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Expert Review of Ophthalmology Volume 8, 2013 - Issue 2
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Perspective

Is antibiotic resistance a problem in the treatment of ophthalmic infections?

Regis P Kowalski Department of Ophthalmology, Charles T Campbell Ophthalmic Microbiology Laboratory, The Eye and Ear Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA. [email protected]
Pages 119-126 | Published online: 09 Jan 2014

References

  • Clinical and Laboratory Standards. Methods for Dilution Antimicrobials Susceptibility Tests for Bacteria That Grow Aerobically. Approved Standard (8th Edition). Clinical and Laboratory Standards Institute, PA, USA. Document M07-A8, Volume 29, No. 2 (2009).
  • Clinical and Laboratory Standards. Performance standards for antimicrobial disk susceptibility tests. Approved Standard (10th Edition). Clinical and Laboratory Standards Institute, PA, USA. Document M02-A10, volume 29, No. 1 (2009).
  • Kowalski RP, Yates KA, Romanowski EG, Karenchak LM, Mah FS, Gordon YJ. An ophthalmologist’s guide to understanding antibiotic susceptibility and minimum inhibitory concentration data. Ophthalmology 112(11), 1987 (2005).
  • Romanowski EG, Mah FS, Yates KA, Kowalski RP, Gordon YJ. The successful treatment of gatifloxacin-resistant Staphylococcus aureus keratitis with Zymar (gatifloxacin 0.3%) in a NZW rabbit model. Am. J. Ophthalmol. 139(5), 867–877 (2005).
  • Kowalski RP, Romanowski EG, Mah FS, Sasaki H, Fukuda M, Gordon YJ. A comparison of moxifloxacin and levofloxacin topical prophylaxis in a fluoroquinolone-resistant Staphylococcus aureus rabbit model. Jpn. J. Ophthalmol. 52(3), 211–216 (2008).
  • Kowalski RP, Romanowski EG, Mah FS, Shanks RM, Gordon YJ. Topical levofloxacin 1.5% overcomes in vitro resistance in rabbit keratitis models. Acta Ophthalmol. 88(4), e120–e125 (2010).
  • Major JC Jr, Engelbert M, Flynn HW Jr, Miller D, Smiddy WE, Davis JL. Staphylococcus aureus endophthalmitis: antibiotic susceptibilities, methicillin resistance, and clinical outcomes. Am. J. Ophthalmol. 149(2), 278–283.e1 (2010).
  • Miller D, Flynn PM, Scott IU, Alfonso EC, Flynn HW Jr. In vitro fluoroquinolone resistance in staphylococcal endophthalmitis isolates. Arch. Ophthalmol. 124(4), 479–483 (2006).
  • Asbell PA, Sahm DF, Shaw M et al. Increasing prevalence of methicillin resistance in serious ocular infection caused by Staphylococcus in the United States: 2000 to 2005. J. Cataract Refract. Surg. 34(5), 814–818 (2008).
  • Fintelmann RE, Hoskins EN, Lietman TM et al. Topical fluoroquinolone use as a risk factor for in vitro fluoroquinolone resistance in ocular cultures. Arch. Ophthalmol. 129(4), 399–402 (2011).
  • Kim SJ, Toma HS. Antimicrobial resistance and ophthalmic antibiotics: 1-year results of a longitudinal controlled study of patients undergoing intravitreal injections. Arch. Ophthalmol. 129(9), 1180–1188 (2011).
  • Hwang DG. Does resistance arise from topical ophthalmic antibiotic use. Topics in Ocular Antiinfectives 29, 4–7 (2012).
  • Mather R, Karenchak LM, Romanowski EG, Kowalski RP. Fourth generation fluoroquinolones: new weapons in the arsenal of ophthalmic antibiotics. Am. J. Ophthalmol. 133(4), 463–466 (2002).
  • Kowalski RP, Dhaliwal DK, Karenchak LM et al. Gatifloxacin and moxifloxacin: an in vitro susceptibility comparison to levofloxacin, ciprofloxacin, and ofloxacin using bacterial keratitis isolates. Am. J. Ophthalmol. 136(3), 500–505 (2003).
  • Kowalski RP, Pandya AN, Karenchak LM et al. An in vitro resistance study of levofloxacin, ciprofloxacin, and ofloxacin using keratitis isolates of Staphylococcus aureus and Pseudomonas aeruginosa. Ophthalmology 108(10), 1826–1829 (2001).
  • Rarey KA, Shanks RM, Romanowski EG, Mah FS, Kowalski RP. Staphylococcus aureus isolated from endophthalmitis are hospital-acquired based on Panton–Valentine leukocidin and antibiotic susceptibility testing. J. Ocul. Pharmacol. Ther. 28(1), 12–16 (2012).
  • Wu EC, Kowalski RP, Romanowski EG, Mah FS, Gordon YJ, Shanks RM. AzaSite® inhibits Staphylococcus aureus and coagulase-negative Staphylococcus biofilm formation in vitro. J. Ocul. Pharmacol. Ther. 26(6), 557–562 (2010).
  • Wingard JB, Romanowski EG, Kowalski RP et al. A novel cell-associated protection assay demonstrates the ability of certain antibiotics to protect ocular surface cell lines from subsequent clinical Staphylococcus aureus challenge. Antimicrob. Agents Chemother. 55(8), 3788–3794 (2011).
  • Bower KS, Kowalski RP, Gordon YJ. Fluoroquinolones in the treatment of bacterial keratitis. Am. J. Ophthalmol. 121(6), 712–715 (1996).
  • Goldstein MH, Kowalski RP, Gordon YJ. Emerging fluoroquinolone resistance in bacterial keratitis: a 5-year review. Ophthalmology 106(7), 1313–1318 (1999).
  • Garg P, Sharma S, Rao GN. Ciprofloxacin-resistant Pseudomonas keratitis. Ophthalmology 106(7), 1319–1323 (1999).
  • Chaudhry NA, Flynn HW Jr, Murray TG, Tabandeh H, Mello MO Jr, Miller D. Emerging ciprofloxacin-resistant Pseudomonas aeruginosa. Am. J. Ophthalmol. 128(4), 509–510 (1999).
  • Rhee MK, Kowalski RP, Romanowski EG, Mah FS, Ritterband DC, Gordon YJ. A laboratory evaluation of antibiotic therapy for ciprofloxacin-resistant Pseudomonas aeruginosa. Am. J. Ophthalmol. 138(2), 226–230 (2004).
  • Kowalski RP, Kowalski TA, Shanks RM, Romanowski EG, Karenchak LM, Mah FS. In vitro comparison of combination and monotherapy for the empiric and optimal coverage of bacterial keratitis based on incidence of infection. Cornea (2012) (In Press).

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