431
Views
0
CrossRef citations to date
0
Altmetric
Editorial

Age-related macular degeneration: the protective effects of omega-3 fatty acids as anti-inflammatory agents

Pages 1-4 | Published online: 09 Jan 2014

References

  • Smith TC, Lee L. Age related macular degeneration – new developments in treatment. Aust. Fam. Physician36, 359–361 (2007).
  • Augustin AJ, Kirchhof J. Inflammation and the pathogenesis of age-related macular degeneration. Expert Opin. Ther. Targets13, 641–651 (2009).
  • Ding X, Patel M, Chan CC. Molecular pathology of age-related macular degeneration. Prog. Retin. Eye Res.28, 1–18 (2008).
  • Ross RJ, Verma V, Rosenberg KI, Chan CC, Tuo J. Genetic markers and biomarkers for age-related macular degeneration. Expert Rev. Ophthalmol.2(3), 443–457 (2007).
  • Ethen CM, Reilly C, Feng X, Olsen TW, Ferrington DA. The proteome of central and peripheral retina with progression of age-related macular degeneration. Invest. Ophthalmol. Vis. Sci.47, 2280–2290 (2006).
  • Hageman GS, Anderson DH, Johnson LV et al. A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc. Natl Acad. Sci. USA102, 7227–7232 (2005).
  • Dastgheib K, Green WR. Granulomatous reaction to Bruch’s membrane in age-related macular degeneration. Arch. Ophthalmol.112, 813–818 (1994).
  • Green WR. Histopathology of age-related macular degeneration. Mol. Vis.5, 27–36 (1999).
  • Gupta N, Brown KE, Milam AH. Activated microglia in human retinitis pigmentosa, late-onset retinal degeneration, and age-related macular degeneration. Exp. Eye Res.76, 463–471 (2003).
  • Hollyfield JG, Bonilha VL, Rayborn ME et al. Oxidative damage-induced inflammation initiates age-related macular degeneration. Nat. Med.14, 194–198 (2008).
  • Takeda A, Baffi JZ, Kleinman ME et al. CCR3 is a target for age-related macular degeneration diagnosis and therapy. Nature460, 225–230 (2009).
  • Tuo J, Bojanowski CM, Zhou M et al. Murine Ccl2/Cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration. Invest. Ophthalmol. Vis. Sci.48, 3827–3836 (2007).
  • Chan CC, Ross RJ, Shen D et al. Ccl2/Cx3cr1-deficient mice: an animal model for age-related macular degeneration. Ophthalmic Res.40, 124–128 (2008).
  • Ross RJ, Zhou M, Shen D et al. Immunological protein expression profile in Ccl2/Cx3cr1 deficient mice with lesions similar to age-related macular degeneration. Exp. Eye Res.86, 675–683 (2008).
  • Seddon JM, George S, Rosner B. Cigarette smoking, fish consumption, omega-3 fatty acid intake, and associations with age-related macular degeneration: the US Twin Study of Age-Related Macular Degeneration. Arch. Ophthalmol.124, 995–1001 (2006).
  • Seddon JM, Rosner B, Sperduto RD et al. Dietary fat and risk for advanced age-related macular degeneration. Arch. Ophthalmol.119, 1191–1199 (2001).
  • Cho E, Hung S, Willett WC et al. Prospective study of dietary fat and the risk of age-related macular degeneration. Am. J. Clin. Nutr.73, 209–218 (2001).
  • Sangiovanni JP, Chew EY. The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina. Prog. Retin. Eye Res.24, 87–138 (2005).
  • Hodge WG, Barnes D, Schachter HM et al. Evidence for the effect of omega-3 fatty acids on progression of age-related macular degeneration: a systematic review. Retina27, 216–221 (2007).
  • Sangiovanni JP, Chew EY, Clemons TE et al. The relationship of dietary lipid intake and age-related macular degeneration in a case–control study: AREDS Report No. 20. Arch. Ophthalmol.125, 671–679 (2007).
  • Sangiovanni JP, Agrón E, Meleth AD et al. Omega-3 long-chain polyunsaturated fatty acid intake and 12-y incidence of neovascular age-related macular degeneration and central geographic atrophy: a prospective cohort study from the Age-Related Eye Disease Study. Am. J. Clin. Nutr.90(6), 1601–1607 (2009).
  • Sangiovanni JP, Agrón E, Clemons TE, Chew EY. Omega-3 long-chain polyunsaturated fatty acid intake inversely associated with 12-year progression to advanced age-related macular degeneration. Arch. Ophthalmol.127, 110–112 (2009).
  • Kang ZB, Ge Y, Chen Z et al. Adenoviral gene transfer of Caenorhabditis elegans n-3 fatty acid desaturase optimizes fatty acid composition in mammalian cells. Proc. Natl Acad. Sci. USA98, 4050–4054 (2001).
  • Fetterman JW Jr, Zdanowicz MM. Therapeutic potential of n-3 polyunsaturated fatty acids in disease. Am. J. Health Syst. Pharm.66, 1169–1179 (2009).
  • Bazan NG. Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection. Curr. Opin. Clin. Nutr. Metab. Care10, 136–141 (2007).
  • Bazan NG. Neurotrophins induce neuroprotective signaling in the retinal pigment epithelial cell by activating the synthesis of the anti-inflammatory and anti-apoptotic neuroprotectin D1. Adv. Exp. Med. Biol.613, 39–44 (2008).
  • Endres S, Ghorbani R, Kelley VE et al. The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N. Engl. J. Med.320, 265–271 (1989).
  • Bouwens M, van de Rest O, Dellschaft N et al. Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells. Am. J. Clin. Nutr.90, 415–424 (2009).
  • Tuo J, Ross RJ, Herzlich AA et al. A high omega-3 fatty acid diet reduces retinal lesions in a murine model of macular degeneration. Am. J. Pathol.175, 799–807 (2009).
  • Seki H, Tani Y, Arita M. Omega-3 PUFA derived anti-inflammatory lipid mediator resolvin E1. Prostaglandins Other Lipid Mediat.89, 126–130 (2009).
  • Connor KM, Sangiovanni JP, Lofqvist C et al. Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis. Nat. Med.13, 868–873 (2007).
  • Schwab JM, Chiang N, Arita M, Serhan CN. Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature447, 869–874 (2007).
  • Delcourt C. Application of nutrigenomics in eye health. Forum Nutr.60, 168–175 (2007).
  • Sangiovanni JP, Mehta S, Mehta S. Variation in lipid-associated genes as they relate to risk of advanced age-related macular degeneration. World Rev. Nutr. Diet99, 105–158 (2009).
  • Bojanowski CM, Shen D, Chew EY et al. An apolipoprotein E variant may protect against age-related macular degeneration through cytokine regulation. Environ. Mol. Mutagen.47, 594–602 (2006).
  • Klein ML, Francis PJ, Rosner B et al. CFH and LOC387715/ARMS2 genotypes and treatment with antioxidants and zinc for age-related macular degeneration. Ophthalmology115, 1019–1025 (2008).
  • Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, β carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch. Ophthalmol.119, 1417–1436 (2001).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.