouse blastocyst. J. Embryol. Exp. Morph.17, 481–490 (1967).
  • Massip A, Mulnard J. Time-lapse cinematographic analysis of hatching of normal and frozen–thawed cow blastocysts. J. Reprod. Fertil.58(2), 475–478 (1980).
  • Grissart B, Massip A, Dessy F. Cinematographic analysis of bovine embryo development in serum-free oviduct-conditioned medium. J. Reprod. Fertil.101, 257–264 (1994).
  • Hardarson T, Löfman C, Coull G, Sjogren A, Hamberger L, Edwards RG. Internalization of cellular fragments in a human embryo: time-lapse recordings. Reprod. Biomed. Online5, 36–38 (2002).
  • Holm P, Booth PJ, Callesen H. Kinetics of early in vitro development of bovine in vivo- and in vitro-derived zygotes produced and/or cultured in chemically defined or serum containing media. Reproduction123, 553–565 (2002).
  • Pribenzsky C, Losonczi E, Molnár M et al. Prediction of in vitro developmental competence of early cleavage-stage mouse embryos with compact time-lapse equipment. Reprod. Biomed. Online20, 371–379 (2010).
  • Pribenszky C, Mátyás S, Kovács P, Losonczi E, Zadori J, Vajta G. Pregnancy achieved by transfer of a single blastocyst selected by time-lapse monitoring. Reprod. Biomed. Online21, 533–536 (2010).
  • Arav A, Aroyo A, Yavin S, Roth Z. Prediction of embryonic developmental competence by time-lapse observation and ‘shortest-half’ analysis. Reprod. Biomed. Online17(5), 669–675 (2008).
  • Cruz M, Gadea B, Garrido N et al. Embryo quality, blastocyst and ongoing pregnancy rates in oocyte donation patients whose embryos were monitored by time-lapse imaging. J. Assist. Reprod. Genet.28(7), 569–573 (2011).
  • Meseguer M, Herrero J, Tejera A, Hilligsoe K, Ramsing N, Remohí J. The use of morphokinetics as a predictor of embryo implantation. Hum. Reprod.26(10), 2658–2671 (2011).
  • Van Blerkom J, Davis P, Alexander S. A microscopic and biochemical study of fragmentation phenotypes in stage-appropriate human embryos. Hum. Reprod.16(4), 719–729 (2001).
  • Hesters L, Prisant N, Fanchin R et al. Impact of early cleaved zygote morphology on embryo development and in vitro fertilization–embryo transfer outcome: a prospective study. Fertil. Steril.89, 1677–1684 (2008).
  • Alikani M, Cohen J, Tomkin G, Garrisi GJ, Mack C, Scott RT. Human embryo fragmentation in vitro and its implications for pregnancy and implantation. Fertil. Steril.71, 836–842 (1999).
  • Lemmen JG, Agerholm I, Ziebe S. Kinetic markers of human embryo quality using time-lapse recordings of IVF/ICSI fertilized oocytes. Reprod. Biomed. Online17(3), 385–391 (2008).
  • Van Royen E, Mangelschots K, Vercruyssen M et al. Multinucleation in cleavage stage embryos. Hum. Reprod.18(5), 1062–1069 (2003).
  • Kligman I, Benadiva C, Alikani M, Munné S. Fertilization and early embryology: the presence of multinucleated blastomerés in human embryos is correlated with chromosomal abnormalities. Hum. Reprod.11(7), 1492–1498 (1996).
  • Pelinck MJ, De Vos M, Dekens M, Van der Elst J, De Sutter P, Dhont M. Embryos cultured in vitro with multinucleated blastomeres have poor implantation potential in human in vitro fertilization and intracytoplasmic sperm injection. Hum. Reprod.13(4), 960–963 (1998).
  • Scott L, Finn A, O’Leary T, McLellan S, Hill J. Morphological parameters of early cleavage-stage embryos that correlate with fetal development and delivery: prospective and applied data for increased pregnancy rates. Hum. Reprod.22(1), 230–240 (2007).
  • Wong CC, Loewke KE, Bossert NL et al. Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage. Nat. Biotechnol.28(10), 1115–1121 (2010).
  • Hnida C, Engenheiro E, Ziebe S. Computer-controlled, multilevel, morphometric analysis of blastomere size as biomarker of fragmentation and multinuclearity in human embryos. Hum. Reprod.19(2), 288–293 (2004).
  • Agerholm IE, Hnida C, Cruger DG et al. Nuclei size in relation to nuclear status and aneuploidy rate for 13 chromosomes in donated four cells embryos. J. Assist. Reprod. Genet.25, 95–102 (2008).
  • Beuchat A, Thevenaz P, Unser M et al. Quantitative morphometrical characterization of human pronuclear zygotes. Hum. Reprod.23(9), 1983–1992 (2008).
  • Neuber E, Mahutte NG, Arici A, Sakkas D. Sequential embryo assessment outperforms investigator-driven morphological assessment at selecting a good quality blastocyst. Fertil. Steril.85(3), 794–796 (2006).
  • Mio Y. Morphological analysis of human embryonic development using time-lapse cinematography. J. Mamm. Ova. Res.23, 27–35 (2006).
  • Mio Y, Maeda K. Time-lapse cinematography of dynamic changes occurring during in vitro development of human embryos. Am. J. Obstet. Gynecol.199, 660 e1–e5 (2008).
  • Mio Y. The beginning of human life under time-lapse cinematography. Periodicum Biologorum111(3), 323–327 (2009).
  • Nakahara T, Iwase A, Goto M et al. Evaluation of the safety of time-lapse observations for human embryos. J. Assist. Reprod. Genet.27, 93–96 (2010).
  • ASEBIR 2008. Cuadernos de embriología clínica. In: Criterios ASEBIR de valoración morfológica de oocitos, embriones tempranos y blastocistos humanos (2° Ed). Asociación para el Estudio de la Biología de la Reproducción (ASEBIR), Madrid, Spain (2008).
  • Montag M, Liebenthron J, Koster M. Which morphological system is relevant in human embryo development? Placenta32, S252–S256 (2011).
  • Fancsovits P, Toth L, Takacs ZF, Murber A, Papp Z, Urbancsek J. Early pronuclear breakdown is a good indicator of embryo quality and viability. Fertil. Steril.84, 881–887 (2005).
  • Milki AA, Hinckley M, Fisch J, Dasig D, Behr B. Comparison of blastocyst transfer with day 3 embryo transfer in similar patient populations. Fertil. Steril.73, 126–129 (2000).
  • Gardner DK, Schoolcraft WB, Wagley L, Schlenker T, Stevens J, Hesla J. A prospective randomized trial of blastocyst culture and transfer in in vitro fertilization. Hum. Reprod.13, 3434–3440 (1998).
  • Marek D, Langley M, Gardner DK, Confer N, Doody KM, Doody KJ. Introduction of blastocyst culture and transfer for all patients in an in vitro fertilization program. Fertil. Steril.73, 1035–1040 (1999).
  • Coskun S, Hollanders J, Al-Hassan S, Al-Sufyan H, Al-Mayman H, Jaroudi K. Day 5 versus day 3 embryo transfer: a controlled randomized trial. Hum. Reprod.15, 1947–1952 (2000).
  • Huisman GJ, Fauser BC, Eijkemans MJ, Pieters MH. Implantation rates after in vitro fertilization and transfer of a maximum of two embryos that have undergone three to five days in culture. Fertil. Steril.73, 117–122 (2000).
  • Scott L, Alvero R, Leondires M, Miller B. Morphology of human pronuclear embryo is positively related to blasotcyst development. Hum. Reprod.15, 2394–2403 (2000).
  • Tesarik J, Greco E. The probability of abnormal preimplantation development can be predicted by a single static observation on pronuclear stage morphology. Hum. Reprod.14, 1318–1323 (1999).
  • Nagy ZP, Janssenswillen C, Janssesns R et al. Timing of oocyte activation, pronucleus formation, and cleavage in humans after intracytoplasmic sperm injection (ICSI) with testicular spermatozoa and after ICSI or in vitro fertilization on sibling oocytes with ejaculated spermatozoa. Hum. Reprod.13, 1060–1612 (1998).
  • Capmany G, Taylor A, Braude PR, Bolton VN. Timing of pronuclear formation, DNA synthesis and cleavage in the human 1-cell embryo. Mol. Hum. Reprod.2, 299–306 (1996).
  • Cummings JM, Breen TM, Harrison KL, Shaw JM, Wilson LM, Hennessey JF. A formula for scoring human embryo growth rates in in vitro fertilization: its values in predicting pregnancy and in comparison with visual estimates of embryo quality. J. In Vitro Fert. Embryo Transf.3, 284–295 (1986).
  • ALPHA Scientists In Reproductive Medicine, ESHRE Special Interest Group Embryology. The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Hum. Reprod.26(6), 1270–1283 (2011).

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