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Editorial

Stem cell therapy for blindness: new developments and implications for the future

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Pages 1-3 | Published online: 09 Jan 2014

References

  • Okita K, Hong H, Takahashi K et al. Generation of mouse-induced pluripotent stem cells with plasmid vectors. Nat. Protocol.5, 418–428 (2010).
  • Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell126(4), 663–676 (2006).
  • Osakada F, Ikeda H, Mandai M et al. Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells. Nat. Biotechnol.26, 215–224 (2008).
  • Resnikoff S, Pascolini D, Etya’ale D et al. Global data on visual impairment in the year 2002. Bull. World Health Organ.82, 844–851 (2004).
  • Bainbridge JW, Smith AJ, Barker SS et al. Effect of gene therapy on visual function in Leber’s congenital amaurosis. N. Engl. J. Med.358, 2231–2239 (2008).
  • Maguire AM, Simonelli F, Pierce EA et al. Safety and efficacy of gene transfer for Leber’s congenital amaurosis. N. Engl. J. Med.358, 2240–2248 (2008).
  • Cideciyan AV, Aleman TS, Boye SL et al. Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics. Proc. Natl Acad. Sci. USA105, 15112–15117 (2008).
  • Coles BL, Angenieux B, Inoue T et al. Facile isolation and the characterization of human retinal stem cells. Proc. Natl Acad. Sci. USA101, 15772–15777 (2004).
  • Cicero SA, Johnson D, Reyntjens S et al. Cells previously identified as retinal stem cells are pigmented ciliary epithelial cells. Proc. Natl Acad. Sci. USA106, 6685–6690 (2009).
  • Gualdoni S, Baron M, Lakowski J et al. Adult ciliary epithelial cells, previously identified as retinal stem cells with potential for retinal repair, fail to differentiate into new rod photoreceptors. Stem Cell28, 1048–1059 (2010).
  • Tropepe V, Coles BL, Chiasson BJ et al. Retinal stem cells in the adult mammalian eye. Science287, 2032–2036 (2000).
  • Meyer JS, Shearer RL, Capowski EE et al. Modeling early retinal development with human embryonic and induced pluripotent stem cells. Proc. Natl Acad. Sci. USA106, 16698–16703 (2009).
  • Lamba DA, Karl MO, Ware CB et al. Efficient generation of retinal progenitor cells from human embryonic stem cells. Proc. Natl Acad. Sci. USA103, 12769–12774 (2006).
  • MacLaren RE, Pearson RA, MacNeil A et al. Retinal repair by transplantation of photoreceptor precursors. Nature444, 203–207 (2006).
  • Pearson RA, Barber AC, West EL et al. Targeted disruption of outer limiting membrane junctional proteins (Crb1 and ZO-1) increases integration of transplanted photoreceptor precursors into the adult wild-type and degenerating retina. Cell Transpl.19, 487–503 (2010).
  • West EL, Pearson RA, Barker SE et al. Long-term survival of photoreceptors transplanted into the adult murine neural retina requires immune modulation. Stem Cell28, 1997–2007 (2010).
  • Lakowski J, Baron M, Bainbridge J et al. Cone and rod photoreceptor transplantation in models of the childhood retinopathy Leber congenital amaurosis using flow-sorted Crx-positive donor cells. Hum. Mol. Genet.19, 4545–4559 (2010).
  • Lamba DA, Gust J, Reh TA. Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in Crx-deficient mice. Cell Stem Cell4, 73–79 (2009).
  • Carr AJ, Vugler AA, Hikita ST et al. Protective effects of human iPS-derived retinal pigment epithelium cell transplantation in the retinal dystrophic rat. PloS One4, e8152 (2009).
  • Lu B, Malcuit C, Wang S et al. Long-term safety and function of RPE from human embryonic stem cells in preclinical models of macular degeneration. Stem Cell27, 2126–2135 (2009).

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